CN103071109B - Traditional Chinese medicinal composition for treating hyperlipidemia - Google Patents
Traditional Chinese medicinal composition for treating hyperlipidemia Download PDFInfo
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- CN103071109B CN103071109B CN201210544979.XA CN201210544979A CN103071109B CN 103071109 B CN103071109 B CN 103071109B CN 201210544979 A CN201210544979 A CN 201210544979A CN 103071109 B CN103071109 B CN 103071109B
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Abstract
The invention provides a traditional Chinese medicinal composition for treating hyperlipidemia. Hovenia acerba Lindl. is used as a monarch medicine, and has the efficacies of spleen invigorating, phlegm reducing and blood stasis eliminating; Radish Seed, haw and Acorus gramineus are used as minister medicines, assist the phlegm reducing and blood stasis eliminating of the monarch medicine, and simultaneously refresh the spleen to avoid the source for the phlegm generation; and Rhizoma Alismatis and Artemisia capillaries are used as assistant medicines, and assist the qi moving and blood stasis eliminating of the monarch medicine and the minister medicines. The combination of the above medicines has the efficacies of spleen invigorating, dampness dispelling, phlegm reducing, qi moving, blood circulation promoting and blood stasis eliminating. The invigorated spleen and stomach can realize water dampness and body fluid elimination, no generation of turbid phlegm, non-static qi movement and smooth blood circulation. Clinic tests show that the formula of the traditional Chinese medicinal composition is scientific and reasonable, accords with the theory of the traditional Chinese medical science, and is supported by the modern medical technology. The traditional Chinese medicinal composition has a reliable curative effect on the hyperlipidemia, has no adverse respond, and can be accepted by general hyperlipidemia patients. The total effective rate of the traditional Chinese medicinal composition on the treatment of the hyperlipidemia is 89.2%, so the traditional Chinese medicinal composition is an effective medicine for treating the hyperlipidemia.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine composition for the treatment of hyperlipemia.
Background technology
Hyperlipemia is also often called dyslipidemia, generally refer to T-CHOL in blood (TC), LDL-C (LDL-C), triglyceride (TG) overrun and (or) highdensity lipoprotein-cholesterol (HDL-C) is low, mainly refer to TC or (with) LDL-C or (with) TG increases.In recent years, cardiovascular and cerebrovascular disease is one of primary killers becoming human health, and hyperlipemia (HLP) is the important risk factor that it occurs, and therefore effectively prevents and treats HLP and has great significance.Lipid modulating not only can prevention of arterial sclerosis, also can alleviate or avoid the sickness rate of coronary heart disease, apoplexy, therefore how anti-curing hyperlipemia, has become one of focus that society pays close attention to most.At present, doctor trained in Western medicine aspect has many lipid lowerers, but its side effect is troubling, long-term taking Western medicine particularly drug combination time, the incidence rate of untoward reaction obviously increases, and after drug withdrawal, blood fat easily rebounds.Along with to the modern research of Chinese medicine, (Wang Ziwang, Han Yan, Lin Chuanxu, the Chinese traditional treatment status and prospects of hyperlipemia western Chinese medicine the 24th volume the 8th phase in 2011) Chinese medicine hyperlipemia truly has outstanding and distinctive feature, and determined curative effect, side effect are little.
Hyperlipemia is common clinical, frequently-occurring disease, according to clinical characters, belongs to the traditional Chinese medical science " phlegm syndrome ", " blood stasis " category.Expectorant is turbid, the formation of blood stasis is a general, gradual pathological process.Polydipsia is addicted to food delicious food savoury, and water paddy is superfluous, do not change angry hemospermia micro-and raw be phlegm-damp; Feelings will is not smooth, the liver failing to maintain the normal flow of QI, and transverse invasion of hyperactive liver-QI violates spleen, and transporting and transforming function of the spleen and stomach mistake department forms phlegm-damp; Aged debility, asthenia of essence and blood, blood vessels are unfavorable, and blood is slow and the hyperamization arteries and veins stasis of blood is stagnant, the turbid cohesion of expectorant." by expectorant to the stasis of blood, the expectorant stasis of blood is with sick ".Visible, formation and the expectorant of hyperlipemia are turbid, blood stasis is closely related.
Summary of the invention
In order to the Chinese medicine of abundant treatment hyperlipemia, the invention provides a kind of Chinese medicine composition for the treatment of hyperlipemia.No matter be that diet delicious food savoury, feelings will are smooth, phlegm-damp is interior raw, or worn with age, stagnation of QI-blood, poly-precise and tiny in become person in cream fat, all can reduce phlegm with a kind of Chinese medicine composition dehumidifying for the treatment of hyperlipemia provided by the invention, circulation of qi promoting repercussive is to adjust fat." expectorant " and " stasis of blood " both have substantial connection, general expectorant is turbid be born in before, after blood stasis is formed in, " General Treatise on the Cause and Symptoms of Diseases phlegm retention sick duke or princess under an emperor " meaning: " all expectorant persons, this is jammed by blood vessels, and drinking-water gathers and do not dissipate, therefore becomes expectorant also." expectorant causes the stasis of blood, the stasis of blood causes expectorant, and both reciprocal causations, transform each other, is cementingly difficult to resolve, therefore the touching difficulty of primary disease is more.
A kind of Chinese medicine composition for the treatment of hyperlipemia provided by the invention, composition and the mass ratio of its formula are as follows: the mass ratio of Semen Hoveniae (Fructus Hoveniae), Semen Raphani, Fructus Crataegi, Rhizoma Acori Graminei, Rhizoma Alismatis, Herba Artemisiae Scopariae and Radix Curcumae is 3:2:3:2:3:2:2.
Semen Hoveniae (Fructus Hoveniae), has invigorating spleen to remove dampness, the effect of Removing Blood Stasis.By observing Semen Hoveniae (Fructus Hoveniae) decocting liquid to the impact of the content of T-CHOL in rat blood serum (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), HDL-C (HDL-C).Learn that Semen Hoveniae (Fructus Hoveniae) decocting liquid can reduce Hyperlipemia model rat serum TC, TG, LDL-C concentration, have the concentration raising Hyperlipemia model rat Serum HDL-C, prompting Semen Hoveniae (Fructus Hoveniae) has obvious effect for reducing fat.Therefore, with its be monarch drug spleen invigorating, reduce phlegm, repercussive.
Semen Raphani, help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Compendium of Material Medica says that it " is controlled expectorant, help digestion ", and normal and Fructus Crataegi is same to be used.Fructus Crataegi, promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis, has the merit that removing food stagnancyization is stagnant, particularly digests the key medicine of greasy meat stagnation, has the merit of current QI and blood blood circulation promoting and blood stasis dispelling simultaneously.Compendium of Material Medica says that " dissipating fluid-retention is eaten for it.The meat that disappears amasss ... phlegm retention ... ".Modern pharmacological research shows that Fructus Crataegi contains lipase, can promote steatolysis, reduces organ cholesterinosis, has the effect of blood fat reducing.Rhizoma Acori Graminei, has removing dampness turbid, the effect of appetizing of being amusing, and " Bencao Congxin " is sayed its " by expectorant removing food stagnancy, appetizing alleviating distention in middle-JIAO ".Take three as ministerial drug, principal drug assistance dissipating phlegm and eliminating blood stasis, is amusing the source of producing phlegm of shutting out simultaneously.
Rhizoma Alismatis, promoting diuresis to eliminate damp pathogen.Compendium of Material Medica says that it can " row phlegm retention ".Modern pharmacological research shows that it has blood sugar lowering, also has lipotropic effect.
Herba Artemisiae Scopariae, dampness removing, outstanding kind clear sharp taste damp, with the two for adjuvant drug, principal drug assistance, ministerial drug reduce phlegm dampness removing.Radix Curcumae, blood-activating and qi-promoting.Radix Curcumae can be invigorated blood circulation, again can promoting QI circulation for relieving depression, the capable then blood of gas, with it for adjuvant drug, and principal drug assistance, ministerial drug regulating qi to disperse stagnation.
A kind of Chinese medicine composition scientific formula for the treatment of hyperlipemia provided by the invention is reasonable.The strong then water of the taste body fluid that wets must be changed, and the turbid not life of expectorant, the not stagnant then blood of mechanism of qi is unobstructed, and all medicines share, and spleen invigorating, damp eliminating are reduced phlegm, the merit of circulation of qi promoting, blood circulation promoting and blood stasis dispelling.Both meet theory of Chinese medical science, have again the support of modern medical techniques.
A kind of Chinese medicine composition for the treatment of hyperlipemia provided by the invention, adopts prior art to make granule.
Instructions of taking is as follows: by 1 dose particles agent medicine, pour in container, warm water 300mL, stirs and makes it abundant mixing, day 2 times, early sub-service in 30 minutes after ante cibum, supper, every day 1 dose.1 dosage is as embodiment 1.1 course for the treatment of of treatment time is 8 weeks.
Taboo: this Chinese medicine composition allergy sufferers is forbidden.
criterion of therapeutical effect and therapeutic outcome:by " new Chinese medicine guideline of clinical investigations (trying) " (Beijing: China Medical Science Press, 2002,88-89), it is as follows to determine criterion of therapeutical effect:
Recovery from illness: clinic control blood fat indices recovers normal.
Effective: TC decline >=20%, TG decline >=40%, HDL-C rising >=0.26mmol/L.
Effective: TC declines >=10%, but <20%; TG declines >=20%, but <40%; HDL-C raises >=0.104 mmol/L, but <0.26 mmol/L.
Invalid: lipids detection does not reach above-mentioned standard.
treatment case and therapeutic effect statistics:according to mentioned above principle, use Drug therapy hyperlipidemia patient 120 of the present invention example, wherein, man 62 example, female 58 example; 30 ~ 65 years old age.Treat 8 weeks, after 1 course for the treatment of, recovery from illness 23 example, man 13 example, female 10 example, cure rate is 19.2%; Effective 32 examples, man 17 example, female 15 example, obvious effective rate is 26.7%; Effective 52 examples, man 25 example, female 27 example, effective percentage is 43.3%; Invalid 13 examples, man 7 example, female 6 example, inefficiency is 10.8%.
Total effective rate is cure rate+cure-remarkable-effectiveness rate+effective percentage, and total effective rate is 89.2%.
1 course for the treatment of of treatment time of therapeutic effect statistics is 8 weeks.
beneficial effect:a kind of Chinese medicine composition for the treatment of hyperlipemia provided by the invention, Semen Hoveniae (Fructus Hoveniae) is monarch drug spleen invigorating, reduce phlegm, repercussive.Semen Raphani, Fructus Crataegi, Rhizoma Acori Graminei, be ministerial drug, principal drug assistance dissipating phlegm and eliminating blood stasis, is amusing the source of producing phlegm of shutting out simultaneously.Rhizoma Alismatis, Herba Artemisiae Scopariae is adjuvant drug, principal drug assistance, ministerial drug regulating qi to disperse stagnation.All medicines share, and spleen invigorating, damp eliminating are reduced phlegm, circulation of qi promoting, blood circulation promoting and blood stasis dispelling.The strong then water of the taste body fluid that wets must be changed, and the turbid not life of expectorant, the not stagnant then blood of mechanism of qi is unobstructed.Clinical observation shows, treatment hyperlipemia curative effect is reliable, and has no adverse reaction, and can be accepted by vast hyperlipidemia patient, and clinic is promoted.A kind of total effective rate for the treatment of hyperlipemia Chinese medicine composition provided by the invention is 89.2%.It is a kind of active drug being used for the treatment of hyperlipemia.
Detailed description of the invention
embodiment 1treat a Chinese medicine composition for hyperlipemia, composition and the mass ratio of its formula are as follows: Semen Hoveniae (Fructus Hoveniae) 15g, Semen Raphani 10g, Fructus Crataegi 15g, Rhizoma Acori Graminei 10g, Rhizoma Alismatis 15g, Herba Artemisiae Scopariae 10g and Radix Curcumae 10g.
Treat a Chinese medicine composition for hyperlipemia, adopt prior art to make granule.
Instructions of taking is as follows: by the granules medicine of above-mentioned 1 dosage, pour in container, warm water 300mL, stirs and makes it abundant mixing, day 2 times, early sub-service in 30 minutes after ante cibum, supper, every day 1 dose.1 course for the treatment of of treatment time is 8 weeks.
Taboo: this Chinese medicine composition allergy sufferers is forbidden.
criterion of therapeutical effect and therapeutic outcome:by " new Chinese medicine guideline of clinical investigations (trying) " (Beijing: China Medical Science Press, 2002,88-89), it is as follows to determine criterion of therapeutical effect:
Recovery from illness: clinic control blood fat indices recovers normal.
Effective: TC decline >=20%, TG decline >=40%, HDL-C rising >=0.26mmol/L.
Effective: TC declines >=10%, but <20%; TG declines >=20%, but <40%; HDL-C raises >=0.104 mmol/L, but <0.26 mmol/L.
Invalid: lipids detection does not reach above-mentioned standard.
Claims (2)
1. treat a Chinese medicine composition for hyperlipemia, it is characterized in that, composition and the mass ratio of its formula are as follows: the mass ratio of Semen Hoveniae (Fructus Hoveniae), Semen Raphani, Fructus Crataegi, Rhizoma Acori Graminei, Rhizoma Alismatis, Herba Artemisiae Scopariae and Radix Curcumae is 3:2:3:2:3:2:2.
2. the Chinese medicine composition for the treatment of hyperlipemia as claimed in claim 1, it is characterized in that, composition and the quality of its formula are as follows: Semen Hoveniae (Fructus Hoveniae) 15g, Semen Raphani 10g, Fructus Crataegi 15g, Rhizoma Acori Graminei 10g, Rhizoma Alismatis 15g, Herba Artemisiae Scopariae 10g and Radix Curcumae 10g
.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804173A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating dyspepsia and preparation method thereof |
| CN102233119A (en) * | 2010-05-08 | 2011-11-09 | 博安兄弟制药（中国）有限公司 | Traditional Chinese medicine composition for treating fatty liver and preparation method thereof |
| CN102698199A (en) * | 2012-06-15 | 2012-10-03 | 仲崇琳 | Traditional Chinese medicine composition for treating alcoholic hepatitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102233119A (en) * | 2010-05-08 | 2011-11-09 | 博安兄弟制药（中国）有限公司 | Traditional Chinese medicine composition for treating fatty liver and preparation method thereof |
| CN101804173A (en) * | 2010-05-28 | 2010-08-18 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating dyspepsia and preparation method thereof |
| CN102698199A (en) * | 2012-06-15 | 2012-10-03 | 仲崇琳 | Traditional Chinese medicine composition for treating alcoholic hepatitis |
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