CN202654265U - Three-dimensional composite bionic nerve conduit - Google Patents
Three-dimensional composite bionic nerve conduit Download PDFInfo
- Publication number
- CN202654265U CN202654265U CN 201220359512 CN201220359512U CN202654265U CN 202654265 U CN202654265 U CN 202654265U CN 201220359512 CN201220359512 CN 201220359512 CN 201220359512 U CN201220359512 U CN 201220359512U CN 202654265 U CN202654265 U CN 202654265U
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- conduit
- nerve
- dimensional composite
- outer tube
- composite bionic
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Abstract
The utility model discloses a three-dimensional composite bionic nerve conduit and provides an internal fixing material which is used for repairing peripheral nerve defects and made of high polymer materials of poly(lactic-co-glycolic acid) (PLGA) and the like. The three-dimensional composite bionic nerve conduit comprises a group of conduits, the conduits are in different sizes and composed of one conduit outer tube and a plurality of conduit inner tubes, the conduit inner tubes are arranged in the conduit outer tube, and micro capsules are distributed on the inner and outer walls of the conduit inner tubes and the inner wall of the conduit outer tube. The three-dimensional composite bionic nerve conduit has the advantages that the mechanical property and the biocompatibility are good, the biotoxicity is absent, the natural degradation is achieved, the fixing is simple, convenient and firm, motion and feeling ectopia occurring rate caused by nerve repairing is reduced, the neurotrophy can be continuously provided, the repairing for the nerve defect is accelerated, the prognosis effect of the nerve repairing is improved, compared with prior methods of suturing, transplantation and the like, the three-dimensional composite bionic nerve conduit is simple and convenient to operate, and the operation time and trauma are reduced.
Description
Technical field
This utility model relates to medical instruments field, is specially the internal fixation material that is used for repairing peripheral nerve defection that the macromolecular material such as a kind of PLGA of employing is made.
Background technology
Peripheral nerve injury is a kind of more common disease, refers to that peripheral nerve is done or its branch is subject to extraneous directly or indirectly strength effect and the damage that occurs, can cause neurologic defect when serious.Typical case's performance after the damage: the dyskinesia, sensory disturbance and dysautonomia.Common peripheral nerve injury has: brachia plexus injury, injury of radial nerve, radial nerve injury, median nerve injury, injury of tibial nerve, common peroneal nerve injury etc.The reparation of nerve injury is relevant with many factors, but the research from present medical circle, the reparation of nerve injury is one and exists the various problems such as time length, poor prognosis than stubborn problem, even part peripheral nerve injury, fracture, damagedly can't repair at all.
The restorative procedure of neurologic defect is mainly suture in situ (repairing effect is poor), the nerve autograft (difficulty of drawing materials at present, and can cause the position neurologic defect of drawing materials), neural substitute transplants several methods such as (showing after deliberation poor effect), all there are various pros and cons in above several method, present international research mainly concentrates on and utilizes nerve trachea to substitute nerve autograft, utilize neural chemotaxis, nerve tract specificity, assist neural broken ends of fractured bone growth with conduit, but the effective technology that also is not similar to is announced at home and abroad.
The utility model content
The technical problem that this utility model solves is to provide a kind of three-dimensional composite bionic nerve trachea, to solve the shortcoming in the above-mentioned background technology.
The technical problem that this utility model solves realizes by the following technical solutions:
Three-dimensional composite bionic nerve trachea, comprise one group of conduit, conduit varies, be respectively a conduit outer tube and some conduit inner tubes, the conduit inner tube is arranged in the conduit outer tube, on the inwall of the inside and outside wall of conduit inner tube and conduit outer tube, be distributed with microcapsule, wherein, the material of conduit is the PLGA(Poly(D,L-lactide-co-glycolide, poly (lactic-co-glycolic acid)), the material of microcapsule is PLGA, in be provided with the BDNF(Brain Derived Neurotrophic Factor, brain derived neurophic factor) and NT-3(nerve growth factor-3, Neurotrophic-3).
The arrangement out of shape of described conduit outer tube and conduit inner tube is three-dimensional out of shape consistent with biological nerve tract, has avoided motion, sensation dystopy due to neural beam tube can not accurately dock in neural reparation the previously, can effectively guarantee neural beam tube end-the end original position is identical.
The tube wall of described conduit is provided with the fine pore, allows the material of nerve tract growth needs to pass through, and also is distributed with nerve growth factor (NGF) and schwann cell on the tube wall simultaneously, and schwann cell is by bone marrow stroma stem cell inducing culture gained.
In this utility model, the specification of described conduit can be adjusted according to actual nerve and nerve tract diameter, enables to fit tightly with the damaged neural broken ends of fractured bone.
Beneficial effect: but this utility model mechanical property is good, good biocompatibility, inanimate object toxicity natural degradation, fixing easy firmly, reduce after neural the reparation due to incidence rate, and the sustainable neurotrophy that provides of motion, sensation dystopy, accelerated the reparation of neurologic defect, promote neural prognosis effect of repairing, more easier than the operation of the methods such as stitching previously, transplanting, reduced operating time and wound.
Description of drawings
Fig. 1 is the cross section structure sketch map of this utility model preferred embodiment.
Fig. 2 is the cutaway view of this utility model preferred embodiment.
The specific embodiment
For technological means, creation characteristic that this utility model is realized, reach purpose and effect is easy to understand, below in conjunction with concrete diagram, further set forth this utility model.
Referring to the three-dimensional composite bionic nerve trachea of Fig. 1, comprise a conduit outer tube and nine conduit inner tubes, the conduit inner tube is arranged in the conduit outer tube, and arranging of conduit outer tube and conduit inner tube is out of shape substantially according to the three-dimensional traveling arrangement of biological neural interior neural beam tube.
Three-dimensional composite bionic nerve trachea described in the utility model can be produced in batches by metal die.
This utility model mechanical structure is stable, applies down without external force to keep own shape, and no matter pipe diameter size all can guarantee uniform form, keeps the as seen unobstructed of pipeline.
Rear visible interior conduit fixation non-loosening is opened in this utility model rip cutting, and is inner noiseless, can effectively reduce the adhesion of neural beam tube.
In this utility model manufacture process, by the processing of special process, make tube wall have certain hole (0.20-0.35mm), extraneous oxygen, nutrient substance are entered, accelerate nerve growth, and pass conduit can avoid the nerve tract growth time.
Added nerve growth factor in this utility model, contained the controllable sustained-release microcapsule (shown in Figure 2) of nerve growth factor, the schwann cell of in vitro cultivation is distributed on the tube wall of nerve trachea, accelerate neuranagenesis speed and provide lasting nutrition for the nerve reparation.
When using this utility model, first this utility model is deposited under the room temperature in the vacuum sterilization container, different according to the neurologic defect position, select suitable operative approach to cut skin, chorista, muscle etc., manifest injured nerve, the injured nerve broken ends of fractured bone is slightly pruned, select the three-dimensional composite bionic nerve trachea of suitable types, the neural near-end broken ends of fractured bone is accessed three-dimensional composite bionic nerve trachea one side, the far-end broken ends of fractured bone is accessed three-dimensional composite bionic nerve trachea opposite side, the affirmation applying is closely seamless (can use biological adhesive afterwards in case of necessity, pressurization, the methods such as stitching are assisted fixing) the cleaning otch, reset, suture muscles, soft tissues etc., last skin suture is finished operation.
More than show and described ultimate principle of the present utility model, principal character and advantage of the present utility model.The technical staff of the industry should understand; this utility model is not restricted to the described embodiments; that describes in above-described embodiment and the description just illustrates principle of the present utility model; under the prerequisite that does not break away from this utility model spirit and scope; this utility model also has various changes and modifications, and these changes and improvements all fall in claimed this utility model scope.The claimed scope of this utility model is defined by appending claims and equivalent thereof
Claims (2)
1. three-dimensional composite bionic nerve trachea is characterized in that, comprises one group of conduit, conduit varies, be respectively a conduit outer tube and some conduit inner tubes, the conduit inner tube is arranged in the conduit outer tube, on the inwall of the inside and outside wall of conduit inner tube and conduit outer tube, be distributed with microcapsule, wherein, the material of conduit is PLGA, and the material of microcapsule is PLGA, in be provided with BDNF and NT-3, the arrangement out of shape of described conduit outer tube and conduit inner tube is three-dimensional out of shape consistent with biological nerve tract.
2. three-dimensional composite bionic nerve trachea according to claim 1 is characterized in that the tube wall of described conduit is provided with the fine pore, also is distributed with nerve growth factor and schwann cell on the tube wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220359512 CN202654265U (en) | 2012-07-24 | 2012-07-24 | Three-dimensional composite bionic nerve conduit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220359512 CN202654265U (en) | 2012-07-24 | 2012-07-24 | Three-dimensional composite bionic nerve conduit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202654265U true CN202654265U (en) | 2013-01-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220359512 Expired - Fee Related CN202654265U (en) | 2012-07-24 | 2012-07-24 | Three-dimensional composite bionic nerve conduit |
Country Status (1)
| Country | Link |
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| CN (1) | CN202654265U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215241A (en) * | 2016-08-24 | 2016-12-14 | 浙江省人民医院 | A kind of nerve trachea based on multiclass cell 3D printing and preparation method thereof |
-
2012
- 2012-07-24 CN CN 201220359512 patent/CN202654265U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215241A (en) * | 2016-08-24 | 2016-12-14 | 浙江省人民医院 | A kind of nerve trachea based on multiclass cell 3D printing and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130109 Termination date: 20150724 |
|
| EXPY | Termination of patent right or utility model |