CN202369590U - Equipment for preparing composite calcium bilirubinate by using fermented ox bile - Google Patents
Equipment for preparing composite calcium bilirubinate by using fermented ox bile Download PDFInfo
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- CN202369590U CN202369590U CN 201120535625 CN201120535625U CN202369590U CN 202369590 U CN202369590 U CN 202369590U CN 201120535625 CN201120535625 CN 201120535625 CN 201120535625 U CN201120535625 U CN 201120535625U CN 202369590 U CN202369590 U CN 202369590U
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
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Abstract
The utility model discloses equipment for preparing composite calcium bilirubinate by using fermented ox bile. The equipment comprises a fermentation tank, a metering tank, a liquid preparation tank and a filter, wherein the metering tank is connected with the liquid preparation tank, and the liquid preparation tank is connected with the fermentation tank through a milk pump; the fermentation tank is provided with an acid and alkali inlet, a steam inlet/outlet, a cooling water inlet/outlet and a compressed air inlet; a temperature probe and a pH probe are arranged in the fermentation tank, and the temperature probe and the pH probe are connected with a master controller through signal wires; and the filter is connected with the bottom of the fermentation tank, and the other end of the filter is connected with a mixer through the milk pump. Through the equipment, integrated operation of fermentation and salt preparation is realized, risks of impure bacteria pollution are reduced, and the production efficiency is greatly improved.
Description
Technical field
The utility model relates to a kind of equipment that utilizes the fermentation oxgall to prepare compound calcium bilirubinate.
Prior art
Calculus Bovis is a cow-bezoar, is precious Chinese medicinal materials.2000, organize the scientific research personnel on the basis of ZL89100505.6 patent of invention by Wuhan Dapeng Pharmaceutical Industry Co., Ltd, according to nineteen ninety version " the Chinese pharmacopoeia requirement has been developed a kind of new for the external method for preparing Calculus Bovis of ox.This method had both adapted to the large-scale production requirement, and the product of producing can satisfy new " Chinese pharmacopoeia requirement again.And declared patent (application number 01133550.5) in calendar year 2001.This method is single bacterium liquid or its composite bacterial solution that adds a certain amount of intestinal bacteria, faecalis, Bacillus proteus at natural oxgall, natural oxgall is carried out fermentation using bacteria handle.Utilize fermentation oxgall and the saturated calcium salt soln of clarification to produce the throw out of effective ingredient again, according to behind medicinal requirements adding an amount of UCB, cholic acid, Deoxycholic Acid and the inorganic salt, make compound calcium bilirubinate then.Utilize compound calcium bilirubinate and fermentation oxgall at the extracorporeal culture Calculus Bovis again.
Compound calcium bilirubinate is the main composition of In vitro cultured Calculus Bovis; The production efficiency of compound calcium bilirubinate has directly determined the output of In vitro cultured Calculus Bovis; Existing compound calcium bilirubinate production unit is made up of fermentor tank, dissolving vessel, Agitation Tank mostly, after fermenting, is transferred to carry out the complex salt operation in the Agitation Tank.Fermentation separates with subsequent disposal and to carry out in the prior art, and material shifts and bothers, and process is loaded down with trivial details, takes longlyer, is unfavorable for boosting productivity.In the transfer process, effective ingredient is prone to be destroyed in the fermented liquid, and fermented liquid is lossy.PH, temperature are not controlled automatically in the fermenting process yet, in the process of MC PH, complicated operation; The risk that pollutes is very big; Carry out dosing when operation in the Agitation Tank, need constantly open the Agitation Tank lid and observe liquid level, and can not guarantee the accuracy of measuring fully.
Summary of the invention
The utility model is the automatic monitoring to fermenting process, and realizes fermentation and the integrated operation of complex salt, need not the transfer process of material; Prevented the destruction of effective ingredient in the fermented liquid; Fermentation realizes control automatically, has reduced the risk of living contaminants, has improved production efficiency greatly.
A kind of equipment that utilizes the fermentation oxgall to prepare compound calcium bilirubinate comprises fermentor tank, test tank, Agitation Tank, and test tank links to each other with Agitation Tank, and Agitation Tank links to each other with fermentor tank through the milk roc;
Soda acid inlet, steam import and export, cooling water intakeoutfall and compressed air inlet are installed on the fermentor tank, and temp probe and pH probe are equipped with in inside, and temp probe is connected with principal controller through SW with the pH probe;
Comprise that also strainer links to each other with the fermentor tank bottom, the strainer the other end links to each other through milk pump with mixing machine.
Test tank is the tank structure with exact scale, and the eyepiece that can observe liquid level position is equipped with in the tank body left side, but the Real Time Observation liquid level position, and Stainless Steel Cloth is equipped with in the Agitation Tank bottom, can filter out insoluble composition in the quicklime, links to each other with fermentor tank through milk pump.Tank body top has the good opening of stopping property.
Fermentor tank is connected to pressurized air, steam, water coolant, and temperature, PH probe are equipped with in inside, link to each other with principal controller through SW; On image display, show temperature, pH value in the fermentor tank in real time, through its inner program that loads, when temperature, when PH departs from setting range; Open or close sour import, the alkali import on fermentor tank top, the size of water coolant; Make temperature, PH in setting range, the fermentor tank bottom is connected to strainer, and five metafiltration nets are housed in the strainer; With pressurized air the intravital liquid of jar is pressed in the strainer calcium salt that leaching produces during filtration.
Mixing machine is through linking to each other with strainer by milk pump, and valve is equipped with in the mixing machine bottom can directly put Stainless Steel Disc with compound calcium bilirubinate, changes in the refrigerated tank again.
Description of drawings
Fig. 1 utilizes the fermentation oxgall to prepare the device structure synoptic diagram of compound calcium bilirubinate.
Among the figure: 1---unit, 2---fermentor tank, 3---Agitation Tank, 4---test tank; The 5---mixing machine, 6---strainer, 7---soda acid inlet, 8---temp probe; The 9---pH probe, 10---vapour inlet, 11---cooling water outlet, 12---vapor outlet port; The 13---cooling water inlet, 14, the 16---milk pump, the 15---compressed air inlet.
Embodiment
Below in conjunction with specific embodiment the utility model is further specified.
A kind of equipment that utilizes the fermentation oxgall to prepare compound calcium bilirubinate comprises fermentor tank 2, test tank 4, Agitation Tank 3, and test tank 4 links to each other with Agitation Tank 3, and Agitation Tank 3 links to each other with fermentor tank 2 through milk pump 14;
Be equipped with on the fermentor tank 2 that soda acid inlet 7, steam import and export 10,12, cooling water intakeoutfall 13,12 and compressed air inlet 15, temp probe 8 and pH probe 9 are equipped with in inside, and temp probe 8 and pH pop one's head in and 9 be connected with unit 1 through SW;
Comprise that also strainer 6 links to each other with fermentor tank 2 bottoms, strainer 6 the other ends link to each other through milk pump 16 with mixing machine 5.
Can know that by the equipment synoptic diagram production work flow process is following:
The first step: extract natural oxgall in fermentor tank, in unit, set suitable PH, rotating speed, temperature, ferment (48 hours).Accurately measure purified water with test tank, the clarifying saturated calcium oxide solution of preparation adds oxidation inhibitor, mixing in Agitation Tank; Beat valve, start milk pump with in the saturated calcium oxide solution suction fermentor tank, valve-off is opened steam valve; Be warmed up to 80 ℃, be incubated 30 minutes, valve-off; Open the pressurized air valve, mixed solution is pressed in the strainer filters, collect reddish brown precipitation.
Second step: add purified water in right amount with in the reddish brown precipitation thing suspension liquid suction mixing machine, fully stir, remove supernatant after leaving standstill, add UCB to its content and reach requirement, add zinc sulfate, sal epsom etc. again, stirring, mixing,
The 3rd step: the compound calcium bilirubinate that will prepare is put into the freezing case, and freezing changing over to afterwards carried out vacuum-drying in the vacuum drying oven.
Claims (3)
1. an equipment that utilizes the fermentation oxgall to prepare compound calcium bilirubinate comprises fermentor tank (2), test tank (4), Agitation Tank (3), and test tank (4) links to each other with Agitation Tank (3), and Agitation Tank (3) links to each other with fermentor tank (2) through milk pump (14);
Soda acid inlet (7), steam import and export (10 are installed on the fermentor tank (2); 12), cooling water intakeoutfall (13; 12) and compressed air inlet (15), temp probe (8) and pH probe (9) are equipped with in inside, temp probe (8) and pH pop one's head in (9) be connected with unit (1) through SW;
Comprise that also strainer (6) links to each other with fermentor tank (2) bottom, strainer (6) the other end links to each other through milk pump (16) with mixing machine (5).
2. equipment according to claim 1 is characterized in that, the eyepiece that can observe liquid level is equipped with in test tank tank body left side.
3. equipment according to claim 1 is characterized in that, Stainless Steel Cloth is equipped with in the Agitation Tank bottom, and top has the good opening of stopping property.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120535625 CN202369590U (en) | 2011-12-20 | 2011-12-20 | Equipment for preparing composite calcium bilirubinate by using fermented ox bile |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120535625 CN202369590U (en) | 2011-12-20 | 2011-12-20 | Equipment for preparing composite calcium bilirubinate by using fermented ox bile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202369590U true CN202369590U (en) | 2012-08-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201120535625 Expired - Lifetime CN202369590U (en) | 2011-12-20 | 2011-12-20 | Equipment for preparing composite calcium bilirubinate by using fermented ox bile |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202369590U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104774885A (en) * | 2015-04-24 | 2015-07-15 | 武汉健民大鹏药业有限公司 | Method for extracting bilirubin from ox bile by using fermentation process |
| CN111635849A (en) * | 2020-05-14 | 2020-09-08 | 浙江兰博生物科技股份有限公司 | Novel fermentation device |
-
2011
- 2011-12-20 CN CN 201120535625 patent/CN202369590U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104774885A (en) * | 2015-04-24 | 2015-07-15 | 武汉健民大鹏药业有限公司 | Method for extracting bilirubin from ox bile by using fermentation process |
| CN104774885B (en) * | 2015-04-24 | 2018-11-09 | 武汉健民大鹏药业有限公司 | A method of bilirubin being extracted from fel bovis using fermentation method |
| CN111635849A (en) * | 2020-05-14 | 2020-09-08 | 浙江兰博生物科技股份有限公司 | Novel fermentation device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20120808 |