CN202198976U - Multifunctional intracranial tumor mesenchyme radiotherapy and chemotherapy pump - Google Patents

Multifunctional intracranial tumor mesenchyme radiotherapy and chemotherapy pump Download PDF

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Publication number
CN202198976U
CN202198976U CN2011202036550U CN201120203655U CN202198976U CN 202198976 U CN202198976 U CN 202198976U CN 2011202036550 U CN2011202036550 U CN 2011202036550U CN 201120203655 U CN201120203655 U CN 201120203655U CN 202198976 U CN202198976 U CN 202198976U
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China
Prior art keywords
tumor
pump
drugs
chemotherapy
multifunctional
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Expired - Fee Related
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CN2011202036550U
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Chinese (zh)
Inventor
张磊
屈延
费舟
刘文博
惠浩
苏宁
王凯
梁景文
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Fourth Military Medical University FMMU
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Fourth Military Medical University FMMU
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Priority to CN2011202036550U priority Critical patent/CN202198976U/en
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Abstract

The utility model discloses a multifunctional intracranial tumor mesenchyme radiotherapy and chemotherapy pump which consists of bifurcated tubes (2 and 3) at the tumor cavity end and double-lumen balloons (4 and 5) at the subcutaneous end, wherein the bifurcated tubes (2 and 3) are connected by a double-cavity tube 1. The multifunctional intracranial tumor mesenchyme radiotherapy and chemotherapy pump is characterized in that the bifurcated tubes (2 and 3) at the tumor cavity end are two elliptical tubes; micro pores 6 are distributed on each tube; a balloon formed by the double-lumen balloons (4 and 5) with different heights and different shapes is arranged at the subcutaneous end; and a gasket 7 is arranged at the bottom of a balloon pump. A combined tube 1 is used for connecting the bifurcated tubes (2 and 3) and the double-lumen balloons (4 and 5) at the two ends and transporting liquid medicine; the bifurcated tubes (2 and 3) at the tumor cavity end are respectively used for containing endovascular radiation drugs and chemotherapy drugs; the balloon 4 at the subcutaneous end is used for injecting the endovascular radiation drugs; the balloon 5 is used for injecting the chemotherapy drugs; and the gasket 7 is used for preventing the exosmosis of the drugs. The multifunctional intracranial tumor mesenchyme radiotherapy and chemotherapy pump not only can slowly, simply, uniformly and efficiently release the drugs into a tumor cavity to achieve the purpose of simultaneously performing combined endovascular radiation and chemotherapy drug therapy, but also can repeatedly delivery the drugs and keep a certain drug concentration within the tumor cavity for a long time, thereby having the significances in ensuring the treatment safety while guaranteeing the life quality of a patient and prolonging the survival time, reducing the economic burden of the patient, reducing the workload of medical personnel and the like. Through document retrieval performed by an applicant, the similar device has not been provided.

Description

Mesenchyma stroma of tumors chemicotherapy pump in a kind of multifunctional skull
Technical field
This utility model belongs to the clinical treatment auxiliary device, relates to the multifunctional treating apparatus of a kind of patients with intracranial tumor radiotherapy, chemotherapy combined, is specifically related to mesenchyma stroma of tumors chemicotherapy pump in a kind of multifunctional skull.
Background technology
In recent years, the intracranial tumor sickness rate is in rising trend, and according to statistics, intracranial tumor accounts for 5% of general tumour; Account for 70% of pediatric tumor, and other malignant tumor finally has 20-30% and changes intracranial over to, because its expansible infiltrative growth; When in a single day intracranial occupies certain space,, intracranial pressure is raise no matter its character is optimum or pernicious; The compressing cerebral tissue causes the nervus centralis infringement, jeopardizes patient's life.The comprehensive treatment that intracranial tumor, particularly cerebral glioma, meningioma etc. are good at present, malignant tumor adopts operative treatment, radiotherapy, chemotherapy and immunization therapy to combine more is improved the quality of living with this, prolongs life span.But because a lot of intracranial tumor does not have complete peplos, be infiltrative growth, operation, Minimally Invasive Surgerys such as particularly present popular guarantor's function can not excise it fully, and postoperative often has recurrence, and surgery alone is treated only 6 months mean survival time (MST).But not the radiotherapy of operation, methods such as chemotherapy and immune drug treatment have become the main treatment means of intracranial tumor postoperative.But because there is this road obstacle of blood brain barrier (BBB) in cerebral tissue, cause usual administered through oral or intravenous medicine effectively to penetrate, cause the intracerebral lesion place not have the effect that enough medicine performances kill and wound residual cell.The therapeutic effect extreme difference if strengthen the increase that drug dose can cause toxic and side effects again, reduces patient's quality of life greatly.Though the appearance of novel chemotherapeutics such as temozolomide, addressing the above problem to a certain degree, it costs an arm and a leg, and the cost course of treatment surpasses 10000 yuan, and strict indication is arranged, and these have all greatly limited it and have applied.
To the problems referred to above; Scientist studies from different angles such as administering mode, method and approach; Found the chemotherapy of mesenchyma stroma method of intracranial tumor local application, this method can make medicine be distribution of specific at tumor by local, long action time; Effectively kill oncocyte, and little to the toxic and side effects of normal structure.Simultaneously, it can also avoid blood brain barrier, reduces the toxic and side effects of systemic administration, improves the drug level of tumor by local, reaches the intracranial tumor excellent curative.And the realization of this method mainly relies on various pharmaceutical carriers or apparatus that the tumor intracavity is placed; Like gelfoam, biogum and medicine gelled block etc., the most frequently used pharmaceutical carrier or aid are the Ommaya pumps, can satisfy the demand of above-mentioned chemotherapy of mesenchyma stroma basically; But still there are a lot of problems: at first; The tumor chamber end of Ommaya pump has only 1 opening, once can only slowly discharge a kind of medicine, comprehensive treatments such as radiation and chemotherapy in can't realizing carrying out simultaneously; Secondly, the tumor chamber end of Ommaya pump only is a single tube opening, and medicinal liquid can only accumulate in the low-lying place in pipe outlet or tumor chamber, can't evenly discharge by regulating medicine the performance curative effect; Once more, the pump of the subcutaneous end of Ommaya pump all is that rubber is processed, and syringe needle is first-class to penetrate pump easily, and causes the medicinal liquid seepage, causes serious consequences such as tissue allergy, necrosis; At last, the Ommaya pump costs an arm and a leg, and each price is at 5000-10000 yuan, and is suitable with novel chemotherapeutics price, and the cost performance that seems is not high, a lot of unable burdens of patient.
Therefore, if can invent a kind ofly can put simultaneously, chemotherapy and good reproducibility, high-efficiency low-toxicity, cost performance high energy raising patient's toleration and the interior mesenchyma stroma of tumors chemicotherapy pump of the multifunctional skull of quality of life, be that this area medical personnel are desired.
Summary of the invention
For overcoming the defective or the deficiency of the treatment measure that above-mentioned prior art exists, the purpose of this utility model is, mesenchyma stroma of tumors chemicotherapy pump in a kind of multifunctional skull is provided, in the hope of reach the intracranial tumor postoperative can carry out simultaneously in purposes such as radiation and chemotherapy.
In order to realize above-mentioned task, the present invention takes following solution:
Mesenchyma stroma of tumors chemicotherapy pump in a kind of multifunctional skull comprises a pump, and pump is made up of the tumor chamber end bifurcated pipe of a double lumen tube connection and the two-chamber capsule of subcutaneous end, it is characterized in that the bifurcated pipe of tumor chamber end is made up of two oval pipes, is covered with micropore on the pipe; Subcutaneous end is two capsules that highly inconsistent, different chamber is formed, and pad is arranged at the bottom of pump.
Other characteristics of this utility model are:
Described double lumen tube is processed by organic rubber;
Described bifurcated pipe is processed by organic rubber;
Described two-chamber capsule is processed by organic rubber;
Described pad is processed by lucite;
Two chambers of the two-chamber capsule of said subcutaneous end, square chamber height is high, and circular chamber is highly low.
Mesenchyma stroma of tumors chemicotherapy pump in the multifunctional skull of this utility model; Be applied to patient's tumor intracavity at the glioma postoperative; Can slow release, easy, all the even medicine that discharges efficiently is in the tumor intracavity; Reach the purpose of carrying out interior radiation and chemicals therapeutic alliance simultaneously, and repeatable administration, can keep certain drug level at the tumor intracavity for a long time; Guarantee the treatment safety at the assurance patients ' life quality with when prolonging life span, it is all significant to alleviate patient economy burden and minimizing medical personnel workload etc.Through the literature search that the applicant did, also do not see similar similar installation.
Description of drawings
Fig. 1 is the structural representation of this utility model;
Below in conjunction with accompanying drawing this utility model is done further detailed description.
The specific embodiment
Referring to accompanying drawing 1; Present embodiment provides mesenchyma stroma of tumors chemicotherapy pump in a kind of multifunctional skull; Comprise a pump; Pump is made up of the tumor chamber end bifurcated pipe (2,3) of a double lumen tube 1 connection and the two-chamber capsule (4,5) of subcutaneous end, and the bifurcated pipe of tumor chamber end is made up of two oval pipes, is covered with micropore 6 on the pipe; Subcutaneous end is two two-chamber capsules (4,5) that highly inconsistent, different chamber is formed, and pad 7 is arranged at the bottom of pump.Double lumen tube 1 is used to connect capsule and the bifurcated pipe and the transportation medicinal liquid at two ends; Radiopharmaceuticals and chemotherapeutics in the bifurcated pipe of tumor chamber end (2,3) holds respectively; The capsule 4 of subcutaneous end is used to inject interior radiopharmaceuticals, and capsule 5 is used to inject chemotherapeutics, and pad 7 prevents drug extravasation.
Uniting pipe 1 is processed by organic rubber; Bifurcated pipe (2,3) is processed by organic rubber; Two-chamber capsule (4,5) is processed by organic rubber; Pad 7 is processed by lucite.
During use, the bifurcated pipe (2,3) of tumor chamber end is put into the tumor intracavity, medicine oozes out from micropore 6; Close cranial cavity; After adjustment double lumen tube 1 length, after being fixed in the preceding or ear of ear after the two-chamber capsule (4,5) of subcutaneous end is connected, be used to inject interior radiopharmaceuticals to capsule 4 respectively; Capsule 5 is used to inject chemotherapeutics, sew up wound then.After the first treatment end course of treatment, when beginning for second course of treatment, with of capsule 4 injections of interior radiopharmaceuticals, with capsule 5 injections of chemotherapeutics from the low circular chamber of the height of subcutaneous end from the high square chamber of subcutaneous end height.The pad 7 that lucite is processed can prevent that entry needle from penetrating the capsule pump.

Claims (5)

1. mesenchyma stroma of tumors chemicotherapy pump in the multifunctional skull; Comprise a pump; Pump is made up of the tumor chamber end bifurcated pipe (2,3) of a double lumen tube (1) connection and the two-chamber capsule (4,5) of subcutaneous end; It is characterized in that the bifurcated pipe of tumor chamber end (2,3) is made up of two oval pipes, is covered with micropore (6) on the pipe; Subcutaneous end is two two-chamber capsules (4,5) that highly inconsistent, different chamber is formed, and pad (7) is arranged at the bottom of pump.
2. mesenchyma stroma of tumors chemicotherapy pump in the multifunctional skull as claimed in claim 1 is characterized in that described double lumen tube (1) is processed by organic rubber.
3. mesenchyma stroma of tumors chemicotherapy pump in the multifunctional skull as claimed in claim 1 is characterized in that described bifurcated pipe (2,3) is processed by organic rubber.
4. mesenchyma stroma of tumors chemicotherapy pump in the multifunctional skull as claimed in claim 1 is characterized in that described two-chamber capsule (4,5) is processed by organic rubber.
5. mesenchyma stroma of tumors chemicotherapy pump in the multifunctional skull as claimed in claim 1 is characterized in that described pad (7) is processed by lucite.
CN2011202036550U 2011-06-16 2011-06-16 Multifunctional intracranial tumor mesenchyme radiotherapy and chemotherapy pump Expired - Fee Related CN202198976U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2011202036550U CN202198976U (en) 2011-06-16 2011-06-16 Multifunctional intracranial tumor mesenchyme radiotherapy and chemotherapy pump

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011202036550U CN202198976U (en) 2011-06-16 2011-06-16 Multifunctional intracranial tumor mesenchyme radiotherapy and chemotherapy pump

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CN202198976U true CN202198976U (en) 2012-04-25

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107174755A (en) * 2017-05-23 2017-09-19 哈尔滨医科大学 Encephalic Radiotherapy chemotherapy one two-chamber primary and secondary capsule

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107174755A (en) * 2017-05-23 2017-09-19 哈尔滨医科大学 Encephalic Radiotherapy chemotherapy one two-chamber primary and secondary capsule

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C14 Grant of patent or utility model
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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120425

Termination date: 20180616

CF01 Termination of patent right due to non-payment of annual fee