CN108578883A - A kind of the cell transplantation pipe and its application method of via intranasal application administration - Google Patents
A kind of the cell transplantation pipe and its application method of via intranasal application administration Download PDFInfo
- Publication number
- CN108578883A CN108578883A CN201810214817.7A CN201810214817A CN108578883A CN 108578883 A CN108578883 A CN 108578883A CN 201810214817 A CN201810214817 A CN 201810214817A CN 108578883 A CN108578883 A CN 108578883A
- Authority
- CN
- China
- Prior art keywords
- cell transplantation
- pipe
- transplanting
- via intranasal
- intranasal application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002054 transplantation Methods 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title claims abstract description 8
- 210000003928 nasal cavity Anatomy 0.000 claims abstract description 19
- 210000000196 olfactory nerve Anatomy 0.000 claims abstract description 10
- 210000002850 nasal mucosa Anatomy 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims description 6
- 210000003128 head Anatomy 0.000 claims description 4
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 7
- 210000003169 central nervous system Anatomy 0.000 abstract description 3
- 230000006378 damage Effects 0.000 abstract description 3
- 230000000472 traumatic effect Effects 0.000 abstract description 2
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 208000014644 Brain disease Diseases 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000005553 drilling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009593 lumbar puncture Methods 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000007472 neurodevelopment Effects 0.000 description 1
- 230000001272 neurogenic effect Effects 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/09—Body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The cell transplantation pipe and its application method being administered the invention discloses a kind of via intranasal application include the transplanting pipe fitting being connected to syringe and transplant cells into the transplanting hose in the schneiderian membrane area of enrichment olfactory nerve below deep nasal cavity sieve plate；One end of the described transplanting hose is connecting pin, and the connecting pin and grafts fittings are simultaneously integrally formed；The other end of the transplanting hose is intervention end, and the intervention end round end structure is provided with dosing holes on the side wall for intervening 2 4mm of end；From outside to inside, the diameter in section is gradually reduced the dosing holes.The present invention aims at cell administration design, and technical solution has the advantages that：For entering the cell transplantation of central nervous system, via intranasal application administering mode compares traditional traumatic administering mode, can mitigate patient suffering, reduce the damage of patient, to reduce the risk of patient；Cell transplantation pipe can go deep into nasal cavity, and when administration can reduce drug loss, improve the efficiency of nasal-cavity administration；The internal diameter of cell transplantation pipe is small, and drug loss is small, suitable for cell nasal-cavity administration and other need the drug of low dosage nasal-cavity administration.
Description
Technical field
The present invention relates to a kind of cell transplantation pipe, the cell transplantation pipe and its application method of specially a kind of nasal-cavity administration,
Belong to the field of medical instrument technology.
Background technology
Cell transplantation plays a significant role in neurodevelopment and reparation damaged nerve tissue.Cell transplantation is reparation and generation
For the effective ways of injured cerebral tissue, partial loop and function can be rebuild, for treatment neurodegenerative disease and nervous centralis
System injury disease has important clinical meaning.
Cell transplantation at present enters central nervous system, and there are mainly two types of modes：Lumbar puncture subarachnoid injection and head
Portion's the former wound of drilling injection is small, the time is short, therapeutic domain is extensive, but still has certain operation difficulty and risk；；The latter is in head
It pushes up and bores one to two apertures on skull, then transplant cells into brain tissue, operation difficulty and risk are larger.
Blood-brain barrier be drug through it is peripherally administered enter brain treat the main bottleneck of central disease, especially treat brain
The cell products of disease.It is located at the neurogenic disease of brain for therapeutic purpose, head drilling injection is of high cost, has wound, side
Method is cumbersome, has security risk.
Nasal cavity is the cell administration approach of more suitable brain diseases, and the schneiderian membrane area below deep nasal cavity sieve plate is rich in
Olfactory nerve, cell aggregation partly can enter nervous system through olfactory nerve in the schneiderian membrane area rich in olfactory nerve across sieve plate.
Cell products are different from conventional medicament, and how to improve operational efficiency and administering effect is a significant challenge.
Currently, not aiming at the medical device product of cell administration design in the world.
Invention content
It is existing to solve the purpose of the invention is to provide a kind of the cell transplantation pipe and its application method of via intranasal application administration
There is the above problem of technology.
A kind of cell transplantation pipe of via intranasal application administration includes the transplanting pipe fitting being connected to syringe and is transplanted cells into
The transplanting hose in the schneiderian membrane area of enrichment olfactory nerve below deep nasal cavity sieve plate；One end of the transplanting hose is connecting pin,
The connecting pin and grafts fittings are simultaneously integrally formed；The other end of the transplanting hose is intervention end, Jie
Enter to hold round end structure, dosing holes are provided on the side wall of distance intervention end 2-4mm；The dosing holes from outside to inside, section
Diameter be gradually reduced.
The maximum a diameter of 0.1-6mm, preferably 3mm of the dosing holes；A diameter of 0.1-3mm at minimum, it is excellent
Choosing is 0.5mm.
The length of the transplanting hose is 30-100mm, preferably 55mm；Outer diameter is 1-5mm, preferably 2mm；
Internal diameter is 0.1-3mm, preferably 0.5mm.
The internal diameter of the transplanting pipe fitting is 4-6mm, preferably 4.5mm.
The cell transplantation tube material is one kind of medical macromolecular materials, preferably medical polyurethane.
The transplanting hose answers surface smooth, slightly soft, stimulates nasal cavity small.
Can be provided on the outer wall of the transplanting pipe fitting it is several play it is anti-skidding, reinforce and it is easy to use the effects that
Transformation, be such as provided with convex stupefied.
The application method of the cell transplantation pipe of above-mentioned via intranasal application administration, step are：
(1), cell transplantation catheter packaging is opened；
(2), transplanting pipe fitting is connected on syringe；
(3), the nose that syringe inner cell is injected to enrichment olfactory nerve below deep nasal cavity sieve plate by transplanting hose glues
Film area；
(4), operation is completed, and takes out cell transplantation pipe.
Technical solution of the present invention has the advantages that：
1, for entering the cell transplantation of central nervous system, via intranasal application administering mode traumatic gives prescription compared to traditional
Formula can mitigate patient suffering, reduce the damage of patient, to reduce the risk of patient；
2, cell transplantation pipe can go deep into nasal cavity and go directly target area, and when administration can reduce drug loss, improve nose
The efficiency of chamber administration；
3, the internal diameter of cell transplantation pipe is small, and drug loss is small, suitable for cell nasal-cavity administration and other need low dosage
The drug of nasal-cavity administration.
Description of the drawings
Fig. 1 is the structural diagram of the present invention；
Fig. 2 is the A-A of Fig. 1 to part section structural representation；
In figure, 1, transplanting pipe fitting 2, transplanting hose 3, dosing holes.
Specific implementation mode
Below in conjunction with the accompanying drawings with the specific embodiment technical characterstic that the present invention is further explained.
A kind of cell transplantation pipe of via intranasal application administration as shown in Figure 1, include the transplanting pipe fitting 1 being connected to syringe and
Transplant cells into the transplanting hose 2 in the schneiderian membrane area of enrichment olfactory nerve below deep nasal cavity sieve plate；The transplanting hose 2
One end is connecting pin, and the connecting pin is connected to and is integrally formed with transplanting pipe fitting 1；The other end of the transplanting hose 2 is
End is intervened, the intervention end round end structure is provided with dosing holes 3 on the side wall for intervening end 3mm；The dosing holes 3
From outside to inside, the diameter in section is gradually reduced.
The a diameter of 3mm of maximum of the dosing holes 3；A diameter of 0.5mm at minimum.
The length of the transplanting hose 2 is 55mm, outer diameter 2mm, internal diameter 0.5mm, wall thickness 0.75mm.
The internal diameter of the transplanting pipe fitting 1 is 4.5mm.
2 material of transplanting hose is medical polyurethane.
It is provided on the outer wall of the transplanting pipe fitting 1 convex stupefied.
In use, opening cell transplantation catheter packaging；Transplanting pipe fitting is connected on syringe；By syringe inner cell
The schneiderian membrane area of enrichment olfactory nerve below deep nasal cavity sieve plate is injected to by transplanting hose；Operation is completed, and cell transplantation is taken out
Pipe.
Claims (12)
1. a kind of cell transplantation pipe of via intranasal application administration, it is characterised in that：Include the transplanting pipe fitting being connected to syringe and general
Cell is transplanted to the transplanting hose in the schneiderian membrane area of enrichment olfactory nerve below deep nasal cavity sieve plate；One end of the transplanting hose
For connecting pin, the connecting pin and grafts fittings are simultaneously integrally formed；The other end of the transplanting hose is intervention end,
The intervention end is round end structure, and dosing holes are provided on the side wall of distance intervention end 2-4mm；The dosing holes by outer and
Interior, the diameter in section is gradually reduced.
2. a kind of cell transplantation pipe of via intranasal application administration according to claim 1, it is characterised in that：It is characterized in that：Institute
The a diameter of 0.1-6mm of maximum for the dosing holes stated；A diameter of 0.1-3mm at minimum.
3. a kind of cell transplantation pipe of via intranasal application administration according to claim 2, it is characterised in that：It is characterized in that：Institute
The a diameter of 3mm of maximum for the dosing holes stated；A diameter of 0.5mm at minimum.
4. a kind of cell transplantation pipe of via intranasal application administration according to claim 1, it is characterised in that：The grafts are soft
The length of pipe is 30-100mm；Outer diameter is 1-5mm；Internal diameter is 0.1-3mm.
5. a kind of cell transplantation pipe of via intranasal application administration according to claim 4, it is characterised in that：The grafts are soft
The length of pipe is 55mm；Outer diameter is 2mm；Internal diameter is 0.5mm.
6. a kind of cell transplantation pipe of via intranasal application administration according to claim 1, it is characterised in that：The grafts connect
The internal diameter of head is 4-6mm.
7. a kind of cell transplantation pipe of via intranasal application administration according to claim 6, it is characterised in that：The grafts connect
The internal diameter of head is 4.5mm.
8. a kind of cell transplantation pipe of via intranasal application administration according to claim 1, it is characterised in that：The cell transplantation
Tube material is one kind of medical macromolecular materials.
9. a kind of cell transplantation pipe of via intranasal application administration according to claim 8, it is characterised in that：The cell transplantation
Tube material is medical polyurethane.
10. a kind of cell transplantation pipe of via intranasal application administration according to claim 1, it is characterised in that：The nasal cavity moves
It is smooth to plant pipe hose surface.
11. a kind of cell transplantation pipe of via intranasal application administration according to claim 1, it is characterised in that：The delivery tube
It is provided on the outer wall of connector convex stupefied.
The application method of the cell transplantation pipe of the via intranasal application administration described in 12. claim 1-11 is one of arbitrary, it is characterised in that：
Its step is：
(1), cell transplantation catheter packaging is opened；
(2), transplanting pipe fitting is connected on syringe；
(3), syringe inner cell is injected to the schneiderian membrane area of enrichment olfactory nerve below deep nasal cavity sieve plate by transplanting hose；
(4), operation is completed, and takes out cell transplantation pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810214817.7A CN108578883A (en) | 2018-03-15 | 2018-03-15 | A kind of the cell transplantation pipe and its application method of via intranasal application administration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810214817.7A CN108578883A (en) | 2018-03-15 | 2018-03-15 | A kind of the cell transplantation pipe and its application method of via intranasal application administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108578883A true CN108578883A (en) | 2018-09-28 |
Family
ID=63626440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810214817.7A Pending CN108578883A (en) | 2018-03-15 | 2018-03-15 | A kind of the cell transplantation pipe and its application method of via intranasal application administration |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108578883A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020241833A1 (en) * | 2019-05-31 | 2020-12-03 | 国立大学法人北海道大学 | Puncture needle, puncture needle kit, and stereotactic brain surgery device |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1388762A (en) * | 2000-06-12 | 2003-01-01 | 帝人株式会社 | Powder medicine multiple dose administration device |
| US20030133877A1 (en) * | 1997-07-21 | 2003-07-17 | Levin Bruce H. | Apparatus for directed intranasal administration of a composition |
| US20040191225A1 (en) * | 2002-08-06 | 2004-09-30 | Dinsmore Jonathan H. | Injection system |
| WO2012156914A2 (en) * | 2011-05-15 | 2012-11-22 | By-Pass, Inc. | Microporous balloon catheter, delivery system, and methods of manufacture and use |
| CN203154575U (en) * | 2013-01-30 | 2013-08-28 | 韩福森 | Atomization drug-spraying device for respiration internal medicine department |
| CN105054979A (en) * | 2015-08-29 | 2015-11-18 | 江阴迪林生物电子技术有限公司 | Electric nasal cavity sampling and spraying device |
| CN206381490U (en) * | 2016-10-18 | 2017-08-08 | 天津中鼎生物医学科技有限公司 | A kind of anal intestine delivery device |
-
2018
- 2018-03-15 CN CN201810214817.7A patent/CN108578883A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030133877A1 (en) * | 1997-07-21 | 2003-07-17 | Levin Bruce H. | Apparatus for directed intranasal administration of a composition |
| CN1388762A (en) * | 2000-06-12 | 2003-01-01 | 帝人株式会社 | Powder medicine multiple dose administration device |
| US20040191225A1 (en) * | 2002-08-06 | 2004-09-30 | Dinsmore Jonathan H. | Injection system |
| WO2012156914A2 (en) * | 2011-05-15 | 2012-11-22 | By-Pass, Inc. | Microporous balloon catheter, delivery system, and methods of manufacture and use |
| CN203154575U (en) * | 2013-01-30 | 2013-08-28 | 韩福森 | Atomization drug-spraying device for respiration internal medicine department |
| CN105054979A (en) * | 2015-08-29 | 2015-11-18 | 江阴迪林生物电子技术有限公司 | Electric nasal cavity sampling and spraying device |
| CN206381490U (en) * | 2016-10-18 | 2017-08-08 | 天津中鼎生物医学科技有限公司 | A kind of anal intestine delivery device |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020241833A1 (en) * | 2019-05-31 | 2020-12-03 | 国立大学法人北海道大学 | Puncture needle, puncture needle kit, and stereotactic brain surgery device |
| EP3978049A4 (en) * | 2019-05-31 | 2023-01-18 | Rainbow Inc. | Puncture needle, puncture needle kit, and stereotactic brain surgery device |
| US12017040B2 (en) | 2019-05-31 | 2024-06-25 | Rainbow Inc. | Puncture needle, puncture needle kit, and stereotactic brain surgery device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11679077B2 (en) | Systems and methods for delivery of a therapeutic agent | |
| JP4871492B2 (en) | Medical connector assembly for fluid transfer | |
| EP3248612A1 (en) | Apparatus, methods and systems for toxin delivery to the nasal cavity | |
| US20140296802A1 (en) | Aid device for intraocular injection | |
| CN106618663A (en) | Device for treating lung of patient | |
| US20150038902A1 (en) | Infusion therapy device | |
| CN208626408U (en) | A kind of nasal-cavity administration pipe of via intranasal application administration | |
| CN108578883A (en) | A kind of the cell transplantation pipe and its application method of via intranasal application administration | |
| US20090131857A1 (en) | Method and apparatus for introducing a medicinal dose directly into a mammalian patient's cerebrospinal fluid | |
| CN204319492U (en) | Three chamber medicine bag Foley catheters | |
| CN110038209B (en) | Balloon dilation device for neurosurgery trigeminal nerve percutaneous treatment | |
| CN205252290U (en) | Two sacculus liquid receiver | |
| CN211357361U (en) | Balloon dilatation device for neurosurgical trigeminal percutaneous treatment | |
| CN203244667U (en) | Dacryocyst catheter | |
| US10335435B2 (en) | Method for endoscopically delivering stem cells to the brain using an intranasal, injectable approach | |
| CN108938137B (en) | Transurethral bladder communication device | |
| CN208838863U (en) | A kind of delivery device suitable for gynemetrics | |
| CN207306982U (en) | A kind of adjustable transdermal delivery device | |
| CN202314641U (en) | Implantable administration device | |
| CN207186890U (en) | A kind of two-chamber side-hole needle | |
| CN205994861U (en) | Intranasal medicator | |
| CN104258478B (en) | Multi-chamber dosage-free airtight sterile medicine injector | |
| RU187055U1 (en) | The cutaneous device of the system of repeated subcutaneous administration of a solution of medicinal substances | |
| CN101920063A (en) | Cavity mucous membrane administration apparatus, administration device and administration method | |
| US20110046116A1 (en) | Sedative for use during eye surgery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |