CN202151073U - Full-automatic hypoxic animal model feeding box - Google Patents
Full-automatic hypoxic animal model feeding box Download PDFInfo
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- CN202151073U CN202151073U CN 201120125318 CN201120125318U CN202151073U CN 202151073 U CN202151073 U CN 202151073U CN 201120125318 CN201120125318 CN 201120125318 CN 201120125318 U CN201120125318 U CN 201120125318U CN 202151073 U CN202151073 U CN 202151073U
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Abstract
The utility model discloses a full-automatic hypoxic animal model feeding box. The full-automatic hypoxic animal model feeding box comprises an external box body, an internal box arranged in the external box body and used for feeding an animal model, and an oxygen concentration control unit, wherein a gas mixing space is formed between the top of the internal box and the top wall of the external box body, gas circulation intervals are respectively formed between each one of other side faces of the internal box and the internal wall of the external box body, and a plurality of gas ports communicated with the inside of the external box body are formed on the sidewalls of the internal box; the top of the external box body is provided with at least external first nitrogen input interface which is provided with a solenoid valve and externally connected with a first nitrogen input pipeline; the top of the external box body is also provided with a centrifugal blower only blowing towards the inside of the external box body, so as to input the air in the external box body, uniformly mix the air with the nitrogen and transmit the mixed gas to the internal box via the gas circulation intervals and the gas ports; and a oxygen concentration sensor of the oxygen concentration control unit is arranged in the internal box, and a control output end of the oxygen concentration control unit is connected with an input control end of the centrifugal blower. The full-automatic hypoxic animal model feeding box is simple in structure, high in full automation degree and simple to operate, and can be used for making steady hypoxic pulmonary hypertension animal models and other hypoxic animals so as to meet the demands of various experiments.
Description
Technical field
The utility model relates to a kind of animal feeding case, particularly relates to a kind of full-automatic anoxic animal model rearing-box.
Background technology
Zoopery is one of most important the most frequently used scientific research methods in the current scientific research, is multi-disciplinary basic research means such as pharmacology, physiology, Pathological Physiology.Laboratory animal is the best research object of research at present and human body relevant disease and pathological state; And the foundation of animal model of human disease is the emphasis of disease research, and animal model should possess with human diseases has good similitude, model quality that characteristics such as good stable property and repeatability are arranged.Pulmonary vascular disease and breathe sleep and suspend the in close relations of disease such as syndrome and body anoxic.Like pulmonary hypertension is that pulmonary hypertension (PAH) is the important complication of COPD (COPD), is the independent hazard factor that influences COPD patient's course of disease, and pulmonary hypertension can cause right heart failure, has increased the COPD mortality in said patients.At present, COPD has become the fourth-largest cause of the death of China, and pulmonary hypertension is the deadly important prognosis of disease of COPD patient, and research thinks that anoxic is the crucial hazards that cause pulmonary hypertension now.Therefore set up the hypoxic pulmonary hypertension animal model and learn change for the pathogenesis and the body pathology of research oxygen-starved pulmonary hypertension, the preclinical study of carrying out new diagnosis and treatment method and medicine all has very important meaning.External at present making pulmonary hypertension all need be used special anoxic animal feeding case; But external import anoxic animal equipment is because of costing an arm and a leg, and the stability of a system is poor, and automaticity is not high; Complicated operation; Interior humidity of case and gas content control are inaccurate, shortcomings such as animal tolerance difference, thus limited carrying out of research work.Therefore we have designed and produced full-automatic anoxic animal incubator voluntarily, make it can satisfy the requirement of making oxygen-starved pulmonary hypertension animal model and other anoxic property animal models, and this invention have the automaticity height; Simple to operate; Experimental cost is low, oxygen concentration and time of exchanging gas in the regulating box arbitrarily, animal better tolerance; Be fit to advantages such as suitability for industrialized production, be superior to external like product greatly.
Summary of the invention
The purpose of the utility model is to provide a kind of full-automatic anoxic animal model rearing-box; This rearing-box simple in structure, full-automatic degree is high, and is simple to operate; Can be used for making stable hypoxic pulmonary hypertension animal model and other anoxic animal models, to satisfy the needs of various experiments.
The purpose of the utility model adopts following technical scheme to realize: a kind of full-automatic anoxic animal model rearing-box; Comprise outer case, place the interior case and the oxygen concentration control module of the letting animals feed model in the outer case; Be provided with mixed headroom between interior box top and the outer case roof; Be equipped with gas communication between other each sides of interior case and the outer case inwall at interval, on the inner box side wall, have the gas port that connects in several and the outer case; The nitrogen input interface of the external first nitrogen intake line of at least one charged magnet valve is offered at the outer case top, is used for the oxygen concentration of case in input nitrogen is regulated in outer case; Said outer case top is equipped with the centrifugal blower of only in outer case, drying, in outer case input air and with air and nitrogen mix through gas communication at interval with the inside case conveying of gas port; In the case, the control output end of oxygen concentration control module connected the input control end of said magnetic valve and centrifugal blower in the oxygen concentration sensor of oxygen concentration control module was installed on; Oxygen concentration is higher than setting value in interior case, controls opens solenoid valve automatically, and nitrogen gets into and mixes the headroom; Magnetic valve cuts out automatically when oxygen concentration is lower than setting value, stops the nitrogen input.
All be fixed with upper and lower two wind deflectors that laterally arrange on each gas port on the case in described; The inclination angle of wind deflector and horizontal plane is an acute angle; Gas is sent in the interior case from top to bottom; And in interior case, forming the gas top-down flow direction from bottom to top and then at interior case middle part earlier, the gas of case evenly distributes in making.
At least one fence type horizontal tray is set, with the space that is divided into two-layer at least placement animal feeding box in the interior case from top to bottom in the case in described.
The utility model also comprises hypoxemia alarm unit and the pressure fan that is used for inside case air intake, and pressure fan is installed on interior case diapire; The triggering input of described hypoxemia alarm unit connects the concentration control signal output of oxygen concentration control module; The warning output of hypoxemia alarm unit connects said pressure fan; When oxygen concentration in the interior case was lower than the warning concentration of setting, air-supply oxygenating in the inside case of pressure fan was opened in control automatically.
The described hypoxemia alarm unit of the utility model also comprises sound or light crossing-signal spare, and the electric connecting terminal of said sound or light crossing-signal spare inserts the warning output of hypoxemia alarm unit.
The utility model comprises that also regularly take a breath control module, exhaust blower and outer case top offer the ventilation nitrogen input interface of the external second nitrogen intake line of the charged magnet valve of at least one; Exhaust blower is installed on interior case diapire, is used for the gas of interior case is drained into outside the outer case; Regularly the take a breath control output end of control module connects exhaust blower, the magnetic valve of ventilation nitrogen input interface and the control input end of said centrifugal blower respectively; Regularly take a breath control module by the parameter timing controlled of setting open exhaust blower with gas in the interior case to effluxing, the magnetic valve of the nitrogen of control ventilation simultaneously input interface is opened input nitrogen and is mixed gas.
The said first nitrogen intake line and the second nitrogen intake line all are provided with and are used to control the gas flow controller that fills nitrogen speed.
Said outer case and interior case rearing-box can be seamless welded stainless steel metal box or integrated plastic box.If adopt integrated plastic box, plastic material can be polysulfone plastic (PCU) or Polycarbonate plastics (PC).
The utility model compared with prior art has following beneficial effect:
(1) the utlity model has oxygen concentration control module and hypoxemia alarm unit; Can oxygen concentration in the casing be set according to the experiment needs; Through regulating nitrogen flow meter control oxygen concentration fall off rate; And control very accurately, be used to make acute, the chronic hypoxia model of various laboratory animal and carry out continuation, the zoopery of discontinuity anoxic.Change the modelling instrument that mechanism and the required animal model of intervening measure thereof provide a kind of good stable for making body pathology physiology that the research hypoxemia causes.
(2) the full-automatic degree of the utility model is high, simple to operate, oxygen concentration threshold value, time of exchanging gas in the case in only needing to set, in can letting in the case in oxygen concentration and the case work such as gas replacing accomplish automatically, need not manual monitoring, very easy to use.
(3) also be provided with regularly take a breath control module and exhaust blower in the utility model, the gas of case in can regularly changing, the steam in ensureing in the case can be not too much, and the feeding environment of relative comfort is provided for animal.
(4) the utility model is reasonable in design, and manufacture craft is simple, can realize large-scale industrial production, has vast market prospect.
Description of drawings
Fig. 1 is the structural representation of the utility model embodiment.
Fig. 2 is the workflow sketch map of the oxygen concentration control module of the utility model.
Fig. 3 is the workflow sketch map of the timing ventilating unit of the utility model.
Fig. 4 is the workflow diagram of the hypoxemia alarm unit of the utility model.
Embodiment
Full-automatic anoxic animal model rearing-box shown in Figure 1 is a preferential embodiment of the utility model, comprises case 2 in outer case 1, the letting animals feed model that places in the outer case 1, centrifugal blower 5, oxygen concentration control module, regularly take a breath control module, exhaust blower 4, hypoxemia alarm unit and pressure fan 3.A wherein side of outer case 1 is provided with the unpacking door of hinged list; Interior case 2 also is provided with and the interior case 2 hinged lists door of unpacking in a corresponding side; Two fence type horizontal trays are set in the interior case 2; The space of interior case 2 is divided into three layers of space of placing the raising box from top to bottom, can places 2 fence types for every layer and raise boxes, can place 4～6 fence types in the promptly interior case 2 and raise boxes.Keep somewhere a mixed headroom 6 between interior case 2 tops and outer case 1 roof, keep somewhere gas communication between each side of interior case 2 and outer case 1 inwall at interval, on interior case 2 sidewalls symmetry have several with outer case 1 in the gas port 21 of perforation.All be fixed with upper and lower two wind deflectors that laterally arrange 22 on the interior case 2 on each gas port 21; Wind deflector 22 is an acute angle with the inclination angle of horizontal plane; Gas is sent in the interior case 2 from top to bottom; And formation gas forms the top-down flow direction from bottom to top and then at interior case 2 middle parts earlier in interior case 2, and the gas in making in the case 2 evenly distributes.The nitrogen input interface of four charged magnet valves is offered at outer case 1 top, and wherein two nitrogen input interfaces are regulated nitrogen input interface 11 as oxygen concentration, and the external first nitrogen intake line is used for the oxygen concentration in the case 2 in input nitrogen is regulated in outer case 1; Two nitrogen input interfaces are as ventilation nitrogen input interface 12 in addition, and the external second nitrogen intake line is imported nitrogen in the inside case 2 when ventilation.Outer case 1 top is equipped with and is provided with the only centrifugal blower 5 of blowing in outer case 1, and the air outlet of this centrifugal blower 5 is communicated with mixed headroom.During centrifugal blower 5 running, its air intake vent is opened with outside air and is communicated with, and to outer case 1 in input air, meanwhile air and nitrogen are mixed through gas communication interval and gas port 21 inside casees 2 conveyings.The oxygen concentration sensor of oxygen concentration control module is installed in the interior case 2, the magnetic valve on the control output end connection oxygen concentration adjusting nitrogen input interface 11 of oxygen concentration control module and the input control end of centrifugal blower; Oxygen concentration is higher than setting value in interior case 2 casings, controls opens solenoid valve automatically, and nitrogen gets into and mixes headroom 6; The magnetic valve that oxygen concentration is regulated on the nitrogen input interface 11 when oxygen concentration is lower than setting value cuts out automatically, stops the nitrogen input.
The diapire of case 2 in pressure fan 4 is installed on; The triggering input of hypoxemia alarm unit connects the concentration control signal output of oxygen concentration control module, and the warning output of hypoxemia alarm unit connects pressure fan 4.The hypoxemia alarm unit also comprises sound or light crossing-signal spare, and the electric connecting terminal of this or light crossing-signal spare inserts the warning output of hypoxemia alarm unit.When the oxygen concentration in the interior case 2 was lower than the warning concentration of setting, sound or light crossing-signal spare were reported to the police, and air-supply oxygenating in the inside case 2 of pressure fan is opened in control automatically simultaneously.
Oxygen concentration control module in the present embodiment, regularly take a breath control module and hypoxemia alarm unit and the connection between them adopts routine techniques to get final product.
With animal place raise be positioned over behind the box in the case 2; The chamber door of case 2 and outer case 1 in closing; Let whole box body is inner to become confined space, set that the oxygen concentration threshold value is 10% in the casing, oxygen concentration warning concentration threshold in the interior case 2, ventilation are 6 minutes and time of exchanging gas 20 seconds blanking time; As shown in Figure 2; Open the oxygen concentration control module and the control module of regularly taking a breath; Oxygen concentration sensor detects whether oxygen concentration is higher than setting oxygen concentration threshold value in the interior case; If testing result is for being, then the oxygen concentration control module starts the magnetic valve that centrifugal blower 5 and oxygen concentration regulate on the nitrogen input interface 11 and in outer case 1, charges into nitrogen and air, and in gas communication interval and gas port 21 are sent in the case 2; Oxygen concentration reaches setting threshold in interior case 2 bodies, closes centrifugal blower 5 and stops to charge into nitrogen.
As shown in Figure 3; Every interval 6 minutes; The control module of regularly taking a breath starts exhaust blower 4 gas in the interior case 2 is discharged outside outer case 1; And open the nitrogen of magnetic valve and centrifugal blower 5 on the ventilation nitrogen input interface 12 input air and the second nitrogen intake line to outer case 1 in simultaneously, thereby interior case 2 gas inside of replacing make animal be in comfortable living environment all the time.When arriving the concluding time of setting, after promptly taking a breath 20 seconds, close magnetic valve and centrifugal blower 5 on exhaust blower 4, the ventilation nitrogen input interface 12, stop ventilation work.When taking a breath work; Whether case 2 interior oxygen concentrations were higher than 10% oxygen concentration threshold value of setting in oxygen concentration sensor detected; If testing result is for being, then the oxygen concentration control module starts oxygen concentration and regulates magnetic valve on the nitrogen input interface 11 charges into the first nitrogen intake line in outer case 1 nitrogen, and in gas communication interval and gas port 21 are sent in the case 2; Oxygen concentration reaches setting threshold in interior case 2, closes centrifugal blower 5 and stops to charge into nitrogen.
As shown in Figure 4, if oxygen concentration sensor detects when oxygen concentration is lower than warning concentration in the interior case 2, start the hypoxemia alarm unit and report to the police, and start the oxygenating of blowing in the pressure fan 3 inside casees 2.
The embodiment of the utility model is not limited thereto; Foregoing according to the utility model; According to the ordinary skill knowledge and the customary means of this area, do not breaking away under the above-mentioned basic fundamental thought of the utility model prerequisite, each apolegamy of forming combination also can be adopted existing other embodiment of identical function in the utility model; Therefore the utility model can also be made modification, replacement or the change of other various ways, all drops within the utility model rights protection scope.
Claims (7)
1. full-automatic anoxic animal model rearing-box; It is characterized in that; Comprise outer case, place the interior case and the oxygen concentration control module of the letting animals feed model in the outer case; Be provided with mixed headroom between interior box top and the outer case roof, be equipped with gas communication between other each sides of interior case and the outer case inwall at interval, on the inner box side wall, have the gas port that connects in several and the outer case; The nitrogen input interface of the external first nitrogen intake line of at least one charged magnet valve is offered at the outer case top; Said outer case top is equipped with the centrifugal blower of only in outer case, drying, in outer case input air and with air and nitrogen mix through gas communication at interval with the inside case conveying of gas port; In the case, the control output end of oxygen concentration control module connected the input control end of said magnetic valve and centrifugal blower in the oxygen concentration sensor of oxygen concentration control module was installed on; Oxygen concentration is higher than setting value in interior case, controls opens solenoid valve automatically, and nitrogen gets into and mixes the headroom; Magnetic valve cuts out automatically when oxygen concentration is lower than setting value, stops the nitrogen input.
2. full-automatic anoxic animal model rearing-box according to claim 1; It is characterized in that; All be fixed with upper and lower two wind deflectors that laterally arrange on each gas port on the case in described, the inclination angle of wind deflector and horizontal plane is an acute angle, and gas is sent in the interior case from top to bottom; And in interior case, forming the gas top-down flow direction from bottom to top and then at interior case middle part earlier, the gas of case evenly distributes in making.
3. full-automatic anoxic animal model rearing-box according to claim 1 and 2 is characterized in that, it also comprises hypoxemia alarm unit and the pressure fan that is used for inside case air intake, the diapire of case in pressure fan is installed on; The triggering input of described hypoxemia alarm unit connects the concentration control signal output of oxygen concentration control module; The warning output of hypoxemia alarm unit connects said pressure fan; When oxygen concentration in the interior case was lower than the warning concentration of setting, air-supply oxygenating in the inside case of pressure fan was opened in control automatically.
4. full-automatic anoxic animal model rearing-box according to claim 3 is characterized in that, described hypoxemia alarm unit also comprises sound or light crossing-signal spare, and the electric connecting terminal of said sound or light crossing-signal spare inserts the warning output of hypoxemia alarm unit.
5. full-automatic anoxic animal model rearing-box according to claim 4; It is characterized in that; It comprises that also regularly take a breath control module, exhaust blower and outer case top offer the ventilation nitrogen input interface of the external second nitrogen intake line of the charged magnet valve of at least one, the diapire of case in exhaust blower is installed on; The control output end of said timing ventilation control module connects exhaust blower, the magnetic valve of ventilation nitrogen input interface and the control input end of said centrifugal blower respectively; Said timing ventilation control module by the parameter timing controlled of setting open exhaust blower with gas in the interior case to effluxing, the magnetic valve of the nitrogen of control ventilation simultaneously input interface is opened input nitrogen and is got into and mix gas.
6. full-automatic anoxic animal model rearing-box according to claim 5 is characterized in that, in the described interior case at least one fence type horizontal tray is set, with the space that is divided into two-layer at least placement animal feeding box in the interior case from top to bottom.
7. full-automatic anoxic animal model rearing-box according to claim 6 is characterized in that the said first nitrogen intake line and the second nitrogen intake line all are provided with and are used to control the gas flow controller that fills nitrogen speed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120125318 CN202151073U (en) | 2011-04-26 | 2011-04-26 | Full-automatic hypoxic animal model feeding box |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201120125318 CN202151073U (en) | 2011-04-26 | 2011-04-26 | Full-automatic hypoxic animal model feeding box |
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| Publication Number | Publication Date |
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| CN202151073U true CN202151073U (en) | 2012-02-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201120125318 Expired - Fee Related CN202151073U (en) | 2011-04-26 | 2011-04-26 | Full-automatic hypoxic animal model feeding box |
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| CN (1) | CN202151073U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102217552A (en) * | 2011-04-26 | 2011-10-19 | 广州医学院第一附属医院 | Full-automatic hypoxic animal model breeding box |
| CN105454063A (en) * | 2015-12-27 | 2016-04-06 | 上海市第一人民医院 | Animal model feeding box capable of achieving full-automatic and multifunctional gas control |
-
2011
- 2011-04-26 CN CN 201120125318 patent/CN202151073U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102217552A (en) * | 2011-04-26 | 2011-10-19 | 广州医学院第一附属医院 | Full-automatic hypoxic animal model breeding box |
| CN105454063A (en) * | 2015-12-27 | 2016-04-06 | 上海市第一人民医院 | Animal model feeding box capable of achieving full-automatic and multifunctional gas control |
| CN105454063B (en) * | 2015-12-27 | 2018-04-10 | 上海市第一人民医院 | Full-automatic multi-functional gas controls animal model rearing-box |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120229 Termination date: 20140426 |