CN202105043U - Device for building spinal cord injury or muscle contusion and laceration animal models - Google Patents
Device for building spinal cord injury or muscle contusion and laceration animal models Download PDFInfo
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- CN202105043U CN202105043U CN2011201759497U CN201120175949U CN202105043U CN 202105043 U CN202105043 U CN 202105043U CN 2011201759497 U CN2011201759497 U CN 2011201759497U CN 201120175949 U CN201120175949 U CN 201120175949U CN 202105043 U CN202105043 U CN 202105043U
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Abstract
The utility model relates to a device for building spinal cord injury or muscle contusion and laceration animal models, which comprises a base, a stand column is arranged on the base, a cross beam is arranged on the stand column to form a crossed support frame, two ends of the cross beam are respectively provided with a cross bracket, the extending ends of the two cross brackets are respectively provided with a pair of forceps that can be adjusted in multiple directions, a cantilever used for supporting a striking device is arranged on the stand column with adjustable height and is positioned below the cross beam, a metal rod used for positioning the height of a weight is arranged on the stand column with adjustable height and is positioned above the cross beam, the extending end of the cantilever is provided with a through hole running through vertically, the upper end of the striking device is a platform and the lower part of the striking device is a round rod, the striking device is in clearance fit with the through hole in the cantilever by the round rod, the lower end of the round rod is a rectangular solid planar foot plate, and a compression spring is sheathed on the round rod and is positioned between the cantilever and the platform. The device has a simple structure, is convenient to produce and use, can ensure controllability on various degrees of injury, and can complete both spinal cord compression and impact dent.
Description
Technical field
This utility model relates to a kind of device of building animal model, particularly a kind of device of building spinal cord injury or muscle contusion animal model.
Background technology
Along with development of modern society, the quickening of rhythm of life, traffic is on the increase with the building falling accident, and the incidence rate of spinal cord injury also is ascendant trend year by year.Spinal cord injury will cause damaging sensation and dyskinesia below the plane, and at present, the spinal cord injury pilosity is born in person between twenty and fifty, owing to can not regenerate after the spinal cord injury, bring extremely serious spirit and economic pressures for family and society.Therefore, be neuroscience worker's a great problem about the Regeneration and Repair research after the spinal cord injury, also be one of the advanced subject in neuroscience field.
Carry out the spinal cord injury Study on Regeneration, at first will prepare animal model with spinal cord damnification.Animal model with spinal cord damnification has spinal cord impact damage model, spinal compression damage model, ischemia of spinal cord and reperfusion injury model, cutting and sucking-off type spinal cord injury model, hydrostatic profile spinal cord injury model, photochemical induction type spinal cord injury model, tractive property spinal cord injury model etc. usually at present.But ideal animal model with spinal cord damnification should possess the condition of following 3 aspects: 1, clinical similarity: the spinal cord injury model of promptly making is as much as possible with clinical close, the pathological change situation during as far as possible near human spinal cord injury.Theoretically, make spinal cord receive to cause injury after the effect of passivity violence, promptly so-called " closure spinal cord injury " can be simulated the impaired under external force and pathological change process thereafter of spinal cord, and is similar with the situation of human spinal cord injury.But find in the practical study that animal model and clinical spinal cord injury still have very big difference, the dysfunction that this closed injury caused is also unstable, is difficult to prepare repeatably classification damage model.2, Modulatory character: can adjust damage strength according to actual needs, copy the spinal cord injury model of different degree of injury.3, operability and repeatability: each committed step of promptly spinal cord injury model being made objectifies, quantification, makes that it is with a high credibility, exploitativeness is strong, can reflect objective problem.Different spinal cord injury models, the characteristics that cause dissimilar anatomical structure damages and function of nervous system to change.At present, still there is certain limitation in the various method for preparinies of animal spinal cord damage model, have influenced the research of spinal cord injury and reparation greatly.So setting up ideal animal model with spinal cord damnification is the matter of utmost importance of carrying out spinal cord injury and repairing research.
Yet existing animal model with spinal cord damnification preparation facilities is because complex structure is not easy to the ordinary laboratory preparation, and very inconvenience of use, in use can not guarantee the damage of various degree controlled; And because said apparatus can only be accomplished a kind of in spinal compression and the impact damage, spinal compression and impact damage can't be accomplished in a device, increased use cost.In addition, said apparatus can not be used for the preparation that animal muscle is frustrated the rhegma wound model.
Summary of the invention
The purpose of this utility model is the deficiency to prior art; A kind of device of building spinal cord injury or muscle contusion animal model is provided; It is simple in structure, is convenient to the ordinary laboratory preparation, and is easy to use; In use can guarantee controlledly, all can accomplish spinal compression and impact damage to the damage of various degree.Simultaneously, this device can be used for the preparation that animal muscle is frustrated the rhegma wound model.
The technical scheme of this utility model is: a kind of device of building spinal cord injury or muscle contusion animal model; Comprise base; One column is installed on the said base; One crossbeam is installed on the column is constituted cross supporting frame, the two ends of said crossbeam respectively are equipped with the lateral frame that extends to same direction, the elongated end of two lateral frames respectively be provided with one can multidirectional adjusting tweezers; One be used to support the cantilever of percussion device height adjustable be installed on the column and be positioned at crossbeam below, be used for being installed on the column and being positioned at the crossbeam top to the localized Metallic rod of counterweight height is height adjustable; The bearing of trend of said cantilever and said Metallic rod is identical with the bearing of trend of lateral frame, and the elongated end of said cantilever is provided with the through hole that runs through up and down, and the upper end of said percussion device is a round bar for the platform bottom; The round bar of this percussion device through its underpart cooperates with via clearance on the cantilever; The lower surface of said round bar is made as orthogonal solid plane sole, is with a compression spring on the round bar of this percussion device, and said compression spring is between the platform of cantilever and percussion device.
Said column is a threaded column, crossbeam, be used to support percussion device cantilever upper and lower respectively through the nut location and installation at column, be used for the installation end of the localized Metallic rod of counterweight height is provided with a nut, and be threaded with column through this nut.
The afterbody of said tweezers that can multidirectional adjusting is with regulating bolted splice a connection piece, and is connected on the lateral frame through this connector, and the clamping part of tweezers that can multidirectional adjusting is provided with hold-down bolt.
The area of said orthogonal solid plane sole is 2 х 5mm
2Or 2 х 2mm
2
The below of the platform of said percussion device is equipped with a supporting seat; The center of said supporting seat is provided with the shoulder hole that runs through up and down; Big footpath section in the path section in the said shoulder hole and the upper end interference fit of round bar (11), shoulder hole is the installing hole that is used to install the compression spring.
Be with a positioning sleeve of deciding bolt with lock on the round bar of said percussion device, this positioning sleeve is positioned at the below of the cantilever that is used to support percussion device.
Said Metallic rod is near circumferentially being provided with an annular groove on the outer wall of elongated end, the symmetrical centre of this annular groove is positioned at same vertical straight line with the hole heart of the through hole of the cantilever that is used to support percussion device.
Adopt technique scheme: a column is installed on the base of this device, a crossbeam is installed on the column is constituted cross supporting frame, guaranteed the stability of strutting system of whole device.The two ends of crossbeam respectively are equipped with the lateral frame that extends to same direction, the elongated end of two lateral frames respectively be provided with one can multidirectional adjusting tweezers, be used for fixing spinous process, reduce the influence of breathing to the spinal cord injury degree.One be used to support the cantilever of percussion device height adjustable be installed on the column and be positioned at crossbeam below, be used for being installed on the column and being positioned at the crossbeam top to the localized Metallic rod of counterweight height is height adjustable, the bearing of trend of cantilever and Metallic rod is identical with the bearing of trend of lateral frame.The elongated end of cantilever is provided with the through hole that runs through up and down, and the upper end of percussion device is a round bar for the platform bottom, and the round bar of this percussion device through its underpart cooperates with via clearance on the cantilever.The lower surface of the round bar of percussion device is made as orthogonal solid plane sole, is used for contacting with the spinal cord of a sections of animal.Be with a compression spring on the round bar of this percussion device, the compression spring is between the platform of cantilever and percussion device.During use; With the spinal cord of animal through tweezers be fixed on percussion device under; The segments of spinal cord of treating animal is with after the orthogonal solid plane sole of the lower surface of the round bar of percussion device is aimed at, and when needs were accomplished spinal compression, directly the counterweight with 50g was placed on the platform of percussion device; Make solid plane sole to lower compression spinal cord 5 minutes, the two lower limb of animal are paralysed fully; When needs are accomplished impact damage; Only need the counterweight of 50g is vertically fallen from the height apart from cantilever 20mm, the platform that hits percussion device is last, makes solid plane sole clash into spinal cord downwards; The two lower limb of animal are paralysed fully, thereby realize the construction of animal spinal cord damage model.Because adopt said structure, this apparatus structure is simple, be convenient to the ordinary laboratory preparation, easy to use, in use can guarantee controlledly to the damage of various degree, all can accomplish spinal compression and impact damage.Simultaneously, this device also can be used for the preparation that animal muscle is frustrated the rhegma wound model.
Description of drawings
Fig. 1 is the structural representation of this utility model;
Fig. 2 is the vertical view of Fig. 1;
Fig. 3 is the structural representation of the column of this utility model;
Fig. 4 is the local enlarged diagram of the Metallic rod of this utility model;
Fig. 5 is the cantilever of this utility model and the sketch map that is connected of percussion device;
Fig. 6 is a kind of embodiment of the solid plane sole of this utility model;
Fig. 7 is the another kind of embodiment of the solid plane sole of this utility model.
In the accompanying drawing, 1 is base, and 2 is column, and 3 is crossbeam, and 4a, 4b are lateral frame, and 5 is tweezers; 6 is cantilever, and 6a is a through hole, and 7 is percussion device, and 8 is counterweight, and 9 is Metallic rod, and 9a is an annular groove; 10 is platform, and 11 is round bar, and 12 is solid plane sole, and 13 are the compression spring, and 14 is connector; 15 for regulating bolt, and 16 is hold-down bolt, and 17 is supporting seat, and 17a is a shoulder hole, and 18 is positioning sleeve.
The specific embodiment
Referring to Fig. 1 to Fig. 7, a kind of device of building spinal cord injury or muscle contusion animal model comprises base 1; One column 2 is installed on the said base 1; This column 2 is a threaded column, a crossbeam 3 is installed on the column is constituted cross supporting frame, to guarantee the stability of strutting system of whole device; Crossbeam 3 upper and lowers pass through the nut location and installation respectively on column 2, and the height of crossbeam 3 on column 2 can freely be adjusted as required.The two ends of said crossbeam 3 respectively are equipped with lateral frame 4a, the 4b that extends to same direction, and two lateral frame 4a, 4b can be fixedly mounted on the crossbeam 3 through welding, also can be installed on the crossbeam 3 through nut is dismountable.The elongated end of two lateral frame 4a, 4b respectively be provided with one can multidirectional adjusting tweezers 5; Be used for fixing spinous process; Reduce the influence of breathing to the spinal cord injury degree; The afterbody of tweezers 5 that can multidirectional adjusting is with regulating bolt 15 hinged a connection piece 14, and is connected on the lateral frame through this connector 14, so that regulate the direction of tweezers 5 as required arbitrarily.This can multidirectional adjusting the clamping part of tweezers 5 be provided with hold-down bolt 16, be used for clamping and unclamping gripped object.One be used to support the cantilever 6 of percussion device 7 height adjustable be installed on the column 2 and be positioned at crossbeam 3 belows, be used for being installed on the column 2 and being positioned at crossbeam 3 tops to the highly localized Metallic rod of counterweight 89 is height adjustable; The bearing of trend of said cantilever 6 and said Metallic rod 9 is identical with the bearing of trend of lateral frame 4a, 4b, the upper and lower of cantilever 6 that wherein is used to support percussion device 7 through the nut location and installation at column 2; Be used for the installation end of the highly localized Metallic rod 9 of counterweight 8 is provided with a nut; And be threaded with column 2 through this nut; The top of the nut of the installation end of Metallic rod 9 also can be provided with one and is used for Metallic rod 9 localized setscrew nuts in the present embodiment, to guarantee the location of Metallic rod 9.Metallic rod 9 is near circumferentially being provided with an annular groove 9a on the outer wall of elongated end; Be used to hang counterweight 8; The symmetrical centre of this annular groove 9a is positioned at same vertical straight line with the hole heart of the through hole 6a of the cantilever 6 that is used to support percussion device 7, to guarantee that counterweight 8 can drop on the platform 10 of percussion device 7 accurately.The elongated end of said cantilever 6 is provided with the through hole 6a that runs through up and down; The upper end of said percussion device 7 is that platform 10 bottoms are round bar 11; This percussion device 7 can move up and down the round bar 11 of percussion device through round bar 11 of its underpart and the through hole 6a matched in clearance on the cantilever 6 in the through hole 6a on the cantilever 6.The lower surface of said round bar 11 is made as orthogonal solid plane sole 12, and the area of orthogonal solid plane sole 12 is 2 х 5mm
2Or 2 х 2mm
2, corresponding with the segments of spinal cord of experimental rat or mice, to guarantee the accuracy and the effectiveness of bump.Be with a compression spring 13 on the round bar of said percussion device 7; This compression spring 13 is between the platform 10 of cantilever 6 and percussion device; Because the below of the platform 10 of percussion device 7 is equipped with a supporting seat 17; The center of supporting seat 17 is provided with the shoulder hole 17a that runs through up and down, and the path section in the shoulder hole 17a and the upper end interference fit of round bar (11) make the upper end of round bar 11 stretch into and to be fixed in the supporting base; Big footpath section in the shoulder hole 17a is the installing hole that is used to install compression spring 13, and an end of compression spring 13 can be stretched into and be fixed in the supporting seat, thus make percussion device 7 can be behind bump self-return.Be with a positioning sleeve 18 of deciding bolt with lock on the round bar 11 of said percussion device 7, this positioning sleeve 18 is positioned at the below of the cantilever 6 that is used to support percussion device 7, is used to locate the round bar 11 of percussion device 7, has further guaranteed the accuracy and the effectiveness of bump.
This utility model is work like this: the female sd inbred rats with 200-250g is an example, and female sd inbred rats is divided into experimental group and sham operated rats at random.At first use 3.6% chloral hydrate intraperitoneal injection of anesthesia, the back QUMAO is a mid point with vertebra (T9); Cut skin of back, about 30mm, passivity separating muscle along the axis; Expose several respective vertebrae (T8-T10) spinous process and vertebral plate; The vertebral plate of excision vertebra (T9) does not damage spinal dura mater, and exposed area is 2 х 5mm
2, to distinguish the spinous process of vertebrae immobiles (T8) and vertebra (T10) and aim at solid plane sole with tweezers, the area of this solid plane sole is 2 х 5mm
2, when needs were accomplished spinal compression, directly the counterweight with 50g was placed on the platform of device, made solid plane sole to lower compression spinal cord 5 minutes, and two lower limb of rat are paralysed fully; When needs are accomplished impact damage; Only need the counterweight of 50g is vertically fallen from the height apart from cantilever 20mm, hit on the platform of percussion device, make solid plane sole clash into spinal cord downwards; Two lower limb of rat are paralysed fully, thereby realize the construction of animal spinal cord damage model.Accomplish experiment back suture operation otch.Sham operated rats is exposing neural spine and vertebral plate, and after doing vertebrae plate resection, suture muscles and skin.
Certainly, this device also can be used for the preparation that animal muscle is frustrated the rhegma wound model, and the basic operation method is identical with said method, at this Ao Shu no longer.
Claims (7)
1. device of building spinal cord injury or muscle contusion animal model; Comprise base (1); It is characterized in that: said base (1) is gone up a column (2) is installed; One crossbeam (3) is installed on the column is constituted cross supporting frame; The two ends of said crossbeam (3) respectively are equipped with the lateral frame (4a, 4b) that extends to same direction; The elongated end of two lateral frames (4a, 4b) respectively be provided with one can multidirectional adjusting tweezers (5); One is used to support the height adjustable column (2) that is installed in of the cantilever (6) of percussion device (7) goes up and is positioned at crossbeam (3) below, and be used for the height adjustable column (2) that is installed in of the highly localized Metallic rod of counterweight (8) (9) is gone up and is positioned at crossbeam (3) top; The bearing of trend of said cantilever (6) and said Metallic rod (9) is identical with the bearing of trend of lateral frame (4a, 4b), and the elongated end of said cantilever (6) is provided with the through hole (6a) that runs through up and down, and the upper end of said percussion device (7) is that platform (10) bottom is round bar (11); This percussion device (7) is through round bar (11) of its underpart and through hole (6a) matched in clearance on the cantilever (6); The lower surface of said round bar (11) is made as orthogonal solid plane sole (12), is with a compression spring (13) on the round bar of this percussion device (7), and said compression spring (13) is positioned between the platform (10) of cantilever (6) and percussion device.
2. the device of construction spinal cord injury according to claim 1 or muscle contusion animal model; It is characterized in that: said column (2) is threaded column; Crossbeam (3), be used to support percussion device (7) cantilever (6) upper and lower respectively through the nut location and installation in column (2); Be used for the installation end of the highly localized Metallic rod of counterweight (8) (9) is provided with a nut, and be threaded with column (2) through this nut.
3. the device of construction spinal cord injury according to claim 1 or muscle contusion animal model; It is characterized in that: the afterbody of said tweezers (5) that can multidirectional adjusting is with regulating hinged a connection piece of bolt (15) (14); And be connected on the lateral frame through this connector (14), the clamping part of tweezers (5) that can multidirectional adjusting is provided with hold-down bolt (16).
4. the device of construction spinal cord injury according to claim 1 or muscle contusion animal model is characterized in that: the area of said orthogonal solid plane sole (12) is 2 х 5mm
2Or 2 х 2mm
2
5. the device of construction spinal cord injury according to claim 1 or muscle contusion animal model; It is characterized in that: the below of the platform (10) of said percussion device (7) is equipped with a supporting seat (17); The center of said supporting seat (17) is provided with the shoulder hole (17a) that runs through up and down; Big footpath section in the path section in the said shoulder hole (17a) and the upper end interference fit of round bar (11), shoulder hole (17a) is for being used for installing the installing hole of compression spring (13).
6. the device of construction spinal cord injury according to claim 1 or muscle contusion animal model; It is characterized in that: be with a positioning sleeve (18) of deciding bolt with lock on the round bar (11) of said percussion device (7), this positioning sleeve (18) is positioned at the below of the cantilever (6) that is used to support percussion device (7).
7. the device of construction spinal cord injury according to claim 1 or muscle contusion animal model; It is characterized in that: said Metallic rod (9) is near circumferentially being provided with an annular groove (9a) on the outer wall of elongated end, the symmetrical centre of this annular groove (9a) is positioned at same vertical straight line with the hole heart of the through hole (6a) of the cantilever (6) that is used to support percussion device (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201759497U CN202105043U (en) | 2011-05-30 | 2011-05-30 | Device for building spinal cord injury or muscle contusion and laceration animal models |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201759497U CN202105043U (en) | 2011-05-30 | 2011-05-30 | Device for building spinal cord injury or muscle contusion and laceration animal models |
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|---|---|
| CN202105043U true CN202105043U (en) | 2012-01-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011201759497U Expired - Fee Related CN202105043U (en) | 2011-05-30 | 2011-05-30 | Device for building spinal cord injury or muscle contusion and laceration animal models |
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| CN (1) | CN202105043U (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006346A (en) * | 2012-12-31 | 2013-04-03 | 中国科学院自动化研究所 | Spinal cord injury percussion apparatus |
| CN103142326A (en) * | 2012-12-14 | 2013-06-12 | 中国科学院自动化研究所 | Electrical control system used for zooperal ventral spinal cord injury impactor |
| CN103505300A (en) * | 2013-09-29 | 2014-01-15 | 四川大学华西医院 | Rat acceleration and deceleration brain trauma striking system |
| CN104771145A (en) * | 2015-04-14 | 2015-07-15 | 中国人民解放军总医院 | Animal dorsal root ganglion-spinal cord fixed imaging and compression injury combining device |
| CN105105864A (en) * | 2015-09-18 | 2015-12-02 | 山东大学齐鲁医院 | Detachable rat spinal cord left/right half transaction molding device |
| CN105147411A (en) * | 2015-08-05 | 2015-12-16 | 中国人民解放军第二军医大学 | Construction method and equipment for SCI (spinal cord injury) animal model |
| CN106073929A (en) * | 2016-06-02 | 2016-11-09 | 复旦大学附属华山医院 | It is applicable to spring percussion device and the striking method of animal foot Skeletal muscle injury |
| CN107049544A (en) * | 2017-04-19 | 2017-08-18 | 中山大学附属第医院 | Brachial plexus root injury closed animal model device and brachial plexus root injury detection method |
| CN108542546A (en) * | 2018-06-26 | 2018-09-18 | 成都市富明珑科技有限责任公司 | A kind of animal spinal cord fixing device |
| CN113141766A (en) * | 2021-04-16 | 2021-07-20 | 中国科学院深圳先进技术研究院 | Electrophysiological experiment shielding box |
-
2011
- 2011-05-30 CN CN2011201759497U patent/CN202105043U/en not_active Expired - Fee Related
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142326A (en) * | 2012-12-14 | 2013-06-12 | 中国科学院自动化研究所 | Electrical control system used for zooperal ventral spinal cord injury impactor |
| CN103142326B (en) * | 2012-12-14 | 2015-01-07 | 中国科学院自动化研究所 | Electrical control system used for zooperal ventral spinal cord injury impactor |
| CN103006346B (en) * | 2012-12-31 | 2015-04-01 | 中国科学院自动化研究所 | Spinal cord injury percussion apparatus |
| CN103006346A (en) * | 2012-12-31 | 2013-04-03 | 中国科学院自动化研究所 | Spinal cord injury percussion apparatus |
| CN103505300A (en) * | 2013-09-29 | 2014-01-15 | 四川大学华西医院 | Rat acceleration and deceleration brain trauma striking system |
| CN104771145B (en) * | 2015-04-14 | 2017-04-12 | 中国人民解放军总医院 | Animal dorsal root ganglion-spinal cord fixed imaging and compression injury combining device |
| CN104771145A (en) * | 2015-04-14 | 2015-07-15 | 中国人民解放军总医院 | Animal dorsal root ganglion-spinal cord fixed imaging and compression injury combining device |
| CN105147411A (en) * | 2015-08-05 | 2015-12-16 | 中国人民解放军第二军医大学 | Construction method and equipment for SCI (spinal cord injury) animal model |
| CN105105864A (en) * | 2015-09-18 | 2015-12-02 | 山东大学齐鲁医院 | Detachable rat spinal cord left/right half transaction molding device |
| CN105105864B (en) * | 2015-09-18 | 2017-04-05 | 山东大学齐鲁医院 | A kind of half cross-section modeling device of dismountable rat spinal cord left/right |
| CN106073929A (en) * | 2016-06-02 | 2016-11-09 | 复旦大学附属华山医院 | It is applicable to spring percussion device and the striking method of animal foot Skeletal muscle injury |
| CN107049544A (en) * | 2017-04-19 | 2017-08-18 | 中山大学附属第医院 | Brachial plexus root injury closed animal model device and brachial plexus root injury detection method |
| CN108542546A (en) * | 2018-06-26 | 2018-09-18 | 成都市富明珑科技有限责任公司 | A kind of animal spinal cord fixing device |
| CN113141766A (en) * | 2021-04-16 | 2021-07-20 | 中国科学院深圳先进技术研究院 | Electrophysiological experiment shielding box |
| CN113141766B (en) * | 2021-04-16 | 2022-10-14 | 中国科学院深圳先进技术研究院 | Electrophysiological experiment shielding box |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120111 Termination date: 20130530 |