CN202049113U - High-sensitivity measuring device for pharmaceutical ingredients - Google Patents
High-sensitivity measuring device for pharmaceutical ingredients Download PDFInfo
- Publication number
- CN202049113U CN202049113U CN2011200858813U CN201120085881U CN202049113U CN 202049113 U CN202049113 U CN 202049113U CN 2011200858813 U CN2011200858813 U CN 2011200858813U CN 201120085881 U CN201120085881 U CN 201120085881U CN 202049113 U CN202049113 U CN 202049113U
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- China
- Prior art keywords
- raman
- dichroscope
- tool housing
- pharmaceutical
- lens
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Abstract
The utility model discloses a high-sensitivity measuring device for pharmaceutical ingredients. The technical key points of the high-sensitivity measuring device are as follows: pharmaceutical to be measured is placed in a spotlighting centre of a lens of a handhold type measurement instrument; 632 nm laser is irradiated on the surface of the pharmaceutical by a dichroic mirror and the lens, and stimulated Raman characteristic spectrum on the surface passes through the dichroic mirror and optical fiber and is received by a spectrometer outside a testing instrument. By analyzing the wavelength and the peak value distribution of Raman signal displayed in the spectrometer, the detection of special microconstituents in the pharmaceutical can be achieved, thus the pharmaceutical effectiveness is determined. The high-sensitivity measuring device for the pharmaceutical ingredients can be applied to monitoring pharmaceutical production of a pharmaceutical company and clinically analyzing the effectiveness of the pharmaceutical in a hospital.
Description
Technical field
The utility model relates to and a kind ofly by Raman spectroscopy drug ingedient is carried out the device of high-sensitivity measurement, and it is mainly used in the detection that particular chemical is formed in the medicine, and can estimate the validity of some drugs according to testing result.
Background technology
Medicine all is made up of the number of chemical material basically, and wherein the ratio of chemical constitution and concentration are for the curative effect decisive role of medicine.But the component content in the medicine is often more small, exists with μ g/ml even ng/ml level mostly, and this detects its concentration and has proposed very high accuracy requirement.
At present, Chang Gui detection method has: chemical-agent technique, chromatography etc.Chemical-agent technique is meant that thereby measured object is added chemical reagent causes chemical reaction, detects reaction result, and then is finally inversed by the method for some chemical composition content in the measured object.Because it is low, easy and simple to handle to detect cost, it is widely used in the conventional medicine detection, but poor specificity, and sensitivity is low also to be the hard defects of this detection method always.Chromatography is meant by the chromatography effect, and the component that physicochemical property is different in the sample is separated.If be equipped with suitable detecting device again, then can finish qualitative, the paced work of composition simultaneously.Its advantage is the specificity height, and can detect the different component in the same sample simultaneously.But the deficiency of multiplicity and operability aspect is also restricting its development in the trace detection field always.
The utility model content
Technical problem to be solved in the utility model provide a kind of to medicine micro constitutent highly sensitive and portable easy-to-use newtype drug component measuring device.The different raman scattering spectrums that it mainly produces under the 632nm wavelength laser according to the different pharmaceutical composition judge that whether it exists, and further drug effectiveness is estimated in medicine to be measured.
The technical scheme that its technical matters that solves the utility model adopts is: a kind of highly sensitive drug ingedient measurement mechanism is characterized in that comprising:
Laser instrument, tool housing and fiber spectrometer, described laser instrument are the Raman detection light source, are semiconductor laser, and wavelength is 632nm; Be connected by incident optical between described laser instrument and the described tool housing, wherein the input end of incident optical is connected with the output terminal of laser instrument, and the output terminal of incident optical is connected with the light source input end of tool housing;
Have convex lens first, Raman dichroscope, objective lens, survey drug sample and convex lens second in the tool housing, the incident laser planoconvex lens first of described incident optical expands bundle back incident Raman dichroscope, and described Raman dichroscope and convex lens first are miter angle; Incident laser after Raman dichroscope reflection, the vertical incidence objective lens, described objective lens and Raman dichroscope are miter angle; The lower end of described objective lens stretches out in described tool housing, drug sample to be measured place objective lens below, excited Raman light by drug sample reflection to be measured enters the Raman dichroscope through objective lens, its transmitted ray is injected convex lens second, and described convex lens second and Raman dichroscope are miter angle; Is connected by collecting optical fiber between fiber spectrometer and the tool housing, described collection fiber-optic output is connected with the input end of fiber spectrometer, and the collection optic fibre input end places the tool housing inboard, and is on the focal plane of convex lens second.
Be specially, a Raman dichroscope is installed in the inside of hand-held measuring instrument, by optical fiber port be that the laser of 632nm is introduced instrument with wavelength, and be connected on the measuring instrument by the Raman spectrometer of optical fiber with the outside from the outside.During use,, open laser instrument, realize the focusing of hot spot on sample, then start the software of Raman spectrometer, the stimulated Raman scattering signal of drug sample is collected the drug sample to be measured of the alignment lens on the hand-held measuring instrument.At last, according to distribution and the strength information of Raman spectrum on different wave numbers the composition of medicine is analyzed, and further drug effectiveness is estimated.
The beneficial effects of the utility model are: the detection that can directly realize fast, can't harm drug sample, avoided original technological means (as chromatography, chemical-agent technique etc.) complicated operation, shortcoming that multiplicity is low, the Raman spectrum of the drug sample that arrives by analyzing and testing, can judge its ingredient information accurately, so that further assess its validity.The mode that this system has adopted the optical fiber light lead, collected light is easy to carry and flexible operating, has good application prospects.
Description of drawings
Fig. 1 is an instrumentation diagram of the present utility model.
1. semiconductor lasers among the figure, 2. incident optical, 3. convex lens first, 4. Raman dichroscope, 5. objective lens, drug sample 6. to be measured, 7. convex lens second is 8. collected optical fiber, 9. fiber spectrometer, 10. tool housing, 11. instrument hand holding handles.
Embodiment
Embodiment describes in further detail the utility model below in conjunction with accompanying drawing.
Test principle figure of the present utility model, as shown in Figure 1.Semiconductor laser 1 is the measurement light source of this test macro, and its wavelength is 632nm.Described semiconductor laser 1 is connected on the tool housing 10 by incident optical 2, and wherein the ring flange that carries of the tail wires of fiber optics of incident optical 2 and semiconductor laser 1 is coupled, and the other end of incident optical 2 is fixed on the inboard of tool housing 10.
Incident optical 2 is positioned on the focal plane of convex lens first 3 with the access point of tool housing 10 inboards, the laser that is imported by incident optical 2 forms directional light in instrument internal through convex lens first 3 expansion bundles, and incide on the Raman dichroscope 4 at the 632nm wavelength, described Raman dichroscope 4 is 45 degree angles with convex lens first 3.Incident laser is introduced on the objective lens 5 through the reflection of Raman dichroscope 4, and finally converges on the drug sample 6 to be measured, and described objective lens 5 is 45 degree angles with Raman dichroscope 4.Described drug sample to be measured 6 is placed on the microslide, and microslide is parallel with objective lens 5.The part of described objective lens 5 is positioned at tool housing 10, and the lower end of objective lens 5 stretches out in described tool housing 10.During measurement, drug sample 6 to be measured place objective lens 5 below, i.e. the outside of tool housing 10 utilizes the burnt focusing that realizes laser facula at sample of fine setting of manual adjustment or camera lens.Laser after the focusing can effective function in the surface of drug sample 6 to be measured, realize exciting of its Raman signal.Backward scattered Raman signal is collected by same objective lens 5, and through forming directional light behind the expansion bundle of objective lens 5 and inciding on the Raman dichroscope 4.Have the transmission of the scattered light of Raman signal through Raman dichroscope 4, incide on the convex lens second 7, described convex lens second 7 is 45 degree angles with Raman dichroscope 4.Raman diffused light converges to the inboard access point place of collecting optical fiber 8 and tool housing 10 through the focusing of convex lens second 7.Described collection optical fiber 8 is used to connect tool housing 10 and fiber spectrometer 9, wherein collects optical fiber 8 and is coupled with the connector that fiber spectrometer 9 carries.
In the software of spectrometer, the Raman spectrum of detected drug sample will be with wave number (cm
-1) form show that its sensing range generally is from 200cm
-1-2600cm
-1, analyze according to the wavelength and the peak Distribution of the Raman signal that shows, can realize the accurate detection of drug sample composition, thereby provide foundation for further estimating its validity.
In addition to the implementation, the utility model also includes other embodiments, and the technical scheme that all employing equivalents or equivalent substitute mode form all should fall within the protection domain of the utility model claim.
Claims (1)
1. highly sensitive drug ingedient measurement mechanism is characterized in that comprising:
Laser instrument (1), tool housing (10) and fiber spectrometer (9), described laser instrument is the Raman detection light source, is semiconductor laser, and wavelength is 632nm; Be connected by incident optical (2) between described laser instrument (1) and the described tool housing (10), wherein the input end of incident optical (2) is connected with the output terminal of laser instrument (1), and the output terminal of incident optical (2) is connected with the light source input end of tool housing (10);
Have convex lens first (3), Raman dichroscope (4), objective lens (5) in the tool housing (10), survey drug sample (6) and convex lens second (7), the incident laser planoconvex lens first (3) of described incident optical (2) expands bundle back incident Raman dichroscope (4), and described Raman dichroscope (4) is miter angle with convex lens first (3); Incident laser after Raman dichroscope (4) reflection, vertical incidence objective lens (5), described objective lens (5) is miter angle with Raman dichroscope (4); The lower end of described objective lens (5) stretches out in described tool housing (10), drug sample to be measured (6) place objective lens (5) below, excited Raman light by drug sample to be measured (6) reflection enters Raman dichroscope (4) through objective lens (5), its transmitted ray is injected convex lens second (7), and described convex lens second (7) is miter angle with Raman dichroscope (4); Be connected by collecting optical fiber (8) between fiber spectrometer (9) and the tool housing (10), described collection optical fiber (8) output terminal is connected with the input end of fiber spectrometer (9), collect optical fiber (8) input end and place tool housing (10) inboard, and be on the focal plane of convex lens second (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011200858813U CN202049113U (en) | 2011-03-28 | 2011-03-28 | High-sensitivity measuring device for pharmaceutical ingredients |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011200858813U CN202049113U (en) | 2011-03-28 | 2011-03-28 | High-sensitivity measuring device for pharmaceutical ingredients |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202049113U true CN202049113U (en) | 2011-11-23 |
Family
ID=44989418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011200858813U Expired - Fee Related CN202049113U (en) | 2011-03-28 | 2011-03-28 | High-sensitivity measuring device for pharmaceutical ingredients |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202049113U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106872401A (en) * | 2017-02-27 | 2017-06-20 | 重庆大学 | A kind of distributed infrared laser multi-parameter gas on-line detecting system |
-
2011
- 2011-03-28 CN CN2011200858813U patent/CN202049113U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106872401A (en) * | 2017-02-27 | 2017-06-20 | 重庆大学 | A kind of distributed infrared laser multi-parameter gas on-line detecting system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111123 Termination date: 20120328 |