CN201930730U - Membrane emulsifier - Google Patents
Membrane emulsifier Download PDFInfo
- Publication number
- CN201930730U CN201930730U CN2011200031622U CN201120003162U CN201930730U CN 201930730 U CN201930730 U CN 201930730U CN 2011200031622 U CN2011200031622 U CN 2011200031622U CN 201120003162 U CN201120003162 U CN 201120003162U CN 201930730 U CN201930730 U CN 201930730U
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- port
- valve
- holding vessel
- microporous barrier
- storage tank
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Abstract
A membrane emulsifier relates to an emulsifier and is capable of decreasing the length and the resistance of a pipeline, improving product yield during preparation and reducing emulsion quantity. The membrane emulsifier is provided with a microporous membrane tube, a storage tank, a pressure gauge, a magnetic drive pump, a sample collecting beaker, a nitrogen gas cylinder, a cross, a discharge valve, an exhaust valve and a gas inlet valve. A feeding port of the microporous membrane tube is respectively connected with a discharging port of the storage tank and the magnetic drive pump; a discharging port of the microporous membrane tube is connected with the sample collecting beaker by the aid of the discharge valve; the sample collecting beaker is connected with the magnetic drive pump by the aid of a pipeline; a feeding port of the storage tank is connected with a first port of the cross; a gas outlet of the nitrogen gas cylinder is connected with a second port of the cross by the aid of the gas inlet valve; a gas inlet of the exhaust valve is connected with a third port of the cross; and the pressure gauge is connected with a fourth port of the cross. The membrane emulsifier is convenient to control, sample treatment capacity can be improved remarkably, and gas flow can be adjusted conveniently, so that the internal pressure of the storage tank is controlled precisely. Besides, the membrane emulsifier is simple in structure and convenient in maintenance.
Description
Technical field
The utility model relates to a kind of emulsifier, especially relates to a kind of small-sized (15～1000mL emulsion) fast flux SPG membrane emulsifier.
Background technology
The existing method that prepare emulsion generally adopts mechanical agitation, homogeneous and method such as ultrasonic, though process conditions are simple, prepares poor repeatability, and particle size uniformity is very poor, and particle size is very difficult to be controlled.
The SPG technology Co., Ltd of Japan has developed a kind of novel membrane emulsifier, its preparation process is: at first method such as the machinery by routine, homogeneous prepares needed initial latex, then initial latex is joined in the holding vessel of membrane emulsifier, the emulsion in the holding vessel is rapid in descending the passway in the capping and pressing the SPG fenestra to obtain the emulsion of uniform particle diameter under elevated pressures.Its holding vessel is a column type cavity, is sealed by a capping respectively up and down, is made up of a charging aperture and discharging opening in the centre of capping.
China utility model patent 200720103949.X discloses a kind of membrane emulsifier, comprise intake valve, air bleeding valve, holding vessel, capping and microporous barrier pipe, the internal structure of described holding vessel is a conical cavity, and the cross-sectional area of the lower pyramid mouth of holding vessel is less than or equal to down the cross-sectional area of passway in the capping.It is circular that the cross section of described lower pyramid mouth is preferably, and the surface, inside of described holding vessel is preferably smooth bevel, and described holding vessel is preferably an overall structure, and also can be in internal structure is that a conulite is inlayed in the inside of the holding vessel of cylindrical cavity.This patent is that the holding vessel in the membrane emulsifier of the SPG technology Co., Ltd exploitation of Japan is improved, and its total arrangement is not transformed.In fact, the membrane emulsifier of the exploitation of Japan exists following design defect: the first, and pipeline is longer, and resistance is big; The second, storage tank and the parallel design of microporous barrier pipe are unfavorable for the circulation of decentralized photo, and its minimum emulsification amount that needs needs 50mL.
Summary of the invention
The purpose of this utility model is to solve the design defect of existing membrane emulsifier, and a kind of pipeline length and resistance of reducing is provided, and improves the product yield in the preparation process, reduces the membrane emulsifier of minimum emulsification liquid measure.
The utility model is provided with microporous barrier pipe, storage tank, Pressure gauge, magnetic drive pump, sample collection beaker, nitrogen cylinder, four-way, blow-off valve, air bleeding valve and intake valve; The charging aperture of microporous barrier pipe is connected with magnetic drive pump with the discharging opening of storage tank respectively, and the discharging opening of microporous barrier pipe connects sample through blow-off valve and collects beaker, and sample is collected beaker and is connected with magnetic drive pump through pipeline; The charging aperture of storage tank connects the 1st port of four-way, and the gas outlet of nitrogen cylinder connects the 2nd port of four-way through intake valve, and the air inlet of air bleeding valve connects the 3rd port of four-way, and Pressure gauge connects the 4th port of four-way.
The charging aperture of described microporous barrier pipe and discharge gate can be located at microporous barrier pipe top and be parallel to each other.
The jar mouth of described holding vessel can adopt snap joint with being connected of cover, convenient charging.
The internal structure of described holding vessel can be cylindrical cavity, and the end opening shape of holding vessel can be arc lower, the curved bottom of cylindrical cavity and cylindrical cavity one, and the outlet of holding vessel is positioned at the center of arcwall face, is beneficial to liquid and all flows out.
Described intake valve can adopt needle-valve, can regulate the air-flow size, thereby accurately controls the holding vessel internal pressure.
Described holding vessel is fixed by iron clamp by vertical iron with the microporous barrier pipe; Magnetic drive pump is fixed on the steel plate.
Compare with existing emulsifier, the utlity model has following outstanding advantage:
Because the charging aperture of microporous barrier pipe links to each other with the discharging opening of holding vessel, the charging aperture of microporous barrier pipe and discharge gate are located at microporous barrier pipe top and are parallel to each other, charging aperture and discharge gate by a valve control, therefore are convenient to the control to device respectively, can significantly improve the ability of handling sample.Because the jar mouth of holding vessel adopts snap joint with being connected of cover, therefore is convenient to charging.Because the internal structure of holding vessel is a cylindrical cavity, the end opening of holding vessel is shaped as arc lower, and outlet is positioned at the center of arcwall face, therefore helps liquid and all flows out.Because intake valve adopts needle-valve, therefore be convenient to regulate the air-flow size, thereby accurately control the holding vessel internal pressure.In addition, of the present utility model simple in structure, be convenient to maintenance.
Description of drawings
Fig. 1 is the structure composition frame chart of the utility model embodiment.
The specific embodiment
Be further described below in conjunction with 1 pair of the utility model of accompanying drawing, but the utility model is not limited only to following specific embodiment.
As shown in Figure 1, the utility model embodiment is provided with microporous barrier pipe 1, storage tank 2, Pressure gauge 3, magnetic drive pump 4, sample collection beaker 5, nitrogen cylinder 6, four-way 7, blow-off valve 8, air bleeding valve 9 and intake valve 10; The charging aperture of microporous barrier pipe 1 is connected with magnetic drive pump 4 with the discharging opening of storage tank 2 respectively, and the discharging opening of microporous barrier pipe 1 connects sample through blow-off valve 8 and collects beaker 5, and sample is collected beaker 5 and is connected with magnetic drive pump 4 through pipeline; The charging aperture of storage tank 2 connects the 1st port of four-way 7, and the gas outlet of nitrogen cylinder 6 connects the 2nd port of four-way 7 through intake valve 10, and the air inlet of air bleeding valve 9 connects the 3rd port of four-way 7, and Pressure gauge 3 connects the 4th port of four-way 7.The charging aperture of described microporous barrier pipe 1 and discharge gate are located at microporous barrier pipe top and are parallel to each other.
The jar mouth of described holding vessel 2 adopts snap joint with being connected of cover, convenient charging.
The internal structure of described holding vessel 2 is a cylindrical cavity, and the end opening of holding vessel 2 is shaped as arc lower, the curved bottom of cylindrical cavity and cylindrical cavity one, and the outlet of holding vessel 2 is positioned at the center of arcwall face, is beneficial to liquid and all flows out.
Described intake valve 10 adopts needle-valve, can regulate the air-flow size, thereby accurately control the holding vessel internal pressure.
Described holding vessel 2 is fixed by iron clamp by vertical iron with microporous barrier pipe 1.Magnetic drive pump 4 can be fixed on the steel plate.
In the emulsion preparation process, the SPG film is loaded in the microporous barrier pipe 1, colostric fluid is joined in the holding vessel 2, each device of link is opened intake valve 10, and the gas pressure that the initial latex in the holding vessel 2 enters via intake valve 10 passes through the discharging opening of holding vessel 2 fast, arrive microporous barrier pipe 1 then, after passing the SPG film, taken away mutually, collect in the beaker 5 at sample at last and obtain the uniform emulsion of particle diameter by flowing in the SPG film.
Below provide specific embodiment:
The internal structure of holding vessel is the cylindrical cavity of camber under the bottom is, its external diameter is 6.2cm, highly be 16cm, the curved bottom of cavity and cylindrical cavity are one, discharging opening is positioned at the central authorities of bottom, its diameter is 0.6cm, and cylindrical cavity suitable for reading has a capping, and the diameter of passway is 0.6cm in the capping.
10mg mitomycin and an amount of surfactant dissolves in the distilled water of 5mL, as interior water, are dissolved in the PLGA (50/50, molecular weight 5000) of 02g in the 10ml carrene, as oil phase; Interior water is mixed with oil phase, and ultrasonic emulsification 10s in the ice-water bath gets in touch ultrasonic 3 times, obtains the w/o type colostrum.Colostrum is joined holding vessel in the above-mentioned membrane emulsifier fast, operating pressure at 50kPa pressed down the microporous barrier device, taken away by the mobile phase in the SPG film (100mL concentration is the PVA aqueous solution of 0.5%WT), obtain double emulsion, again with under the double emulsion room temperature, stir 24h to remove organic solvent dichloromethane, both obtained the microballoon of medicine carrying again through centrifuge washing.With the microballoon vacuum drying of gained, be 0.165g through weighing, yield is 82.5%.The minimum emulsification amount of this emulsifier is 15mL.
Below provide Comparative Examples:
The membrane emulsifier of Comparative Examples utilization Japan SPG membrane technology Co., Ltd carries out the preparation of emulsion, and specific implementation process and result are as follows:
40mg mitomycin and an amount of surfactant dissolves in the distilled water of 20mL, as interior water, are dissolved in the PLGA (50/50, molecular weight 5000) of 0.8g in the 40mL carrene, as oil phase; Interior water is mixed with oil phase, and ultrasonic emulsification 10s in the ice-water bath gets in touch ultrasonic 3 times, obtains the w/o type colostrum.Colostrum is joined holding vessel in the above-mentioned membrane emulsifier fast, operating pressure at 50kPa pressed down the microporous barrier device, taken away by the mobile phase in the SPG film (400mL concentration is the PVA aqueous solution of 0.5%WT), obtain double emulsion, again with under the double emulsion room temperature, stir 24h to remove organic solvent dichloromethane, both obtained the microballoon of medicine carrying again through centrifuge washing.With the microballoon vacuum drying of gained, be 0.52g through weighing, yield is 61.9%.The minimum emulsification amount that this emulsifier needs is 60mL.
Claims (5)
1. a membrane emulsifier is characterized in that being provided with microporous barrier pipe, storage tank, Pressure gauge, magnetic drive pump, sample collection beaker, nitrogen cylinder, four-way, blow-off valve, air bleeding valve and intake valve; The charging aperture of microporous barrier pipe is connected with magnetic drive pump with the discharging opening of storage tank respectively, and the discharging opening of microporous barrier pipe connects sample through blow-off valve and collects beaker, and sample is collected beaker and is connected with magnetic drive pump through pipeline; The charging aperture of storage tank connects the 1st port of four-way, and the gas outlet of nitrogen cylinder connects the 2nd port of four-way through intake valve, and the air inlet of air bleeding valve connects the 3rd port of four-way, and Pressure gauge connects the 4th port of four-way.
2. a kind of membrane emulsifier as claimed in claim 1 is characterized in that the charging aperture of described microporous barrier pipe and discharge gate are located at microporous barrier pipe top and are parallel to each other.
3. a kind of membrane emulsifier as claimed in claim 1, the internal structure that it is characterized in that described holding vessel is a cylindrical cavity, the end opening of holding vessel is shaped as arc lower, the curved bottom of cylindrical cavity and cylindrical cavity one, and the outlet of holding vessel is positioned at the center of arcwall face.
4. a kind of membrane emulsifier as claimed in claim 1 is characterized in that described intake valve adopts needle-valve.
5. a kind of membrane emulsifier as claimed in claim 1 is characterized in that described holding vessel fixed by iron clamp by vertical iron with the microporous barrier pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011200031622U CN201930730U (en) | 2011-01-07 | 2011-01-07 | Membrane emulsifier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011200031622U CN201930730U (en) | 2011-01-07 | 2011-01-07 | Membrane emulsifier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201930730U true CN201930730U (en) | 2011-08-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011200031622U Expired - Fee Related CN201930730U (en) | 2011-01-07 | 2011-01-07 | Membrane emulsifier |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201930730U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102489226A (en) * | 2011-11-23 | 2012-06-13 | 清华大学 | Sol boiling system |
| CN106139943A (en) * | 2016-06-28 | 2016-11-23 | 山东省科学院能源研究所 | A kind of membrane emulsifier and emulsion preparation method |
-
2011
- 2011-01-07 CN CN2011200031622U patent/CN201930730U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102489226A (en) * | 2011-11-23 | 2012-06-13 | 清华大学 | Sol boiling system |
| CN106139943A (en) * | 2016-06-28 | 2016-11-23 | 山东省科学院能源研究所 | A kind of membrane emulsifier and emulsion preparation method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110817 Termination date: 20150107 |
|
| EXPY | Termination of patent right or utility model |