CN201006421Y - Membrane emulsifier - Google Patents
Membrane emulsifier Download PDFInfo
- Publication number
- CN201006421Y CN201006421Y CNU200720103949XU CN200720103949U CN201006421Y CN 201006421 Y CN201006421 Y CN 201006421Y CN U200720103949X U CNU200720103949X U CN U200720103949XU CN 200720103949 U CN200720103949 U CN 200720103949U CN 201006421 Y CN201006421 Y CN 201006421Y
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- Prior art keywords
- holding vessel
- membrane emulsifier
- storage pot
- utility
- model
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Abstract
The utility model discloses a membrane emulsifier, comprising an air inlet valve, an air outlet valve, a storage pot, a seal cover and a porous membrane tube, wherein the storage pot has a cone chamber which lower cone opening is not larger than the channel opening of a lower seal cover, the lower taper opening is round as best, the inner surface of the storage pot is smooth incline as best, and the storage pot is an integral structure as best, or the storage pot with a cylinder chamber can be embedded with a hollow cone. The utility model can avoid left on the lower seal cover when prepares emulsion and microcapsule with controllable and uniform size, to improve product yield.
Description
Technical field
The utility model relates to the emulsion preparation device, and more particularly, the utility model relates to the membrane emulsifier of the controlled emulsion of a kind of quick preparation size homogeneous.
Background technology
Medicine carrying microcapsule occupies an important position in the medicine controlled releasing system, adopt solvent evaporates/extraction to prepare the existing very long phase of history of medicine microspheres, but great majority also rest on the laboratory research stage so far, still exist many problems restricting microball preparation and enter Clinical Application.Traditional preparation method adopt mechanical agitation, homogeneous, etc. method prepare emulsion, though process conditions are simple, but preparation repeatability is very poor, the product of different batches exists on performance than big difference, be not easy to industry's enlarging production, and the uniform particle diameter for preparing is very poor, and particle size is difficult to control.
Chinese patent (publication number CN1605359) discloses and has a kind ofly prepared the preparation method of homogeneous microballoon with conventional film emulsifying device, but this method preparation efficiency is low, complicated operation and be difficult to prepare the micro emulsion or the microballoon of small particle diameter.The SPG technology Co., Ltd of Japan has developed a kind of novel membrane emulsifier, its preparation process is, at first emulsifying manner such as the methods such as mechanical agitation, homogeneous by routine prepare needed initial latex (as W/O/W double emulsion etc.), then initial latex is joined in the holding vessel of membrane emulsifier, emulsion in the holding vessel under elevated pressures rapidly by the passway in the capping down and then pressed the SPG fenestra to obtain the emulsion of uniform particle diameter, in this process microporous barrier actual be to be used as a kind of special low pressure homogenizing valve.But in the existing membrane emulsifier, the internal structure of holding vessel is the column type cavity, after initial latex adds holding vessel again, evenly be tiled in down on the capping, when organic solvent dichloromethane the most commonly used prepares in adopting the medicine carrying microcapsule preparation process, because the density of carrene is bigger than water, the oil phase that is embedded with medicine in the double emulsion sinks to the bottom rapidly and is tiled in lower seal and covers, the passway cross-sectional area of the following outlet cross-sectional area of column type cavity in the capping, therefore there is the oil phase of considerable part to be retained on the capping, seriously influenced the product yield of preparation process.
Summary of the invention
The purpose of this utility model solves shortcoming of the prior art exactly, and a kind of improved membrane emulsifier is provided, to improve the product yield in the preparation process.
The membrane emulsifier that the utility model provides comprises intake valve, air bleeding valve, holding vessel, capping and microporous barrier pipe, the internal structure of described holding vessel is a conical cavity, and the cross-sectional area of the lower pyramid mouth of holding vessel is less than or equal to down the cross-sectional area of passway in the capping.
It is circular that the cross section of described lower pyramid mouth is preferably, the surface, inside of described holding vessel is preferably smooth bevel, described holding vessel preferably prepares with stainless steel material, described holding vessel is preferably an overall structure, and also can be in internal structure is that a conulite is inlayed in the inside of the holding vessel of cylindrical cavity.
The membrane emulsifier that the utility model provides can avoid that emulsion can significantly improve the product yield in the preparation process holding back that lower seal covers in preparation process.
Description of drawings
Fig. 1 is the device schematic diagram of the utility model membrane emulsifier;
Fig. 2 is the profile of the holding vessel in the utility model membrane emulsifier;
Fig. 3 is the vertical view of the holding vessel in the utility model membrane emulsifier;
Fig. 4 is the profile of the holding vessel in the membrane emulsifier in the prior art;
The specific embodiment
Below in conjunction with drawings and Examples the utility model is further described, but the utility model is not limited only in this specific embodiment.
As figure, membrane emulsifier comprises intake valve 1, Pressure gauge 2, air bleeding valve 3, holding vessel 4, capping 5 and microporous barrier pipe 8, in the medicine carrying microcapsule preparation process, fully wetting SPG film 7 is loaded in the microporous barrier pipe 8, initial latex is joined in the holding vessel 4, connect each device, open intake valve 1, initial latex in the holding vessel 4 reaches SPG film 7 surfaces by the passway 6 in the following capping 5 fast via the gas pressure that intake valve 1 enters, and passes SPG film 7 backs and is collected the emulsion that promptly obtains uniform particle diameter by beaker 9.
Embodiment
The internal structure of the holding vessel in the membrane emulsifier is a conical cavity, and the cross section of last lower pyramid mouth is circle, and the diameter of epicone mouth is 5.5cm, and the diameter of lower pyramid mouth is 0.7cm, and the diameter of passway is 0.9cm in the capping, and the holding vessel height is 10cm.
The 10mg lysozyme is dissolved in the deionized water of 2mL,, the PLGA film material (molecular weight 30,000) of 0.2g is dissolved in the 8mL carrene, as oil phase as interior water.Interior water is mixed with oil phase, and ultrasonic emulsification 15s in the ice-water bath obtains the w/o type colostrum.This is joined colostrum in the PVA aqueous solution of 1%wt of 40mL, magnetic agitation 300rpm stirs 30s and prepares pre-double emulsion, again will this pre-double emulsion add the holding vessel in the above-mentioned membrane emulsifier, operating pressure at 300kPa pressed down the microporous barrier device, obtain double emulsion, with under the double emulsion room temperature, stir 24h again, promptly obtain medicine carrying microcapsule through centrifuge washing again to remove organic solvent dichloromethane.The micro-capsule vacuum drying 48h of gained is obtained the finished product micro-capsule, is 0.15g through weighing, and yield is 71%.
Comparative Examples
The internal structure of the holding vessel in the membrane emulsifier is a cylindrical cavity, and the diameter of the upper and lower opening of cavity is 5.5cm, and the diameter of passway is 0.9cm in the capping, and the holding vessel height is 10cm.
The 10mg lysozyme is dissolved in the deionized water of 2mL,, the PLGA film material (molecular weight 30,000) of 0.2g is dissolved in the 8mL carrene, as oil phase as interior water.Interior water is mixed with oil phase, and ultrasonic emulsification 15s in the ice-water bath obtains the w/o type colostrum.This is joined colostrum in the PVA aqueous solution of 1%wt of 40mL, magnetic agitation 300rpm stirs 30s and prepares pre-double emulsion, again will this pre-double emulsion add the holding vessel in the above-mentioned membrane emulsifier, operating pressure at 300kPa pressed down the microporous barrier device, obtain double emulsion, with under the double emulsion room temperature, stir 24h again, promptly obtain medicine carrying microcapsule through centrifuge washing again to remove organic solvent dichloromethane.The micro-capsule vacuum drying 48h of gained is obtained the finished product micro-capsule, is 0.07g through weighing, and yield is 33%.
Claims (5)
1. membrane emulsifier, comprise intake valve, air bleeding valve, holding vessel, capping and microporous barrier pipe, it is characterized in that the internal structure of described holding vessel is a conical cavity, the cross-sectional area of the lower pyramid mouth of holding vessel is less than or equal to down the cross-sectional area of passway in the capping.
2. membrane emulsifier as claimed in claim 1 is characterized in that, the surface, inside of described holding vessel is a smooth bevel.
3. membrane emulsifier as claimed in claim 1 is characterized in that, the cross section of the lower pyramid mouth of described holding vessel is circular.
4. membrane emulsifier as claimed in claim 1 is characterized in that, the as a whole structure of described holding vessel.
5. membrane emulsifier as claimed in claim 1 is characterized in that, described holding vessel is for being that a conulite is inlayed in the inside of the holding vessel of cylindrical cavity in internal structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU200720103949XU CN201006421Y (en) | 2007-03-23 | 2007-03-23 | Membrane emulsifier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU200720103949XU CN201006421Y (en) | 2007-03-23 | 2007-03-23 | Membrane emulsifier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201006421Y true CN201006421Y (en) | 2008-01-16 |
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ID=39002366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU200720103949XU Expired - Lifetime CN201006421Y (en) | 2007-03-23 | 2007-03-23 | Membrane emulsifier |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201006421Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101683592B (en) * | 2008-09-28 | 2011-12-14 | 中国科学院过程工程研究所 | Membrane emulsifier and method of preparing emulsion |
| CN103301762A (en) * | 2013-06-04 | 2013-09-18 | 北京中医药大学 | Emulsifying membrane component |
-
2007
- 2007-03-23 CN CNU200720103949XU patent/CN201006421Y/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101683592B (en) * | 2008-09-28 | 2011-12-14 | 中国科学院过程工程研究所 | Membrane emulsifier and method of preparing emulsion |
| CN103301762A (en) * | 2013-06-04 | 2013-09-18 | 北京中医药大学 | Emulsifying membrane component |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20080116 |
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| CX01 | Expiry of patent term |