CN201852800U - Helicobacter pylori 14C detection device - Google Patents
Helicobacter pylori 14C detection device Download PDFInfo
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- CN201852800U CN201852800U CN2010202710835U CN201020271083U CN201852800U CN 201852800 U CN201852800 U CN 201852800U CN 2010202710835 U CN2010202710835 U CN 2010202710835U CN 201020271083 U CN201020271083 U CN 201020271083U CN 201852800 U CN201852800 U CN 201852800U
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- helicobacter pylori
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Abstract
The utility model relates to a helicobacter pylori 14C detection device which comprises a 14C collection module used for collecting 14C in gas exhaled by a patient, a pulse generation module used for exciting the 14C to generate beta rays and converting the beta rays into pulse electric signals, a pulse counting module used for counting the pulse electric signals, and a diagnosis module used for diagnosing whether the patient is affected by helicobacter pylori or not on the basis of the counted number of the pulse electric signals. The helicobacter pylori 14C detection device has the advantages that: a) since liquid absorbent containing methanol is not used, the risk of sucking the corrosive toxic liquid back into the mouth of the patient can be avoided; b) since toxic and carcinogenic substances such as methylbenzene and dimethylbenzene are not used, operators and the patient are not jeopardized at all, the environmental pollution is not caused and the device is an environment-friendly product; and c) the automation level is high and the device is simple to operate.
Description
Technical field
The utility model relates to the detection of helicobacter pylori, more particularly, relates to a kind of helicobacter pylori
14The C pick-up unit.
Background technology
Helicobacter pylori is that nineteen eighty-three Australia scholar's Luo Bin Warren (J.Robin Warren) and Barry Marshall (Barry J.Marshall) at first are separated to from a chronic active gastritis patient gastric mucosa biopsy specimen.The people is unique natural reservoir (of bird flu viruses) of helicobacter pylori, and the crowd infection rate is very high, and whole world crowd infection rate is up to 30～50%.Helicobacter pylori can cause the generation of a lot of diseases, and therefore clinical diagnosis and the treatment to it is very important.
Urea [
14C] breath test is the at present international and domestic helicobacter pylori diagnostic method that generally adopts.It is based on radioactive isotope
14The breathing detection principle of C utilizes helicobacter pylori to be rich in the characteristics of urease, by the oral little dosage of person under inspection
14C-urea makes the urease catalyzes of helicobacter pylori in the stomach
14C-urea, at last by lung with
14CO
2Form is breathed out.
Common helicobacter pylori tester all is to adopt liquid sudden strain of a muscle method to detect at present
14C.As on January 23rd, 2007, the patented claim CN 200710073016 of proposition disclosed a kind of " kit of diagnosing helicobacter pylori ", and it comprises different components such as absorbing agent, scintillator, polar solvent at least.When actual clinical was used, the patient blew in absorbing agent earlier, gives the doctor after having blown.The doctor will prepare scintillation solution and polar solvent on request, and the solution after will preparing again adds in the absorbing agent just can be measured.The defective that such kit exists is that patient sucks absorbing agent easily when exhaling operation, and needs the doctor to carry out a large amount of manually-operateds, and these liquid itself also can pollute environment.
Also have some helicobacter pylori detection companies to adopt mass spectrometer or infrared detector to detect
14C.Yet the defective of this detection method is, detects about 2～3 minutes consuming time an of sample, and apparatus expensive, detects the cost height.
The utility model content
The technical problems to be solved in the utility model is, at prior art otherwise complicated operation, and the solution that produces can pollute environment, or length consuming time and apparatus expensive, detects defect of high cost, and a kind of helicobacter pylori is provided
14The C pick-up unit.
The technical scheme that its technical matters that solves the utility model adopts is: construct a kind of helicobacter pylori
14The C pick-up unit comprises:
14The C collection module is used for collecting patient expired gas
14C;
The pulse generation module is used to excite described
14C to be producing the β ray, and described β ray is changed into pulse electrical signal;
Pulse counter module is counted described pulse electrical signal;
Whether diagnostic module infects helicobacter pylori based on the counting diagnosis of described pulse electrical signal.
Helicobacter pylori described in the utility model
14In the C pick-up unit, described
14The C collection module is the gas collection card.
Helicobacter pylori described in the utility model
14In the C pick-up unit, described pulse generation module comprises:
Circuit for producing high voltage is used to produce the driving high pressure that drives the GM pipe;
The GM pipe is used to receive described driving high pressure, excites described
14C is to produce the β ray and described β ray is changed into pulse electrical signal.
Helicobacter pylori described in the utility model
14In the C pick-up unit, described pulse generation module further comprises the potentiometer of the magnitude of voltage that is used to regulate the driving high pressure that described circuit for producing high voltage produces.
Helicobacter pylori described in the utility model
14In the C pick-up unit, described pulse counter module further comprises:
Counting unit is used to count described pulse electrical signal;
The detector switch circuit is used for opening and closing in setting-up time, and then controls described counting unit at the described pulse electrical signal of described setting-up time inside counting;
Pulse shaping circuit is used for the described pulse electrical signal of shaping.
Helicobacter pylori described in the utility model
14In the C pick-up unit, described diagnostic module further comprises:
Judging unit is used for when the counting of the described pulse electrical signal that receives is higher than setting threshold, judges that patient has infected helicobacter pylori;
Tip element is used for judging that at described judging unit patient has infected helicobacter pylori and pointed out;
Storage unit, the result of determination that is used to store described judging unit.
Helicobacter pylori described in the utility model
14In the C pick-up unit, described Tip element comprises hummer and/or LCD.
Helicobacter pylori described in the utility model
14In the C pick-up unit, described diagnostic module further comprises the printer that is used to print described result of determination.
Helicobacter pylori described in the utility model
14In the C pick-up unit, described judging unit is a central controller, and by bus driving circuits and described Tip element, storage unit and printer communication.
Implement helicobacter pylori of the present utility model
14The C pick-up unit, the utility model is by collecting in the patient expired gas
14C; Excite described
14C to be producing the β ray, and described β ray is changed into pulse electrical signal, judges whether patient infects helicobacter pylori thereby count described pulse electrical signal again, so has the following advantages:
A) do not use the liquid-absorbant that contains methyl alcohol, thereby the danger that corrosivity toxic liquid absorbing agent suck-back is not entered the mouth;
B) do not use toluene poisonous carcinogens such as (dimethylbenzene).Operating personnel and patient are safe from harm fully, also can pollute, belong to environment-friendly products environment;
C) the automaticity height is simple to operate.
Description of drawings
The utility model is described in further detail below in conjunction with drawings and Examples, in the accompanying drawing:
Fig. 1 is a helicobacter pylori of the present utility model
14The theory diagram of first embodiment of C pick-up unit;
Fig. 2 is a helicobacter pylori of the present utility model
14The structural representation of second embodiment of C pick-up unit;
Fig. 3 is the helicobacter pylori of the present utility model shown in Fig. 2
14The software flow pattern of C pick-up unit.
Embodiment
As shown in Figure 1, helicobacter pylori of the present utility model
14The C pick-up unit comprises:
14C collection module, pulse generation module, pulse counter module and diagnostic module.Wherein said
14The C collection module is used for collecting patient expired gas
14C.In a preferred embodiment of the present utility model, should
14The C collection module can be in the adsorbable patient expired gas
14The gas collection card of C.In other embodiment of the present utility model, should
14The C collection module also can be that other can adsorb in the patient expired gas
14The gas extractor of C.Any gas extractor as known in the art as long as it can finish the required basic function of the utility model, may be used to the utility model.At this, the utility model is not subjected to
14The restriction of the specific implementation form of C collection module.
This pulse generation module can be used to excite described
14C to be producing the β ray, and described β ray is changed into pulse electrical signal.In a preferred embodiment of the present utility model, it can be to have highly sensitive GM pipe (Geiger-Muller, Geiger-Miller) pipe.
This pulse counter module can be used for counting described pulse electrical signal, and for example it can be an impulse meter.
This diagnostic module can receive the counting of described pulse electrical signal from this pulse counter module, and whether infects helicobacter pylori based on the counting diagnosis of described pulse electrical signal.For example, when the counting of the pulse electrical signal that obtains during, can judge that patient has infected helicobacter pylori greater than an original start value.
Below in conjunction with the helicobacter pylori shown in Fig. 1
14The C pick-up unit is done further introduction to its principle and operating process.At first patient should be in the morning on an empty stomach or take food and tested later in two hours.The test patient with about 20ml cold potable water take urea [
14C] behind one of the capsule, sat quietly 25 minutes.During this period, but patient's stomach in the contained urease catalysis of helicobacter pylori
14C-urea, at last by lung with
14CO
2Form is breathed out.At this moment, patient can blow to the gas collection card.When the gas collection card has adsorbed in the patient expired gas
14After the C, the gas collection card is inserted in the window of GM pipe.The GM pipe under high drive,
14C can discharge the β ray, and changes pulse electrical signal into by the GM pipe.Subsequently, but the number of pulse electrical signal in the record unit time when it surpasses certain threshold value, is represented in the patient expired gas
14C content exceeds certain threshold value, that is to say that patient's helicobacter pylori infections is diagnosed as the positive, otherwise negative.
Fig. 2 is a helicobacter pylori of the present utility model
14The structural representation of second embodiment of C pick-up unit.In the embodiment shown in Fig. 2, the gas collection card is used for collecting patient expired gas
14C.Subsequently, enrichment
14The gas collection card of C is inserted in the window of GM pipe.Circuit for producing high voltage can produce 800 volts driving high pressure in order to drive this GM pipe.In a preferred embodiment of the present utility model, can adopt potentiometer to regulate the magnitude of voltage of the driving high pressure of circuit for producing high voltage generation.At this moment, described
14C is excited to produce the β ray, and at this moment, the GM pipe changes into pulse electrical signal with described β ray.
In the present embodiment, for the pulse electrical signal number of analytical unit in the time more accurately, described pulse counter module further comprises: counting unit, detector switch circuit and pulse shaping circuit.Wherein, this counting unit is used for the count pulse electric signal, and it can be a counter.This pulse shaping circuit can be used for the pulse electrical signal that the GM pipe transforms is carried out shaping, thereby better realizes counting.This detector switch circuit is used for opening and closing in setting-up time, and then controls described counting unit at the described pulse electrical signal of described setting-up time inside counting.Such as, after this detector switch circuit was opened, counting unit began counting, and after 250s (can certainly be 100s, the time of any needs such as 500s), the detector switch circuit is closed, and counting unit stops counting.In an embodiment of the present utility model, the opening and closing time of this detector switch circuit can set in advance.In optional embodiment of the present utility model, this pulse shaping circuit is connected to after this detector switch circuit, the pulse electrical signal that need count with shaping.In other embodiment of the present utility model, also can carry out shaping by first paired pulses electric signal.
In a preferred embodiment of the present utility model, the opening and closing time of this detector switch circuit can be directly built-in, for example realizes by built-in timer in the detector switch circuit.In another preferred embodiment of the present utility model, can be set the opening and closing time of detector switch circuit by diagnostic module.In such embodiments, this diagnostic module can comprise that a central controller is used as judging unit.Can set in advance in this central controller or can by keyboard input opening and closing time of detector switch circuit be arranged by the user, thus the opening and closing of control detection on-off circuit.
In addition, open the setting threshold that further stores pulse electrical signal in this central controller.In other embodiment of the present utility model, also can be by the setting threshold of keyboard input pulse electric signal.This central controller
From the counting of counting unit received pulse electric signal, itself and storage setting threshold are wherein compared.When the counting of the pulse electrical signal of this reception during, show in the gas that the people breathes out greater than this setting threshold
14C content exceeds certain threshold value, that is to say that patient's helicobacter pylori infections is diagnosed as the positive, otherwise negative.
In the preferred embodiment shown in Fig. 2, this diagnostic module has also further comprised and has been used for judging that at described central controller patient has infected the Tip element that helicobacter pylori points out and has been used to store the storage unit of the result of determination of described central controller.For example, this Tip element can comprise hummer and/or LCD.This central controller can be connected with this hummer, LCD and storage unit by bus driving circuits.When central controller judges that patient has infected helicobacter pylori, hummer will toot cry, and LCD will show relevant informations such as patient has infected.In another embodiment of the present utility model, central controller also is connected with printer by bus driving circuits, and then can print result of determination.
Those skilled in the art know, though be the function that judging unit is described with central controller in the utility model, other can carry out the controller of aforesaid operations, or control module, as microprocessor, microcontroller, PC or the like may be used to the utility model.Above-mentioned Tip element can also comprise the LED lamp except comprising hummer and LCD, can glimmer by it to represent testing result.Storage unit can be connected with central controller by communication bus or other communication interfaces in the central controller outside, also can be built in central controller inside.In addition, also can adopt as hand-written touch screen and substitute keyboard, be used to import correlation parameter or the like.
Fig. 3 is the helicobacter pylori of the present utility model shown in Fig. 2
14The software flow pattern of C pick-up unit.As shown in Figure 3, before detecting, to whole helicobacter pylori
14The C pick-up unit carries out initialization, just to IO extended chip, real-time clock, the timer of central controller and be connected to central controller, LCD, printer carry out initialization.At this moment, LCD display system self check interface.Subsequently, pulse counter module begins initialization.Enter background and demarcate subroutine this moment.Timer initialization, timer are to be used to prevent various long-time non-responsive states.After this, liquid crystal display displays standby condition master interface.At this moment, the circular wait button triggers.Do not trigger if 30s has button, then close liquid crystal, the standby lamp is bright.If there is this moment the button of detection to be triggered, then enter the detection subroutine, just implement helicobacter pylori of the present utility model
14C detects.If parameter is provided with button and is triggered, then carry out parameter subroutine is set, the user can be provided with correlation parameter voluntarily, as the setting-up time of detector switch circuit opening and closing, setting threshold of pulse electrical signal counting or the like.If background is demarcated button and is triggered, then advance as background and demarcate subroutine, carry out background and demarcate.
By foregoing description, those skilled in the art know, helicobacter pylori of the present utility model
14The C pick-up unit has the following advantages:
A) do not use the liquid-absorbant that contains methyl alcohol, thereby the danger that corrosivity toxic liquid absorbing agent suck-back is not entered the mouth;
B) do not use toluene poisonous carcinogens such as (dimethylbenzene).Operating personnel and patient are safe from harm fully, also can pollute, belong to environment-friendly products environment;
C) the automaticity height is simple to operate.
Though the utility model describes by specific embodiment; it will be appreciated by those skilled in the art that; under the situation that does not break away from the utility model scope, can also carry out various conversion and be equal to alternatively the utility model, all should fall into protection domain of the present utility model.
Claims (9)
1. helicobacter pylori
14The C pick-up unit is characterized in that, comprising:
14The C collection module is used for collecting patient expired gas
14C;
The pulse generation module is used to excite described
14C to be producing the β ray, and described β ray is changed into pulse electrical signal;
Pulse counter module is counted described pulse electrical signal;
Whether diagnostic module infects helicobacter pylori based on the counting diagnosis of described pulse electrical signal.
2. helicobacter pylori according to claim 1
14The C pick-up unit is characterized in that, and is described
14The C collection module is the gas collection card.
3. helicobacter pylori according to claim 1
14The C pick-up unit is characterized in that, described pulse generation module comprises:
Circuit for producing high voltage is used to produce the driving high pressure that drives the GM pipe;
The GM pipe is used to receive described driving high pressure, excites described
14C is to produce the β ray and described β ray is changed into pulse electrical signal.
4. helicobacter pylori according to claim 3
14The C pick-up unit is characterized in that, described pulse generation module further comprises the potentiometer of the magnitude of voltage that is used to regulate the driving high pressure that described circuit for producing high voltage produces.
5. helicobacter pylori according to claim 1
14The C pick-up unit is characterized in that, described pulse counter module further comprises:
Counting unit is used to count described pulse electrical signal;
The detector switch circuit is used for opening and closing in setting-up time, and then controls described counting unit at the described pulse electrical signal of described setting-up time inside counting;
Pulse shaping circuit is used for the described pulse electrical signal of shaping.
6. helicobacter pylori according to claim 1
14The C pick-up unit is characterized in that, described diagnostic module further comprises:
Judging unit is used for when the counting of the described pulse electrical signal that receives is higher than setting threshold, judges that patient has infected helicobacter pylori;
Tip element is used for judging that at described judging unit patient has infected helicobacter pylori and pointed out;
Storage unit, the result of determination that is used to store described judging unit.
7. helicobacter pylori according to claim 6
14The C pick-up unit is characterized in that, described Tip element comprises hummer and/or LCD.
8. helicobacter pylori according to claim 6
14The C pick-up unit is characterized in that, described diagnostic module further comprises the printer that is used to print described result of determination.
9. helicobacter pylori according to claim 8
14The C pick-up unit is characterized in that, described judging unit is a central controller, and by bus driving circuits and described Tip element, storage unit and printer communication.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010202710835U CN201852800U (en) | 2010-07-26 | 2010-07-26 | Helicobacter pylori 14C detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010202710835U CN201852800U (en) | 2010-07-26 | 2010-07-26 | Helicobacter pylori 14C detection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201852800U true CN201852800U (en) | 2011-06-01 |
Family
ID=44095188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010202710835U Expired - Lifetime CN201852800U (en) | 2010-07-26 | 2010-07-26 | Helicobacter pylori 14C detection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201852800U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102338757A (en) * | 2010-07-26 | 2012-02-01 | 深圳市中核海得威生物科技有限公司 | Helicobacter pylori 14C detection device and method |
| CN104049077A (en) * | 2014-06-27 | 2014-09-17 | 安徽养和医疗器械设备有限公司 | Helicobacter pylori detector |
| CN104919317A (en) * | 2012-12-26 | 2015-09-16 | K干细胞有限公司 | Cancer diagnosis method using respiratory gas |
| CN105717187A (en) * | 2016-02-02 | 2016-06-29 | 长沙三相医疗器械有限公司 | Reagent and kit for helicobacter pylori detection and method for detecting ammonia gas exhaled from human body |
| CN111599457A (en) * | 2020-06-18 | 2020-08-28 | 深圳市人民医院 | Self-service noninvasive helicobacter pylori detection system and method |
-
2010
- 2010-07-26 CN CN2010202710835U patent/CN201852800U/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102338757A (en) * | 2010-07-26 | 2012-02-01 | 深圳市中核海得威生物科技有限公司 | Helicobacter pylori 14C detection device and method |
| CN104919317A (en) * | 2012-12-26 | 2015-09-16 | K干细胞有限公司 | Cancer diagnosis method using respiratory gas |
| US9955898B2 (en) | 2012-12-26 | 2018-05-01 | Jeong-Chan Ra | Cancer diagnosis method using respiratory gas |
| CN104049077A (en) * | 2014-06-27 | 2014-09-17 | 安徽养和医疗器械设备有限公司 | Helicobacter pylori detector |
| CN105717187A (en) * | 2016-02-02 | 2016-06-29 | 长沙三相医疗器械有限公司 | Reagent and kit for helicobacter pylori detection and method for detecting ammonia gas exhaled from human body |
| CN111599457A (en) * | 2020-06-18 | 2020-08-28 | 深圳市人民医院 | Self-service noninvasive helicobacter pylori detection system and method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20110601 |
|
| CX01 | Expiry of patent term |