CN202974939U - Self-calibration exhaled-gas analysis equipment - Google Patents
Self-calibration exhaled-gas analysis equipment Download PDFInfo
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- CN202974939U CN202974939U CN 201220612742 CN201220612742U CN202974939U CN 202974939 U CN202974939 U CN 202974939U CN 201220612742 CN201220612742 CN 201220612742 CN 201220612742 U CN201220612742 U CN 201220612742U CN 202974939 U CN202974939 U CN 202974939U
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Abstract
The utility model discloses self-calibration exhaled-gas analysis equipment. The self-calibration exhaled-gas analysis equipment comprises an exhaled-gas control module, a sampling module, a detecting module and a control module, wherein all the modules are respectively used for discharging and sampling exhaled gas on a tester; the control module is used for controlling the exhaled-gas control module, the sampling module and the detecting module and carrying out acquisition, processing, storage and communication of information; the sampling module comprises at least two gas chambers for storing one part of the exhaled gas temporarily, wherein the gas in at least one gas chamber is used for direct measurement, and the gas in at least one gas chamber is measured after the concentration is quantitatively changed by electrolysis; the two gas chambers are connected with the detecting module by the valve; and the detecting module comprises a valve, a sensor, a gas pump and a pipeline and is used for introducing gas in at least two gas chambers into the sensor respectively to carry out measurement.
Description
Technical field
The present invention relates to the expiration gas detection field.
Background technology
Expiration nitric oxide is analyzed for the detection of the respiratory diseases such as asthma as the mark of airway inflammation and has been obtained the medical profession abundant affirmation.Europe has been formulated expiration nitric oxide at 1997 and 1999 respectively with the U.S. and has been detected proposed standard, and united in 2005 and formulate and announced this standard (" ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Low Respiratory Nitric Oxide and Nasal Nitric Oxide; 2005 ", ATS is the abbreviation of U.S. throat association, ERC is that European pneumatology can be abridged, hereinafter to be referred as " standard ").Be somebody's turn to do " standard " and be used for instructing diagnosis and the therapeutic evaluation that how to detect and testing result is used for the respiratory diseases such as asthma.
" standard " detects exhaling and proposed high sensitivity and high selectivity requirement, for example, must be lower than 5ppb to precision and lower limit that nitrogen monoxide detects, detection must be carried out in the air-flow of controlling and pressure limit, and the result of detection must not be subject to the interference of temperature, humidity and other gas.What usually can satisfy this requirement is chemiluminescent analyzer by this standard development.This instrument belongs to laboratory analytical instrument, and is not only valuable, and needs to demarcate frequently and special maintenance, so clinical practice and popularization are extremely restricted.For this reason, people attempt to utilize the small portable expiration detector of gas sensor exploitation always, even can as the diabetes blood-sugar detecting instrument, be used for the family health care nursing.
Publication number is that the Chinese patent (corresponding Application No. US20040082872) of CN16814635 has been announced a kind of portable expiration nitric oxide detector.This invention mainly utilizes standard recommendation, also is that constant temperature, constant voltage, constant current and constant humidity equal controller that chemiluminescent analyzer adopts avoid exhaling temperature, pressure, air-flow and the humidity of sample and environment to the interference of nitric oxide sensor.Yet the interference of other gas and elimination or the method avoided in this invention and undeclared expiration.These control device that are generally used in laboratory analytical instrument make the detector structure very complicated in addition, and can only realize effectively controlling under the indoor temperature of stipulating and damp condition.
Publication number is that 7352465 United States Patent (USP) has disclosed a kind of detector that utilizes the Photobiology sensor to detect expiration nitric oxide.The same with electrochemical sensor, in the sensing range lower than ppm, this sensor to humidity with exhale in some gases, very responsive such as carbon dioxide etc.This patent adopts the porous mediums such as 3A molecular sieve and aluminium oxide to remove respectively hydrone and carbon dioxide.Yet, also there is other interference gas in exhaling, even it is possible to remove one by one all interference gas, but also very complicated and expensive.
Another one extremely important but above-mentioned and other the invention still NM problem be the scaling method of sensor and detection.Be subject to the impact of outside (temperature, humidity, interference gas etc.) and inner (inactivation of detection part or aging) condition, the performance of all the sensors and detector or analyser all can decay, and is usually expressed as the drift of zero point and signal.Therefore need in using demarcating frequently at zero point and sensitivity, and these are demarcated and usually need external accessory and specialty to operate.Although can take the method for frequent more emat sensor and detection part to avoid demarcating, the cost of for this reason paying may be higher than demarcating.
Summary of the invention
The present invention will disclose a kind of can directly the measurement breath and need not the method and apparatus that Standard Gases is demarcated sensor, and these apparatus and method can improve selectivity, accuracy and the stability of test simultaneously.
This equipment comprises expiration control module, sampling module, detection module and control module, be respectively used to discharging and sampling that the tester is exhaled, to described expiration control module, sampling module and detection module is controlled and carry out collection, processing, storage and the communication of information; Described sampling module comprises at least two air chambers, be used for temporarily depositing the part of breath, wherein the gas at least one air chamber is used for directly measuring, gas at least one air chamber is measured after electrolysis causes its concentration quantitative to change again, and two air chambers are connected with detection module by three-way solenoid valve; Described detection module is comprised of valve, sensor, air pump and pipeline, passes into respectively sensor for the gas with at least two air chambers and measures.
Two air chambers in the said equipment can be connected in series by two position three-way valve, at this moment the public termination detection module of three-way solenoid valve.
Two air chambers in the said equipment also can be connected in parallel, and this moment, described two air chamber air inlet and outlet ends were connected with detection module with the expiration control module by after the two position two-way valve parallel connection respectively.
Utilize the said equipment to carry out the process that breath analysis measures as follows:
(1) exhale in described equipment by predetermined flow, pressure and expiratory duration;
(2) will adjust gas in air chamber without concentration and pass into sensor and measure, measurement result satisfies measures equation;
(3) gas at least one air chamber is carried out electrolysis, record electrolysis electricity and be used for calculating the concentration change that electrolysis causes, this concentration change satisfies mass equation;
(4) at least one gas in over-richness adjustment air chamber is passed into sensor and measure, result satisfies measures equation;
The sensitivity of (5) calculating expiration sample gas concentration and sensor by above-mentioned a plurality of measurement equations and mass equation.
in addition, present device and method utilize the electrochemical electrolysis technology to on-the-spot breath sample concentration quantitative adjusting, then directly calculate the expiration sample concentration by the differential analysis algorithm, be equivalent to measure at every turn and carried out under expiration condition at the scene once from demarcating, thereby can farthest eliminate and exhale and environment temperature, humidity, the impact of pressure and interference gas, guaranteed the selectivity to the nitrogen monoxide detection, accuracy and stability, do not need during detection in the ppb concentration range detecting device and the gas that detects are carried out accurate Temperature and Humidity Control yet, simplified Instrument Design, also need not maintenance is demarcated in the sensitivity of detecting device.
Description of drawings
Be combined in reference to the accompanying drawings following concrete implementation, embodiment and claim and describe in further detail the present invention.In the accompanying drawings, identical Reference numeral represents identical feature all the time, wherein:
Fig. 1 is one of equipment gas circuit result schematic diagram of the present invention;
Fig. 2 is two of equipment gas circuit result schematic diagram of the present invention;
Fig. 3 utilizes result that this analytical equipment tests 0～300ppb NO gas and the relation between distribution concentration;
Fig. 4 utilizes this analytical equipment to 15,75 and the 200ppbNO gas continuous coverage stability data of 40 days.
Embodiment
Detection to expiration nitric oxide, the expiratory gas flow that " standard " recommends and pressure are respectively in 50 milliliters/second and the 5-20 millimeter of water, expiratory duration was greater than 6 seconds, at least breathe out thus and be approximately the expiration sample of 300 milliliters, front portion is owing to being that oral cavity but not the gas of air flue or lung must discharge, rear portion for detection of.What must consider in addition is how to discharge simultaneously unborn gas in detector gas circuit and parts, avoids these gases to sneak into the expiration that enters, the reliability that impact detects.
the design of expiration control module takes into full account above-mentioned standard to expiratory gas flow, pressure, the requirement that time is controlled, by the adjustment of gas circuit resistance being realized the control to breath pressure, by the realization of flow pressure feedback assembly being set to the control of expiratory gas flow, realize control to the sampling time by software, and emptying for original gas in gas circuit, principle of design is the flow state that the parts of assurance detector gas circuit and gas process all keep piston flow, the unborn gas in gas push front, the gas mixing of flow direction front and back does not occur, until the gas of front and the front a part of gas of expiration are discharged detector.The generation of piston flow and the geometric configuration that keeps depending on flow velocity, flowing distance, flow area and mobile parts, modal piston flow device is elongated pipeline.It is the dead volume of as far as possible avoiding in detector interior arrangement or parts that design is in addition considered.
Fig. 1 is the analytical equipment of the demarcation expiration gas certainly gas circuit structure schematic diagram according to the requirement of expiration nitric oxide examination criteria and the design of self-calibration gas testing requirement, it comprises expiration control module 100, sampling module, detection module and control module, be respectively used to discharging and sampling that the tester is exhaled, to described expiration control module, sampling module and detection module is controlled and carry out collection, processing, storage and the communication of information:
Described sampling module comprises two air chambers 201,202, be used for temporarily depositing the part of breath, gas in one of them air chamber 201 is used for directly measuring, another air chamber 202 consists of the circulation gas circuit with valve 304, air pump 502, galvanochemistry nitrogen monoxide electrolytic cell 601 and valve 305, gas in this air chamber is measured after galvanochemistry nitrogen monoxide electrolytic cell 601 cyclic electrolysis cause its concentration quantitative to change again, two air chambers are connected with detection module by two-position three way magnetic valve 302, and the volume of 2 air chambers is 30ml; Described detection module is comprised of two-position three way magnetic valve 302, nitric oxide sensor 401, air pump 501 and pipeline, passes into respectively nitric oxide sensor 401 for the gas with two air chambers and measures.
Open valve 301,303, control T-valve 302, valve-off 304,305,75ppb nitrogen monoxide Standard Gases is passed into and carries out follow-up measurement in described equipment through valve 301, air chamber 201, T-valve 302, air chamber 202, valve 303, and its measuring process is as follows:
1) control T-valve 302, through sensor 401, record the steady-state response electric current of sensor 401 by the gas in pump 501 extraction air chambers 201, relation is satisfied in the response of this sensor:
S
1=kC=0.165（uA） （1）
S wherein
1For sensor response, k are that transducer sensitivity, C are gas concentration
2) open valve 304,305, valve-off 303 makes gas get back to air chamber 202 after air chamber 202, valve 304, air pump 502, galvanochemistry nitrogen monoxide electrolytic cell 601, valve 305 by air pump 502.In this cyclic process, electrolytic cell carries out electrolysis to the nitric oxide gas in air chamber and causes its concentration to descend, and this process satisfies relation:
Q=∫i
201dt=nFV*△C=4.95(uC) （2）
Wherein Q is that electrolytic cell 201 Faradaic currents, t are that cyclic electrolysis time, n are that Faraday constant, V are that air chamber volume, △ C are the variable quantity that electrolysis causes gas concentration for response consumes power, i201.
3) switch three-way valve 302, through sensor 401, record the steady-state response electric current of sensor 401 by the gas in pump 501 extraction air chambers 202, and relation is satisfied in the response of this sensor:
S
2=k(C-△C)=0.123（uA） （3）
Can be tried to achieve by equation (1)～(3) simultaneous:
k=nFV(S1-S2)/∫i
201dt=2.21(nA/ppb) （4）
C=S
1/(S1-S2)
*∫i
201dt/(nFV)=75.2(ppb) （5）
The transducer sensitivity that said method is tried to achieve is 2.2nA/ppb, coincide with the sensitivity that directly calculates with Standard Gases (formula (1)).
Directly the equipment breath of exhaling is just collected in air chamber 201 and 202 by the expiration control module, it is 2.25nA/ppb that repetition above-mentioned steps (1), (2), (3) calculate 401 pairs of nitric oxide production sensitivity of sensor, mouthful expiration nitric oxide concentration is 16.7ppb, sensitivity and Standard Gases test result access hole breath tester result also with the test result 17.2ppb of the NIOX of Sweden Aerocrine company without significant difference.
This shows, said apparatus and method can be in the situation that when not needing calibrating gas to determine the sensitivity of sensor 202, also can measure sample gas concentration.
Fig. 3 is the result of utilizing this analytical equipment that 0～300ppb NO gas is tested, result show this tester in 0～300ppb scope measurement result and distribution concentration substantially identical.
Fig. 4 utilizes this analytical equipment to 15,75 and the 200ppbNO gas continuous coverage data of 40 days, and result shows that its stability is very good.
Above principle of work and the process that this device has been described by the example of demarcating by nitric oxide sensor, by principle as can be known, as long as response equation (1) is satisfied in the response of sensor, process (2) can be set up mass equation (2), carrying out double measurement by step (3) just can demarcate the sensitivity of sensor 401, and to not restriction of sensor type, can be electrochemical sensor, semiconductor transducer, catalytic combustion sensor, infrared sensor etc.
If the response of nitric oxide sensor 401 is nonlinear, also can be by a plurality of air chambers be set, each air chamber is controlled the different cyclic electrolysis time, the gas that produces different varied concentrations is measured, construction is by a plurality of mass equations and measure the system of equations that equation forms, and completes the demarcation of nonlinear transducer parameter and the measurement of gas concentration.
as seen from the above analysis, present device and method utilize the electrochemical electrolysis technology to on-the-spot breath sample concentration quantitative adjusting, then directly calculate the expiration sample concentration by the differential analysis algorithm, be equivalent to measure at every turn and carried out under expiration condition at the scene once from demarcating, thereby can farthest eliminate and exhale and environment temperature, humidity, the impact of pressure and interference gas, guaranteed the selectivity to the nitrogen monoxide detection, accuracy and stability, do not need during detection in the ppb concentration range detecting device and the gas that detects are carried out accurate Temperature and Humidity Control yet, simplified Instrument Design, also need not maintenance is demarcated in the sensitivity of detecting device.
Fig. 2 is the another kind of implementation of the breath analysis of demarcation certainly equipment gas circuit of building according to same invention thinking, different from above-described embodiment is, in this implementation, two air chambers are connected in parallel, during expiration by expiration control module 100a with gas simultaneously incoming call air chamber 201a and 202a, during analytical test respectively by- pass valve control 301a, 302a, 303a and 306a make the gas of two air chambers pass into respectively sensor to measure, the test analysis process is the same.
Above-described embodiment introduction be the apparatus and method for that utilizes galvanochemistry nitric oxide sensor test expiration nitric oxide, in fact, from above-mentioned analysis principle and test process, the type selecting not restriction of described apparatus and method for to sensor, thereby by selecting different sensors, as sensors such as carbon monoxide, hydrogen, ammonia, aldehydes, described method and apparatus also can be used for the analysis of demarcation certainly of above-mentioned gas.
Above-described embodiment is to provide to being familiar with the person in the art and realizes or use of the present invention; those skilled in the art can be in the situation that do not break away from invention thought of the present invention; above-described embodiment is made various modifications or variation, thereby protection scope of the present invention is not limit by above-described embodiment.
Claims (3)
1. certainly demarcate the breath analytical equipment, comprise expiration control module, sampling module, detection module and control module, be respectively used to discharging and sampling that the tester is exhaled, to described expiration control module, sampling module and detection module is controlled and carry out collection, processing, storage and the communication of information; It is characterized in that: described sampling module comprises at least two air chambers, be used for temporarily depositing the part of breath, wherein the gas at least one air chamber is used for directly measuring, gas at least one air chamber is measured after electrolysis causes its concentration quantitative to change again, and two air chambers are connected with detection module by valve; Described detection module is comprised of valve, sensor, air pump and pipeline, passes into respectively sensor for the gas with at least two air chambers and measures.
2. as claimed in claim 1 from demarcating the breath analytical equipment, it is characterized in that wherein said two air chambers are connected in series by two-position three way magnetic valve, the public termination detection module of three-way solenoid valve.
3. as claimed in claim 1 from demarcating the breath analytical equipment, it is characterized in that wherein said two air chamber air inlet and outlet ends are connected with detection module with the expiration control module by after the two position two-way valve parallel connection respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220612742 CN202974939U (en) | 2012-08-13 | 2012-11-20 | Self-calibration exhaled-gas analysis equipment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220398270 | 2012-08-13 | ||
| CN201220398270.9 | 2012-08-13 | ||
| CN 201220612742 CN202974939U (en) | 2012-08-13 | 2012-11-20 | Self-calibration exhaled-gas analysis equipment |
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| CN202974939U true CN202974939U (en) | 2013-06-05 |
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| CN 201220612742 Expired - Lifetime CN202974939U (en) | 2012-08-13 | 2012-11-20 | Self-calibration exhaled-gas analysis equipment |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102937617A (en) * | 2012-08-13 | 2013-02-20 | 尚沃医疗电子无锡有限公司 | Self-calibration exhaled gas analysis device |
| CN106066348A (en) * | 2016-08-23 | 2016-11-02 | 武汉和生科技有限公司 | Hospital blood sugar test instrument and noninvasive management system |
| CN115266846A (en) * | 2022-07-29 | 2022-11-01 | 天津大学 | Hydrogen sensor device of normal position self-checking |
| CN115728446A (en) * | 2022-10-17 | 2023-03-03 | 杭州纳瑙新材料科技有限公司 | Nitrogen-oxygen sensor calibration method and calibration system |
-
2012
- 2012-11-20 CN CN 201220612742 patent/CN202974939U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102937617A (en) * | 2012-08-13 | 2013-02-20 | 尚沃医疗电子无锡有限公司 | Self-calibration exhaled gas analysis device |
| CN102937617B (en) * | 2012-08-13 | 2014-06-25 | 无锡市尚沃医疗电子股份有限公司 | Self-calibration exhaled gas analysis device |
| CN106066348A (en) * | 2016-08-23 | 2016-11-02 | 武汉和生科技有限公司 | Hospital blood sugar test instrument and noninvasive management system |
| CN115266846A (en) * | 2022-07-29 | 2022-11-01 | 天津大学 | Hydrogen sensor device of normal position self-checking |
| CN115728446A (en) * | 2022-10-17 | 2023-03-03 | 杭州纳瑙新材料科技有限公司 | Nitrogen-oxygen sensor calibration method and calibration system |
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