CN203561610U - Self-calibrated expiration nitrogen monoxide analyzer - Google Patents

Self-calibrated expiration nitrogen monoxide analyzer Download PDF

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Publication number
CN203561610U
CN203561610U CN201320636176.7U CN201320636176U CN203561610U CN 203561610 U CN203561610 U CN 203561610U CN 201320636176 U CN201320636176 U CN 201320636176U CN 203561610 U CN203561610 U CN 203561610U
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gas
sensor
self
expiration
nitric oxide
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谢雷
邓中全
郭世英
韩杰
曹青
韩益苹
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Wuxi Sunvou Medical Treatment Electronic Co Ltd
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Wuxi Sunvou Medical Treatment Electronic Co Ltd
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Abstract

The utility model provides a self-calibrated expiration nitrogen monoxide analyzer. One time of expiration measurement is carried out on the analyzer and an expiration nitrogen monoxide concentration is calculated by two algorithms; the repeatability, the accuracy and the reliability of a measurement result are improved by comparison and mutual authentication of results of the two algorithms.

Description

Self-calibration expiration nitric oxide analyser
Technical field
The present invention relates to expiration gas detection field.
Background technology
Expiration nitric oxide is analyzed and has been obtained medical profession abundant affirmation for the detection of the respiratory diseases such as asthma as the mark of airway inflammation.U.S. thoracic cavity association and Europe are breathed association and in 2005, are combined formulation and announced the standardized method < < ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Low Respiratory Nitric Oxide and Nasal Nitric Oxide that carries out this measurement, 2005 > >, its clinical practice guide (An Official ATS Clinical Practice Guideline:Interpretation of exhaled Nitric Oxide Level (F has been proposed for 2011 eNO) for Clinical Applications), these standards and guide are used for instructing and how detect and diagnosis and the therapeutic evaluation for respiratory diseases such as asthma by testing result.
< < standard > > detects and has proposed high sensitivity and high selectivity requirement exhaling, for example: precision and lower limit that nitrogen monoxide is detected must be lower than 5ppb, detection must be carried out in the air-flow of controlling and pressure limit, and the result of detection must not be subject to the interference of temperature, humidity and other gas.What conventionally can meet this requirement is the chemiluminescent analyzer by this standard development, in order to reach above-mentioned requirements, except accurate Instrument Design, instrument use procedure also needs to demarcate frequently and special maintenance, therefore in clinical practice and popularization, has been subject to very big restriction.
U.S. Patent Application No. US20040082872 has announced a kind of portable expiration nitric oxide detector.The main utilization of this invention adopts electrochemical gas sensing technology to measure, by transducer sensitivity being demarcated in advance to (below the method being called to scaling method), the constant temperature passing through, constant voltage, constant current and constant humidity equal controller reduce temperature, the impact of humidity guarantees the stability of sensor, and suppose that its sensitivity keeps stable within a certain period of time, compare above-mentioned chemiluminescent analyzer and on ease of use, had larger lifting, but these control device make detector structure very complicated, and can only under the indoor temperature of stipulating and damp condition, realize effectively and controlling.The reliability of this hypothesis is suspectable, and when drift occurs sensor, client cannot realize in time and calibrate.
In fact, gas sensor in use its response signal can be subject to comprising the impact of airflow rate, pressure, temperature, humidity and other gas composition, and transducer sensitivity also can change due to aging, inactivation, activation or the impact such as poisoning, thereby the angle from measuring, the use of all the sensors all require with approaching airflow rate, pressure, temperature, humidity and the gas composition of service condition, condition under demarcate, and nominal time and Measuring Time approach as far as possible to avoid above-mentioned interference.
Chinese patent 2,012 1,020 7872.6 discloses a kind of device and method that utilizes electrochemical gas sensor to carry out self-calibration measurement, still fertile medical electronics is received coulomb Analysis of NO instrument carried out the stability test of 3 years with it according to this technical design manufacture, although result shows the sensitivity meeting of sensor in instrument and fluctuates up and down, as long as but revised zero point, receive the measurement result kept stable of coulomb Analysis of NO instrument, irrelevant with the variation of extraneous humiture and the sensitivity of sensor, this has improved accuracy and the reliability of gasmetry greatly.
But also there is the place requiring further improvement in above-mentioned instrument in actual application:
1) said method utilization circulation gas circuit is carried out twice circulation measurement to sample gas, according to twice measurement result and Faraday's law by solving Simultaneous Equations calculation sample gas concentration.When gas concentration is lower, transducer sensitivity is lower or analyze, gas flow rate comparatively fast causes between twice measurement that current responsing signal gap is little, because the transmission of measuring error can cause larger calculation deviation;
2)nO sensor is comparatively responsive to humidity, when sample gas is flowed through sensor at every turn can with sensor in electrolyte carry out humidity exchange, sample gas humidity can change, the difference of twice measurement just can not be deducted the interference of humidity completely, now need the impact that humidity is changed to revise, otherwise also can cause larger measured deviation, because electrolyte concentration, environment temperature, sample gas humidity and flow velocity in the variation of this humidity and sensor all have relation, thereby this correction factor also changes.Although this impact can be revised by zero gas measurement, revise too frequently in actual application and inconvenience.
Summary of the invention
Expiration nitric oxide analyser of the present invention is by sampling module, analysis module and control module form, the discharge that is respectively used to tester to exhale and sampling, gathered expiration gas is carried out to Measurement and analysis, to described sampling module, analysis module is controlled, and carry out the collection of information, process, storage and communication, wherein: described sampling module (100) is by gas flow sensor or pressure transducer (101), the first valve (102), sample chamber (103), the second valve (104) is composed in series, when flow range is 20 ~ 100ml/s, whole gas circuit resistance is 5 ~ 25cmH 2o, preferably expiratory gas flow is 45 ~ 55ml/s, and gas circuit resistance is 10cmH 2o, wherein sample chamber structure is complicated elongate conduit, and volume is 10 ~ 200ml.
Described analysis module (200) is composed in series by T-valve (201), pump (202), humidistat (203), nitric oxide sensor (204), and by capillary paralleling, in sample chamber, (103) two ends form circulation gas circuit to described analysis module; Pipe at zero point (205) two ends are connected between T-valve (201) and air chamber (103); Wherein said humidistat comprises pipeline and the Nafion pipe of filling gel or molecular sieve.
While utilizing above-mentioned instrument to measure carrying out Exhaled nitric oxide, first in the sample chamber of device, according to ATS, the requirement of expiration nitric oxide sampling is collected the breath of q.s, then by the following Measurement and analysis of carrying out:
1) gas in sample chamber is circulated at least three times in described analysis gas circuit by air pump, wherein without zero point, manage for first twice, the steady-state response electric current that respective sensor measures is the first steady-state current (I 1) and the second steady-state response electric current (I 2), the sample gas that circulates for the third time enters sensor by zero point after pipe, and the steady-state response electric current that sensor is corresponding is zero current (I 0);
2) by the first steady-state current (I 1), zero current (I 0) and transducer sensitivity (k) calculation sample chamber in gas concentration (C 1=(I 1-I 0)/k);
3) by the first steady-state current (I 1), the second steady-state response electric current (I 2) and zero current (I 0), the Simultaneous Equations of the mass equation of setting up according to Faraday's law and the current-responsive establishing equation of twice measurement solves gas concentration C in calculation sample chamber 2, by this result and C 1relatively for the reliability of judged result;
4) according to reliability judgement output analysis to measure result, its criterion is as follows:
Work as C 2while being less than 50ppb, output C 1;
Work as C 2while being more than or equal to 50ppb, output C 2, as C 1with C 2deviation is greater than 20%, transducer sensitivity k is calculated by formula: k=(I 1-I 0)/C 2again demarcate.
The method is by relatively demarcating and self-calibrating method relative merits separately: self-calibrating method is reliable and stable, but the repeatability of measuring is not as described current measuring method, on same device, will realize two kinds of methods simultaneously, by the comparatively validate of two kinds of methods, repeatability, accuracy and the reliability measured have been improved simultaneously.
When instrument environment of living in is comparatively stable and transducer sensitivity is affected when little, can adopt the measuring method of simplification, only the gas in sample chamber is circulated twice in described analysis gas circuit by air pump, wherein, once without pipe at zero point, the steady-state response electric current that respective sensor measures is the first steady-state current (I 1), the sample gas that circulates for the second time enters sensor by zero point after pipe, and the steady-state response electric current that sensor is corresponding is zero current (I 0); By the first steady-state current (I 1), zero current (I 0) and transducer sensitivity (k) calculation sample chamber in gas concentration (C 1=(I 1-I 0)/k) and directly output measurement result, is when carrying out device measuring accuracy testing, and the NO gas (needn't know its concentration, as nasal cavity gas) by high concentration carries out self-calibration to transducer sensitivity as stated above.
Because described instrument can directly utilize NO in nasal cavity gas, sensor is demarcated, do not needed use to be difficult to the low concentration standard NO gas of preparing and preserving, solved the demarcation difficult problem of expiration NO sensor in actual application, there is larger using value.
Accompanying drawing explanation
The concrete implementation, embodiment and the claim that are combined in reference to the accompanying drawings are below described the present invention in further detail.In the accompanying drawings, identical Reference numeral represents identical feature all the time, wherein:
Fig. 1 is one of equipment gas circuit structure schematic diagram of the present invention;
Fig. 2 is the response curve of this analytical equipment to Analysis of NO test.
Embodiment
Detection to expiration nitric oxide, the expiratory gas flow that < < standard > > recommends and pressure are respectively at 50ml/s and 5-20 cmH 2o, expiratory duration is greater than 6s, at least breathes out thus and is approximately the expiration sample of 300ml, front portion is owing to being that oral cavity but not the gas of air flue or lung must discharge, rear portion for detection of.What must consider in addition is how to discharge unborn gas in detector gas circuit and parts simultaneously, avoids these gases to sneak into the expiration entering, the reliability that impact detects.
The design of expiration control module takes into full account above-mentioned standard to expiratory gas flow, pressure, the requirement that time is controlled, by the adjustment to gas circuit resistance, realize the control to breath pressure, by being set, flow pressure feedback assembly realizes the control to expiratory gas flow, by software, realize the control to the sampling time, and emptying for original gas in gas circuit, principle of design is the flow state that the parts of assurance detector gas circuit and gas process all keep piston flow, unborn gas before gas push, the gas that flow direction front and back do not occur mixes, until the front a part of gas of gas above and expiration is discharged to detector.The generation of piston flow and the geometric configuration that keeps depending on flow velocity, flowing distance, flow area and mobile parts, modal piston flow device is elongated pipeline.It is the dead volume of as far as possible avoiding in detector interior arrangement or parts that design is in addition considered.
Fig. 1 is according to the self-calibration expiration gas analytical equipment gas circuit structure schematic diagram of the requirement of expiration nitric oxide examination criteria and the design of self-calibration gas testing requirement, it is comprised of sampling module 100, analysis module 200 and control module 300, the discharge that is respectively used to tester to exhale and sampling, gathered expiration gas is carried out to Measurement and analysis, described sampling module, analysis module are controlled, and carried out collection, processing, storage and the communication of information.
Sampling module 100 is composed in series by gas flow sensor or pressure transducer 101, the first valve 102, sample chamber 103, the second valve 104, when flow range is 20 ~ 100ml/s, whole gas circuit resistance is 5 ~ 25cmH2O, preferred condition is under the condition of 45 ~ 55ml/s, and gas circuit resistance is 10cmH 2o.Wherein sample chamber structure is complicated elongate conduit, gas flowing for piston flow therein, and its volume is 10 ~ 200ml, preferably 20 ~ 100ml.
Analysis module 200 is composed in series by T-valve 201, pump 202, humidistat 203, nitric oxide sensor 204, and by capillary paralleling, in sample chamber, 103 two ends form circulation gas circuit to described analysis module; Manage 205 two ends zero point and be connected to 103 of T-valve 201 and air chambers.If sensor used in exhaling some not principal component have response, and manage filtering material used zero point, only filter NO, this connected mode contributes to improve the selectivity of measuring, certainly zero point pipe air inlet port also can directly be communicated with atmosphere, as measure gas concentrations higher (as nose expiratory measurements) always, and measurement environment also only contains on a small quantity and can, by the active component that zero point, pipe was removed, can select extraction loop border gas to enter zero point and manage 205.
Control module 300 is comprised of correlation function electricity modules such as realizing control, measurement, storage, communication and printing.
While exhaling sampling, open the first valve 102 and the second valve 104 in sampling module 100, press the expiration sampling request expiration that ATS measures expiration nitric oxide, flow sensor or pressure transducer 101 are used for measuring expiratory gas flow and provide exhalation flow rate information, for tester, expiratory gas flow is carried out to FEEDBACK CONTROL, will meet expiration sample collection that ATS exhale to require in sample chamber 103.
During analysis, close the first valve 102 and the second valve 104, open pump 202, make the gas in sample chamber get back to sample chamber 103 through T-valve 201, pump 202, humidity control apparatus 203, nitric oxide sensor 204, through twice circulation, sensor there will be two platform electric currents to the gas response in sample gas, and first platform electric current is corresponding is the steady-state response electric current I of sample gas during for the first time by sensor 1, second platform counter sample gas is for the second time by the steady-state response electric current I of sensor 2(due to gas when the sensor because the NO in sample gas is by electrolysis, its concentration can reduce, the size of its reduction and transducer sensitivity, gas flow rate are relevant, and gas flowing in whole pipeline is piston flow, these sample gases that change concentration only just pass through sensor at circulation time for the second time), after twice circulation, switch three-way valve 201, makes sample gas first in zero crossing pipe 205(pipe, fill activated charcoal or carry KMnO 4activated alumina) remove after electrochemical activity component (as NO) wherein, then arrive nitric oxide sensors 204 by pump 202, humidistat 203, that now sensor records is the zero current I removing in sample gas after NO 0.Income analysis result curve is as Fig. 2.
Because the response of NO gas sensor is to humidity sensitive, and when sample gas is flowed through sensor can with sensor in electrolyte carry out humidity exchange, humidity can change, when twice circulation of gas is through sensor like this, humidity is different (difference of twice measurement just can not be deducted the interference of humidity completely), and gas humidity when zero crossing pipe also can change, in order to reduce its interference, it can be the pipeline of filling gel or molecular sieve that the present invention has introduced humidity control apparatus 203(in gas circuit, but be preferably can balance pipe the Nafion pipe of inside and outside humidity), humidity when its object guarantees gas at every turn through sensor is consistent, so just can deduct the interference of humidity to measurement result by difference.
After completing above-mentioned measurement, the concentration of sample gas can be calculated acquisition by several different methods, and traditional method is to pass through I 1, I 0and the sensitivity k of sensor calculates gas concentration C 0:
C 0=(I 1-I 0)/k (1)
Wherein transducer sensitivity k can demarcate (hereinafter referred to as the method, being calibration algorithm) by concentration known gas.Because transducer sensitivity also can change due to aging, inactivation, activation or the impact such as poisoning, thereby the accuracy of demarcation to guarantee to measure that need to carry out appropriate frequency according to the variation of environment (temperature, humidity etc.) and oneself state of described sensor.
Because the NO Standard Gases of low concentration is difficult for obtaining and is difficult to stable preservation, in practical application, with said method, demarcate unrealistic.The selected method of Aerocine is that constant temperature, constant voltage, constant current and the constant humidity equal controller minimizing temperature of passing through, the impact of humidity guarantee the stability of sensor, and suppose that its sensitivity keeps stable within a certain period of time, this hypothesis is difficult to guarantee its reliability, when drift occurs sensor, client cannot realize in time and calibrate.
Chinese patent 2,012 1,020 7872.6 discloses a kind of device and method that utilizes electrochemical gas sensor to carry out self-calibration measurement, makes successively at least twice process electrochemical sensor of sample, the each response of measuring of record during use; Between the response by each measurement of electrochemical sensor and sample concentration, measure equation relation and solve surveyed sample concentration and transducer sensitivity because electrolysis causes mass equation relation between its concentration change and consumes power to form Simultaneous Equations.In above-mentioned whole measuring process, between three steady-state currents of sensor, meet relation:
I 1= kC 0 + I 0 (2)
I 2= kC 1 + I 0 (3)
I wherein 1,i 2for twice steady-state response electric current of sensor in circulation measuring process, k is transducer sensitivity, I 0for zero current, C 0, C 1sample concentration when being respectively sample original concentration and measuring for the 2nd time, its unknown number has k, C 0, C 1three.
According to Faraday's law, sensor is measured electrolysis sample at every turn and is caused its concentration change Relationship Quality equation can be expressed as: nFV (C 1-C 0)=i 0* t (4)
Wherein n is reaction electron number, and F is that Faraday constant, V are sample chamber volume, and t is cycle period.
The I that passes through like this simultaneous equations (2), (3), (4) and directly measure 0can solve sample concentration C 0and transducer sensitivity k.Below the method is called to self-calibration algorithm.
The sensitivity of the measurement result of the method and the variation of extraneous humiture and sensor is irrelevant, can farthest eliminate the impact of expiration and environment temperature, humidity, pressure and interference gas, from principle, guaranteed nitrogen monoxide to detect selectivity, accuracy and the stability of measuring, improved the reliability of result, during detection in ppb concentration range, do not need detecting device and the gas that detects to carry out accurate Temperature and Humidity Control yet, guaranteeing to measure accurately and reliably simultaneously, simplified Instrument Design.But because computing formula is comparatively complicated, due to propagation of error, the precision of measurement can decrease, and is in particular in that reappearance when low concentration is measured is not so good as above-mentioned computing method, NO concentration is greater than to 50ppb calibrating gas, and its measuring repeatability can be controlled in 5%.
In sum, self-calibration is measured with current method and is measured and respectively have its relative merits, described calibration algorithm is reproducible, but need to demarcate, guarantee its accuracy, described self-calibration algorithm is reliable and stable, but the repeatability of measuring is not as described current measuring method, and analysis to measure required time is longer, adopt apparatus of the present invention can realize above-mentioned two kinds of algorithm measurements simultaneously, repeatability, accuracy and the reliability by the mutual comparison assurance of the two, measured, its implementation is as follows:
1) as mentioned above the gas in sample chamber is circulated at least three times in described analysis gas circuit by air pump, wherein without zero point, manage for first twice, the steady-state response electric current that respective sensor measures is the first steady-state current (I 1) and the second steady-state response electric current (I 2), the sample gas that circulates for the third time enters sensor by zero point after pipe, and the steady-state response electric current that sensor is corresponding is zero current (I 0);
2) by the first steady-state current (I 1), zero current (I 0) and transducer sensitivity (k) utilize gas concentration (C in calibration algorithm calculation sample chamber 1=(I 1-I 0)/k);
3) by the first (I 1), the second steady-state response electric current (I 2) and zero current (I 0), the Simultaneous Equations of the mass equation of setting up according to Faraday's law and the current-responsive establishing equation of twice measurement solves gas concentration C in calculation sample chamber 2(self-calibration algorithm), and by this result and C 1relatively for the reliability of judged result;
4) as result of calculation C 2while being less than 50ppb, output calibration algorithm result C 1with the repeatability that guarantees to measure, as result of calculation C 2while being more than or equal to 50ppb, output C 2with the accuracy that guarantees to measure, as C 1with C 2deviation is greater than 20%, with C 2be as the criterion transducer sensitivity k is revised, correction formula is: k=(I 1-I 0)/C 2.
When instrument environment of living in is comparatively stable and transducer sensitivity is affected when little, can adopt the measuring method of simplification, only the gas in sample chamber is circulated twice in described analysis gas circuit by air pump, wherein, once without pipe at zero point, the steady-state response electric current that respective sensor measures is the first steady-state current (I 1), the sample gas that circulates for the second time enters sensor by zero point after pipe, and the steady-state response electric current that sensor is corresponding is zero current (I 0); By the first steady-state current (I 1), zero current (I 0) and transducer sensitivity (k) calculation sample chamber in gas concentration (C 1=(I 1-I 0)/k) and directly export measurement result; When ambient temperature and humidity changes, or when the sensitivity of sensor is thrown doubt upon, can enable at any time self-calibration measurement function, utilize as stated above the NO sample gas of higher concentration (as nose exhale (concentration range 200 ~ 2000ppb) etc., needn't know its accurate concentration) sensitivity of sensor is demarcated, guarantee the accuracy of its measurement.
The method can directly utilize NO in nasal cavity gas to demarcate sensor, does not need to be difficult to the low concentration standard NO gas preparing and preserve, has solved the demarcation difficult problem of expiration NO sensor in actual application, has larger using value.
It is below measured data of experiment.
Table 1 listed described equipment within a period of time (during it has been carried out to height gentle storage, humiture change the experiments such as storage) by described two kinds of computing method to the test result of the nitrogen monoxide airbag of standard 60ppb (mean values of three times), C in result 2the result of calculation of (self-calibration algorithm) and distribution concentration are coincide, and C 1(C 1=(I 1-I 0)/k) result of calculation and distribution concentration deviation are larger, and this has shown that the transducer sensitivity k of described equipment is subject to the impact of environmental change, need to demarcate; And adopt self-calibration algorithm can eliminate the drift phenomenon that these impacts bring.
It is 15,60 and the result data (repeatability represents by standard deviation or the relative standard deviation of 10 measurements) of the nitrogen monoxide airbag repeated test of 250ppb ten times to concentration that table 2 has been listed by described two kinds of computing method, and result shows self-calibration algorithm (C 2) repeatability compared with calibration algorithm (C 1) poor.
Table 3 is to utilize the device transducer sensitivity of this equipment result that for k, different calibration (demarcation that concentration known Standard Gases is demarcated, unknown concentration Standard Gases is demarcated and nose is bled) is demarcated, result shows that the result of the resulting sensitivity k of various scaling methods value is substantially identical, in actual use, can select flexibly demarcation mode according to actual conditions.
Table 4 is results of utilizing this analytical equipment to test 0 ~ 1000ppb NO gas, result show this tester within the scope of 0 ~ 1000ppb measurement result and distribution concentration substantially identical.
Table 5 be utilize this analytical equipment to humidity for <10%, 55% and 100% 0,15, three kinds of Standard Gases of 60ppb measure, the mean deviation of computation and measurement value and distribution concentration, result shows that this tester is substantially identical to the gas test result of different humidity and distribution concentration.
Table 6 be utilize this analytical equipment to 15,60, the relative standard deviation of the result of 250ppb NO gas duplicate measurements 10 times, result show this tester to 15,60, the repeatability of 250ppb NO gas test is good.
Above-described embodiment introduction be the apparatus and method for that utilizes galvanochemistry nitric oxide sensor test expiration nitric oxide, in fact, from above-mentioned analysis principle and test process, described apparatus and method for is to the not restriction of the type selecting of sensor, thereby by selecting different sensors, as sensors such as carbon monoxide, hydrogen, ammonia, aldehydes, described method and apparatus also can be used for the measurement of above-mentioned gas.
Above-described embodiment is to provide to being familiar with person in the art and realizes or use of the present invention; those skilled in the art can be without departing from the present invention in the case of the inventive idea; above-described embodiment is made to various modifications or variation, thereby protection scope of the present invention is not limit by above-described embodiment.

Claims (4)

1. a self-calibration expiration nitric oxide analyser, by sampling module, analysis module and control module form, the discharge that is respectively used to tester to exhale and sampling, gathered expiration gas is carried out to Measurement and analysis, to described sampling module, analysis module is controlled, and carry out the collection of information, process, storage and communication, it is characterized in that: described sampling module (100) is by gas flow sensor or pressure transducer (101), the first valve (102), sample chamber (103), the second valve (104) is composed in series, when flow range is 20 ~ 100ml/s, whole gas circuit resistance is 5 ~ 25cmH 2o, described analysis module (200) is composed in series by T-valve (201), pump (202), humidistat (203), nitric oxide sensor (204), and by capillary paralleling, in sample chamber, (103) two ends form circulation gas circuit to described analysis module, pipe at zero point (205) two ends are connected between T-valve (201) and air chamber (103).
2. a kind of self-calibration expiration nitric oxide analyser as claimed in claim 1, is characterized in that: wherein said sampling module gas circuit is under the expiratory gas flow condition of 45 ~ 55ml/s, and gas circuit resistance is 10cmH 2o.
3. a kind of self-calibration expiration nitric oxide analyser as claimed in claim 1, is characterized in that: in wherein said sampling module, sample chamber structure is complicated elongate conduit, and volume is 10 ~ 200ml.
4. a kind of self-calibration expiration nitric oxide analyser as claimed in claim 1, is characterized in that: wherein said humidistat comprises pipeline and the Nafion pipe of filling gel or molecular sieve.
CN201320636176.7U 2013-10-16 2013-10-16 Self-calibrated expiration nitrogen monoxide analyzer Active CN203561610U (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103487489A (en) * 2013-10-16 2014-01-01 无锡市尚沃医疗电子股份有限公司 Self-calibration exhaled nitric oxide analyzer
CN105388274A (en) * 2015-12-04 2016-03-09 无锡市尚沃医疗电子股份有限公司 Measuring apparatus for concentrations of nitric oxide and carbon monoxide in expired air
CN105527414A (en) * 2015-12-31 2016-04-27 无锡市尚沃医疗电子股份有限公司 Method and apparatus for measuring concentrations of various exhaled gases by use of one gas sensor
CN109142643A (en) * 2018-10-16 2019-01-04 浙江省计量科学研究院 The detection method and detection device of diesel vehicle nitrogen oxides detector conversion ratio
CN109164837A (en) * 2018-08-13 2019-01-08 力合科技(湖南)股份有限公司 Flow constant device and its application method, quick analytic instrument device and its detection method

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103487489A (en) * 2013-10-16 2014-01-01 无锡市尚沃医疗电子股份有限公司 Self-calibration exhaled nitric oxide analyzer
CN103487489B (en) * 2013-10-16 2017-01-25 无锡市尚沃医疗电子股份有限公司 Self-calibration exhaled nitric oxide analyzer
CN105388274A (en) * 2015-12-04 2016-03-09 无锡市尚沃医疗电子股份有限公司 Measuring apparatus for concentrations of nitric oxide and carbon monoxide in expired air
CN105388274B (en) * 2015-12-04 2017-09-15 无锡市尚沃医疗电子股份有限公司 A kind of measurement apparatus of expiration nitric oxide and carbonomonoxide concentration
CN105527414A (en) * 2015-12-31 2016-04-27 无锡市尚沃医疗电子股份有限公司 Method and apparatus for measuring concentrations of various exhaled gases by use of one gas sensor
CN109164837A (en) * 2018-08-13 2019-01-08 力合科技(湖南)股份有限公司 Flow constant device and its application method, quick analytic instrument device and its detection method
CN109164837B (en) * 2018-08-13 2021-08-03 力合科技(湖南)股份有限公司 Flow constant device and using method thereof, rapid analysis instrument and detection method thereof
CN109142643A (en) * 2018-10-16 2019-01-04 浙江省计量科学研究院 The detection method and detection device of diesel vehicle nitrogen oxides detector conversion ratio

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