CN201841011U - Device for preparing medical high-molecular material containing nano silver and porous structure - Google Patents
Device for preparing medical high-molecular material containing nano silver and porous structure Download PDFInfo
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- CN201841011U CN201841011U CN2010205877233U CN201020587723U CN201841011U CN 201841011 U CN201841011 U CN 201841011U CN 2010205877233 U CN2010205877233 U CN 2010205877233U CN 201020587723 U CN201020587723 U CN 201020587723U CN 201841011 U CN201841011 U CN 201841011U
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Abstract
The utility model relates to a device for preparing a medical high-molecular material containing nano silver and a porous structure. Two parts which are an operating chamber (2) and an air chamber (3) are contained in a casing (1) of a reaction box made of anti-corrosion organic glass or glass and are connected by an air inlet (4), the operating chamber is communicated with the outside by four fore-and-aft sample introduction windows (5), samples are placed into the operating chamber through the sample introduction windows, the film forming operation is carried out, and a water receiving tray (6) is arranged below the sample introduction windows and is used for storing and cleaning coagulated excess water; a ceramic heater (7) is hung above the operating chamber and is used for providing a heat source; a temperature and humidity probe (8) is hung at the side edge of the operating chamber and is used for monitoring the temperature and the humidity in the reaction box; and a humidifier (9) is installed below the air chamber, a temperature and humidity controller (10) is arranged outside the reaction box, and the real-time conditions of the temperature and the humidity in the reaction box are obtained by a port (11) so as to control the switching-on and the switching-off of the power supplies of the heater and the humidifier which are connected to a port (12) and a port (13).
Description
Technical field
The utility model relates to a kind of medical macromolecular materials antibacterial surface processing method and preparation facilities thereof that contains Nano Silver and loose structure, by the water auxiliary law, under certain temperature and humidity, realize that Nano Silver/polymer composites forms the antibiotic overlay film layer of Nano Silver/polymer honeycomb structure on the medical macromolecular materials surface.Belong to technical field of medical instruments.
Background technology
Medical macromolecular materials have a purposes extremely widely clinical, and its topmost use aspect is exactly a medical catheter.Along with the development of new diagnostic techniques and methods of treatment, the application of medical catheter is increasingly extensive, yet complication, the particularly infection that causes owing to bacterium absorption have often limited the use of conduit.This be one the most difficult also be the most general problem.Known now, bacterium can form biomembrane on the surface of tissue such as tooth, gum, skin, lung, urethra and other organs, causes such as diseases such as periodontosis, carious tooth, chronic bronchitis, septicaemia, thrombophlebitis, intractable pulmonary infection and endocarditises.Biomembranous formation is the important root that medical science infects, and according to estimates, about 65% human bacterial infection is relevant with bacterial biof iotalm.Therefore, the medical material with antibiotic property can effectively reduce the absorption and the growth of bacterium material surface, and then reduce clinical infection and improve cure rate.
The anti-microbial property of Nano Silver is the most normal in biomedicine to be familiar with and to be used by people.Silver is as a kind of the most frequently used inorganic antiseptic, has advantages such as efficient, safety, has a broad antifungal spectrum, be widely used in antibiotic and the mildew-resistant goods in.A long time ago, people just recognize that silver has bactericidal action, are difficult for the fermentation souring with silverware food, and silver compound can be treated the coated wound of burn etc.Now, Nano Silver has also entered into people's life with forms such as cosmetics, packaging for foodstuff, wound dressing, washing agent.Because quantum effect, small-size effect and great specific area have the incomparable antibacterial effect of conventional antiseptic, and be simultaneously safe, it is lasting to render a service.It is bactericide that the anti-microbial property of Nano Silver is far longer than traditional silver.
At present Nano Silver is used for medical material and adopts finishing or surface-coated to contain the method for the antiseptic of Nano Silver more, and shortcoming is that the surface coverage efficient of antimicrobial component is lower and more easily by wash-out.Also have research that Nano Silver is mixed in the masterbatch as the high score material, extrusion molding formation medical material again is as tube material etc.The shortcoming of this method is that the method for mixing of mixing is easy to cause the reunion of Nano Silver, and then loses its special nanoscale antimicrobial effect.The applicability of this method is not high simultaneously, and does not have independence, and equipment is had relatively high expectations, and also may change the mechanical performance of macromolecular material etc. simultaneously.
The utility model adopts the water auxiliary law at medical macromolecular materials surface preparation Nano Silver/polymer honeycomb structure film, can realize the firm load of Nano Silver at catheter surface, when Nano Silver and honeycomb structure combination, honeycomb structure can reach the effect at surface storage Nano Silver and silver ion, reduction bacterium that can maximal efficiency is in the absorption of catheter surface, kill the bacterium on nearly surface, its effect and effectiveness persistence all are higher than conventional method.Water assistant preparation method controllability is higher, and parameters such as molecular weight that can be by suitable temperature humidity of control and polymer and concentration realize the regulation and control preparation of surface hole defect structure.This method simple economy simultaneously, less demanding to equipment, applicability is strong, and the commercially available macromolecular material of common commercial all can carry out antibacterial surface with the method to be handled.
Summary of the invention:
Technical problem:The utility model purpose is to provide a kind of preparation facilities that contains the medical macromolecular materials of Nano Silver and loose structure, by the water auxiliary law, under certain temperature and humidity, can form the antibiotic overlay film layer of Nano Silver/polymer honeycomb structure on the medical macromolecular materials surface.
Technical scheme:The structure of the preparation facilities of the medical macromolecular materials that contain Nano Silver and loose structure of the present utility model is as follows: in the reaction chamber shell that corrosion-resistant lucite or glass are made, contain operating room and air chamber two parts, between two parts, connect by air inlet, operating room is by 4 sample introduction windows in front and back and extraneous the connection, sample is put into operating room thus and is carried out the film forming operation, there is drip tray sample introduction window below, is used to store and clear up the excessive moisture that condenses; Ceramic heater of the overhung of operating room is used to provide thermal source; Temperature humidity probe of the side-hung of operating room is used for the temperature and humidity in the monitoring reaction case; Humidifier is installed, in order to moist source of the gas to be provided below air chamber; Outside reaction chamber, a control appliance of temperature and humidity is arranged, obtain temperature humidity real-time condition in the reaction chamber by port, so by control connection at the heater of port and port and the on/off of humidifier, reach control temperature humidity purpose.
Constant temperature and humidity reaction unit controlled humidity scope is at 50%-99%, 10 ℃-60 ℃ of temperature ranges.
Beneficial effect:Advantage of the present utility model is:
1. can realize that by the utility model method Nano Silver keeps stablizing the character of difficult drop-off again in the high-efficient carrier of medical macromolecular materials surface.
2. this antibacterial surface processing method is simple to operate, and equipment requires not, and raw material obtains easily and be relatively cheap.
3. this antibacterial surface processing method controllability height by regulating and controlling temperature, humidity, polymer concentration and kind and molecular weight, can obtain the honeycomb structure surface of different size.
4. Nano Silver/antibiotic overlay film the composition of layer of polymer honeycomb structure overlay film safety can not produce harm to human body through external biological compatibility experiment confirm.
5. this surface treatment method can not change the mechanical property of medical catheter.Have universality, can realize on the surface of the medicine equipment of commercially available medical macromolecular materials.
Description of drawings
Fig. 1 is used for the constant temperature and humidity reaction chamber of water auxiliary law preparation.
The specific embodiment
The preparation facilities of the medical macromolecular materials that contain Nano Silver and loose structure that the utility model provides, its characteristic and innovation part are to have used economical simple, the water auxiliary law that controllability is high is realized the antibiotic property perforated membrane overlay film of Nano Silver/polymer composites on the medical macromolecular materials surface.
A kind of medical macromolecular materials antibacterial surface processing method and preparation facilities structure thereof that contains Nano Silver and loose structure described in the utility model is as follows: in the reaction chamber shell 1 that corrosion-resistant lucite or glass are made, contain operating room 2 and air chamber 3 two parts, between two parts, connect by air inlet 4, operating room is by 4 sample introduction windows in front and back 5 and extraneous the connection, sample is put into operating room thus and is carried out the film forming operation, there is drip tray 6 sample introduction window below, is used to store and clear up the excessive moisture that condenses; Ceramic heater 7 of the overhung of operating room is used to provide thermal source; Temperature humidity probe 8 of the side-hung of operating room is used for the temperature and humidity in the monitoring reaction case; Humidifier 9 is installed, in order to moist source of the gas to be provided below air chamber; Outside reaction chamber, a control appliance of temperature and humidity 10 is arranged, obtain temperature humidity real-time condition in the reaction chamber by port one 1, so by control connection at the heater of port one 2 and port one 3 and the on/off of humidifier, reach control temperature humidity purpose.
Constant temperature and humidity reaction unit controlled humidity scope is at 50%-99%, 10 ℃-60 ℃ of temperature ranges.
The preparation method of preparation facilities that employing contains the medical macromolecular materials of Nano Silver and loose structure is:
At first, adopt the water auxiliary law then, make this solution evaporation form the porous rete that contains Nano Silver and have honeycomb structure at medical macromolecular materials surface adhesion Nano Silver/polymer composite solution.
In this Nano Silver/polymer composite solution, Nano Silver is dispersed in the polymer solution, and its content is 0.01% ~ 10% by polymer weight ratio, and the Nano Silver surface exposure directly contacts with polymeric material, and the particle diameter of Nano Silver is at 10-100nm.The solvent of this composite solution is oxolane or chloroform, and the mass volume ratio of polymer in solution is 1% ~ 10%, and polymer is for being dissolved in any medical polymer in these two kinds of solvents, as PLA, polyurethane, polyvinyl chloride, polystyrene etc.
By the preparation of water auxiliary law, can form Nano Silver/polymer honeycomb structure overlay film layer to this Nano Silver/polymer composite solution at polymer surface, concrete steps are as follows:
A. under the environment of humidity, Nano Silver/polymer organic solution volatilizees rapidly, causes that the liquid level temperature sharply descends, and makes that the hydrone in the humid air condenses into water droplet and is suspended in the gas/liquid interface.
B. along with the continuous volatilization of organic solution, water droplet is also big in the change of slowly growing, and this moment, nano-Ag particles will be adsorbed onto the drop surface.
C. organic solvent continues volatilization, and this moment, the concentration of polymer will constantly increase, and water droplet lecture stops growing.
D. organic solvent at first volatilizees and finishes, and the polymer film that contains Nano Silver forms, and the drop that is embedded in the gas/liquid interface then also evaporates, and will stay as honey comb like pore space structure at polymer film surface.
Above-mentioned water assistant preparation method, can be by regulating suitable temperature (20 ℃-40 ℃ of temperature ranges) and humidity (humidity range 60%-99%), and the mass volume ratio (0.5%-40% of polymer in Nano Silver/polymer organic solution,) and molecular weight (5000-300000), will obtain pore diameter range at the loose structure of 200 nm to 20um.
Nano Silver/polymer honeycomb structure overlay film by the preparation of water auxiliary law can firmly be attached on the medical macromolecular materials surface, and nano-Ag particles is embedded on the inwall of honeycomb structure hole specifically, also is uniformly distributed in the polymer substrate simultaneously.
Claims (2)
1. preparation facilities that contains the medical macromolecular materials of Nano Silver and loose structure, it is characterized in that this apparatus structure is as follows: in the reaction chamber shell (1) that corrosion-resistant lucite or glass are made, contain operating room (2) and air chamber (3) two parts, between two parts, connect by air inlet (4), operating room is by 4 sample introduction windows in front and back (5) and extraneous the connection, sample is put into operating room thus and is carried out the film forming operation, there is drip tray (6) sample introduction window below, is used to store and clear up the excessive moisture that condenses; A ceramic heater of the overhung of operating room (7) is used to provide thermal source; A temperature humidity probe of the side-hung of operating room (8) is used for the temperature and humidity in the monitoring reaction case; Humidifier (9) is installed, in order to moist source of the gas to be provided below air chamber; Outside reaction chamber, a control appliance of temperature and humidity (10) is arranged, obtain temperature humidity real-time condition in the reaction chamber by port (11), so by control connection at port (12) and the heater of port (13) and the on/off of humidifier, reach the purpose of controlling temperature humidity.
2. the preparation facilities that contains the medical macromolecular materials of Nano Silver and loose structure according to claim 1 is characterized in that, constant temperature and humidity reaction unit controlled humidity scope is at 50%-99%, 10 ℃-60 ℃ of temperature ranges.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010205877233U CN201841011U (en) | 2010-11-02 | 2010-11-02 | Device for preparing medical high-molecular material containing nano silver and porous structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010205877233U CN201841011U (en) | 2010-11-02 | 2010-11-02 | Device for preparing medical high-molecular material containing nano silver and porous structure |
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| Publication Number | Publication Date |
|---|---|
| CN201841011U true CN201841011U (en) | 2011-05-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010205877233U Expired - Lifetime CN201841011U (en) | 2010-11-02 | 2010-11-02 | Device for preparing medical high-molecular material containing nano silver and porous structure |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102010514A (en) * | 2010-11-02 | 2011-04-13 | 东南大学 | Method and device for preparing nano silver- and porous structure-containing medical high molecular material |
-
2010
- 2010-11-02 CN CN2010205877233U patent/CN201841011U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102010514A (en) * | 2010-11-02 | 2011-04-13 | 东南大学 | Method and device for preparing nano silver- and porous structure-containing medical high molecular material |
| CN102010514B (en) * | 2010-11-02 | 2012-06-27 | 东南大学 | Method and device for preparing nano silver- and porous structure-containing medical high molecular material |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20110525 Effective date of abandoning: 20130227 |
|
| RGAV | Abandon patent right to avoid regrant |