CN201822867U - Jugular vein micro dialysis probe and probe guide device for biological sampling - Google Patents
Jugular vein micro dialysis probe and probe guide device for biological sampling Download PDFInfo
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- CN201822867U CN201822867U CN2009202004463U CN200920200446U CN201822867U CN 201822867 U CN201822867 U CN 201822867U CN 2009202004463 U CN2009202004463 U CN 2009202004463U CN 200920200446 U CN200920200446 U CN 200920200446U CN 201822867 U CN201822867 U CN 201822867U
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Abstract
The utility model discloses a jugular vein micro dialysis probe and a probe guide device for biological sampling. The probe comprises a dialysis membrane, a connecting pipe, a liquid feeding pipe, a liquid drain pipe, an inner sleeve and an outer sleeve. The probe guide device comprises a guiding tube, a fixing base, a fixed rotary plate, and a guiding tube cap. The utility model has the advantages that the micro dialysis probe is infiltrated in the human body for a shorter time, and the service performance of the probe is improved.
Description
Technical field
This utility model relates to a kind of biomedical micro-dialysis device, and relating in particular to is a kind of Jugular vein microdialysis probe and probe guiding device that is used under the animal free movement state.
Background technology
Micro-dialysis device be based on small-molecule substance can be by dialyzer, spread and macromolecular substances can not see through a kind of biological living sampling device that dialyzer designs along Concentraton gradient.Behind appointed area in the microdialysis probe implantation animal body, external micro pump makes the perfusate dialyzer of flowing through, measured matter sees through dialyzer and diffuses into perfusate in the tissue, and reach a kind of dynamic equilibrium, by the level and the change procedure of determinand in the outer liquid of test substance concentration studies histiocyte in the mensuration effluent.
Microdialysis probe is the core of micro-dialysis device, and various ways is arranged.Roughly be divided into four classes by its structure: (1) concentric circular probe (concentric cannula probe), (2) flexible stylet (flexible probe), (3) linear probe (linear probe), (4) shunting probe (shunt probe).Wherein concentric circular probe external diameter is less and have cecum, makes probe be convenient to implant.So the concentric circular probe can be used for many places samplings such as fat, tranquillization muscle, liver, gastrointestinal tract, especially positions such as compatible blood, spinal cord, the ventricles of the brain, articular cavity.
The concentric circular probe is difficult to be fixed on blood vessel and the internal's parenchima, and moving of animal may cause probe to come off from blood vessel or internal's parenchima.So existing commercial experiment concentric circular probe is produced by offshore company, the A-I-X-Y series probe as the CMA20 Elite type of U.S. CMA company and Japanese EICO company all can only carry out microdialysis in the blood vessel under narcotism.And the domestic present commercial Jugular vein microdialysis probe that is used for free moving animals that also do not have.Simultaneously, the conventional method of microdialysis experiment at present is that probe is directly implanted in the animal body, waits to recover to carry out the microdialysis experiment after some days, studies show that this microdialysis probe method that implants for a long time, the one, the probe rapid wear causes the failure of an experiment, and the 2nd, the dialyzer performance descends.So press for and a kind ofly can be embedded into the probe guiding device, the implantable probe method is avoided the problems referred to above when treating that animal recovers the back experiment.
The utility model content
The purpose of this utility model is at the deficiencies in the prior art, and a kind of Jugular vein microdialysis probe and probe guiding device that is used for biological sampling is provided, this utility model experiment favorable reproducibility, easy to operate, with low cost.
The purpose of this utility model is achieved through the following technical solutions:
A kind of Jugular vein microdialysis probe, be used for biological sampling under the animal free movement state, it mainly is made up of dialyzer, connection tube, feed tube, drain pipe, inner sleeve, trocar sheath, wherein, connection tube front end and dialyzer sealing-in, the connection tube rear end is with feed tube and drain pipe adhesive seal; Bonding between inner sleeve and trocar sheath, fixedly feed tube and drain pipe.
A kind of probe guiding device of above-mentioned Jugular vein microdialysis probe is mainly by guiding tube, fixed pedestal, fixedly blade, guiding pipe cap are formed.Guiding tube passes and is bonded in the fixed pedestal mesopore.Equal in length between the length of guiding tube and probe connection tube and the inner sleeve or slightly short, the external diameter of internal diameter and probe inner sleeve is complementary, and the front opening place becomes oblique shape otch.
The beneficial effects of the utility model are: this utility model integral body is line style, has certain rigid and flexibility, can free bend, and be convenient to the implantation and the employing of probe, and supporting probe guiding device is arranged.Before the microdialysis experiment, the guiding tube front end is implanted in the animal jugular vein, the rear end by subcutaneous draw back of the body cervical region and by fixed pedestal and fixedly blade be fixed on the skin.Seal with the guiding pipe cap after in guiding tube, injecting heparin.Treat to carry out can directly by guiding tube microdialysis probe being implanted in the jugular vein when microdialysis is tested after the animal surgery recovery, microdialysis probe is transferred in the experiment back, seals behind the injection heparin in guiding tube.This pre-implantable probe guiding device can reduce microdialysis probe infiltrating time in vivo, improves the serviceability of probe, simultaneously needs is detected repeatedly that the experiment of material information provides a kind of very good method in the animal body.
Description of drawings
Fig. 1 is a Jugular vein microdialysis probe vertical section structure sketch map of the present utility model.
Fig. 2 is a probe guiding arrangement structure sketch map of the present utility model.
The specific embodiment
Now in conjunction with the accompanying drawings and embodiments this utility model is done detailed description.
Jugular vein microdialysis probe of the present utility model is made up of dialyzer 1, connection tube 2, feed tube 3, drain pipe 4, inner sleeve 5, trocar sheath 6.End closure before the dialyzer 1, feed tube 3 are inserted into the dialyzer front end near sealing part.Connection tube 2 front ends and dialyzer 1 sealing-in, the rear end is with feed tube 3 and drain pipe 4 adhesive seal.Feed tube 3 is two capillary silicone tubes that diameter is identical with drain pipe 4, and drain pipe 4 front openings are close dialyzer 1 end in connection tube 2.Inner sleeve 5 is terminal bonding with trocar sheath 6 front ends, fixedly feed tube 3 and drain pipe 4.Trocar sheath 6 terminal fixedly feed tube 3 and drain pipes 4, the gap of sealing feed tube 3, drain pipe 4 and outer catheter 6.
Probe guiding device of the present utility model is by guiding tube 7, fixed pedestal 8, fixedly blade 9, guiding pipe cap 10 are formed.Guiding tube 7 is bonded in fixed pedestal 8 central authorities, and the lower-upper length ratio is set according to practical situation.During operation, fixedly blade revolves hole 12 and enters behind fixed pedestal card flag 11 belows 150 ° of fixedly blade 9 dextrorotation, is used for guiding tube 7 and is fixed on back of the body skin of neck.Microdialysis probe is in guiding tube 7 time, guiding pipe cap 10 sealing guiding tubes 7 ports of export.
During the implant surgery of probe guiding device, centripetal direction is implanted guiding tube 7 at about 10mm place, the right jugular vein clavicle crotch upstream of animal, and the about 12mm of implantation depth guarantees guiding tube 7 front ends in right cardinal vein, and guiding tube 7 is fixed on the Musclar layer.Guiding tube 7 rear ends are by the subcutaneous back of the body cervical region of drawing, and by fixed pedestal 8 and fixedly blade 9 be fixed on the skin.In guiding tube 7, inject about 0.05mL heparin sodium aqua in case hemostasis-coagulation.Guide pipe cap 10 sealing guiding tubes 7 ports of export then.During the microdialysis experiment, extract guiding pipe cap 10, in guiding tube 7, implant microdialysis probe behind the about 0.05mL heparin sodium aqua of injection.Microdialysis probe is transferred in the experiment back, injects about 0.05mL heparin sodium aqua in guiding tube 7, guiding pipe cap 10 sealing guiding tubes 7 ports of export.
Jugular vein microdialysis probe length overall 125mm, the material of dialyzer 1 is a Merlon, long 10mm, external diameter 0.15mm, molecular cut off 13,000 dalton.The dialyzer end seals.Feed tube 3 external diameter 0.1mm, internal diameter 0.05mm, long 125mm.Drain pipe 4 external diameter 0.1mm, internal diameter 0.05mm, long 105mm.Connection tube 2 external diameter 0.4mm, internal diameter 0.25mm, long 5mm.Inner sleeve 5 external diameter 0.6mm, internal diameter 0.2mm, long 10mm.Trocar sheath 6 external diameter 0.8mm, internal diameter 0.3mm, the long 15mm of liquid feeding end, the long 10mm of liquid outlet.Guiding tube 7 external diameter 1mm, internal diameter 0.6mm, long 95mm.Fixed pedestal 8 diameter 20mm, plate face thickness 1mm, mesopore internal diameter 1.1mm.Fixing blade 9 diameter 20mm, plate face thickness 1mm, mesopore internal diameter 3mm.Guiding pipe cap 10 external diameter 1.4mm, internal diameter 1mm, long 15mm.The guiding tube 7 long 75mm of fixed pedestal 8 belows.Bonding, sealing part all adopts resin glue bonding.
Embodiment 2: a kind of rabbit jugular vein microdialysis probe and probe guiding device of being used for,
Jugular vein microdialysis probe length overall 225mm, the material of dialyzer 1 is a Merlon, long 30mm, external diameter 0.15mm, molecular cut off 13,000 dalton.The dialyzer end seals.Feed tube 3 external diameter 0.1mm, internal diameter 0.05mm, long 245mm.Drain pipe 4 external diameter 0.1mm, internal diameter 0.05mm, long 205mm.Connection tube 2 external diameter 0.4mm, internal diameter 0.25mm, long 5mm.Inner sleeve 5 external diameter 0.6mm, internal diameter 0.2mm, long 10mm.Trocar sheath 6 external diameter 0.8mm, internal diameter 0.3mm, the long 15mm of liquid feeding end, the long 10mm of liquid outlet.Guiding tube 7 external diameter 1mm, internal diameter 0.6mm, long 195mm.Fixed pedestal 8 diameter 20mm, plate face thickness 1mm, mesopore internal diameter 1.1mm.Fixing blade 9 diameter 20mm, plate face thickness 1mm, mesopore internal diameter 3mm.Guiding pipe cap 10 external diameter 1.4mm, internal diameter 1mm, long 15mm.The guiding tube 7 long 175mm of fixed pedestal 8 belows.Bonding, sealing part all adopts resin glue bonding.
The foregoing description is used for this utility model of explaining; rather than this utility model limited; in the protection domain of spirit of the present utility model and claim, any modification and change to this utility model is made all fall into protection domain of the present utility model.
Claims (2)
1. a Jugular vein microdialysis probe that is used for biological sampling is characterized in that, it mainly is made up of dialyzer (1), connection tube (2), feed tube (3), drain pipe (4), inner sleeve (5), trocar sheath (6); Wherein, connection tube (2) front end and dialyzer (1) sealing-in, connection tube (2) rear end is with feed tube (3) and drain pipe (4) adhesive seal; Bonding between inner sleeve (5) and trocar sheath (6), fixedly feed tube (3) and drain pipe (4).
2. a probe guiding device is characterized in that, it is mainly by guiding tube (7), fixed pedestal (8), fixedly blade (9), guiding pipe cap (10) are formed; Guiding tube (7) passes and is bonded in fixed pedestal (8) mesopore; Equal in length between the length of guiding tube (7) and probe connection tube (2) and the inner sleeve (5) or slightly short, the external diameter of internal diameter and probe inner sleeve (5) is complementary, and the front opening place becomes oblique shape otch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202004463U CN201822867U (en) | 2009-11-23 | 2009-11-23 | Jugular vein micro dialysis probe and probe guide device for biological sampling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202004463U CN201822867U (en) | 2009-11-23 | 2009-11-23 | Jugular vein micro dialysis probe and probe guide device for biological sampling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201822867U true CN201822867U (en) | 2011-05-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009202004463U Expired - Fee Related CN201822867U (en) | 2009-11-23 | 2009-11-23 | Jugular vein micro dialysis probe and probe guide device for biological sampling |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201822867U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525569A (en) * | 2011-12-28 | 2012-07-04 | 浙江省肿瘤医院 | Array type microdialysis probe |
| CN105596012A (en) * | 2015-12-23 | 2016-05-25 | 苏州药明康德新药开发股份有限公司 | Animal jugular vein microdialysis method |
-
2009
- 2009-11-23 CN CN2009202004463U patent/CN201822867U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525569A (en) * | 2011-12-28 | 2012-07-04 | 浙江省肿瘤医院 | Array type microdialysis probe |
| CN102525569B (en) * | 2011-12-28 | 2013-12-25 | 浙江省肿瘤医院 | Array type microdialysis probe |
| CN105596012A (en) * | 2015-12-23 | 2016-05-25 | 苏州药明康德新药开发股份有限公司 | Animal jugular vein microdialysis method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110511 Termination date: 20131123 |