CN201519152U - Noninvasive blood sugar detecting system - Google Patents
Noninvasive blood sugar detecting system Download PDFInfo
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- CN201519152U CN201519152U CN2009202054570U CN200920205457U CN201519152U CN 201519152 U CN201519152 U CN 201519152U CN 2009202054570 U CN2009202054570 U CN 2009202054570U CN 200920205457 U CN200920205457 U CN 200920205457U CN 201519152 U CN201519152 U CN 201519152U
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Abstract
A noninvasive blood sugar detecting system belongs to the field of physiologic parameter detecting systems. The noninvasive blood sugar detecting system comprises a light source module capable of transmitting near-infrared light to two channels, a light transmission module connected with the light source module, a light detection module connected with the light transmission module and used for detecting and processing near-infrared light, and a data processing module connected with the light detection module and used for processing the output data of the light detection module to obtain blood sugar density; the light transmission module enables the near-infrared light in one channel to act with the human body to obtain signal light, the near-infrared light in the other channel serves as reference light; and the data processing module utilizes the spectrum subtraction method to obtain blood sugar density information according to the signal light and reference light. The spectrum subtraction method measures the light intensity difference during the filling of (blood) penetrating the artery and contraction of (blood) penetrating the artery, eliminates the difference generated by influences on skin tissue, muscular tissue, temperature, measuring conditions and so on during measurement to obtain the pure arteria blood spectrum, thereby improving the blood sugar detection accuracy.
Description
[technical field]
This utility model relates to a kind of physio-parameter detection system, especially relates to a kind of noninvasive system for detecting blood sugar.
[background technology]
Diabetes are typically to need the long-term chronic disease of monitoring continually, are second killers in the modern disease, and it can cause a series of metabolic disorder.The main means of monitoring diabetes are also to adjust the consumption of body orally-taken blood sugar reducing medicine and insulin, effectively blood sugar control concentration accurately, in time on this basis by monitoring blood sugar concentration continually at present.
Existing blood sugar concentration detection means, will draw blood and detect twice average every day, brings great misery and inconvenience to the patient.Seek a kind of can be convenient, continuous, effective, accurate, noinvasive ground detects the method for blood constituent, is the ideal of dreaming of in the process of human for a long time antagonism disease.Mainly comprise optical means and non-optical method in the feasible noinvasive blood constituent detection method of studying at present, a large amount of experimentatioies shows that near-infrared spectrum technique is more feasible a kind of in the optical means, thereby also maturation relatively of this technology.But factors such as the spectra overlapping of interindividual difference (individual variation) and different variations in temperature, metabolite concentration, other materials constantly, the repeatability of detection position, contact pressure all can be introduced error in testing result, become a great problem in the Woundless blood sugar concentration testing process, thereby the influence that whether can successfully remove individual variation and measuring condition is that the near infrared spectrum noinvasive detects the key that can blood constituent successful implementation.How improving the signal to noise ratio of spectral signal, also is a key factor that accurately detects blood sugar concentration.
In addition, in traditional noinvasive detection system or method, often need to design complicated circuit and light path, bring inconvenience to measurement.
[utility model content]
Given this, be necessary in the existing blood sugar test because of there are differences between the individuality and the measuring condition influence makes testing result have problem than mistake, a kind of noninvasive system for detecting blood sugar of eliminating individual variation and measuring condition influence is provided.
A kind of noninvasive system for detecting blood sugar, the light source module of the near infrared light of two passages of emission, the light conduction module that links to each other with described light source module, the light detection module that the detection near infrared light that links to each other with described light conduction module is also handled, and link to each other with described smooth detection module the dateout of described smooth detection module is handled the data processing module that obtains blood sugar concentration, described light conduction module obtains flashlight after with the near infrared light of one of them passage and human body effect, the near infrared light of another passage is as reference light, and described data processing module utilizes the spectrum subtractive method to obtain to be used to detect the optical signal of blood sugar concentration according to described flashlight and reference light.
Transmitted light intensity when the method that spectrum subtracts each other fills with the arterial blood contraction by measuring arterial blood respectively, and it is poor that the two is done, eliminate the difference that produces owing to influences such as skin histology, muscular tissue, temperature, measuring conditions in the measurement, thereby obtain purified arterial blood spectrum, improve the blood sugar test accuracy.
Preferably, described light conduction module includes penetrates probe, loading magazine and outgoing probe, and described incident probe and outgoing probe all are located on the loading magazine, and near infrared light enters the loading magazine by the incident probe and by the outgoing direct light detection module of popping one's head in.
Preferably, described outgoing probe comprises at least a in reflective measuring probe and the transmission-type measuring probe, described reflective measuring probe and incident probe are close to a side of being located at the loading magazine, described transmission-type probe relatively is located at the opposite side of loading magazine with the incident probe, and is provided with plus lens before the described transmission-type measuring probe.。
Preferably, described light source module is connected by optical fiber with the incident probe, infrared light is conducted to the loading magazine, and described smooth detection module and outgoing probe is connected by optical fiber, and being popped one's head in by outgoing after the near infrared light of outgoing is converged through plus lens conducts to the light detection module.
Optical fiber can be simplified the light path system design as light transmissive device, reduces the optical component of analytical tool, reduces the adjustment difficulty of Guan Xue system, is convenient to the miniaturization of device; Reduce the light energy loss simultaneously, improve utilization ratio of optical energy; Be easy for installation and maintenance, flexible and convenient to use, light conduction orientation personality is lived.
Preferably, described optical fiber is the optical fibre ring bundle.
The outgoing signal of optical fibre ring bundle is an annular light source, with respect to point source of light, has increased irradiated area, helps improving incoming signal intensity.
Preferably, be provided with adjusting device in the described loading magazine.
Adjusting device front and back is up and down regulated the measured object body position that is put in above it, to reach the measurement requirement that is fit to different testees, reaches and more accurately measures purpose more accurately.
Preferably, described smooth detection module comprise receive infrared light and be converted into the photoelectric conversion module of the signal of telecommunication, the analog signal processing module of handling the described signal of telecommunication of linking to each other with described photoelectric conversion module and to link to each other analog signal conversion with described analog signal processing module be the analog-to-digital conversion module of digital signal.
Preferably, described photoelectric conversion module comprises indium gallium arsenic photodiode.
Preferably, described photoelectric conversion module comprises the temperature chiller.
Utilize the temperature chiller can effectively suppress noise.
Preferably, described analog signal processing module comprises the analogy signal processing unit of 16 passages, and described analogy signal processing unit comprises the temperature-compensation circuit that links to each other successively, extremely low bias current operational amplifier, low-pass filter circuit, trap circuit, second amplifying circuit and low-pass filtering; Extremely low bias current operational amplifier also links to each other with noise suppression circuit, zeroing circuit and power supply, and wherein power supply is through providing power supply for amplifier behind the low dropout voltage regulator.
Analogy signal processing unit amplifies, after the filtering, elimination noise jamming, useful signal is proposed, and make it to reach analog-to-digital requirement the faint signal of telecommunication.
Preferably, described analogy signal processing unit outside is provided with metallic shield.
Metallic shield can be eliminated the influence of the interference of near field 50Hz power frequency to signal extraction.
[description of drawings]
Fig. 1 is a noninvasive system for detecting blood sugar structure chart among the embodiment;
Fig. 2 is a light guided modes block structure sketch map;
Fig. 3 light detection module structure and module map;
Fig. 4 is the mechanism map of analogy signal processing unit.
[specific embodiment]
As shown in Figure 1, be the noninvasive system for detecting blood sugar structure chart of present embodiment.This noninvasive system for detecting blood sugar comprises light source module 100, light conduction module 200, light detection module 300, data processing module 400 and power supply 500.Light source module 100 emissions two bundle near infrared lights obtain flashlight after light conduction module 200 makes wherein a branch of near infrared light and human body effect to be measured, and another bundle near infrared light is as reference light.Light detection module 300 detects above-mentioned flashlight and reference light and handles and obtains dateout, data processing module 400 utilizes the spectrum subtractive method to eliminate background noise according to the dateout after flashlight and reference light are handled, and then obtains the purified optical signal that contains blood sugar concentration information.Power supply 500 is light source module 100, light detection module 300 and data processing module 400 power supplies.
Adopt halogen tungsten lamp as near-infrared light source in the light source module 100, connect because of it has stable performance, compact conformation, low price, highly versatile, light output stablizing, be easy to optical fiber, bulb service life is long, the little plurality of advantages such as in light weight of volume.In addition, light source module 100 also carries regulated power supply efficiently, stablizes fine near-infrared light source for this detection system provides.
As shown in Figure 2, conduct the structural representation of module 200 for light.Light conduction module 200 comprises incident probe 210, loading magazine 220 and outgoing probe 230.Incident probe 210 and outgoing probe 230 all are located on the loading magazine 220, and near infrared light enters the loading magazine by incident probe 210 and by the outgoing 230 direct light detection modules 300 of popping one's head in.
In the present embodiment, carry out blood sugar test for tested human object with finger.The one side of loading magazine 220 is provided with into thing hole 221, and finger can enter loading magazine 220 inside and be in the position that near infrared light can shine from entering thing hole 221.
Present embodiment adopts optical fiber that light source module 100 is connected with incident probe 210, and near infrared light is conducted to loading magazine 220.Light detection module 300 also is connected by optical fiber with outgoing probe 230, and near infrared light is conducted to light detection module 300 by loading magazine 220.Optical fiber can be simplified the light path system design as light transmissive device, reduces the optical component of analytical tool, reduces the adjustment difficulty of optical system, is convenient to the miniaturization of device; Reduce the light energy loss simultaneously, improve utilization ratio of optical energy; Be easy for installation and maintenance, flexible and convenient to use, light conduction orientation personality is lived.
In addition, also can further optimize, as using the optical fibre ring bundle optical fiber, and cooperating the optical fibre ring bundle to use corresponding incident probe 210, the outgoing signal of optical fibre ring bundle is an annular light source, with respect to point source of light, increase irradiated area, helped improving incoming signal intensity.
The noninvasive system for detecting blood sugar of present embodiment can further comprise being located at and is provided with adjusting device 240 in the loading magazine 220.This adjusting device 240 comprises article carrying platform and adjusting bracket, article carrying platform is positioned on the adjusting bracket, adjusting bracket front and back is up and down regulated the measured object body position that is put in above it, to reach the measurement requirement that is fit to different testees, reaches and more accurately measures purpose more accurately.
As shown in Figure 3, be the structure and the module map of light detection module 300.Light detection module 300 comprises the photoelectric conversion module 310 that receives infrared light and be converted into the signal of telecommunication, handle the analog signal processing module 320 of the described signal of telecommunication and be the analog-to-digital conversion module 330 of digital signal with analog signal conversion.
Analog signal processing module 320 comprises the analogy signal processing unit of 16 passages, as shown in Figure 4, is the structure chart of analogy signal processing unit.The analogy signal processing unit of each passage comprises the temperature-compensation circuit that links to each other successively, extremely low bias current operational amplifier, low-pass filter circuit, trap circuit, second amplifying circuit and low-pass filtering.Extremely low in addition bias current operational amplifier also links to each other with noise suppression circuit, zeroing circuit and power supply, and wherein power supply can be through providing power supply for amplifier behind the low dropout voltage regulator.The signal of telecommunication that analogy signal processing unit is carried photoelectric conversion module 310 amplifies, after the filtering, elimination noise jamming, useful signal is proposed, and make it to reach analog-to-digital requirement.
In addition and since the near-infrared light source light intensity a little less than, the output intensity after the interaction of incident illumination and biological tissue is more weak, is subjected to the interference of near field 50Hz power frequency in the process of signal extraction easily.Therefore can further on analogy signal processing unit, install metallic shield additional,, improve signal to noise ratio in order to eliminate the influence of power frequency interference to signal extraction.
Analog-to-digital conversion module 330 is a digital signal with the analogue signal conversion of signals, is convenient to follow-up processing.
The detection system of present embodiment has been utilized near-infrared spectral analysis technology.Because blood is a kind of high scattering, the strong material that absorbs, after light and blood interaction, mutual relation according to light and biological tissue, its emergent light must contain the relevant information of blood, by analyzing its spectrum, set up analytical model, thereby unknown blood is carried out qualitative or quantitative analysis.Mainly comprise the steps:
Make incident probe 210 send twin-channel near infrared light, and the near infrared light that makes one of them passage is as reference light;
Obtain the spectrum after the near infrared light of another passage and tissue interact, and it is poor that the spectrum of two passages is done, and utilizes the spectrum subtractive method to obtain purified spectral information through arterial blood once more, calculates absorbance according to spectral information;
Utilize the conventional method that wound or Wicresoft are arranged to obtain the real blood glucose value of human body;
Blood sugar concentration data and spectral information that utilization obtains are set up relevant blood sugar concentration calibration model by chemometrics method;
Measure the near infrared spectrum of unknown blood sugar concentration, the blood sugar concentration of the unknown is predicted according to calibration model.
The above embodiment has only expressed several embodiment of the present utility model, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to this utility model claim.Should be pointed out that for the person of ordinary skill of the art under the prerequisite that does not break away from this utility model design, can also make some distortion and improvement, these all belong to protection domain of the present utility model.Therefore, the protection domain of this utility model patent should be as the criterion with claims.
Claims (11)
1. noninvasive system for detecting blood sugar, it is characterized in that, the light source module that comprises the near infrared light of launching two passages, the light conduction module that links to each other with described light source module, the light detection module that the detection near infrared light that links to each other with described light conduction module is also handled, and link to each other with described smooth detection module the dateout of described smooth detection module is handled the data processing module that obtains blood sugar concentration, described light conduction module obtains flashlight after with the near infrared light of one of them passage and human body effect, the near infrared light of another passage is as reference light, and described data processing module utilizes the spectrum subtractive method to obtain to be used to detect the optical signal of blood sugar concentration according to described flashlight and reference light.
2. noninvasive system for detecting blood sugar as claimed in claim 1, it is characterized in that, described light conduction module includes penetrates probe, loading magazine and outgoing probe, described incident probe and outgoing probe all is located on the loading magazine, and near infrared light enters the loading magazine by the incident probe and by outgoing probe direct light detection module.
3. noninvasive system for detecting blood sugar as claimed in claim 2, it is characterized in that, described outgoing probe comprises at least a in reflective measuring probe and the transmission-type measuring probe, described reflective measuring probe and incident probe are close to a side of being located at the loading magazine, described transmission-type measuring probe and incident probe relatively are located at the opposite side of loading magazine, and are provided with plus lens before the described transmission-type measuring probe.
4. as claim 2 or 3 described noninvasive system for detecting blood sugar, it is characterized in that, described light source module is connected by conduction optical fiber with the incident probe, near infrared light is conducted to the loading magazine, described smooth detection module is connected by conduction optical fiber with the outgoing probe, and near infrared light is conducted to the light detection module by the loading magazine.
5. noninvasive system for detecting blood sugar as claimed in claim 4 is characterized in that, described conduction optical fiber is the optical fibre ring bundle.
6. as claim 2 or 3 described noninvasive system for detecting blood sugar, it is characterized in that, be provided with adjusting device in the described loading magazine.
7. noninvasive system for detecting blood sugar as claimed in claim 1, it is characterized in that, described smooth detection module comprise receive near infrared light and be converted into the photoelectric conversion module of the signal of telecommunication, the analog signal processing module of handling the described signal of telecommunication of linking to each other with described photoelectric conversion module and to link to each other analog signal conversion with described analog signal processing module be the analog-to-digital conversion module of digital signal.
8. noninvasive system for detecting blood sugar as claimed in claim 7 is characterized in that, described photoelectric conversion module comprises indium gallium arsenic photodiode.
9. as claim 7 or 8 described noninvasive system for detecting blood sugar, it is characterized in that described photoelectric conversion module comprises the temperature chiller.
10. as claim 7 or 8 described noninvasive system for detecting blood sugar, it is characterized in that, described analog signal processing module comprises the analogy signal processing unit of 16 passages, and described analogy signal processing unit comprises the temperature-compensation circuit that links to each other successively, extremely low bias current operational amplifier, low-pass filter circuit, trap circuit, second amplifying circuit and low-pass filtering; Extremely low bias current operational amplifier also links to each other with noise suppression circuit, zeroing circuit and power supply, and wherein power supply is through providing power supply for amplifier behind the low dropout voltage regulator.
11., it is characterized in that described analogy signal processing unit outside is provided with metallic shield as claim 7 or 8 described noninvasive system for detecting blood sugar.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202054570U CN201519152U (en) | 2009-09-25 | 2009-09-25 | Noninvasive blood sugar detecting system |
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|---|---|---|---|
| CN2009202054570U CN201519152U (en) | 2009-09-25 | 2009-09-25 | Noninvasive blood sugar detecting system |
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| CN201519152U true CN201519152U (en) | 2010-07-07 |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013411A (en) * | 2014-05-15 | 2014-09-03 | 哈尔滨工业大学 | Transmission type noninvasive blood sugar detection device |
| CN104856696A (en) * | 2015-06-05 | 2015-08-26 | 张晓晓 | Intelligent blood glucose test instrument, method and system |
| CN105232055A (en) * | 2015-10-20 | 2016-01-13 | 上海交通大学 | Noninvasive glucometer |
| CN107334477A (en) * | 2017-05-02 | 2017-11-10 | 北京理工大学深圳研究院 | A kind of double spectrum noninvasive dynamics monitoring devices |
| CN107684431A (en) * | 2016-08-04 | 2018-02-13 | 中国计量大学 | A kind of noninvasive portable glucose meter based on array CCD |
| WO2018032749A1 (en) * | 2016-08-19 | 2018-02-22 | 深圳市前海康启源科技有限公司 | Glucose concentration detection device |
| CN107860722A (en) * | 2017-10-30 | 2018-03-30 | 内蒙古农业大学 | A kind of honeydew melon inside quality online test method and system |
| CN108593593A (en) * | 2018-04-24 | 2018-09-28 | 深圳市英谱科技有限公司 | Serial double infrared spectrum Woundless blood sugar measuring devices |
| WO2018214299A1 (en) * | 2017-05-20 | 2018-11-29 | 深圳市前海安测信息技术有限公司 | Non-invasive blood glucose data collection apparatus |
| WO2018214297A1 (en) * | 2017-05-20 | 2018-11-29 | 深圳市前海安测信息技术有限公司 | Portable device and method for non-invasive blood glucose detection |
| CN109490248A (en) * | 2018-12-27 | 2019-03-19 | 四川精方智慧科技有限公司 | A kind of blood glucose spectral detection system and detection method based on modulation reverse phase cancellation |
| CN109946231A (en) * | 2019-03-13 | 2019-06-28 | 上海交通大学 | The differential photoacoustic measurement system and method for having temperature-compensating |
| US10918319B2 (en) | 2016-07-25 | 2021-02-16 | Samsung Electronics Co.. Ltd. | Apparatus and method for estimating biological substance, apparatus for acquiring unit spectrum, and wearable device |
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2009
- 2009-09-25 CN CN2009202054570U patent/CN201519152U/en not_active Expired - Lifetime
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104013411A (en) * | 2014-05-15 | 2014-09-03 | 哈尔滨工业大学 | Transmission type noninvasive blood sugar detection device |
| CN104856696A (en) * | 2015-06-05 | 2015-08-26 | 张晓晓 | Intelligent blood glucose test instrument, method and system |
| CN105232055A (en) * | 2015-10-20 | 2016-01-13 | 上海交通大学 | Noninvasive glucometer |
| US11826144B2 (en) | 2016-07-25 | 2023-11-28 | Samsung Electronics Co., Ltd. | Apparatus and method for estimating biological substance, apparatus for acquiring unit spectrum, and wearable device |
| US10918319B2 (en) | 2016-07-25 | 2021-02-16 | Samsung Electronics Co.. Ltd. | Apparatus and method for estimating biological substance, apparatus for acquiring unit spectrum, and wearable device |
| CN107684431A (en) * | 2016-08-04 | 2018-02-13 | 中国计量大学 | A kind of noninvasive portable glucose meter based on array CCD |
| WO2018032749A1 (en) * | 2016-08-19 | 2018-02-22 | 深圳市前海康启源科技有限公司 | Glucose concentration detection device |
| CN107334477A (en) * | 2017-05-02 | 2017-11-10 | 北京理工大学深圳研究院 | A kind of double spectrum noninvasive dynamics monitoring devices |
| WO2018214297A1 (en) * | 2017-05-20 | 2018-11-29 | 深圳市前海安测信息技术有限公司 | Portable device and method for non-invasive blood glucose detection |
| WO2018214299A1 (en) * | 2017-05-20 | 2018-11-29 | 深圳市前海安测信息技术有限公司 | Non-invasive blood glucose data collection apparatus |
| CN107860722B (en) * | 2017-10-30 | 2020-04-21 | 内蒙古农业大学 | Method and system for online detection of internal quality of honeydew melons |
| CN107860722A (en) * | 2017-10-30 | 2018-03-30 | 内蒙古农业大学 | A kind of honeydew melon inside quality online test method and system |
| CN108593593A (en) * | 2018-04-24 | 2018-09-28 | 深圳市英谱科技有限公司 | Serial double infrared spectrum Woundless blood sugar measuring devices |
| CN109490248A (en) * | 2018-12-27 | 2019-03-19 | 四川精方智慧科技有限公司 | A kind of blood glucose spectral detection system and detection method based on modulation reverse phase cancellation |
| CN109946231A (en) * | 2019-03-13 | 2019-06-28 | 上海交通大学 | The differential photoacoustic measurement system and method for having temperature-compensating |
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