CN204654954U - A kind of Terahertz continuous blood sugar measuring apparatus - Google Patents
A kind of Terahertz continuous blood sugar measuring apparatus Download PDFInfo
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- CN204654954U CN204654954U CN201520314271.4U CN201520314271U CN204654954U CN 204654954 U CN204654954 U CN 204654954U CN 201520314271 U CN201520314271 U CN 201520314271U CN 204654954 U CN204654954 U CN 204654954U
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Abstract
This utility model relates to a kind of Terahertz continuous blood sugar measuring apparatus, comprise THz wave circulation generating unit, THz wave probe unit, signal processing unit, output unit, continuous terahertz wave signal is there is in described THz wave circulation generating unit to region to be measured, described THz wave probe unit detection continuous print terahertz wave signal, described THz wave circulation generating unit occurrence frequency is 1GHz to 100GHz, described signal processing unit receives the terahertz wave signal of described THz wave probe unit detection, described signal processing unit carries out signal conversion processes to the terahertz wave signal received, described output unit exports blood sugar measured according to the process of described signal processing unit.Blood sugar measuring system based on THz wave of the present utility model, collects THz wave spectral information, obtains corresponding blood glucose value according to spectral data.More can return and accurately obtain blood sugar measured, the precision and stability of device measuring is improved.
Description
Technical field
This utility model relates to a kind of blood sugar measuring system, particularly relates to a kind of noninvasive Terahertz continuous blood sugar measuring apparatus.
Background technology
The method of traditional detection blood glucose is that puncture extraction blood is undertaken by biochemical analysis in body, this have the blood sugar test technology of wound to can be used for hospital clinical diagnosis and family health care health care, but due to needs blood drawing, there is the risk that measuring frequency is limited, easily cause discomfort, even infect in this technology, make troubles to diabetics, therefore, the research carrying out novel noninvasive dynamics monitoring technology very tool is of great significance.Current Noninvasive Blood Glucose Detection Methods mainly contains polarimetry, optoacoustic method, Raman spectroscopy, light scattering coefficient method, infrared spectrometry etc.
Polarimetry utilizes glucose to have stable polarized light property, and predict human blood glucose concentration by the deflection angle measuring transillumination (or reflected light), the shortcoming of the method is that deflection angle is less, measures difficulty large, and simultaneously because be measure human eye, patient not easily receives.The photoacoustic signal that photoacoustic spectroscopy method utilizes near-infrared laser pulse and tissue interaction to produce, the content of certain composition of organization internal is detected by the relation between the amplitude of photoacoustic signal and absorptance, the method is comparatively responsive to the change of organization internal structure, thus higher to the requirement of detector.Laser Raman spectrometry is the principle according to can there is Raman scattering when laser action is in glucose, utilize Raman spectrum analysis to obtain the concentration of glucose, due to absorption and the scattering effect of biological tissue, this signal detection, by other biological macromole serious interference, is still in the starting stage to In vivo study.Light scattering coefficient method is a kind of novel optics Non-invasive detection technology, and it is the scattered reflection light that detection space is differentiated, and calculates tissue simplification scattering coefficient, obtains the situation of change of component content in body by following the trail of the change simplifying scattering coefficient.Infrared spectrometry is also the principle of the concentration by calculating composition to be measured after Infrared Spectrum Technology process, remain at present choose at measuring condition, measuring point is selected, extract the critical problems such as faint semiochemical method in overlapped spectra needs to solve.Prior art Woundless blood sugar measuring method causes for measurement impact greatly because of other factors.
Utility model content
The technical problem that this utility model solves is: build a kind of Terahertz continuous blood sugar measuring apparatus, overcomes prior art external factor to the technical problem measuring impact.
The technical solution of the utility model is: build a kind of Terahertz continuous blood sugar measuring apparatus, comprise THz wave circulation generating unit, THz wave probe unit, signal processing unit, output unit, continuous terahertz wave signal is there is in described THz wave circulation generating unit to region to be measured, described THz wave probe unit detection continuous print terahertz wave signal, described THz wave circulation generating unit occurrence frequency is 1GHz to 100GHz, described signal processing unit receives the terahertz wave signal of described THz wave probe unit detection, described signal processing unit carries out signal conversion processes to the terahertz wave signal received, described output unit exports blood sugar measured according to the process of described signal processing unit.
Further technical scheme of the present utility model is: described THz wave circulation generating unit comprises pulse laser generation module, photoconductive device, THz wave emitter.
Further technical scheme of the present utility model is: described signal processing unit obtains amplitude and the phase offset of terahertz wave signal according to the THz wave echo-signal that described THz wave probe unit receives.
Further technical scheme of the present utility model is: described THz wave emitter and described THz wave probe unit are multiple, and described THz wave emitter and described THz wave probe unit successively interval are arranged.
Further technical scheme of the present utility model is: the terahertz wave signal of different frequency occurs described THz wave emitter mutually, and described THz wave probe unit interval gathers the THz wave echo-signal of region to be measured different frequency.
Further technical scheme of the present utility model is: described THz wave circulation generating unit launches a terahertz light in every ten seconds.
Further technical scheme of the present utility model is: also comprise memory module, and described memory module stores respectively according to Measuring Time order.
Technique effect of the present utility model is: build a kind of Terahertz continuous blood sugar measuring apparatus, comprise THz wave circulation generating unit, THz wave probe unit, signal processing unit, output unit, continuous terahertz wave signal is there is in described THz wave circulation generating unit to region to be measured, described THz wave probe unit detection continuous print terahertz wave signal, described THz wave circulation generating unit occurrence frequency is 1GHz to 100GHz, described signal processing unit receives the terahertz wave signal of described THz wave probe unit detection, described signal processing unit carries out signal conversion processes to the terahertz wave signal received, described output unit exports blood sugar measured according to the process of described signal processing unit.Of the present utility modelly carry out circulation based on THz wave circulation generating unit and recur THz wave, received continuously by THz wave probe unit and collect THz wave spectral information, obtain corresponding blood glucose value according to spectral data and realize monitoring continuously.More can return and accurately obtain blood sugar measured, the precision and stability of device measuring is improved.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
Fig. 2 is coaxial probe circuit diagram of the present utility model.
Fig. 3 is that this utility model MOE and MADALINE integrates neural net method schematic diagram.
Detailed description of the invention
Below in conjunction with specific embodiment, technical solutions of the utility model are further illustrated.
As shown in Figure 1, detailed description of the invention of the present utility model is: build a kind of Terahertz continuous blood sugar measuring apparatus, comprise THz wave circulation generating unit 1, THz wave probe unit 2, signal processing unit 3, output unit 4, continuous terahertz wave signal is there is in described THz wave circulation generating unit 1 to region to be measured, described THz wave probe unit 2 detects continuous print terahertz wave signal, described THz wave circulation generating unit 1 occurrence frequency is 1GHz to 100GHz, described signal processing unit 3 receives the terahertz wave signal of described THz wave probe unit 2 detection, described signal processing unit 3 carries out signal conversion processes to the terahertz wave signal received, described output unit 4 exports blood sugar measured according to the process of described signal processing unit.THz wave circulation generating unit 1 comprises cycling circuit, and described cycling circuit is also self-contained within built-in circuit board, writes recursive call program in microcontroller, and measuring process, after triggering, will be monitored continuously.This cycling circuit can control THz wave circulation generating unit and launch a terahertz light in 1 every ten second, and synchronous signal is received and calculate, and the result at every turn measured is stored respectively according to Measuring Time order, and each data measured are able to independent storage.And order controls output unit 4, is presented in real time by the blood glucose level data measured on the LED display on shell simultaneously at every turn.Continuous measurement, until obtain the finish command, namely triggers and terminates to measure button.
As shown in Figure 1, specific implementation process of the present utility model is: described THz wave circulation generating unit 1 occurrence frequency is 1GHz to 100GHz, and the THz wave that described THz wave circulation generating unit 1 occurs passed human body parts angiosomes.The blood glucose that described THz wave probe unit 2 gathers tissue absorbs information, produces the signal of telecommunication, realizes opto-electronic conversion, complete the sampling of described THz wave.The signal of telecommunication that each passage photoelectric sensor produces delivers to described signal processing unit 3, in described signal processing unit 3, be sent to that multichannel preamplifier carries out amplifying, filtering, Integral Processing, signal is made to reach amplitude and the signal to noise ratio of detection identification, the transformation of analogue signal to digital signal is realized again by A/D converter, digital signal after conversion delivers to the process that microprocessor carries out array signal, finally exports blood glucose value.Wave spectrum absorption/reflection characteristic special is separately had based on various material, utilize the wave spectrum absorption/reflection characteristic of blood glucose, just other material informations in its spectral information and blood can be made a distinction, simultaneously, blood glucose solution is in the special frequency channel of THz wave, there is certain absorbing window and reflection windows, show in these wavelength band, by the measurement to the reflectance spectrum/absorption spectrum of THz wave after blood glucose, under certain frequency can being obtained by statistical method, the corresponding relation of its echo-signal and blood glucose, obtains blood glucose value by corresponding relation.Also can be more responsive to dielectric property according to its absorptance/reflection coefficient, therefore, finally can be passed through algorithm and perform the blood glucose concentration value drawing its correspondence.The art of this patent scheme is in order to overcome the difficult problem existed in THz wave noninvasive dynamics monitoring, make the embodiment human blood glucose concentration that faint spectroscopic signal change energy is correct, devise multi-frequency THz wave blood-sugar detection sensor array, the frequency separation measured is decided to be 1GHz-100GHz, specific frequency is segmented to each sensor in sensor array, again through the information of each sensor of detection model algorithm fusion, the precision and stability of THz wave noninvasive dynamics monitoring is made to be improved like this.
As shown in Figure 1, preferred implementation of the present utility model is: described THz wave circulation generating unit comprises pulse laser generation module, photoconductive device, THz wave emitter.Pulse laser generation module is fiber laser device, comprises the laser instrument of the pulse producing laser beam, fiber amplifier and pulse shortener.Laser instrument produces pulsed light, is amplified by former light, recovers damage, then carry out pulse compression via pulse shortener, then Emission Lasers bundle through fiber amplifier.And then the laser beam irradiation that impulse laser unit produces, in photoconductive device, produces terahertz pulse, and this terahertz pulse, by terahertz transmitter, emits, exposes to region to be measured.
As shown in Figure 1, preferred implementation of the present utility model is: described THz wave probe unit comprises lens.Described lens are off-axis aspheric mirror.Wherein probe unit is to have the high electron mobility field-effect transistor of higher Two-dimensional electron concentration for basic structural unit, and field-effect transistor has three electrodes, is respectively source electrode, gate electrode and drain electrode.The detecting element structure of described terahertz wave detector comprises three lead-in wires electrode, three low pass filters and one group of THz wave coupled antenna, and three electrodes of described field-effect transistor are connected with THz wave coupled antenna, jointly as antenna; And described three electrodes are connected with corresponding lead-in wire electrode respectively by low pass filter.Described high electron mobility field-effect transistor is the transistor with higher two-dimensional electron gas, at least comprises the one in aluminum gallium nitride/gallium nitrogen transistor and gallium aluminium arsenic/gallium arsenic transistor.Detecting module also comprises signal amplifier, amplifies the Terahertz echo-signal received.
As shown in Figure 1, preferred implementation of the present utility model is: described signal processing unit 3 obtains amplitude and the phase offset of terahertz wave signal according to the Terahertz echo-signal that described THz wave probe unit detects.Described signal processing unit 3 determines the blood glucose value in region to be measured according to the terahertz wave signal amplitude of acquisition and the corresponding relation of phase offset and blood glucose.Because the amplitude of microwave signal and phase offset and blood glucose have corresponding relation, by the measurement of real-time mass data, set up the amplitude of microwave signal and the homologous thread figure of phase offset and blood glucose, by the corresponding relation of curve chart, obtain the blood glucose value of its correspondence according to real-time measurement values.
As shown in Figure 1, preferred implementation of the present utility model is: also comprise the duty detecting sensor 23 be arranged on described THz wave probe unit 2.In order to the change of the certainty of measurement that the factor such as drift of the response and variations in temperature of considering THz wave probe unit 2 duration of work causes, stablize on the basis of THz wave wave source at employing constant-current circuit, THz wave probe unit is provided with duty detecting sensor 23, the duty drift that temperature, sample variation etc. cause is controlled, duty is calibrated, monitors compensation, work with making sensor stabilization.The time that array is measured at every turn is about 5s, and the interval time of measuring during monitoring can set.Described signal processing unit 3 also comprises correction module 41, and described correction module corrects according to the information of described duty detecting sensor sensing 23.
As shown in Figure 1, preferred implementation of the present utility model is: described THz wave emitter and described THz wave probe unit 2 are multiple, there is the terahertz wave signal of different frequency in described THz wave emitter, described THz wave probe unit 2 interval gathers the THz wave echo-signal of region to be measured different frequency mutually.Described microwave sounding unit 2 interval gathers the microwave echoes signal of region to be measured different frequency, the microwave echoes signal of region to be measured different frequency is gathered by interval, complete the collection repeatedly blood glucose in region to be measured being absorbed to information, the blood glucose value in region to be measured is obtained by obtaining its meansigma methods, more accurate like this.
As shown in Figure 1, preferred implementation of the present utility model is: described THz wave emitter and described THz wave probe unit 2 successively interval are arranged.Arranged by the interval successively of single described THz wave emitter and described THz wave probe unit 2, echo-signal can be obtained more easily.
Specific implementation process is as follows:
Preferred implementation of the present utility model is: described signal processing unit obtains the dielectric property value of blood to be measured according to the terahertz signal that described Terahertz receiver module receives, and then obtains the blood sugar measured of blood to be measured according to the dielectric property value of blood to be measured.What adopt in the measuring process of non-invasive blood sugar instrument is that coaxial probe is measured, and the equivalent circuit of its dielectric constant measurement principle as shown in Figure 2.
As shown in Figure 2,
for the mould electricity energy storage that disappears in beginning place's coaxial line,
for the initial energy storage of coaxial circuit,
be the beginning place be diffused in stray capacitance in outside measured medium,
represent the output rating relevant with circuit, then the Linear Double capacitor model of upper figure can be expressed as:
By distortion:
Wherein:
represent dielectric property value,
angular frequency,
represent reflection coefficient,
represent reflection radian.
The method that described signal processing unit 3 adopts Mixture of expert algorithm and Madaline linear neural net to integrate is to process the signal of Terahertz reception antenna.
Data message between the human normal scope that Madaline Linear Network reception MOE transmits and GG, according to blood sugar test model, accuracy of detection, carry out linear approximation by dielectric property value W, calculate the blood glucose concentration value A of corresponding precision.Namely
Wherein weights W and parameter b obtain for benchmark carries out convergence computing with network minimum error quadratic sum, specifically using the GG of some different blood sugar concentration that obtains as the input of network, the same time is carried out successive iteration by the accurate blood glucose value of blood sample concentration as output accordingly and optimizes weights W, b until convergence can obtain.
As shown in Figure 1, Figure 3, because blood glucose is relevant with some physical factors of people itself, in order to obtain more accurate blood glucose value, need to correct some factors.In order to extract corresponding blood sugar concentration information from wave spectrum, obtain sufficiently high signal to noise ratio, to pick out faint glucose absorption signal from wave spectrum, certainty of measurement and the non-linear all reasonable method integrated by Mixture of expert algorithm (Mixture of Expert, MOE) and Madaline linear neural net is adopted to process array signal.
Mixture of expert algorithm can the comprehensive blood glucose spectral information of extraction comparison exactly, by Madaline linear neural net linear approximation methods, and the demarcation of process high accuracy blood glucose concentration value and display.Its algorithm is specific as follows:
Setting input parameter is
, four elements
be respectively body parameter,
represent sex, wherein, men's 1 represents, female is 0 expression;
represent human body correction factor;
represent quantity of motion correction factor;
represent the instrumental correction factor.Four built-in elements
initialize according to the various factors of influence in detection model.The interference of the overlap of the wave spectrum of blood glucose in each channel wavelength and other factors except blood glucose can be eliminated, as the difference according to factor correction individualities such as age, height, body weight, can blood glucose information be made as far as possible accurate.
Each correction parameter
m test input parameter
linear sums add constant term
, that is:
The output of blood glucose ripple absorption parameter GG accurately records correction parameter by n sensor
summation, simultaneously each variable has a corresponding dielectric property value
, its relation is as follows:
Dielectric property value
with parameter
relevant, its expression formula is:
, wherein
.
Technique effect of the present utility model is: build a kind of Terahertz continuous blood sugar measuring apparatus, comprise THz wave circulation generating unit 1, THz wave probe unit 2, signal processing unit 3, output unit 4, continuous terahertz wave signal is there is in described THz wave circulation generating unit 1 to region to be measured, described THz wave probe unit 2 detects continuous print terahertz wave signal, described THz wave circulation generating unit 1 occurrence frequency is 1GHz to 100GHz, described signal processing unit 3 receives the terahertz wave signal of described THz wave probe unit 2 detection, described signal processing unit 3 carries out signal conversion processes to the terahertz wave signal received, described output unit 4 exports blood sugar measured according to the process of described signal processing unit.Blood sugar measuring system based on THz wave of the present utility model, collects THz wave spectral information, obtains corresponding blood glucose value according to spectral data.More can return and accurately obtain blood sugar measured, the precision and stability of device measuring is improved.
Above content is in conjunction with concrete preferred implementation further detailed description of the utility model, can not assert that concrete enforcement of the present utility model is confined to these explanations.For this utility model person of an ordinary skill in the technical field, without departing from the concept of the premise utility, some simple deduction or replace can also be made, all should be considered as belonging to protection domain of the present utility model.
Claims (7)
1. a Terahertz continuous blood sugar measuring apparatus, it is characterized in that, comprise THz wave circulation generating unit, THz wave probe unit, signal processing unit, output unit, continuous terahertz wave signal is there is in described THz wave circulation generating unit to region to be measured, described THz wave probe unit detection continuous print terahertz wave signal, described THz wave circulation generating unit occurrence frequency is 1GHz to 100GHz, described signal processing unit receives the terahertz wave signal of described THz wave probe unit detection, described signal processing unit carries out signal conversion processes to the terahertz wave signal received, described output unit exports blood sugar measured according to the process of described signal processing unit.
2. Terahertz continuous blood sugar measuring apparatus according to claim 1, it is characterized in that, described THz wave circulation generating unit comprises pulse laser generation module, photoconductive device, THz wave emitter.
3. Terahertz continuous blood sugar measuring apparatus according to claim 1, is characterized in that, described signal processing unit obtains amplitude and the phase offset of terahertz wave signal according to the THz wave echo-signal that described THz wave probe unit receives.
4. Terahertz continuous blood sugar measuring apparatus according to claim 1, it is characterized in that, described THz wave emitter and described THz wave probe unit are multiple, and described THz wave emitter and described THz wave probe unit successively interval are arranged.
5. Terahertz continuous blood sugar measuring apparatus according to claim 1, it is characterized in that, there is the terahertz wave signal of different frequency in described THz wave emitter, described THz wave probe unit interval gathers the THz wave echo-signal of region to be measured different frequency mutually.
6. Terahertz continuous blood sugar measuring apparatus according to claim 1, is characterized in that, described THz wave circulation generating unit launches a terahertz light in every ten seconds.
7. Terahertz continuous blood sugar measuring apparatus according to claim 1, it is characterized in that, also comprise memory module, described memory module stores respectively according to Measuring Time order.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873207A (en) * | 2015-05-15 | 2015-09-02 | 深圳市一体太糖科技有限公司 | Terahertz wave-based continuous blood glucose measurement system |
| CN105054945A (en) * | 2015-09-25 | 2015-11-18 | 巫立斌 | Intelligent glucometer |
| CN116138771A (en) * | 2023-04-18 | 2023-05-23 | 江西科技师范大学 | Energy correction method for multispectral blood glucose photoacoustic detection |
-
2015
- 2015-05-15 CN CN201520314271.4U patent/CN204654954U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873207A (en) * | 2015-05-15 | 2015-09-02 | 深圳市一体太糖科技有限公司 | Terahertz wave-based continuous blood glucose measurement system |
| CN105054945A (en) * | 2015-09-25 | 2015-11-18 | 巫立斌 | Intelligent glucometer |
| CN116138771A (en) * | 2023-04-18 | 2023-05-23 | 江西科技师范大学 | Energy correction method for multispectral blood glucose photoacoustic detection |
| CN116138771B (en) * | 2023-04-18 | 2023-06-30 | 江西科技师范大学 | Energy correction method for multispectral blood glucose photoacoustic detection |
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Effective date of registration: 20171116 Address after: Two road 518000 Guangdong city of Shenzhen province Nanshan District Xili Street North No. 15 on the third floor of the 301 science and technology Patentee after: SHENZHEN YITI TERAHERTZ TECHNOLOGY CO., LTD. Address before: 518000 Guangdong city of Shenzhen province Nanshan District Xiangshan overseas Chinese overseas Chinese town west two North Road, building six floor 601 10 Maohua Patentee before: One Tai Tang Science and Technology Ltd. of Shenzhen |
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Address after: 518000 building 3, 5A, Taihua Indus Industrial Park, Baoan District City, Shenzhen, Guangdong. Patentee after: Shenzhen Terahertz Technology Co., Ltd. Address before: 518000 Guangdong, Shenzhen, Nanshan District Xili street, Technology north two Road 15, third floor 301 Patentee before: SHENZHEN YITI TERAHERTZ TECHNOLOGY CO., LTD. |
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