CN201271399Y - Filtering equipment for removing leucocyte from soft mass blood ingredient - Google Patents
Filtering equipment for removing leucocyte from soft mass blood ingredient Download PDFInfo
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- CN201271399Y CN201271399Y CNU2008201539048U CN200820153904U CN201271399Y CN 201271399 Y CN201271399 Y CN 201271399Y CN U2008201539048 U CNU2008201539048 U CN U2008201539048U CN 200820153904 U CN200820153904 U CN 200820153904U CN 201271399 Y CN201271399 Y CN 201271399Y
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Abstract
The utility model provides a soft blood-ingredient filtering apparatus, comprising an inlet pipeline (1), an inlet connection (2), a reinforcement part (3), an inner-layer transition membrane (4), a filtering core (5), a flexible package membrane (6), a slit (7), an outlet connection (8) and an outlet pipeline (9). The filtering apparatus comprises the filtering core (5), the inner-layer transition membrane (4) and the outer-layer flexible package membrane (6) from inward to outward. The appearance of the filtering apparatus is artistic and the surface is smooth and neat without any prominence. A hot melting part can not be broken when high-temperature and high-pressure steam sterilization is carried out, and can endure expansion and contraction. The flexible package membrane is closed into one body with the edge of the filtering core, when in blood filtration, no edge leakage appears. The filtering apparatus is suitable for filtering whole blood, red cell suspension, blood plasma, and more than 99 percent of white blood cells in blood platelet; the usage is convenient, the removing effect of the white blood cells is good and blood loss is less.
Description
Technical field
This utility model relates to medical apparatus and instruments, is specifically related to soft blood constituent leucocyte-removing filter device.
Background technology
Infusion contains leukocytic blood constituent can cause many blood transfusion untoward reaction,, graft versus host disease (GVHD) invalid as nonhemolytic febrific reaction (FNHTR), platelet infusion etc.Simultaneously, leukocyte is still had a liking for the carrier of leukocyte virus, as cytomegalovirus (MCV), human T-lymphocyte leukemia virus, (HTLV-I/II) and human defective immunity virus (HIV), blood transfusion may cause these viruses to be propagated and the activation of latent virus through blood.Adopt the leukocyte in the special-purpose leucocyte-removing filter of blood constituent filtering blood/blood constituent, can reduce the blood transfusion untoward reaction relevant greatly with leukocyte.
Existing nearly 30 years of the generation of leucocyte-removing filter is historical, early stage leucocyte-removing filter, as descriptions such as CN2595372Y, CN201101771Y, generally form by puncture needle, leucocyte filtration device, exhaust apparatus and blood reservoir bag, during use, be connected with treating the leukocytic blood constituent of filtering by puncture needle, blood enters leucocyte filtration device, successively by intake chamber, filter course and liquid outtake chamber, intake chamber and liquid outtake chamber lay respectively at the both sides of filter course, are pooled at last in the blood reservoir bag.The leucocyte-removing filter of this form can be used for whole blood, red cell suspension, platelet product and blood plasma etc. according to the filter material different in kind, can be behind blood collection in effect duration the random time point carry out the blood leucocyte-removing and filter.Its deficiency is that piercing process has caused blood open, to whole blood or red cell suspension 4 ℃ of preservations, then its filter back blood constituent must be in 24h infusion, otherwise just must scrap.In order to reduce blood waste risk, the user can filter before blood infusion is given the patient, make processed blood component collection after the holding time longer, even soon expired.Like this, though the leukocyte in the blood all by filtering, but leukocyte metabolite and the toxin that produces because of apoptosis are stayed in the blood between storage life, can't remove, and after the patient imports this blood, still various transfusion reactions can take place.
For this reason, filtering notion before the blood transfusion circle has proposed to preserve, mainly contain 2 kinds of forms now: connect (STDC method) with the sterile catheter adapter aseptic the connection with the storage life of prolongation filter back blood or with the leucocyte-removing filter of pending blood and leucocyte-removing filter is connected into multi-joint bag system, reach blood sampling, filtration, the incorporate purpose of leucocyte-removing, handle its inconvenience of preservation of back blood constituent, safety improves greatly.As what use on CN 1110313A, US2006/0229547 A1, CN2678657 Y, the disclosed and present markets such as CN 1964751A, CN2681750Y mostly is the leucocyte-removing filter device that has above-mentioned hard shell, generally is made up of the blood bag and the preservation liquid of blood taking bag, the whole blood type duricrust leucocyte-removing filter that has exhaust apparatus, appropriate configuration.During use, gather whole blood earlier, whole blood is carried out leucocyte-removing filter, again to filtering back whole blood centrifugal preparation leucocyte-removing red cell suspension and leucocyte-removing blood plasma.Because filter material, the platelet major part is by filtering.The leucocyte-removing filter blood bag of this spline structure, because of defecator is a hard, and the import and export joint of projection is arranged, with a whole set of plastic blood bag place, in the process of cryopreservation, can the infringement plastic blood bag, can not carry out more that low-temperature and high-speed is centrifugal to come separating blood constituents with plastic blood bag.Thereby can only after the whole blood collection, carry out leucocyte-removing to whole blood earlier and handle, centrifugal to the whole blood behind the leucocyte-removing again, the preparation blood constituent, it is pressed for time simultaneously, the defecator of this duricrust since housing be inflexible, can not shrink, in the high pressure steam sterilization process because of huge steam pressure and high temperature, expanding with heat and contract with cold etc. in the confined space causes housing solder side cracking, filter material impaired etc., and influence is used.
Patents such as WO 01/91880A1, CN 1720070A, a kind of embodiment of flexible package filter is disclosed, the import and export joint of a moulding is all arranged on these filter surfaces or directly be welded on the lip-deep short tube of filter each other, be respectively applied for the inflow and the outflow of blood.Its shortcoming is can not form the centrifugally operated purpose and the flat surfaces wishing to have.
And the shortcoming of EP0526678 B2 and the known filter of EP0684866 B1 is reasonable inadequately at the frame area inner flow passage that surrounds filter material, produce wherein can not filtering blood inactive area, the one, can not make full use of filter material; The 2nd, valuable blood constituent is detained in this inactive area, causes waste.
The utility model content
Technical problem to be solved in the utility model is to overcome above-mentioned weak point, a kind of high pressure resistant steam sterilization, side leakage free are provided, and leukocyte removal efficiency height, blood constituent response rate conformance with standard require and can be used for centrifugal flexible package leucocyte-removing blood defecator.
For solving the problems of the technologies described above, this utility model by the following technical solutions:
A kind of soft package blood defecator of this utility model comprises inlet ducts 1, inlet union 2, reinforces position 3, internal layer transition film 4, filter element 5, flexible packaging film 6, slit 7, outlet connection 8 and delivery channel 9.Described defecator is followed successively by from the inside to the outside reinforces position 3, internal layer transition film 4, filter element 5 and flexible packaging film 6.Described filter element 5 is processed into by ultra-fine polyester non-woven fabric filtering material and internal layer medical PVC transition film 4 peripheral hot melts; Described filter element 5 is reinforced position 3 in central authorities and is adopted ultrasound wave that internal layer membrane and non-woven fabrics filter material appropriateness are fixed together, and purpose is to compress filtering material in the blood filtration process, reduces blood and is detained in filter material, improves the blood response rate, reduces blood loss; Internal layer transition film 4 adopts common soft medical PVC thin film; Flexible packaging film 6 adopts the soft medical PVC thin film of thickening.Described internal layer membrane is between nonwoven cloth filter material and outer flexible packaging film 6, its interconnect function, be the non-woven fabrics filter material by and internal layer membrane fusion one after, forms a filter element edge that relatively approaches, be in the same place by high frequency fused with outer flexible packaging film again in this filter element edge.Described inlet union 2 is positioned at filter element 5 top centres, and the one end inserts non-woven fabrics filter element inside, other end bonding inlet ducts 1; Described outlet connection 8 is positioned at position placed in the middle, filter element 5 peripheral bottoms, and connects delivery channel 9 formation blood flow pass.Described internal layer transition film 4 has a slit 7 at filter element 5 near outlet connection 8 places, and the effect of slit 7 is to allow flow out from filter element 5 through filter element 5 filtering blood.The internal layer transition film 4 of described inlet union 2, outlet connection 8, filter element 5 outer wrapping is processed by high frequency with outer flexible packaging film 6, forms incorporate hot melt driving fit edge, can stand the 50kPa clean compressed air and keep 2min not have the gas seepage.The soft package blood defecator uses by being connected into multi-joint bag with inlet union 2 and outlet connection 8 agglutinating import and export conduits.This utility model can be with after the blood bag of any structure be connected, and integrated production, whole sterilization and reprocessing are used.Leukocyte removal efficiency is greater than 99.9% in the blood constituent after filtering, and the blood constituent response rate is effectively improved the quality of blood products and the safety of clinical blood transfusion greater than 85%.
Soft package blood component leucocyte-removing filter device of the present utility model is drops, circle, heart or oval.Its filter element 5 is made of 2～20 metafiltration materials, and its total number of plies is even numbers.Filter element 5 thickness are between 5mm-20mm.Inlet union 2, outlet connection 8, inlet ducts 1 and delivery channel 9 all adopt soft medical PVC material; Whole soft, good looking appearance, smooth surface is smooth, does not have any projection, the high temperature resistant sterilization of anti-extruding.
After adopting said structure, this utility model can be connected with multi-joint bag with delivery channel 9 by means of inlet ducts 1 with the blood bag of any structure, and integrated production, integral body are sterilized, finished blood collection and the preparation of leucocyte-removing blood composition and preserves.Leukocyte removal efficiency is greater than 99.9% in the blood constituent after filtering, and the blood constituent response rate helps improving the quality of blood products and the safety of clinical blood transfusion greater than 85%, reduces the blood transfusion untoward reaction and takes place.
Description of drawings
Fig. 1 is: soft leucocyte-removing filter device profile of the present utility model and structural representation.
The specific embodiment
The utility model is described in further detail below in conjunction with accompanying drawing:
The soft leucocyte-removing blood of this utility model defecator comprises inlet ducts 1, inlet union 2, reinforces position 3, internal layer transition film 4, ultra-fine non-woven fabrics filter element 5, flexible packaging film 6, slit 7, outlet connection 8 and delivery channel 9 as shown in Figure 1.
Described defecator is followed successively by from the inside to the outside reinforces position 3, internal layer transition film 4, filter element 5 and flexible packaging film 6.Described ultra-fine non-woven fabrics filter element 5 is made by ultra-fine polyester non-woven fabric filtering material and internal layer medical PVC transition film periphery hot melt; Described inlet union 2 is positioned at position placed in the middle, filter element 5 tops, and the one end inserts non-woven fabrics filter element 5 inside, other end bonding inlet ducts 1; Described outlet connection 8 is positioned at position placed in the middle, filter element 5 peripheral bottoms, and and delivery channel 9 formation blood flow pass.Described internal layer transition film 4 has a slit 7 at filter element 5 near outlet connection 8 places, and the internal layer transition film 4 of described inlet union 2, outlet connection 8, filter element 5 outer wrapping is processed by high frequency with outer flexible packaging film 6, forms incorporate hot melt driving fit edge.
During use, blood enters filter element 5 inside through inlet ducts 1, inlet union 2, filters through ultra-fine nonwoven cloth filter material, behind the removal leukocyte, flow to space between filter element 5 and the outer packaging film 6 from slit 7, flow out in the collecting bag through outlet connection 8 and delivery channel 9 again.Because filtering material is integrated by means of internal layer transition film and outer package fusion, has stopped the side leakage of blood between filter material and its packaging material fully, has improved the leucocyte-removing effect.Whole defecator all is soft medical PVC material except the ultra-fine non-woven fabrics filter material of porous, makes this defecator whole soft, can be with the multi-joint bag of blood sampling high speed centrifugation.
The soft leucocyte-removing blood of this utility model defecator can be connected in the multi-joint bag of appropriate configuration as required, the leukocyte that is used for blood constituents such as filtering red cell suspension, blood plasma, platelet adsorbs blood fat, cell debris, little aggressiveness and blood clot etc. simultaneously.Reach and improve blood quality, reduce the purpose of blood transfusion risk.
Above-mentioned embodiment only is used for this utility model is described, and does not constitute the restriction to the claim scope.
Claims (9)
1, a kind of soft blood component filter is characterized in that described defecator comprises inlet ducts (1), inlet union (2), reinforces position (3), internal layer transition film (4), filter element (5), flexible packaging film (6), slit (7), outlet connection (8) and delivery channel (9); Described defecator is followed successively by from the inside to the outside reinforces position (3), internal layer transition film (4), filter element (5) and flexible packaging film (6).
2,, it is characterized in that described filter element (5) made by ultra-fine polyester non-woven fabric filtering material and internal layer medical PVC transition film periphery hot melt according to the described a kind of soft blood component filter of claim 1; Internal layer transition film (4) adopts common soft medical PVC thin film; Flexible packaging film (6) adopts the soft medical PVC thin film of thickening.
3, according to the described a kind of soft blood component filter of claim 1, it is characterized in that described inlet union (2) is positioned at filter element (5) top centre, the one end inserts filter element (5) inside, other end bonding inlet ducts (1); Described outlet connection (8) is positioned at position placed in the middle, the peripheral bottom of filter element (5), and connects delivery channel (9) formation blood flow pass.
4,, it is characterized in that described internal layer transition film (4) located a slit (7) at filter element (5) near outlet connection (8) according to the described a kind of soft blood component filter of claim 1.
5, according to the described a kind of soft blood component filter of claim 1, the internal layer transition film (4) that it is characterized in that described inlet union (2), outlet connection (8), filter element (5) outer wrapping is processed by high frequency with outer flexible packaging film (6), forms incorporate hot melt driving fit edge.
6, soft blood component filter according to claim 1 is characterized in that described filter element (5) is made of 2～20 layers of ultra-fine polyester non-woven fabric filtering material, and its total number of plies is even numbers.
7, soft blood component filter according to claim 1 is characterized in that described filter element (5) thickness is 1.5～3.0mm.
8, soft blood component filter according to claim 1 is characterized in that described device is drops, circle, heart or oval; Smooth surface is smooth, does not have any projection.
9, soft blood component filter according to claim 1 is characterized in that described inlet union (2), outlet connection (8), inlet ducts (1) and delivery channel (9) all adopt soft medical PVC material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008201539048U CN201271399Y (en) | 2008-10-10 | 2008-10-10 | Filtering equipment for removing leucocyte from soft mass blood ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008201539048U CN201271399Y (en) | 2008-10-10 | 2008-10-10 | Filtering equipment for removing leucocyte from soft mass blood ingredient |
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| Publication Number | Publication Date |
|---|---|
| CN201271399Y true CN201271399Y (en) | 2009-07-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNU2008201539048U Expired - Lifetime CN201271399Y (en) | 2008-10-10 | 2008-10-10 | Filtering equipment for removing leucocyte from soft mass blood ingredient |
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| CN (1) | CN201271399Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103282063A (en) * | 2010-12-27 | 2013-09-04 | 旭化成医疗株式会社 | Blood processing filter, and priming method for blood processing filter |
| CN105435320A (en) * | 2015-11-06 | 2016-03-30 | 南京双威生物医学科技有限公司 | Double-layer-membrane soft-shell leucocyte filter and preparation method thereof |
-
2008
- 2008-10-10 CN CNU2008201539048U patent/CN201271399Y/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103282063A (en) * | 2010-12-27 | 2013-09-04 | 旭化成医疗株式会社 | Blood processing filter, and priming method for blood processing filter |
| CN105435320A (en) * | 2015-11-06 | 2016-03-30 | 南京双威生物医学科技有限公司 | Double-layer-membrane soft-shell leucocyte filter and preparation method thereof |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20090715 |