CN105435320A - Double-layer-membrane soft-shell leucocyte filter and preparation method thereof - Google Patents
Double-layer-membrane soft-shell leucocyte filter and preparation method thereof Download PDFInfo
- Publication number
- CN105435320A CN105435320A CN201510752286.3A CN201510752286A CN105435320A CN 105435320 A CN105435320 A CN 105435320A CN 201510752286 A CN201510752286 A CN 201510752286A CN 105435320 A CN105435320 A CN 105435320A
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- China
- Prior art keywords
- filter
- membrane
- filter membrane
- cephacoria
- caudacoria
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/3406—Physical characteristics of the filtrate, e.g. urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3413—Diafiltration
- A61M1/3417—Diafiltration using distinct filters for dialysis and ultra-filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3482—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses a double-layer-membrane soft-shell leucocyte filter and a preparation method thereof, and belongs to the filed of medical treatment and public health. The double-layer-membrane soft-shell leucocyte filter comprises an inlet connector, a front membrane, a filter membrane, a rear membrane and an outlet connector. The front membrane and the rear membrane are pressed into a whole from the outer edges of the two side faces of the filter membrane. A pre-filtration cavity is formed between the front membrane and the filter membrane. A post-filtration cavity is formed between the rear membrane and the filter membrane. The design of traditional filter membranes is broken through, the liquid inlet direction and the liquid outlet direction are perpendicular to the filter membrane, filtration of blood constituents is efficiently achieved although only two filter membranes are arranged, filtration is uniform, and the flow speed is stable.
Description
Technical field
The present invention relates to medicine and hygiene fields, relate in particular to a kind of duplicature soft shell leucocyte filter and preparation method thereof.
Background technology
Often need to use filter to carry out composition filtering in blood constituent filtration art, existing soft shell filter often adopts three layers or the design of four tunics, and it is parallel for entering blood with hemorrhage direction and film.And find in practice, existing design for filtration elements mode is not optimum, and its problem caused has:
(1) filter uneven: horizontal direction is filtered, and the up and down suffered pressure of filter membrane is different, causes filter membrane upper and lower to be adsorbed also different with the number of white blood cells of interception, impact filter white effect;
(2) rate of filtration is slow: after the blood in blood bag is covered, the blood that the filter ante-chamber of soft shell filter is put aside, and horizontal direction can only slowly penetrate into filter back cavity, speed is very slow.
Summary of the invention
Goal of the invention: the object of this invention is to provide a kind ofly to realize fast, uniform filtering and do not cause the duplicature soft shell leucocyte filter of obstruction, another object of the present invention is to provide the preparation method of producing aforementioned duplicature soft shell leucocyte filter.
Technical scheme: for achieving the above object, a kind of duplicature soft shell leucocyte filter of the present invention, comprises inlet union, cephacoria, filter membrane, caudacoria, outlet connection, described cephacoria and caudacoria as a whole from the outer rim pressing of filter membrane two sides.Form filter ante-chamber between cephacoria and filter membrane, between caudacoria and filter membrane, form filter back cavity.
Described filter membrane comprises the organic fiber film of coated with resins and/or the ultra-fine fibre glass film of coated with resins, and described organic fiber film comprises the combination of any one or two kinds of non-woven membrane or polyester fiber film.
The present invention only carries out heat seal by 2 tunics, from membrane material compared to 3 layers, the design of 4 tunics will save half nearly, in order to ensure heat sealing quality in heat seal, make before after filter ante-chamber and filter completely isolated, carry out further optimization: described cephacoria and rear membrane area are slightly larger than filter membrane area, cephacoria and caudacoria form heat seal internal ring by being once heat sealing at filter membrane outer rim, form heat seal outer shroud between cephacoria and caudacoria without the place of filter membrane by secondary heat seal.
Unlike the prior art, inlet union of the present invention is vertical with filter membrane with outlet connection opening direction.The design of vertical joint is corresponding with filtering direction, adds filter efficiency, relatively reduces the pressure load of 2 tunics in heat seal place of filter membrane outer rim.
Due to aforesaid design, described filter membrane shape is any one of circular, oval, tetragon.Its filter membrane shape has more more options, and the impact of shape on filter effect does not almost have.By further improving inlet union, outlet connection and filter membrane shape, being that inlet and liquid outlet are evenly distributed in intracavity, reducing local pressure, increase filter effect.As one preferred embodiment, described inlet union is provided with 3, and filter membrane shape is circular, and 3 inlet union are centrosymmetric relative to the filter membrane center of circle, and 3 inlet union upper ends are connected with infusion pipeline by four-way.The feed liquor simultaneously of 3 somes when filtering above filter membrane, ensure that and filter evenly, better than the filter effect of an inlet union, alleviates localised load.
Described cephacoria and caudacoria are PVC film.Heat pressing process adopts High frequency heating, has excellent heat seal seal in conjunction with PVC film.
For producing the preparation method of aforementioned duplicature soft shell leucocyte filter, the shaped slightly due to cephacoria and caudacoria is greater than the shape of filter membrane, and the outer rim of cephacoria, caudacoria and filter membrane is carried out High frequency heating by first time heat seal; Second time will exceed cephacoria and the thick film part High frequency heating of filter membrane outer rim.
Beneficial effect: the present invention breaks traditions filter membrane design, and feed liquor is vertical with filter membrane with fluid direction, only has 2 metafiltration films but achieves the filtration of blood constituent efficiently, the even and flow speed stability of filtration.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is further described.
As shown in Figure 1, a kind of duplicature soft shell leucocyte filter, comprises inlet union 1, cephacoria 2, filter membrane 3, caudacoria 4, outlet connection 5, cephacoria 2 and caudacoria 4 as a whole from the outer rim pressing of filter membrane 3 two sides.Form filter ante-chamber 8 between cephacoria 2 and filter membrane 3, between caudacoria 4 and filter membrane 3, form filter back cavity 9.Filter membrane comprises the organic fiber film of coated with resins and the ultra-fine fibre glass film of coated with resins, and organic fiber film comprises the combination of any one or two kinds of non-woven membrane or polyester fiber film.Cephacoria 2 and caudacoria 4 are PVC film.Filter membrane 3 shape is any one of circular, oval, tetragon.Heat pressing process adopts High frequency heating, has excellent heat seal seal in conjunction with PVC film.Inlet union 1 is vertical with filter membrane 3 with outlet connection 5 opening direction.
Cephacoria 2 and caudacoria 4 area are slightly larger than filter membrane 3 area, and cephacoria 2 and caudacoria 4 form heat seal internal ring 6 by being once heat sealing at filter membrane 3 outer rim, form heat seal outer shroud 7 between cephacoria 2 and caudacoria 4 without the place of filter membrane 3 by secondary heat seal.
As one preferred embodiment, inlet union is provided with 3, and filter membrane shape is circular, and 3 inlet union are centrosymmetric relative to the filter membrane center of circle, and 3 inlet union upper ends are connected with infusion pipeline by four-way.The feed liquor simultaneously of 3 somes when filtering above filter membrane, ensure that and filter evenly, better than the filter effect of an inlet union, alleviates localised load.
For producing the preparation method of aforementioned duplicature soft shell leucocyte filter, the shaped slightly due to cephacoria and caudacoria is greater than the shape of filter membrane, and the outer rim of cephacoria, caudacoria and filter membrane is carried out High frequency heating by first time heat seal; Second time will exceed cephacoria and the thick film part High frequency heating of filter membrane outer rim.
The above is only the preferred embodiment of the present invention; be noted that for those skilled in the art; under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (7)
1. a duplicature soft shell leucocyte filter, is characterized in that: comprise inlet union, cephacoria, filter membrane, caudacoria, outlet connection, described cephacoria and caudacoria as a whole from the outer rim pressing of filter membrane two sides.
2. a kind of duplicature soft shell leucocyte filter according to claim 1, it is characterized in that: described filter membrane comprises the organic fiber film of coated with resins and/or the ultra-fine fibre glass film of coated with resins, described organic fiber film comprises the combination of any one or two kinds of non-woven membrane or polyester fiber film.
3. a kind of duplicature soft shell leucocyte filter according to claim 2, it is characterized in that: described cephacoria and rear membrane area are slightly larger than filter membrane area, cephacoria and caudacoria form heat seal internal ring by being once heat sealing at filter membrane outer rim, form heat seal outer shroud between cephacoria and caudacoria without the place of filter membrane by secondary heat seal.
4. a kind of duplicature soft shell leucocyte filter according to claim 1, is characterized in that: described inlet union is vertical with filter membrane with outlet connection opening direction.
5. a kind of duplicature soft shell leucocyte filter according to Claims 1-4 any one, is characterized in that: described filter membrane shape is any one of circular, oval, tetragon.
6. a kind of duplicature soft shell leucocyte filter according to claim 5, is characterized in that: described cephacoria and caudacoria are PVC film.
7. prepare a method for duplicature soft shell leucocyte filter as claimed in claim 1, it is characterized in that: the shaped slightly of cephacoria and caudacoria is greater than the shape of filter membrane, the outer rim of cephacoria, caudacoria and filter membrane is carried out High frequency heating by first time heat seal; Second time will exceed cephacoria and the thick film part High frequency heating of filter membrane outer rim.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510752286.3A CN105435320A (en) | 2015-11-06 | 2015-11-06 | Double-layer-membrane soft-shell leucocyte filter and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510752286.3A CN105435320A (en) | 2015-11-06 | 2015-11-06 | Double-layer-membrane soft-shell leucocyte filter and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105435320A true CN105435320A (en) | 2016-03-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510752286.3A Pending CN105435320A (en) | 2015-11-06 | 2015-11-06 | Double-layer-membrane soft-shell leucocyte filter and preparation method thereof |
Country Status (1)
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| CN (1) | CN105435320A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2436161Y (en) * | 2000-05-29 | 2001-06-27 | 北京伏尔特技术有限公司 | White blood cell filter |
| US20040251195A1 (en) * | 2000-07-10 | 2004-12-16 | Shin-Ichiroh Oka | Blood processing filter |
| CN201192487Y (en) * | 2008-04-23 | 2009-02-11 | 山东威高集团医用高分子制品股份有限公司 | Leucocyte-removing filterr |
| CN201271399Y (en) * | 2008-10-10 | 2009-07-15 | 上海输血技术有限公司 | Filtering equipment for removing leucocyte from soft mass blood ingredient |
| US20100108596A1 (en) * | 2007-04-25 | 2010-05-06 | Maco Pharma | Biological fluid filtration unit provided with an offset inlet and/or outlet member |
| US20120228207A1 (en) * | 2011-03-11 | 2012-09-13 | Jean Marie Mathias | Plasma Filter With Laminated Prefilter |
| CN102861365A (en) * | 2012-09-14 | 2013-01-09 | 南京双威生物医学科技有限公司 | Leukocyte filter with soft shell and manufacturing method of leukocyte filter |
| WO2015147896A1 (en) * | 2014-03-24 | 2015-10-01 | Fenwal, Inc. | Flexible biological fluid filters |
| CN104998311A (en) * | 2015-07-24 | 2015-10-28 | 南京双威生物医学科技有限公司 | Composite membrane and soft housing leukocyte filter using the same |
-
2015
- 2015-11-06 CN CN201510752286.3A patent/CN105435320A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2436161Y (en) * | 2000-05-29 | 2001-06-27 | 北京伏尔特技术有限公司 | White blood cell filter |
| US20040251195A1 (en) * | 2000-07-10 | 2004-12-16 | Shin-Ichiroh Oka | Blood processing filter |
| US20100108596A1 (en) * | 2007-04-25 | 2010-05-06 | Maco Pharma | Biological fluid filtration unit provided with an offset inlet and/or outlet member |
| CN201192487Y (en) * | 2008-04-23 | 2009-02-11 | 山东威高集团医用高分子制品股份有限公司 | Leucocyte-removing filterr |
| CN201271399Y (en) * | 2008-10-10 | 2009-07-15 | 上海输血技术有限公司 | Filtering equipment for removing leucocyte from soft mass blood ingredient |
| US20120228207A1 (en) * | 2011-03-11 | 2012-09-13 | Jean Marie Mathias | Plasma Filter With Laminated Prefilter |
| CN102861365A (en) * | 2012-09-14 | 2013-01-09 | 南京双威生物医学科技有限公司 | Leukocyte filter with soft shell and manufacturing method of leukocyte filter |
| WO2015147896A1 (en) * | 2014-03-24 | 2015-10-01 | Fenwal, Inc. | Flexible biological fluid filters |
| CN104998311A (en) * | 2015-07-24 | 2015-10-28 | 南京双威生物医学科技有限公司 | Composite membrane and soft housing leukocyte filter using the same |
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| C10 | Entry into substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160330 |
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| RJ01 | Rejection of invention patent application after publication |