CN201046258Y - A degradable soft tissue mending tablet configured by various knitting method - Google Patents
A degradable soft tissue mending tablet configured by various knitting method Download PDFInfo
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- CN201046258Y CN201046258Y CNU200720069408XU CN200720069408U CN201046258Y CN 201046258 Y CN201046258 Y CN 201046258Y CN U200720069408X U CNU200720069408X U CN U200720069408XU CN 200720069408 U CN200720069408 U CN 200720069408U CN 201046258 Y CN201046258 Y CN 201046258Y
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- soft tissue
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- patch
- degradable
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Abstract
The utility model relates to a degradable soft tissue repair patch which is knitted by various methods, belonging to biological medicine, in particular to a technical field of biodegradable artificial organic. The utility model is characterized in that: flat strip-shaped or single silk-shaped polydioxanone are adopted to be kitted with a plurality of holes, the shape of the repair patch shell is matched with the to-be-repaired polydioxanone; the holes on the repair patch are evenly penetrated and enclosed by collagen; natural polymer biological chitosan is covered evenly on the shell surface of organic and then is subject to sterilization and drying processing so as to form a complete patch; either flat-shaped repair patch or silk shaped repair patch may be provided. The utility model has the advantages that: during embedment forepart, the function for repairing defect and soft tissue growth support is exerted in place of common traditional non-degradation material; after embedment anaphase, the utility model is degraded and absorbed gradually until the soft tissue is repaired completel; the utility model is degraded and absorbed completely, and is replaced by autogenous tissue, thereby avoiding forward complication resulted from traditional materials.
Description
Technical field
Belong to biological medicine, particularly the artificial organ technical field of biodegradability.
Background technology
Bulk tissue damaged reparation in position such as thoracic wall, stomach wall is very difficult, not only need also suitable preparing structure will be arranged by suitable patching material.Use more artificial patching material at present and mainly comprise polypropylene net (Marlex, Prolene net), politef sticking patch (PTFE, Gore-Tex sticking patch), dacron patch etc.Yet traditional artificial material implants can increase the chance of wound infection, and postoperative infection is its maximum complication; Can deform after long-term the implantation, complication such as fold can cause granulation hyperplasia, pain discomfort and seroma, infection, fistulization angiolysis, so need to seek even more ideal organ pipe tissue renovation material.
In recent years, degradation material begins to attempt being applied to thoracic wall rebuilds, and the degradation material repair deficiency can be brought into play and the traditional material same purpose in early days, and the later stage is degraded and absorbed progressively, replaces material by autologous tissue, thereby avoids corresponding long term complication; Simultaneously since embedded material finally can be in vivo degraded and absorbed fully, can be applied to non-clean wounds such as low-grade infection, enlarged the range of application of artificial organ repair materials.Available clinically at present biodegradable net is Vicryl net (polyglactin 910), in repairing, chest wall defect, hernia use to some extent, but the polyglactin compliance is not good, its fiber can only adopt multifilament structure, increase the embedded material infection chance, and Vicryl net degradation speed is very fast, soak time is in 8-10 week fully, keeping the mechanical strength time only is 2-3 week, can not meet the demands for the draw money on credit large tracts of land tissue defect of the time of holding of needs, and its application is restricted.Simultaneously, for the defect repair of Different Organs or tissue, also require to provide the patching material of different braiding structures.
Summary of the invention
This utility model provides a kind of energy to satisfy the different requirements of repairing, can repair deficiency and degraded and absorbed progressively, and the different weaving methods of a kind of usefulness constitute degradable soft tissue patch.
The technical scheme that this utility model is taked: adopt PPDO, be woven into porous by flat strip shaped or monofilament shape, shape with wait to repair the sticking patch shell that soft tissue coincide; By hole on collagen protein uniformly penetrating, the covering sealing sticking patch; By the shell face of the even coverage rate of natural polymer biomaterial chitosan, and, become complete sticking patch through sterilization treatment and dried to internal organs; It can be flat formula sticking patch or silk weaving shape sticking patch.
Flat formula sticking patch is by flat strip shaped degradable PPDO, takes crisscrossly, and the structure braiding that interts up and down constitutes; Silk weaving shape sticking patch is adopted by the latch closure ring by monofilament degradable PPDO, encircles out and colludes, and colludes the ring hooking structure of ring formation and forms.
Good effect behind enforcement this utility model is: owing to adopt Biodegradable reticular repair materials a kind of and that the organ-tissue reparation is complementary, degradation property is suitable, make it implant early stage performance repair deficiency and the effect of tissue growth support, in order to substitute tradition non-degradation material commonly used; Make this biology Web materials possess suitable degradation property simultaneously, implant later stage degraded and absorbed progressively in vivo, treat that tissue repair finishes back degraded and absorbed and be autologous tissue's replacement fully, thus the long term complication of avoiding traditional material to bring.And two kinds of braiding structures are proposed to satisfy the requirement that different parts and organ-tissue are repaired.
Description of drawings
Fig. 1 is a flat formula sticking patch braiding structure (machine-knitted structure)
Fig. 2 is ring hooking structure sticking patch braiding structure (knitted structure)
The specific embodiment
Now the utility model is described in further detail in conjunction with the accompanying drawings
The different weaving methods of a kind of usefulness constitute degradable soft tissue patch, are the PPDO that adopts by flat strip shaped or monofilament shape, are woven into holey, shape with wait to repair the patching material that soft tissue coincide; By hole on natural polymer biomaterial collagen protein uniformly penetrating, the covering sealing sticking patch; By the shell face of the even coverage rate of natural polymer biomaterial chitosan, and, become complete sticking patch through sterilization treatment and dried to internal organs.The sticking patch shell of flat strip shaped braiding is by flat strip shaped degradable PPDO, takes crisscrossly, and the structure braiding that interts up and down constitutes, and can adopt the plain woven method to weave.The sticking patch shell of monofilament shape braiding is by monofilament degradable PPDO, adopts by the latch closure ring, encircles out and colludes, and the ring hooking structure braiding of colluding ring formation forms, can be by being woven into net on the tricot machine.
Diameter is that the polydioxanone monofilament fiber of 0.28mm adopts the plain woven method to weave end count in small sample loom: 320/10cm, and filling density: 230/10cm.Gained fabric warp-wise tightness: 89.6%, the broadwise tightness: 64.4%, thickness 0.8mm, mesh gap 200～300 μ m; Then it was formalized 5 seconds in 90 ℃ of hot pressing; Again it is dipped in 2% collagen solution and takes out after 3 minutes, be placed on 40 ℃ of baking oven inner dryings, repeat aforesaid operations 2 times; Be coated on net wall with 2.0% chitosan coat agent then towards internal organs, and, repeat aforesaid operations 2 times in 40 ℃ of baking oven inner drying typings, obtaining internal layer is the mesh support, the top layer is the complete patching material of coating material, and ethane via epoxyethane sterilization final vacuum drying is sealed under 4 ℃ of conditions preserves.
The polydioxanone monofilament fiber of diameter 0.20mm is to be woven into net on the tricot machine of 14-18 pin in plane No., and organizational structure is through flat (as Fig. 2) tissue of floss, vertical close 55/5cm, the close 32/5cm of horizontal stroke.Gained fabric pore rate 72%, thickness are 0.65 millimeter, can cut randomly, and do not decoherence in the edge.Then it is dipped in 2% collagen solution and takes out after 3 minutes, be placed on 40 ℃ of baking oven inner dryings, repeat aforesaid operations 2 times; Reuse 2.0% chitosan coat agent is coated on the net wall towards internal organs, and in 40 ℃ of baking oven inner drying typings, repeats aforesaid operations 2 times, and ethane via epoxyethane sterilization final vacuum drying is sealed under 4 ℃ of conditions preserves.
Claims (3)
1. one kind constitutes degradable soft tissue patch with different weaving methods, it is characterized in that: adopt degradable PPDO, be woven into porous by flat strip shaped or monofilament shape, shape with wait to repair the sticking patch shell that soft tissue coincide; It is to be made of flat formula sticking patch or silk weaving shape sticking patch.
2. soft tissue patch according to claim 1 is characterized in that: described flat formula sticking patch is by flat strip shaped degradable PPDO, and is crisscross, and the structure braiding that interts up and down constitutes.
3. soft tissue patch according to claim 1 is characterized in that: described silk weaving shape sticking patch is by monofilament shape degradable PPDO, by the latch closure ring, encircles out and colludes, and colludes the ring hooking structure of ring formation and forms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU200720069408XU CN201046258Y (en) | 2007-04-28 | 2007-04-28 | A degradable soft tissue mending tablet configured by various knitting method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU200720069408XU CN201046258Y (en) | 2007-04-28 | 2007-04-28 | A degradable soft tissue mending tablet configured by various knitting method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201046258Y true CN201046258Y (en) | 2008-04-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU200720069408XU Expired - Fee Related CN201046258Y (en) | 2007-04-28 | 2007-04-28 | A degradable soft tissue mending tablet configured by various knitting method |
Country Status (1)
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| CN (1) | CN201046258Y (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829369A (en) * | 2010-05-18 | 2010-09-15 | 贾蔚 | Dacron patch for repairing haemodialysis fistula |
| US8956394B1 (en) | 2014-08-05 | 2015-02-17 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems and methods |
| USD740427S1 (en) | 2014-10-17 | 2015-10-06 | Woven Orthopedic Technologies, Llc | Orthopedic woven retention device |
| US9585695B2 (en) | 2013-03-15 | 2017-03-07 | Woven Orthopedic Technologies, Llc | Surgical screw hole liner devices and related methods |
| US9907593B2 (en) | 2014-08-05 | 2018-03-06 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems and methods |
| US9943351B2 (en) | 2014-09-16 | 2018-04-17 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems, packaging, and related methods |
| US10555758B2 (en) | 2015-08-05 | 2020-02-11 | Woven Orthopedic Technologies, Llc | Tapping devices, systems and methods for use in bone tissue |
| CN111529758A (en) * | 2020-06-24 | 2020-08-14 | 东华大学 | Negative poisson ratio structure myocardial patch with conductive stability and preparation method thereof |
| US11395681B2 (en) | 2016-12-09 | 2022-07-26 | Woven Orthopedic Technologies, Llc | Retention devices, lattices and related systems and methods |
-
2007
- 2007-04-28 CN CNU200720069408XU patent/CN201046258Y/en not_active Expired - Fee Related
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829369B (en) * | 2010-05-18 | 2012-05-16 | 贾蔚 | Dacron patch for repairing haemodialysis fistula |
| CN101829369A (en) * | 2010-05-18 | 2010-09-15 | 贾蔚 | Dacron patch for repairing haemodialysis fistula |
| US9585695B2 (en) | 2013-03-15 | 2017-03-07 | Woven Orthopedic Technologies, Llc | Surgical screw hole liner devices and related methods |
| US10588677B2 (en) | 2014-08-05 | 2020-03-17 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems and methods |
| US8956394B1 (en) | 2014-08-05 | 2015-02-17 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems and methods |
| US8992537B1 (en) | 2014-08-05 | 2015-03-31 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems and methods |
| US9532806B2 (en) | 2014-08-05 | 2017-01-03 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems and methods |
| US9808291B2 (en) | 2014-08-05 | 2017-11-07 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems and methods |
| US9907593B2 (en) | 2014-08-05 | 2018-03-06 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems and methods |
| US11376051B2 (en) | 2014-08-05 | 2022-07-05 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems and methods |
| US9943351B2 (en) | 2014-09-16 | 2018-04-17 | Woven Orthopedic Technologies, Llc | Woven retention devices, systems, packaging, and related methods |
| USD740427S1 (en) | 2014-10-17 | 2015-10-06 | Woven Orthopedic Technologies, Llc | Orthopedic woven retention device |
| US10555758B2 (en) | 2015-08-05 | 2020-02-11 | Woven Orthopedic Technologies, Llc | Tapping devices, systems and methods for use in bone tissue |
| US11395681B2 (en) | 2016-12-09 | 2022-07-26 | Woven Orthopedic Technologies, Llc | Retention devices, lattices and related systems and methods |
| CN111529758A (en) * | 2020-06-24 | 2020-08-14 | 东华大学 | Negative poisson ratio structure myocardial patch with conductive stability and preparation method thereof |
| CN111529758B (en) * | 2020-06-24 | 2021-05-04 | 东华大学 | Negative poisson ratio structure myocardial patch with conductive stability and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080416 Termination date: 20150428 |
|
| EXPY | Termination of patent right or utility model |