CN200963204Y - Biological degradable netted artificial chest wall - Google Patents
Biological degradable netted artificial chest wall Download PDFInfo
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- CN200963204Y CN200963204Y CN 200620044851 CN200620044851U CN200963204Y CN 200963204 Y CN200963204 Y CN 200963204Y CN 200620044851 CN200620044851 CN 200620044851 CN 200620044851 U CN200620044851 U CN 200620044851U CN 200963204 Y CN200963204 Y CN 200963204Y
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- chest wall
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- artificial chest
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Abstract
A bio-degradable reticular artificial chest wall belongs to bio-medicine, in particular to a bio-degradable simulated organs technical field. The artificial chest wall is characterized in that a porous reticular structure weaved by poly (p-dioxanone) monofilament is used as the material of artificial chest wall bracket; the collagen permeates homogeneously to cover and close the net holes; the natural polymeric biomaterial chitosan is used to cover the net wall towards the viscera evenly; the preparation method of the artificial chest wall is that plain woven method is used to weave the poly (p-dioxanone) monofilament to make the artificial chest wall network bracket; the network bracket is fixed the shape by heat press; the collagen is used to cover the surface and close the net holes of the network bracket fixed the shape; the net wall towards the viscera is covered with a coat of natural polymeric biomaterial chitosan, sterilizing and drying for use. The utility model is used to prevent the paradoxical respiration and maintain the stabilization of the chest wall at the early stage, additionally, the artificial chest wall is used as a tissue bracket to promote the growth of the tissue; then the artificial chest wall is degraded and absorbed gradually and finally is replaced by self tissue, thereby finishing the repair of the body and avoiding the long term complications caused by traditional materials.
Description
Technical field
Belong to biological medicine, particularly the simulated organ technical field of biodegradability exactly is a kind of manufacturing and application technology with reticular artificial chest wall of biodegradability.
Background technology
Treatment tumor of chest wall, radiation ulcer, infection, injure the chest wall defect that disease such as congenital malformation forms outward and need rebuild.Artificial material is used conveniently and is occupied an leading position in thoracic wall is rebuild owing to wide material sources.Yet at present still there is variety of issue in the material of using clinically: hard materials such as metal, lucite are because hardness is too high, and with the tissue bond ability, the later stage often can become flexible, be shifted, activity even deviate from; Soft material such as polypropylene (Marlex) net, polytetrafluoroethylene (PTFE) sticking patch and thoracic wall are organized more coupling, the reconstruction effect is better, but the long-term complication such as still often causing seroma, fistulization, pain, angiolysis and initiation infection of implanting, part patient's later stage needs operation once more to take out.
In recent years, the emphasis of biomaterial development is from avoiding causing body reaction, emphasizing that it is to pay attention to producing certain bioactive ingredients that biologically inert is transferred, to promote body and the favourable interaction of material production.The degradable macromolecule biomaterial provides new approach owing to have excellent biological compatibility, degradability and superior processing characteristics for developing ideal artificial breast wall material.
According to literature search, Chinese patent title: biodegradable artificial breast wall and preparation method thereof, Chinese patent application number: 200410025389.1, this patent mentions that adopting chitin fiber to strengthen polycaprolactone composite material is prepared into moulded board and the artificial rib of lath-shaped, with stainless steel silk with composite panel or rib and rib broken ends of fractured bone sutured.Though the composite of this method preparation is applied to the thoracic wall reparation and can guarantees thoracic wall stability, has certain feasibility, but as plate or strip hard material, still be difficult to combine together with tissue bond, poly-caprolactone degradation is slow simultaneously, reach more than 2 years, the implantation later stage still has possibility such as the complication that causes the material displacement, and the advantage of degradation material does not well embody.
Summary of the invention
This utility model provides a kind of and organizes more coupling with thoracic wall, and degradation property is good, the Biodegradable reticular artificial chest wall that degradation time is short.
The technical scheme that this utility model is taked:
Biodegradable reticular artificial chest wall, its scheme of taking is: the artificial breast wall support that is become porous network structure by polydioxanone monofilament fibrage; By collagen protein uniformly penetrating, covering, sealing mesh; And by the net wall of the even coverage rate of natural polymer biomaterial chitosan to internal organs.
The preparation method of Biodegradable reticular artificial chest wall is to operate according to the following steps, finishes the preparation of artificial breast wall:
1) adopts the plain woven method, the network of the thoracic wall form that braiding polydioxanone monofilament one-tenth is to be repaired;
2) with network on JX-826 electric heating hydraulic molding machine, hot pressing setting;
3) network of setting is done collagen protein covering surfaces and the processing of sealing mesh;
4) the net wall towards internal organs covers natural polymer biomaterial chitosan coat;
5) standby after sterilization, the dried.
The woven mesh support, its parameter is as follows: fibre diameter: 0.28mm, end count: 320/10cm, filling density: 230/10cm, the warp-wise tightness: 89.6%, broadwise tightness: 64.4%;
The hot pressing setting is at temperature 85-95 ℃, formalizes 5-10 second.
Doing collagen protein covering surfaces and the processing of sealing mesh, is network to be dipped in 2% collagen solution take out after 3 minutes, is placed on 40 ℃ of baking oven inner dryings, repeats aforesaid operations 2-3 time;
Cover natural polymer biomaterial chitosan coat towards the net wall of internal organs, be to be coated on net wall, and finalize the design in 40 ℃ of baking oven inner dryings towards internal organs with 2.0% chitosan coat agent; Repeat aforesaid operations 2-3 time.
Good effect behind enforcement this utility model is:
Play and prevent paradoxical breathing, keep the thoracic wall Stabilization in early days,, play the effect of promotion tissue growth simultaneously as organization bracket; Later stage finally for autologous tissue replaces, is finished body self reparation along with progressively degraded and absorbed is repaired by body autologous tissue, and the long term complication of having avoided traditional material to bring.
Description of drawings
Fig. 1, artificial breast wall planar structure sketch map;
Fig. 2, coating not, artificial breast wall vertical profile sketch map;
After Fig. 3, the coating (mesh clearance seal), artificial breast wall vertical profile sketch map.
The specific embodiment
Now the utility model is described in further detail in conjunction with the accompanying drawings
Biodegradable reticular artificial chest wall is woven into the thoracic wall form to be repaired of porous network structure by polydioxanone monofilament fiber 1; By collagen protein 2 uniformly penetratings, topped, sealing mesh; And by the net wall of the even coverage of natural polymer biomaterial chitosan to internal organs.
The preparation method of Biodegradable reticular artificial chest wall, operation according to the following steps, finish the preparation of artificial breast wall:
1) adopts the plain woven method, the network of the thoracic wall form that braiding polydioxanone monofilament one-tenth is to be repaired;
2) with network on JX-826 electric heating hydraulic molding machine, hot pressing setting;
3) network of setting is done collagen protein covering surfaces and the processing of sealing mesh;
4) the net wall towards internal organs covers natural polymer biomaterial chitosan coat;
5) standby after sterilization, the dried.
The woven mesh support, its parameter is as follows: fibre diameter: 0.28mm, end count: 320/10cm, filling density: 230/10cm, the warp-wise tightness: 89.6%, broadwise tightness: 64.4%; The hot pressing setting is at temperature 85-95 ℃, formalizes 5-10 second.Doing topped surface of collagen protein and the processing of sealing mesh, is network to be dipped in 2% collagen solution take out after 3 minutes, is placed on 40 ℃ of baking oven inner dryings, repeats aforesaid operations 2-3 time; Towards the topped natural polymer biomaterial of the net wall chitosan coat of internal organs, be to be coated on net wall towards internal organs with 2.0% chitosan coat agent, and in 40 ℃ of baking oven inner dryings typings; Repeat aforesaid operations 2-3 time;
Embodiment
The polydioxanone monofilament fiber is (fibre diameter: 0.28mm under the certain parameter condition, end count: 320/10cm, filling density: 230/10cm, warp-wise tightness: 89.6%, broadwise tightness: 64.4%) be woven into net, make this network material possess good tensile and structural stability, have certain bending rigidity through the plain woven method, thickness 0.8mm, mesh gap 200~300 μ m; With its hot pressing setting (90 ℃ of temperature) 5 seconds on JX-826 electric heating hydraulic molding machine, be cut into 8cm * 8cm size; Then it is dipped in 2% collagen solution and takes out behind the 3min, be placed on baking oven inner drying (40 ℃), make collagen protein seal netted material hole crack, repeat aforesaid operations 2 times; Adopt 2.0% chitosan coat agent to be coated on artificial breast wall material inboard (dirty side), be placed on (40 ℃) dryness finalization in the baking oven, take out dry back, repeats aforesaid operations 2 times; The dry sealing of the final vacuum of artificial breast wall ethane via epoxyethane sterilization then is as for preserving under 4 ℃ of conditions.
Select endotracheal intubation behind the healthy hybrid dog general intravenous anesthesia, mechanical ventilation, one section in en bloc resection dog right side thoracic wall six, seven, eight ribs, form 8cm * 8cm size chest wall defect, with silk thread Biodegradable reticular artificial chest wall and damaged surrounding tissue are sewed up, upper and lower costal margin and tissue are striden intercostal holostrome interrupted suture, note keeping net non-wrinkled, stitching finishes and forms certain tension force, close breast after placing closed thoracic drainage tube, connect thoracic cavity drainage bottle, material and flesh interlayer are kept somewhere the negative pressure ball drain, close otch behind the stitching thoracic wall shallow-layer muscle.
Embodiment result:
The postoperative dog is movable normal, the apnea difficulty.There is slight abnormal breathing in early stage observation small part dog, weakens gradually, disappears in 3~4 all paradoxical breathings; Postoperative 8 during week palpation show that damaged reconstruction position thoracic wall fixes, to 24 weeks of postoperative, the thoracic wall good stability, profile is satisfied.Postoperative is regularly put to death experimental dog, sees a large amount of fibrous tissue PDO mesh gap of growing into 8 weeks, merges with timbering material and forms integrative-structure, combines closely with surrounding tissue, and it is stable that thoracic wall keeps, and it is good that the reticular artificial chest wall structure keeps; The artificial breast wall material begins obvious degradation absorption minimizing during 12 weeks, is progressively replaced by regeneration thoracic wall tissue, and regenerating tissues is made up of volume fibroblast, new vessels and collagen fiber, a small amount of therebetween chronic inflammation cellular infiltration; To 24 weeks of postoperative, the complete degraded and absorbed of implantable artificial thoracic wall material is replaced by a thick fiber organized layer.
Claims (1)
1, Biodegradable reticular artificial chest wall comprises the artificial breast wall of structure, it is characterized in that: be made of the porous rack that matches with thoracic wall form to be repaired polydioxanone monofilament fiber (1); Mesh and rack surface uniformly penetrating, covering one deck collagen protein (2); And evenly cover one deck natural polymer biomaterial chitosan at net wall surface towards internal organs.
Priority Applications (1)
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CN 200620044851 CN200963204Y (en) | 2006-08-16 | 2006-08-16 | Biological degradable netted artificial chest wall |
Applications Claiming Priority (1)
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CN 200620044851 CN200963204Y (en) | 2006-08-16 | 2006-08-16 | Biological degradable netted artificial chest wall |
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CN200963204Y true CN200963204Y (en) | 2007-10-24 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100441238C (en) * | 2006-08-16 | 2008-12-10 | 徐志飞 | Biodegradable reticular artificial chest wall and preparation method thereof |
CN101548916B (en) * | 2009-05-08 | 2012-10-10 | 乐普(北京)医疗器械股份有限公司 | A medical equipment carrying extracellular matrix and its production method |
CN111821064A (en) * | 2015-11-04 | 2020-10-27 | 聚合-医药有限公司 | Time-dependent tissue scaffolds |
-
2006
- 2006-08-16 CN CN 200620044851 patent/CN200963204Y/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100441238C (en) * | 2006-08-16 | 2008-12-10 | 徐志飞 | Biodegradable reticular artificial chest wall and preparation method thereof |
CN101548916B (en) * | 2009-05-08 | 2012-10-10 | 乐普(北京)医疗器械股份有限公司 | A medical equipment carrying extracellular matrix and its production method |
CN111821064A (en) * | 2015-11-04 | 2020-10-27 | 聚合-医药有限公司 | Time-dependent tissue scaffolds |
CN111821064B (en) * | 2015-11-04 | 2023-10-31 | 聚合-医药有限公司 | time-dependent physiological tissue scaffold |
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Legal Events
Date | Code | Title | Description |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20071024 Termination date: 20110816 |