CN1997383B - 含水母发光蛋白的组合物及使用它的方法 - Google Patents

含水母发光蛋白的组合物及使用它的方法 Download PDF

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Publication number
CN1997383B
CN1997383B CN200580024585XA CN200580024585A CN1997383B CN 1997383 B CN1997383 B CN 1997383B CN 200580024585X A CN200580024585X A CN 200580024585XA CN 200580024585 A CN200580024585 A CN 200580024585A CN 1997383 B CN1997383 B CN 1997383B
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China
Prior art keywords
aequorin
calcium
acid
compositions
present
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Expired - Lifetime
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CN200580024585XA
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Chinese (zh)
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CN1997383A (zh
Inventor
M·Y·安德伍德
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Quincy Bioscience LLC
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Quincy Bioscience LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
CN200580024585XA 2004-06-21 2005-06-21 含水母发光蛋白的组合物及使用它的方法 Expired - Lifetime CN1997383B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/872,795 2004-06-21
US10/872,795 US20060229243A1 (en) 2004-06-21 2004-06-21 Aequorin-containing compositions and methods of using same
PCT/US2005/021770 WO2006010004A2 (en) 2004-06-21 2005-06-21 Aequorin-containing compositions and methods of using same

Publications (2)

Publication Number Publication Date
CN1997383A CN1997383A (zh) 2007-07-11
CN1997383B true CN1997383B (zh) 2011-01-05

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ID=35785748

Family Applications (1)

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CN200580024585XA Expired - Lifetime CN1997383B (zh) 2004-06-21 2005-06-21 含水母发光蛋白的组合物及使用它的方法

Country Status (20)

Country Link
US (3) US20060229243A1 (enExample)
EP (2) EP1768691B1 (enExample)
JP (1) JP4971150B2 (enExample)
KR (1) KR101213555B1 (enExample)
CN (1) CN1997383B (enExample)
AU (1) AU2005265266B2 (enExample)
BR (1) BRPI0512392B1 (enExample)
CA (1) CA2571542C (enExample)
CY (1) CY1114307T1 (enExample)
DK (1) DK1768691T3 (enExample)
ES (1) ES2422173T3 (enExample)
IL (1) IL180195A (enExample)
MX (1) MXPA06015037A (enExample)
NZ (1) NZ552274A (enExample)
PL (1) PL1768691T3 (enExample)
PT (1) PT1768691E (enExample)
SG (1) SG153848A1 (enExample)
SI (1) SI1768691T1 (enExample)
WO (1) WO2006010004A2 (enExample)
ZA (1) ZA200610688B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060229243A1 (en) * 2004-06-21 2006-10-12 Quincy Resource Group, Inc. Aequorin-containing compositions and methods of using same
GB0625678D0 (en) 2006-12-21 2007-01-31 Lux Biotechnology Ltd Composition and method for detection of demineralisation
BRPI0909435A2 (pt) * 2008-03-11 2017-06-13 Quincy Bioscience Llc composição e método para tratar de um sintoma ou distúrbio associado com o desequilíbrio do cálcio, uso da apoequorina, e, apoaequorina
JP2010143860A (ja) * 2008-12-19 2010-07-01 Chisso Corp タンパク質の安定化剤
US20110130336A1 (en) * 2009-10-16 2011-06-02 Quincy Bioscience, Llc Method of treating ischemic injury using apoaequorin
CA2822594A1 (en) * 2010-12-24 2012-06-28 Otsuka Pharmaceutical Co., Ltd. Bioassay method for detecting physiologically active substance
WO2013074798A1 (en) * 2011-11-15 2013-05-23 Quincy Bioscience, Llc Apoaequorin for reducing neuronal injury due to ischemia
GB201700317D0 (en) 2017-01-09 2017-02-22 Calcivis Ltd Detection device
USD1042180S1 (en) 2020-05-28 2024-09-17 Calcivis Limited Dental detection device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800492B2 (en) * 2000-06-01 2004-10-05 Institute Pasteur Chimeric GFP-aequorin as bioluminescent Ca++ reporters at the single cell level

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001240855A (ja) * 2000-03-01 2001-09-04 Masashi Sugimoto 生物発光方法及び発光物品
US6930169B2 (en) * 2000-06-12 2005-08-16 University Of Baltimore Biotechnology Institute Method of controlling the binding of calmyrin to presenilin
US20060229243A1 (en) * 2004-06-21 2006-10-12 Quincy Resource Group, Inc. Aequorin-containing compositions and methods of using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800492B2 (en) * 2000-06-01 2004-10-05 Institute Pasteur Chimeric GFP-aequorin as bioluminescent Ca++ reporters at the single cell level

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAUBET等.Chimeric green fluorescent protein-aequorin as bioluminescentCa2+ reporters at the single-cell level.Proc.Natl.Acad.Sci.97 13.2000,97(13),第7260-7265页.
BAUBET等.Chimeric green fluorescent protein-aequorin as bioluminescentCa2+ reporters at the single-cell level.Proc.Natl.Acad.Sci.97 13.2000,97(13),第7260-7265页. *
MITHOFER等.Aequorin-based measurements of intracellularCa2+-signatures in plant cells.Biological Procedures4 1.2002,4(1),第105-118页.
MITHOFER等.Aequorin-based measurements of intracellularCa2+-signatures in plant cells.Biological Procedures4 1.2002,4(1),第105-118页. *
姜云飞等.测定血小板胞浆游离钙中水母发光蛋白导入液的重复应用.中华血液学杂志12 2.1991,12(2),第96-97页.
姜云飞等.测定血小板胞浆游离钙中水母发光蛋白导入液的重复应用.中华血液学杂志12 2.1991,12(2),第96-97页. *

Also Published As

Publication number Publication date
EP1768691A4 (en) 2010-08-04
CN1997383A (zh) 2007-07-11
PT1768691E (pt) 2013-06-20
ZA200610688B (en) 2007-12-27
HK1109576A1 (en) 2008-06-13
JP2008503581A (ja) 2008-02-07
KR101213555B1 (ko) 2012-12-18
NZ552274A (en) 2010-06-25
BRPI0512392A (pt) 2008-03-11
BRPI0512392B1 (pt) 2022-12-13
US20060229243A1 (en) 2006-10-12
IL180195A0 (en) 2007-06-03
SG153848A1 (en) 2009-07-29
WO2006010004A2 (en) 2006-01-26
ES2422173T3 (es) 2013-09-09
KR20070070154A (ko) 2007-07-03
AU2005265266B2 (en) 2011-05-12
CY1114307T1 (el) 2016-08-31
US20100152117A1 (en) 2010-06-17
AU2005265266A1 (en) 2006-01-26
SI1768691T1 (sl) 2013-07-31
WO2006010004A3 (en) 2007-03-08
PL1768691T3 (pl) 2013-09-30
EP2545934A1 (en) 2013-01-16
JP4971150B2 (ja) 2012-07-11
CA2571542C (en) 2014-08-19
EP1768691B1 (en) 2013-05-22
US7671015B2 (en) 2010-03-02
US20080287350A1 (en) 2008-11-20
EP1768691A2 (en) 2007-04-04
MXPA06015037A (es) 2007-07-11
DK1768691T3 (da) 2013-07-01
CA2571542A1 (en) 2006-01-26
EP2545934B1 (en) 2014-12-10
IL180195A (en) 2014-03-31

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