CN1973871A - Largngopharyngitis treating medicine composition and its prepn - Google Patents
Largngopharyngitis treating medicine composition and its prepn Download PDFInfo
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Abstract
The medicine composition for treating laryngopharyngitis is prepared with rehmannia root 5-100 weight portions, date coating 3-100 weight portions, and tortoise plastron 5-200 weight portions. The preparation process includes the steps of decoction, filtering, concentrating the filtrate to obtain paste of density 1.00-1.15, dissolving the paste in alcohol, filtering, concentrating the filtrate to obtain dense paste of density 1.20-1.50 while recovering alcohol, and drying to obtain the medicine composition. The medicine composition is used in treating laryngopharyngitis, and has high safety, low cost, high effective component content and high stability.
Description
Technical field
The present invention relates to the Chinese herbal medicine is the nourishing YIN and clearing away heat that forms of feedstock production, pharmaceutical composition of vital energy benefiting and the kidney invigorating medicament and preparation method thereof, refers to a kind of pharmaceutical composition for the treatment of pharyngolaryngitis and preparation method thereof particularly, belongs to the field of Chinese medicines.
Background technology
Pharyngolaryngitis with a kind of disease of having sore throat, clinical symptoms such as hoarseness, cough occur, is brought great inconvenience to people's life and work as a kind of, and is also very painful, many clinically based on chronic.Generally Chinese and western medicine is consistent thinks: can not cure, still not have desirable medicine so far, make the clinicist rather thorny.Particularly in the last few years.Along with people's living standard improves, people contacts gradually with deleterious chemical ornament materials and increase, and because weather cold and hot changeable gets more and more people of its trouble pharyngolaryngitis; Especially teacher teaches for a long time, and throat can not obtain suitable rest, and becomes occupation disease.
At present domestic for this kind of treatment disease medicine commonly used have LIUSHEN WAN, Wu too Yanyan slice, swallow class medicines such as oxazepam, Yanyan slice, larynx oxazepam, Herba Pileae Scriptae Tabellae, JINSANGZIHOUBAO slowly, this type of drug main will play heat clearing away, detoxifcation, lung moistening, but poor effect, curative effect about about 60%, after taking, only can only the respite symptom, can not thoroughly cure.Patent documentation also has the medicine of many treatment acute pharyngolaryngitises, but therapeutic effect is all not satisfactory.
Summary of the invention
For overcoming said medicine in the deficiency aspect the drug effect, a kind of safety is good, cost is low, effective component content is higher in order to provide for one of the object of the invention, the better a kind of pure Chinese medicine pharmaceutical composition for the treatment of pharyngolaryngitis of stability.
Another object of the present invention is to provide a kind of treatment pharyngolaryngitis preparation of drug combination method.
The present invention thinks according to China's theory of Chinese medical science and practice: the morbidity key of pharyngitis is suffer from a deficiency of the kidney (deficiency of the kidney yin), and the deficiency of YIN is given birth to interior-heat, remerges affection due to external wind and heat or wind and cold or long-term speech, makes vocal cords tired and fall ill.Take nourishing YIN and clearing away heat, the Chinese medicine of vital energy benefiting and the kidney invigorating makes transference cures such as the throat pain of pharyngitis, hoarseness, cough, recovery from illness gradually, and its clinical effect is better than the effect of simple heat clearing away, detoxifcation, antiinflammatory greatly.By the nourishing YIN and clearing away heat that the inventive method is prepared from, the Chinese medicine preparation of vital energy benefiting and the kidney invigorating not only can heat-clearing and toxic substances removing, relief of symptoms, and reach radical cure, do not recur substantially by the medicine of vital energy benefiting and the kidney invigorating, the effect of treatment pharyngitis is quite remarkable, and nontoxic, side effect.
The present invention with reference to modern pharmacological research, filters out the natural Chinese medicine of nourishing YIN and clearing away heat, vital energy benefiting and the kidney invigorating according to above-mentioned theory of Chinese medical science from China's medicine treasure-house.By theory of Chinese medical science and applicant's clinical experience composing prescription preparation for many years, extract wherein elite, make its performance greatest benefit, not only can heat clearing away, detoxifcation, sore-throat relieving, and can strengthen patient's kidney qi (being healthy energy), and the healthy energy foot, heresy can not be done, thereby reduce the probability of morbidity, and then reach the purpose of eradicating disease.
A kind of pharmaceutical composition for the treatment of pharyngolaryngitis of the present invention, the consumption of drug component is groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following weight parts:
Major ingredient is: Radix Rehmanniae 5-100 part Fructus Corni 3-100 part Carapax et Plastrum Testudinis 5-200 part
Be preferably: Radix Rehmanniae 8-30 part Fructus Corni 5-30 part Carapax et Plastrum Testudinis 8-40 part
Elitely be: 30 parts of 15 parts of Carapax et Plastrum Testudiniss of 15 parts of Fructus Cornis of the Radix Rehmanniae
The pharmaceutical composition of above-mentioned treatment pharyngolaryngitis can also comprise:
Radix Platycodonis 2-100 part Cortex Phellodendri 2-100 part Fructus Gardeniae 3-100 part
Gypsum Fibrosum 5-100 part Radix Scrophulariae 3-100 part Rhizoma Belamcandae 3-100 part
Be preferably:
Radix Platycodonis 3-20 part Cortex Phellodendri 3-20 part Fructus Gardeniae 5-30 part
Gypsum Fibrosum 8-40 part Radix Scrophulariae 5-20 part Rhizoma Belamcandae 5-20 part
Elitely be:
8 parts of 8 portions of Fructus Gardeniaes of 8 portions of Cortex Phellodendris of Radix Platycodonis
8 parts of 8 parts of Rhizoma Belamcandae of 20 portions of Radix Scrophulariaes of Gypsum Fibrosum
The pharmaceutical composition of above-mentioned treatment pharyngolaryngitis can also comprise:
Herba Menthae 3-100 part Radix Paeoniae Rubra 3-100 part Radix Panacis Quinquefolii 3-100 part
Pericarpium Citri Reticulatae 3-100 part
Be preferably:
Herba Menthae 5-20 part Radix Paeoniae Rubra 5-20 part Radix Panacis Quinquefolii 5-30 part
Pericarpium Citri Reticulatae 5-20 part
Elitely be:
8 parts of 10 parts of Radix Panacis Quinquefoliis of 8 parts of Radix Paeoniae Rubra of Herba Menthae
8 parts of Pericarpium Citri Reticulataes
A kind of preparation of drug combination method of above-mentioned treatment pharyngolaryngitis, it is made up of the following step:
By above-mentioned weight portion proportioning the Radix Rehmanniae, Fructus Corni, Carapax et Plastrum Testudinis or the Radix Rehmanniae, Fructus Corni, Carapax et Plastrum Testudinis, Radix Platycodonis, Cortex Phellodendri, Fructus Gardeniae, Gypsum Fibrosum, Radix Scrophulariae, Rhizoma Belamcandae or the Radix Rehmanniae, Fructus Corni, Carapax et Plastrum Testudinis, Radix Platycodonis, Cortex Phellodendri, Fructus Gardeniae, Gypsum Fibrosum, Radix Scrophulariae, Rhizoma Belamcandae, Herba Menthae, Radix Paeoniae Rubra, Radix Panacis Quinquefolii, Pericarpium Citri Reticulatae etc. are counted flavor Chinese medicine, decoct with water 2-5 time, add as raw material weight 3-9 decocting doubly boiled 0.5-3 hour at every turn, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.00-1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30-80%, stirs evenly, and leaves standstill 6-24 hour, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20-1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Pharmaceutical composition of the present invention can be aided with the various adjuvants on the pharmaceutics, is prepared into various common formulations, as oral liquid, syrup, medicated wine and tincture, injection, lyophilized injectable powder, capsule, tablet, granule etc.; When being prepared as solid preparations such as capsule, tablet, granule, used adjuvant can be: mannitol, starch, beta-schardinger dextrin-, low-substituted hydroxypropyl cellulose, micropowder silica gel, carboxymethyl starch sodium, crospolyvinylpyrrolidone, magnesium stearate, cross-linking sodium carboxymethyl cellulose, carboxymethylcellulose calcium, xylitol, microcrystalline Cellulose, honey peach essence etc.
Pharmaceutical composition of the present invention can also add various conventional adjuvant required when preparing different dosage form, prepare any peroral dosage form commonly used as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as the dispersible tablet in pill, powder, capsule or the tablet, oral cavity disintegration tablet, effervescent tablet, general thin coated tablet etc.
Pharmaceutical composition of the present invention has the function of nourishing YIN and clearing away heat, vital energy benefiting and the kidney invigorating, is a kind of ideal (present stage) pharmaceutical composition for the treatment of pharyngolaryngitis.
The dose of medicine of the present invention can be according to variations such as route of administration, pill taker's age, body weight, and its daily dose can be the 0.01-10mg/kg body weight, and preferred 2-6mg/kg body weight can be taken by one or many.
The invention has the advantages that, selecting 13 flavor crude drugs for use is that raw material carries out assembly, particularly wherein the Radix Rehmanniae, Fructus Corni, Carapax et Plastrum Testudinis three flavor principal agents merge and use, and have well solved YIN nourishing, heat clearing away, the QI invigorating of pharyngitis, the problem of the kidney invigorating, have the unique effects of nourishing YIN and clearing away heat, vital energy benefiting and the kidney invigorating.Can cure mainly the suffering from a deficiency of the kidney of patient, the deficiency of YIN give birth to internally heatedly have sore throat, itching of the throat, xerostomia, hoarseness, symptom such as cough, breathe hard.
Through clinical observation, confirm that its curative effect height, adaptability are strong, the effective percentage of treatment pharyngitis reaches more than 90%, significantly is better than existing Western medicine and similar Chinese medicine compound preparation.And selected natural material is no rare animal medical material, no valuable medicinal, avirulence or limiting the use of property medical material, the outer medical material of no grade III Standard, and each component meets the pharmaceutical control law regulation.It organically combines, and the co-action for treating pharyngitis does not almost have any toxicity, side effect, simultaneously prepared and Chinese medicine need not to decoct, it is all convenient to take, carry.Because of cost of drugs is low, reduced patient's medical expense, be easy to clinical application, have the wide development prospect.
The specific embodiment:
The following examples can make the professional and technical personnel understand the present invention comprehensively, better, but cannot any way restriction the present invention.
Embodiment 1 the present invention treats the pharyngolaryngitis preparation of pharmaceutical compositions
With 5 parts in the Radix Rehmanniae, 100 parts of Fructus Cornis, 5 parts of Carapax et Plastrum Testudiniss, decoct with water 2 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 2 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 100 parts in the Radix Rehmanniae, 3 parts of Fructus Cornis, 200 parts of Carapax et Plastrum Testudiniss, decoct with water 5 times, the decocting that at every turn adds as 3 times of raw material weights boiled 3 hours, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 80%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 3 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 8 parts in the Radix Rehmanniae, 5 parts of Fructus Cornis, 40 parts of Carapax et Plastrum Testudiniss, decoct with water 3 times, the decocting that at every turn adds as 6 times of raw material weights boiled 2.5 hours, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 60%, stirs evenly, and leaves standstill 12 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 4 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 30 parts in the Radix Rehmanniae, 30 parts of Fructus Cornis, 8 parts of Carapax et Plastrum Testudiniss, decoct with water 5 times, the decocting that at every turn adds as 9 times of raw material weights boiled 3 hours, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 50%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 5 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss, decoct with water 3 times, the decocting that at every turn adds as 6 times of raw material weights boiled 2 hours, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.10 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 55%, stirs evenly, and leaves standstill 15 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.30 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 6 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 5 parts in the Radix Rehmanniae, 100 parts of Fructus Cornis, 5 parts of Carapax et Plastrum Testudiniss, 2 parts of Radix Platycodoniss, 100 parts of Cortex Phellodendris, 3 parts of Fructus Gardeniaes, 100 parts of Gypsum Fibrosum, 3 parts of Radix Scrophulariaes, 100 parts of Rhizoma Belamcandae, decoct with water 2 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 7 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 100 parts in the Radix Rehmanniae, 3 parts of Fructus Cornis, 200 parts of Carapax et Plastrum Testudiniss, 100 parts of Radix Platycodoniss, 2 parts of Cortex Phellodendris, 100 parts of Fructus Gardeniaes, 5 parts of Gypsum Fibrosum, 100 parts of Radix Scrophulariaes, 3 parts of Rhizoma Belamcandae, decoct with water 5 times, the decocting that at every turn adds as 3 times of raw material weights boiled 3 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 80%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 8 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss, 8 parts of Radix Platycodoniss, 8 parts of Cortex Phellodendris, 8 parts of Fructus Gardeniaes, 20 parts of Gypsum Fibrosum, 8 parts of Radix Scrophulariaes, 8 parts of Rhizoma Belamcandae, decoct with water 3 times, the decocting that at every turn adds as 6 times of raw material weights boiled 2 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.10 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 55%, stirs evenly, and leaves standstill 15 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.30 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 9 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss, 3 parts of Radix Platycodoniss, 20 parts of Cortex Phellodendris, 5 parts of Fructus Gardeniaes, 40 parts of Gypsum Fibrosum, 5 parts of Radix Scrophulariaes, 20 parts of Rhizoma Belamcandae, decoct with water 3 times, the decocting that at every turn adds as 3 times of raw material weights boiled 0.5 hour, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 40%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 10 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss, 20 parts of Radix Platycodoniss, 3 parts of Cortex Phellodendris, 30 parts of Fructus Gardeniaes, 8 parts of Gypsum Fibrosum, 20 parts of Radix Scrophulariaes, 5 parts of Rhizoma Belamcandae, decoct with water 5 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 11 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss, 8 parts of Radix Platycodoniss, 8 parts of Cortex Phellodendris, 8 parts of Fructus Gardeniaes, 20 parts of Gypsum Fibrosum, 8 parts of Radix Scrophulariaes, 8 parts of Rhizoma Belamcandae, 3 parts of Herba Menthaes, 100 parts of Radix Paeoniae Rubra, 3 parts of Radix Panacis Quinquefoliis, 100 parts of Pericarpium Citri Reticulataes, decoct with water 2 times, the decocting that at every turn adds as 3 times of raw material weights boiled 3 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 12 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss, 8 parts of Radix Platycodoniss, 8 parts of Cortex Phellodendris, 8 parts of Fructus Gardeniaes, 20 parts of Gypsum Fibrosum, 8 parts of Radix Scrophulariaes, 8 parts of Rhizoma Belamcandae, 100 parts of Herba Menthaes, 3 parts of Radix Paeoniae Rubra, 100 parts of Radix Panacis Quinquefoliis, 3 parts of Pericarpium Citri Reticulataes, decoct with water 5 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 13 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss, 8 parts of Radix Platycodoniss, 8 parts of Cortex Phellodendris, 8 parts of Fructus Gardeniaes, 20 parts of Gypsum Fibrosum, 8 parts of Radix Scrophulariaes, 8 parts of Rhizoma Belamcandae, 8 parts of Herba Menthaes, 10 parts of Radix Paeoniae Rubra, 8 parts of Radix Panacis Quinquefoliis, 8 parts of Pericarpium Citri Reticulataes, decoct with water 3 times, the decocting that at every turn adds as 6 times of raw material weights boiled 2 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.10 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 55%, stirs evenly, and leaves standstill 15 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.30 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 14 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss, 8 parts of Radix Platycodoniss, 8 parts of Cortex Phellodendris, 8 parts of Fructus Gardeniaes, 20 parts of Gypsum Fibrosum, 8 parts of Radix Scrophulariaes, 8 parts of Rhizoma Belamcandae, 5 parts of Herba Menthaes, 20 parts of Radix Paeoniae Rubra, 5 parts of Radix Panacis Quinquefoliis, 20 parts of Pericarpium Citri Reticulataes, decoct with water 2 times, the decocting that at every turn adds as 9 times of raw material weights boiled 3 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
EXAMPLE l 5 the present invention treat the pharyngolaryngitis preparation of pharmaceutical compositions
With 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss, 8 parts of Radix Platycodoniss, 8 parts of Cortex Phellodendris, 8 parts of Fructus Gardeniaes, 20 parts of Gypsum Fibrosum, 8 parts of Radix Scrophulariaes, 8 parts of Rhizoma Belamcandae, 20 parts of Herba Menthaes, 5 parts of Radix Paeoniae Rubra, 30 parts of Radix Panacis Quinquefoliis, 5 parts of Pericarpium Citri Reticulataes, decoct with water 5 times, the decocting that at every turn adds as 9 times of raw material weights boiled 3 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 80%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats pharyngolaryngitis.
Embodiment 16 the present invention treat the preparation of pharyngolaryngitis medicament composition capsule agent
Get the pharmaceutical composition that any the present invention that embodiment of the invention 1-15 makes treats pharyngolaryngitis, according to 1: 1 ratio and medical auxiliary materials and mixing commonly used, incapsulate, the 500mg/ grain promptly makes medicament composition capsule of the present invention.Instructions about how to take medicine, every day 6 times, each 6, the 2-3 month of taking medicine continuously is a course of treatment.
Embodiment 17 the present invention treat the preparation of pharyngolaryngitis pharmaceutical composition tablet
Get the pharmaceutical composition that any the present invention that embodiment of the invention 1-15 makes treats pharyngolaryngitis, according to 1: 1 ratio and medical auxiliary materials and mixing commonly used, be pressed into tablet, the 500mg/ sheet promptly makes pharmaceutical composition tablet of the present invention.Instructions about how to take medicine, every day 6 times, each 6, the 2-3 month of taking medicine continuously is a course of treatment.
Embodiment 18 the present invention treat the preparation of pharyngolaryngitis medicament composition granule agent
Get the pharmaceutical composition that any the present invention that embodiment of the invention 1-15 makes treats pharyngolaryngitis, add right amount of auxiliary materials, spray drying with beta-schardinger dextrin-, micropowder silica gel mixing, is granulated, and the 2g/ bag promptly makes medicament composition granule agent of the present invention.Instructions about how to take medicine, boiled water is taken after mixing it with water, a 2-3 bag, 3-4 time on the one or follow the doctor's advice, the 2-3 month of taking medicine continuously is a course of treatment.
Below further set forth the beneficial effect of medicine of the present invention by testing example, comprise that the pharmacodynamics test of medicine of the present invention and clinical observation on the therapeutic effect test.
Test example 1 is observed the analgesic activity of medicine of the present invention to mice
Test material:
(1) pharmaceutical composition of the present invention is prepared into thick paste by the embodiment of the invention 1, and Xiantao City institute of traditional Chinese medicine in Hubei Province's provides lot number: 060517.Facing the time spent is mixed with 50%, 100% medicinal liquid with distilled water, and high dose group is concentrated into 200% medicinal liquid, uses for gastric infusion.The rotundine sulfate injection (chemical name: 2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydrochysene-6H-dibenzo [a, g] quinolizine), Guangdong Boluo Pioneer Medicinal Group Co., Ltd. provides, lot number: 970301.
(2) animal: the ICR white mice, female 50, the equal 18-22g of body weight, Professional School provides by Hubei Province's Xiantao City.
(3) condition: room temperature 20-25 ℃, humidity 50-60%.
Test method:
Regulate thermostat and be controlled at 55 ± 0.5 ℃, make the water surface all contact hot plate, hot plate preheating 10 minutes.Get 50 of the female white mice of healthy ICR, body weight 18-22g, each 1 is placed on the hot plate, and white mice is from being placed on the hot plate to the pain threshold of metapedes required time as this Mus occurring licking, allly licks the metapedes time less than 5 seconds or discarded greater than 30 seconds need not.Qualified white mice is divided into five groups at random, 10 every group, repeat to survey its pain threshold, get two subnormal threshold of pain meansigma methodss, as pain threshold before this Mus administration.First group is the normal saline group, and the 2nd, 3,4 group is of the present invention group (5.00g/Kg, 10.00g/Kg, 20.00g/Kg), and the 5th group is rotundine sulfate group (25mg/Kg), more than is gastric infusion.Measure the pain threshold of each Mus after the administration respectively at 30min, 1,3,4 (h), surpass 60 seconds, calculated with 60 seconds its threshold of pain, and calculate the percentage rate of paroxysmal pain with the pain threshold of each group.
The result shows that 30 minutes pain thresholds of low dose group of the present invention obviously improve, and middle and high dosage group pain threshold improves also obvious, and the persistent period is longer.Rotundine group pain threshold all has highly significant to improve.Low dose group of the present invention improves percentage rate to the threshold of pain and is respectively 105%, 117%, 112%, 81%, 75% 30 minutes, 1,2,3,4h; Middle dosage group is respectively 96%, 99%, 105%, 78%, 66%; High dose group is respectively 85%, 136%, 127%, 100%, 85%; The Hyndarin group is respectively 143%, 161%, 161%, 135%, 112%, sees Table 1.
Table 1: the present invention to the analgesic activity (hot plate method) of mice (x ± SD, n=10)
| Group | Dosage (g/kg) | Animal (only) | Average pain threshold before the administration | Different time pain threshold (s) after the administration | ||||
| 30min | 1h | 2h | 3h | 4h | ||||
| The normal saline group | Deng capacity | 10 | 23.2±5.3 | 24.5±4.7 | 26.7±5.8 | 25.8±5.8 | 24.3±5.5 | 25.2±9.9 |
| Of the present invention group | 5.00 | 10 | 21.5±5.6 | 44.2±14.5 ** (105) | 46.6±14.6 ** (117) | 90.6±13.9 ** (112) | 38.9±14.5 * (81) | 38.1±19.8 (75) |
| Of the present invention group | 10.00 | 10 | 25.1±4.5 | 49.8±10.7 *** (96) | 50.2±12.1 *** (99) | 51.6±6.7 ** (105) | 90.2±10.6 *** (78) | 41.8±14.4 * (66) |
| Of the present invention group | 20.00 | 10 | 23.6±5.4 | 43.6±12.3 *** (85) | 56.1±9.3 ** (136) | 54.2±6.4 *** (127) | 47.5±15.4 ** (100) | 43.7±13.6 ** (85) |
| The rotundine group | 25mg/kg | 10 | 22.8±5.5 | 56.1±9.1 *** (143) | 60.00±0 *** (161) | 60.0±0 *** (161) | 53.6±10.0 *** (135) | 48.2±13.5 ** (112) |
Compare with the physiology matched group: * P＜0.5, * * P＜0.01, * * * P＜0.001.
Result of the test: administration group of the present invention and matched group and treatment comparable group compare, and medicine of the present invention has the obvious treatment effect to the analgesia therapy of mice.
Test example 2 xylol cause the inhibitory action of swelling
Test material:
(1) pharmaceutical composition of the present invention is prepared into thick paste by the embodiment of the invention 2, and Xiantao City institute of traditional Chinese medicine in Hubei Province's provides lot number: 060518; The larynx oxazepam, Wan Shida pharmaceutical Co. Ltd in Nanning provides lot number: 20050901.
(2) dosage: larynx oxazepam 3g crude drug/kg (the 1.6g sheet is heavy/kg), calculate 20 times that are equivalent to clinical Coming-of-Age Day consumption by kg body weight; Medicine group of the present invention, little: 1.33g crude drug/kg, in: 2.66g crude drug/kg, big: 5.32g crude drug/kg, calculate by kg body weight, be equivalent to 5,10 and 20 times of clinical Coming-of-Age Day consumption.
(3) animal: 50 of ICR white mice, the equal 18-22g of body weight, Professional School provides by Hubei Province's Xiantao City.
(4) condition: room temperature 20-25 ℃, humidity 50-60%,
Test method: get 50 of mices, male and female half and half, be divided into 5 groups at random, continuous 7 days, after the last administration 90 minutes, be coated with dimethylbenzene 0.05ml at every mouse right ear, mice is put to death in the cervical vertebra dislocation after 1 hour, cuts auricle and respectively gets an auricle with the 0.8cm card punch in mice two ear same area, weighs in torsion balance, as the swelling degree, the results are shown in Table 2. with two ear weight differences
Table 2 medicine xylol of the present invention induced mice ear
| Group | Animal (n) | Dosage (g/kg) | Ear swelling degree (mg) |
| The distilled water group | 10 | Deng capacity | 9.78±1.21 |
| The larynx oxazepam | 10 | 3.00 | 6.53±1.16** |
| Medicine of the present invention | 10 | 1.33 | 7.26±1.26** |
| Medicine of the present invention | 10 | 2.66 | 6.39±1.12** |
| Medicine of the present invention | 10 | 5.32 | 5.88±1.01** |
Result of the test: as shown in Table 1, medicine of the present invention obviously suppresses dimethylbenzene induced mice ear swelling, with distilled water group ratio, significant differences is arranged; With larynx oxazepam group ratio, no significant difference.
The clinical observation contrast test of test example 3 Drug therapy pharyngolaryngitis of the present invention
Test material:
Pharmaceutical composition of the present invention is prepared into granule by the embodiment of the invention 3, and Xiantao City institute of traditional Chinese medicine in Hubei Province's provides lot number: 060519; Yanyan slice, the gloomy medicine pharmacy company limited in Chengdu provides lot number: 051202; The larynx oxazepam, Wan Shida pharmaceutical Co. Ltd in Nanning provides lot number: 20050901.
Test method: select example surplus the case 80 from outpatient service, random packet is observed.Wherein:
Test group 50 examples are treated male 30 examples, women 20 examples, 10 ~ 70 years old age with Chinese medicine granules of the present invention, 40 years old mean age, pharyngitis 8 examples of chronic heavy type wherein, chronic medium-sized pharyngitis 42 examples, the course of disease 3 ~ 120 months, average 61.5 months, first visit 22 examples, further consultation 28 examples; This group patient all takes Chinese medicine granules of the present invention, 2 bags of the each clothes of dosage adult, sooner or later respectively once.
1 group of 15 example of matched group is with Yanyan slice treatment, male 10 examples, women 5 examples, 12 ~ 68 years old age, 40 years old mean age; Matched group is all taken Yanyan slice for 1 group, adult every day three times, each 5.
2 group of 15 example of matched group is with the treatment of larynx oxazepam, male 11 examples, women 4 examples, 10 ~ 64 years old age, 37 years old mean age; Contrast 2 groups of patients and all take the larynx oxazepam, adult every day three times, obey 4 at every turn.
Three groups of patient treatments were a course of treatment with three months all, and test is 2 courses of treatment.
In pharyngitis typing (heavy, plain edition) ratio, the age, sex, the course of disease, just, the symptom of further consultation and reflection state of an illness weight compares, and sees Table 3.
Table 3 take behind Chinese medicine of the present invention and Yanyan slice, the larynx oxazepam clinical efficacy relatively
| Group | Case load | The basic number (%) of curing | Alleviate (%) | Obviously progressive (%) | Invalid (%) | Overall efficiency (%) | ||||
| The course of treatment several 2 | The course of treatment several 2 | The course of treatment several 2 | The course of treatment several 2 | |||||||
| Test group | 50 | 40 | 80 | 4 | 8 | 6 | 12 | 0 | 0 | 100 |
| Contrast one group | 15 | 0 | 0 | 4 | 26 | 6 | 40 | 5 | 34 | 66 |
| Contrast two groups | 15 | 0 | 0 | 5 | 33 | 5 | 33 | 5 | 34 | 66 |
Conclusion (of pressure testing): from above-mentioned data as can be seen, test group is cured substantially, alleviates and total effective rate obviously is better than contrasting two groups of one group and contrasts.
In the above-mentioned test example, no matter adopting the inventive method still is other method, needs only its component, content within the scope of the present invention, all has essentially identical therapeutic effect.
Claims (10)
1, a kind of pharmaceutical composition for the treatment of pharyngolaryngitis is characterized in that it mainly is made up of following components in part by weight: Radix Rehmanniae 5-100 part, Fructus Corni 3-100 part, Carapax et Plastrum Testudinis 5-200 part.
2, a kind of pharmaceutical composition according to claim 1 is characterized in that in the described component: Radix Rehmanniae 8-30 part, Fructus Corni 5-30 part, Carapax et Plastrum Testudinis 8-40 part.
3, a kind of pharmaceutical composition according to claim 1 is characterized in that in the described component: 15 parts in the Radix Rehmanniae, 15 parts of Fructus Cornis, 30 parts of Carapax et Plastrum Testudiniss.
4, according to any one pharmaceutical composition among the claim 1-3, it is characterized in that also comprising in the described component: Radix Platycodonis 2-100 part, Cortex Phellodendri 2-100 part, Fructus Gardeniae 3-100 part, Gypsum Fibrosum 5-100 part, Radix Scrophulariae 3-100 part, Rhizoma Belamcandae 3-100 part.
5, according to a kind of pharmaceutical composition described in the claim 4, it is characterized in that in the described component: Radix Platycodonis 3-20 part, Cortex Phellodendri 3-20 part, Fructus Gardeniae 5-30 part, Gypsum Fibrosum 8-40 part, Radix Scrophulariae 5-20 part, Rhizoma Belamcandae 5-20 part.
6, according to a kind of pharmaceutical composition described in the claim 5, it is characterized in that in the described component: 8 parts of Radix Platycodoniss, 8 parts of Cortex Phellodendris, 8 parts of Fructus Gardeniaes, 20 parts of Gypsum Fibrosum, 8 parts of Radix Scrophulariaes, 8 parts of Rhizoma Belamcandae.
7, according to a kind of pharmaceutical composition described in the claim 4, it is characterized in that also comprising in the described component: Herba Menthae 3-100 part, Radix Paeoniae Rubra 3-100 part, Radix Panacis Quinquefolii 3-100 part, Pericarpium Citri Reticulatae 3-100 part.
8, according to a kind of pharmaceutical composition described in the claim 7, it is characterized in that in the described component: Herba Menthae 5-20 part, Radix Paeoniae Rubra 5-20 part, Radix Panacis Quinquefolii 5-30 part, Pericarpium Citri Reticulatae 5-20 part.
9, a kind of pharmaceutical composition described in according to Claim 8 is characterized in that in the described component: 8 parts of Herba Menthaes, 10 parts of Radix Paeoniae Rubra, 8 parts of Radix Panacis Quinquefoliis, 8 parts of Pericarpium Citri Reticulataes.
10, any one preparation of drug combination method in the claim 1,4,7 is characterized in that comprising the steps:
A) by weight ratio described Chinese medicine is decocted with water 2-5 time, add as raw material weight 3-9 decocting doubly at every turn and boiled 0.5-3 hour, filter, merging filtrate is condensed into clear paste then, and its relative density is 1.00-1.15 in the time of 90 ℃;
B) in the above-mentioned clear paste that makes, add ethanol, make ethanol content reach 30-80%, stir evenly, left standstill 6-24 hour, filter, filtrate recycling ethanol, and be condensed into thick paste, its relative density is 1.20-1.50 in the time of 90 ℃;
C) paste is carried out dried, get final product.
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| CN103028032A (en) * | 2012-12-23 | 2013-04-10 | 丁常燕 | Traditional Chinese medicine composition for treating cough |
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| CN1103595A (en) * | 1994-06-14 | 1995-06-14 | 魏新华 | Dispensation and preparation process of respiratory immune tablets |
| CN1054525C (en) * | 1995-11-10 | 2000-07-19 | 陈金燕 | Medicinal composition for treating diabetes involving lower jiao |
| CN1213759C (en) * | 2002-06-15 | 2005-08-10 | 合肥神鹿双鹤药业有限责任公司 | Chinese medicine granule for treating chronic pharyngitis and its prepn process |
| CN100391514C (en) * | 2005-08-05 | 2008-06-04 | 张德军 | Chinese traditional medicine preparation for curing laryngopharyngitis |
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| CN103028032A (en) * | 2012-12-23 | 2013-04-10 | 丁常燕 | Traditional Chinese medicine composition for treating cough |
| CN103028032B (en) * | 2012-12-23 | 2014-12-03 | 丁常燕 | Traditional Chinese medicine composition for treating cough |
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