CN1961850A - Implantable vision prosthesis - Google Patents
Implantable vision prosthesis Download PDFInfo
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- CN1961850A CN1961850A CN 200610119252 CN200610119252A CN1961850A CN 1961850 A CN1961850 A CN 1961850A CN 200610119252 CN200610119252 CN 200610119252 CN 200610119252 A CN200610119252 A CN 200610119252A CN 1961850 A CN1961850 A CN 1961850A
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Images
Abstract
The invention relates to a vision artificial element as medical tool, wherein it comprises that micro camera false eye and needle micro electrode array which can be planted into orbit; said micro camera false eye comprises solar energy battery board or charge device, micro optical lens group, photoelectric converter, signal processing converter, false eye base, and false eye sheet; the solar-energy battery board or charge device, micro optical lens group, photoelectric converter and signal processing converter are packed into false eye base; the signal processing converter is outside the false eye base; the micro camera false eye is planted into the orbit; the needle micro electrode array comprises base, micro electrode, inner wire, interface base, fixing hole, wire, and fixing plate; the fixing plate is fixed on the skull; the micro electrode via the drill hole of skull enters into vision layer; the vision electric signal via wire is transmitted into micro electrode array. The invention can improve the spatial accuracy of false eye.
Description
Technical field
The present invention relates to a kind of device of medical equipment technical field, specifically is a kind of implantable vision prosthesis that the blind person is partly recovered lost eyesight.
Background technology
People's visual system is that the imaging, visual system of object obtain visually-perceptible to the processing of image information and visual centre to the processing again of visual information to external world by the optics of the eye system.But some diseases is arranged,, tend to cause the forfeiture of visual performance, and can't recover visual performance by conventional medicine or therapeutic method of surgery at present as retinal pigment degeneration, senile degeneration of macula and ophthalmic injuries that wound caused.In fact, the afunction of any ingredient on the visual channel all will cause the afunction of whole visual system.Operation principle according to visual system is carried out bionical, the image information of external object by handling and conversion, is formed visual information, then by the formed neural interface of microstimulation electrod-array, visual information is delivered to visual centre, thereby forms a kind of phosphene.This device is called vision prosthesis.Utilization is implanted vision prosthesis at the visual system corresponding site, be expected to make above-mentioned can not healing property persons suffering from ocular disorders recovered part visual performance.There is method to produce phosphene at present by direct stimulation retinal ganglial cells, but this method can't remedy the visual disorder that optic nerve injury causes, remaining amphiblestroid damage also be can not be ignored, and in addition, this method also has shortcomings such as the little efficient in the visual field is low; The method that has is to obtain the external image signal by external camera system, produce optic nerve signal stimulus optic nerve or visual cortex after treatment, the shortcoming of this method is that the field range of external camera is relatively limited, also can influence attractive in appearance, because electrode density and scope can not be too big, field range and spatial resolution have been reduced simultaneously.In addition, the potential risk factor of performing the operation is also bigger, causes mental pressure to the patient.
Find through literature search prior art, U.S. Patent number is US6658299B1, be December in 2003 2 days date issued, the patent documentation readme of " ARTIFICIAL SYSTEM FOR VISION AND THE LIKE " by name (" manual system of vision and suitable organ ") is: " manual system of a kind of vision or homologous organs is to object image-forming and produce the nervous system that corresponding signal passes to the patient; make the patient produce phosphene, and the effectiveness of this systems communicate artificial signs is strengthened by the dark bright counterpart that the bright dark counterpart that photographing unit is produced signal converts actual sensation generation signal to.Other reinforcement comprises and produces institute's object edge of looking brighter signal relatively, signal by Port Multiplier to a certain local generation pulse train.In addition, this invention also comprises providing to the patient makes sensation, and as the periodically variable localizer of brightness, period of change is corresponding to the far and near distance of looking object, and provides adjustable signal amplifier to produce controlled focus effect ".This invention adopts the method for laying camera system on external glasses to come the images acquired signal, and need decode to picture signal and the coding of visual signal by the external computer system.This method has not only limited the field range of vision prosthesis on function, place the heavy and inaesthetic external camera system of patient face and place the computer system of waist to greatly reduce vision prosthesis by patient's acceptable degree.In addition, the design of its single stimulating electrode array and stimulation protocol also are unfavorable for making full use of the effective coverage of visual cortex, and visual range is diminished.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of implantable vision prosthesis that the blind person is partly recovered lost eyesight is provided.Make its location that had both helped visual-field space, can improve the spatial resolution of vision prosthesis again, make vision prosthesis more effective.
The present invention is achieved by the following technical solutions, the present invention includes: implantable intra little camera false eye and pin type microelectrode array.Described implantable intra little camera false eye is carried out object imaging and is converted picture signal to the signal of telecommunication, and passing to the pin type microelectrode array behind the encoded one-tenth visual stimulus of the signal of telecommunication signal stimulates visual cortex.
Described implantable intra little camera false eye comprises: ocular prosthesis sheet, micro optical lens group, solar panel or charging device, electrooptical device, signal processing and converting unit, ocular prosthesis seat, described micro optical lens group is fixed on the solar panel endoporus, described electrooptical device is positioned on the rear focus of micro optical lens group, and the image that the micro optical lens group is become carries out opto-electronic conversion; Described signal processing and converting unit are a microcomputer, the signal of telecommunication that described electrooptical device generated is further handled, and generated two-phase vision electrical stimulation signal; Described signal processing and converting unit are packaged in the ocular prosthesis seat, or place outside the ocular prosthesis seat; Described ocular prosthesis seat is an encapsulation object, and profile is the spherical crown shape, and described micro optical lens group, solar panel, electrooptical device and signal processing and converting unit are fixed and encapsulated; The ocular prosthesis seat is flat shape foremost, and described solar panel is fixed on it, and the ocular prosthesis sheet covers the place ahead of ocular prosthesis seat.
Described pin type microelectrode array comprises microelectrode, fixing head, fixing hole, substrate, inside conductor, interface block and lead, described microelectrode is a needle electrode, be welded in described substrate surface, mutual insulating between each electrode interface, described substrate below is fixed on the fixing head; Described inside conductor connects described microelectrode and interface block, and described inside conductor is distributed in the surface of described substrate; Described interface block is a cable conversion mouth, is positioned at the fixing head surface, connects inside conductor and lead respectively; Described lead connects described signal processing and converting unit and interface block, and the visual stimulus signal of telecommunication is transferred to described interface block through described lead, is transformed into described inside conductor through described interface block, further is transferred to described microelectrode.
Work process of the present invention and operation principle are: little camera false eye of implantable eye socket converts the signal of telecommunication to by object image-forming to external world and by electrooptical device, the signal of telecommunication generates the two-phase vision signal of telecommunication by signal processing and converting unit again, be transferred to interface block by the percutaneous lead then, further be transferred to microelectrode with the stimulation visual cortex, thereby produce phosphene by inside conductor.The interface seat board is fixed in the skull relevant position by nail.Microelectrode penetrates by boring on skull and enters and stimulate visual cortex.Microelectrode array can one or more be distributed in visual cortex, to increase field range and spatial resolution.
The invention has the beneficial effects as follows: the design that the present invention is packaged into ocular prosthesis with little camera system and implants the method for eye socket and pass through the method introducing electrode of sphenotresia, can avoid external installation photographic head and signal processing computer; The needle electrode array is fixed on the skull by fixing head, and microelectrode is passed in to hole on the skull and penetrates visual cortex, has avoided operation of opening cranium, has alleviated patient's mental pressure greatly; The pin type microelectrode array is fixed on the skull, has increased stability, because softish substrate has with the little function of moving of cerebral tissue microelectrode, has increased the compatibility of microelectrode; Microelectrode array can one or more be distributed in visual cortex, and visual-field space is located easily, has increased field range, has increased the spatial resolution of vision prosthesis simultaneously, improves the efficient of electricity irritation.
Description of drawings
Fig. 1 is that signal processing of the present invention and converting unit are packaged in the structural representation in the ocular prosthesis seat.
Fig. 2 is that signal processing of the present invention and converting unit are placed on the outer structural representation of ocular prosthesis seat.
Fig. 3 is implantable intra little camera false eye structural representation that the present invention adopts solar panel.
Fig. 4 is implantable intra little camera false eye structural representation that the present invention adopts charging device.
Fig. 5 is the side-looking structure chart of pin type microelectrode array of the present invention.
Fig. 6 is the plan structure figure of pin type microelectrode array of the present invention.
Fig. 7 is the scattergram of inside conductor in the substrate of the present invention.
Fig. 8 is the distribution schematic diagram of pin type microelectrode array of the present invention on visual cortex.
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment is being to implement under the prerequisite with the technical solution of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1 and Figure 2, present embodiment comprises: implantable intra little camera false eye 1 and pin type microelectrode array 10.Described implantable intra little camera false eye 1 is carried out object imaging and is converted picture signal to the signal of telecommunication, and passing to 10 pairs of visual cortexs of pin type microelectrode array behind the encoded one-tenth visual stimulus of the signal of telecommunication signal stimulates.
Described implantable intra little camera false eye 1 comprises: ocular prosthesis sheet 2, micro optical lens group 3, solar panel 4 or charging device 16, electrooptical device 5, signal processing and converting unit 6, ocular prosthesis seat 7, micro optical lens group 3 is object image-forming and convert optical image signal to the corresponding signal of telecommunication by electrooptical device 5 to external world, the signal of telecommunication that is generated is encoded by signal processing and converting unit 6 again, generates the visual stimulus signal with stimulating visual cortex.
Described micro optical lens group 3 is fixed on solar panel 4 endoporus; Described electrooptical device 5 is positioned on the rear focus of micro optical lens group 3; The image that micro optical lens group 3 is become carries out opto-electronic conversion; Described signal processing and converting unit 6 are a microcomputer, the signal of telecommunication that described electrooptical device 5 is generated is further handled, and generating two-phase vision electrical stimulation signal, described signal processing and converting unit 6 can be packaged in the ocular prosthesis seat 7, also can place outside the ocular prosthesis seat 7.Ocular prosthesis seat 7 is an encapsulation object, and profile is the spherical crown shape, to described micro optical lens group 3, and solar panel 4, electrooptical device 5 and signal processing and converting unit 6 are fixed and are encapsulated; Ocular prosthesis seat 7 is flat shape foremost, and described solar panel 4 is fixed on it.The arc thin slice that ocular prosthesis sheet 2 is made for transparent material covers the place ahead of ocular prosthesis seat 7, works hiding and beautification function.
Described implantable intra little camera false eye 1 is the spherical crown shape, and front end is the plane, can fixed solar cell panel 4, can implant in the eye socket behind blind person's eyeball excise.
Described ocular prosthesis sheet 2 can be the arc thin slice with making with ocular prosthesis seat 7 identical materials, and mid-diameter is that the zone of 8-12mm has the transparency, is covered in ocular prosthesis seat 7 foremost, and is perhaps detachable.
Described micro optical lens group 3 is a Radix Rumicis short focal length lens group or Zoom lens group, and focal length is at 2-10mm, and to the infinity, the angle of visual field is more than 30 degree at 20cm for the imaging scope, and micro optical lens group 3 lateral dimensions are equivalent to human eye pupil size, between 2-6mm.
Described electrooptical device 5 can be that CCD or CMOS make, and is positioned at after the micro optical lens group 3, and the image transitions that micro optical lens became is become the signal of telecommunication, generates two-phase visual stimulus signal through signal processing and converting unit 6 then.
As shown in Figure 3, described solar panel 4 is the ring discoid structure, external diameter 8-12mm, internal diameter 2-6mm, be positioned at the front end of micro optical lens group 3, can become transform light energy electric energy and have the electric energy hold function, can be implantable intra little camera false eye 1 and continue to provide energy.
As shown in Figure 4, described charging device 16 comprises energy storage unit, and the mode by external charging provides energy for whole system, to replace solar panel 4.
Described solar panel 4 or charging device 16, micro optical lens group 3, electrooptical device 5 and signal processing and converting unit 6 become ocular prosthesis seat 7 with the material package of good biocompatibilities such as coral hydroxyapatite or special glass, silica gel, resin, bioceramic, special glass.
As shown in Figure 5 and Figure 6, described pin type microelectrode array 10 comprises lead 8, microelectrode 9, fixing head 11, substrate 12, fixing hole 13, inside conductor 14, interface block 15.Visual stimulus signal from implantable intra little camera false eye 1 is delivered to interface block 15 by lead 8, is delivered to microelectrode 9 by inside conductor 14 again and carries out cortical stimulation.Described microelectrode 9 is welded in described substrate 12 surfaces, mutual insulating between the different electrode interfaces; Described substrate 12 belows are fixed on the fixing head 11; Described inside conductor 14 connects described microelectrode 9 and interface block 15, is distributed in the surface of described substrate 12; Described interface block 15 is cable conversion mouths, is positioned at fixing head 11 surfaces, connects inside conductor 14 and lead 8 respectively; Described lead 8 connects described signal processing and converting unit 6 and interface block 14; The visual stimulus signal of telecommunication is transferred to interface block 15 through lead 8, is transformed into inside conductor 14 through interface block 15, further is transferred to microelectrode 9, thereby plays the electricity irritation to visual cortex, forms the phosphene of visual centre.
Described lead 8 is made with proof gold or the little metal material of other impedance, diameter 10-200 μ m, and the thick dielectric resin material thin layer of 1-5 μ m is coated in the lead outside, with microbonding technical battery connection interface seat 15 and signal processing and converting unit 6.
Described microelectrode 9 is a needle electrode, adopt nickel alloy or other hardness material to make, periphery is coated good biocompatibility and is had the material coating such as the Parylene of insulation function, thick coating 1-10 μ m, the bottom is connected with substrate 12 with the microwelding technology, and coats insulant.
Described microelectrode 9 is the aciculiform structure, and total length is 1-5mm, and root diameter (RD) is 50-100 μ m, and the needle point diameter is 2-10 μ m, and length of needlepoint is 2-4 μ m, and needle point plates platinum, increases conductive capability, and microelectrode 9 is with rectangular arranged, at interval 100-1000 μ m.
Described fixing head 11 is made with resin or other biocompatible materials, and thickness is 50-1000 μ m, and available titanium bone nail is fixed on the skull by fixing hole 13.
Described substrate 12 is made for the material of softish good biocompatibility such as epoxy resin, and thickness is 50-500 μ m.
As shown in Figure 7, described inside conductor 14 connects microelectrode 9 roots and interface block 15, and diameter is 10-100 μ m, can be that proof gold or the little metal material of other impedance are made, and the thick dielectric resin material thin layer of 1-5 μ m is coated in the outside.
As shown in Figure 8, the one or more pin type microelectrode array 10 that can distribute on the visual cortex is to increase field range and spatial resolution.
Claims (10)
1, a kind of implantable vision prosthesis, comprise: implantable intra little camera false eye and pin type microelectrode array, implantable intra little camera false eye is carried out object imaging and is converted picture signal to the signal of telecommunication, passing to the pin type microelectrode array behind the encoded one-tenth visual stimulus of the signal of telecommunication signal stimulates visual cortex, it is characterized in that:
Described implantable intra little camera false eye comprises: ocular prosthesis sheet, micro optical lens group, solar panel or charging device, electrooptical device, signal processing and converting unit, ocular prosthesis seat, the micro optical lens group is fixed on the solar panel endoporus, electrooptical device is positioned on the rear focus of micro optical lens group, the image that the micro optical lens group is become carries out opto-electronic conversion, signal processing and converting unit are further handled the signal of telecommunication that electrooptical device generated, and generate two-phase vision electrical stimulation signal; Signal processing and converting unit are packaged in the described ocular prosthesis seat, or place outside the described ocular prosthesis seat, the ocular prosthesis seat is fixed and is encapsulated micro optical lens group, solar panel, electrooptical device and signal processing and converting unit, solar panel is fixed on the ocular prosthesis seat foremost, and the ocular prosthesis sheet covers the place ahead of described ocular prosthesis seat;
Described pin type microelectrode array comprises microelectrode, fixing head, fixing hole, substrate, inside conductor, interface block and lead, microelectrode is welded in substrate surface, mutual insulating between each electrode interface, the substrate below is fixed on the fixing head, inside conductor connects microelectrode and interface block, inside conductor is distributed in the surface of substrate, interface block is positioned at the fixing head surface, connect inside conductor and lead respectively, lead connects described signal processing and converting unit and interface block, the visual stimulus signal of telecommunication is transferred to interface block through lead, is transformed into inside conductor through interface block, further is transferred to microelectrode.
2, implantable vision prosthesis according to claim 1 is characterized in that, described implantable intra little camera false eye is the spherical crown shape, and front end is the plane, with the fixed solar cell panel.
3. implantable vision prosthesis according to claim 1 is characterized in that, described ocular prosthesis sheet is the arc thin slice, and mid-diameter is the transparent region of 8-12mm.
4, implantable vision prosthesis according to claim 1 is characterized in that, described micro optical lens group is a Radix Rumicis short focal length lens group or Zoom lens group, focal length is at 2-10mm, the imaging scope is greater than 20cm, and the angle of visual field is more than 30 degree, and micro optical lens group lateral dimension is between 2-6mm.
5, implantable vision prosthesis according to claim 1 is characterized in that, described solar panel is the ring discoid structure, and external diameter is 8-12mm, and internal diameter is 2-6mm.
6, implantable vision prosthesis according to claim 1 is characterized in that, described lead, diameter are 10-200 μ m, and the lead outside scribbles the thick dielectric resin material thin layer of 1-5 μ m.
7, implantable vision prosthesis according to claim 1 is characterized in that, described microelectrode is a needle electrode, and periphery scribbles insulation coating, and coating layer thickness is 1-10 μ m.
8, according to claim 1 or 7 described implantable vision prosthesis, it is characterized in that, described microelectrode, total length is 1-5mm, and root diameter (RD) is 50-100 μ m, and the needle point diameter is 2-10 μ m, length of needlepoint is 2-4 μ m, needle point plates platinum, and microelectrode is spaced apart 100-1000 μ m with rectangular arranged.
9, implantable vision prosthesis according to claim 1 is characterized in that, described fixing head, thickness are 50-1000 μ m.
10, implantable vision prosthesis according to claim 1 is characterized in that, described substrate, and thickness is 50-500 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101192521A CN100490767C (en) | 2006-12-07 | 2006-12-07 | Implantable vision prosthesis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101192521A CN100490767C (en) | 2006-12-07 | 2006-12-07 | Implantable vision prosthesis |
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| CN1961850A true CN1961850A (en) | 2007-05-16 |
| CN100490767C CN100490767C (en) | 2009-05-27 |
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| CNB2006101192521A Active CN100490767C (en) | 2006-12-07 | 2006-12-07 | Implantable vision prosthesis |
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Cited By (19)
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| CN101904776A (en) * | 2010-07-07 | 2010-12-08 | 重庆大学 | Method and device for pressure regulation and fixation of epidural microstimulation (EMS) visual cortex neural prosthesis |
| CN102793592A (en) * | 2012-08-09 | 2012-11-28 | 上海交通大学 | Optic nerve implantable neural interface device with fan-shaped attaching function |
| CN102970942A (en) * | 2010-04-26 | 2013-03-13 | 斯特拉设备公司 | Ocular implant iris diaphragm |
| CN103271781A (en) * | 2013-05-06 | 2013-09-04 | 上海交通大学 | Artificial eyeball device capable of simulating eyeball movement and visual signal collecting function |
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| CN105496643A (en) * | 2016-01-18 | 2016-04-20 | 戴国群 | Intelligent wearing device for vision recovery of patient with posteriority blindness and making method thereof |
| CN106137531A (en) * | 2010-02-26 | 2016-11-23 | 康奈尔大学 | Retina prosthese |
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| TWI569817B (en) * | 2015-07-08 | 2017-02-11 | 國立交通大學 | Artificial retinal prosthesis system, optical device and retina chip |
| CN107995391A (en) * | 2017-11-28 | 2018-05-04 | 信利光电股份有限公司 | A kind of ocular prosthesis and electronic equipment |
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