CN108310625A - The implanted device of retinal prosthesis system without bandage and retinal prosthesis system - Google Patents
The implanted device of retinal prosthesis system without bandage and retinal prosthesis system Download PDFInfo
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- CN108310625A CN108310625A CN201810192171.7A CN201810192171A CN108310625A CN 108310625 A CN108310625 A CN 108310625A CN 201810192171 A CN201810192171 A CN 201810192171A CN 108310625 A CN108310625 A CN 108310625A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0543—Retinal electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Prostheses (AREA)
- Electrotherapy Devices (AREA)
Abstract
The present invention provides a kind of implanted device of the retinal prosthesis system of no bandage, including：Matrix is covered on eyeball and is fixed on eyeball；Electronic packing body is installed on matrix, and at least has the processing circuit for handling electric signal；Stimulating electrode structure has and is connect with electronic packing body；And reception antenna, it is embedded in matrix, and connect with electronic packing body, wherein matrix is formed as non-closed loop shape.In the present invention, the matrix of the implanted device of artificial retina is covered in the outer surface of eyeball, and it is formed as non-closed loop shape, in addition, the stimulated side of stimulating electrode structure is close to intraocular retina via epibulbar notch, thereby, it is possible to reduce the operation wound in the implanted device operation implantation process of artificial retina to eyeball especially eyeball flesh.
Description
The application isOn 08 22nd, 2016, application No. is201610700140.9, it is entitledNothing is tied up The implanted device and artificial retina of the artificial retina of bandPatent application divisional application.
Technical field
The present invention relates to the implanted device of retinal prosthesis system of no bandage a kind of and retinal prosthesis systems.
Background technology
In normal vision forming process, the photosensory cell of intraocular retina (including cone cell and retinal rod it is thin
Born of the same parents) convert external optical signal to visual signal, visual signal is along the vertical passage of vision successively via the double of retina
Beale's ganglion cell, gangliocyte etc., and be finally collected to optic nerve and pass to the cortex of brain, to form light sensation.
In part retinal disease such as retinal pigment degeneration (RP) and age-related macular degeneration (AMD), due to view
Membranochromic pigments denaturation and age-related macular degeneration etc. cause the decline of photosensory cell, disease of the above-mentioned normal pathways for vision because of photosensory cell
Become and it is hindered, visual signal can not be transformed by normally entering the light of intraocular, cause patient that can not perceive light sensation, and forfeiture regards
Feel.Fortunately, the Beale's ganglion cells of the retina of the retinal diseases patient such as retinal pigment degeneration and age-related macular degeneration, god
Largely retained through functions such as ganglion cells.Currently, artificial retina product by replacing because of retinal pigment degeneration and
The function of the photosensory cell of retinal damage caused by age-related macular degeneration, such as generate stimulation letter by using stimulating electrode
Number retinal ganglial cells or Beale's ganglion cells are stimulated, and retain intact pathways for vision using other, also can
It is enough to generate light sensation in cerebral cortex, so as to partly restore the vision of patient.Just because of artificial retina product is regarded to above-mentioned
The life of Omental lesion patient can bring very big improvement, and artificial retina is more obtained as implantable medical devices in recent years
Pay attention to and develops.
Invention content
However, in existing artificial retina, for a long time, the implanted device to implant is usually by by silica gel system
At bandage the implanted device of artificial retina is banded in outside the sclera of eyeball to realize that the implanted device of artificial retina exists
Epibulbar fixation.In the implantation process of above-mentioned implanted device, it usually needs the full conjunctiva of 360 ° of opening eyes, and hang
All 4 internus are hung, encircling band is passed through under 4 rectus, and each quadrant in eye is required to be respectively provided with fixed seam
Line could be completed.Here, the quadrant of eye can be defined as：Look straight ahead is made a horizontal line through pupil center, and is extended
Cross the endocanthion and outer canthus of eye, then make a vertical line mutually orthogonal with the horizontal line through pupil center, and extended on eye socket of the eye with
Lower socket of the eye, thus eye is divided into four quadrants by horizontal line and vertical line.
The inventors of the present invention by long-term implant surgery the study found that in above-mentioned cerclage operation, although using tying up
There is no the fastnesses greatly improved between implanted device and eyeball on eyeball by implanted device cerclage for band, but on implementing
State the cerclage of implanted device and many harmful effects but brought to eyeball, for example, it is big to the wound of eyeball, eye muscle is caused damage,
Surgical procedure is cumbersome, time-consuming for post operative recovery procedures, eyes of patients irritation is apparent etc., but also usually due to rings such as bandages
Pricking object oppression eyeball venae vorticosae causes intra-ocular blood cycle unsmooth, leads to the complication such as treat retinal ischemic even choroidal leekage
Problem.
To solve the above-mentioned problems, the inventors of the present invention concentrate on studies, by overcoming above-mentioned technology prejudice, using no bandage knot
The implanted device of the artificial retina of structure reduces the utilization to eyeball eye muscle, so as to improve the implantation hand of artificial retina
Art process reduces wound of the implant surgery process to eyeball, and significantly reduces the postoperative complications of patient.
That is, the present invention completes to solve above-mentioned existing issue, its purpose is to provide one kind capable of improving plant
Enter surgical procedure and reduces the implanted device of the artificial retina without bandage of postoperative complications.
For this purpose, providing a kind of implanted device of the artificial retina of no bandage, packet involved by an aspect of of the present present invention
It includes：Matrix is covered in outside eyeball and is fixed on the eyeball；Electronic packing body is installed on described matrix, and at least has
It is useful for the processing circuit of processing electric signal；Stimulating electrode structure, have connect with the electronic packing body cardinal extremity, via
The epibulbar notch and stimulated side and the connection cardinal extremity and the stimulation for being close to the intraocular retina
The electronic cable at end；And reception antenna, it is embedded in described matrix, and connect with the electronic packing body, described matrix
It is formed as non-closed loop shape.
In the present invention, the matrix of the implanted device of artificial retina is covered in the outer surface of eyeball, and is formed as
Non- closed loop shape, in addition, the stimulated side of stimulating electrode structure is close to intraocular retina via epibulbar notch, by
This, can reduce the operation wound to eyeball especially eyeball flesh in the implanted device operation implantation process of artificial retina.
In addition, in the implanted device of artificial retina according to the present invention, optionally, described matrix includes being distributed in
Multiple suturing parts at the edge of described matrix, the multiple suturing part by being seamed to the sclera of the eyeball by described matrix
It is fixed on the eyeball.Thereby, it is possible to matrix is fixed on eyeball securely.
In addition, in the implanted device of artificial retina according to the present invention, optionally, described matrix is in band-like, institute
State the both sides that multiple suturing parts are distributed in described matrix.In this case, since suturing part to be distributed in the both sides of matrix, because
Matrix can be fixed on eyeball by this more securely.
In addition, in the implanted device of artificial retina according to the present invention, optionally, close to the electronic packing body
The suturing part number be more than close to the reception antenna the suturing part number.In this case, due to planting
The center of gravity for entering device is more biased towards electronic packing body, therefore, can be more firm by the way that multiple suturing parts are being arranged close to electronic packing body
Admittedly implanted device is fixed on eyeball.
In addition, in the implanted device of artificial retina according to the present invention, optionally, in the electronic packing body
Around, three suturing parts of distribution triangular in shape are disposed with, and two in three suturing parts are arranged in
The both sides of the cardinal extremity of the stimulating electrode structure.In this case, since the cardinal extremity of stimulating electrode structure is fixed on base
On body, and the stimulated side of stimulating electrode structure needs to enter in eyeball (in vitreous chamber) across epibulbar notch, therefore,
It, can be more secured by the matrix side of the cardinal extremity with stimulating electrode structure by the way that three suturing parts of distribution triangular in shape are arranged
Ground is fixed on eyeball.
In addition, in the implanted device of artificial retina according to the present invention, optionally, described matrix is shaped to and institute
State the matched non-closed loop shape of outer profile of eyeball.Thereby, it is possible to so that the matrix of implanted device is preferably bonded in eyeball.
In addition, in the implanted device of artificial retina according to the present invention, optionally, described matrix is in band-like, institute
The side that multiple suturing parts are distributed in described matrix is stated, and the other side of described matrix is fixed by the rectus of the eyeball.By
This, further can be fixed on eyeball by matrix.
In addition, in the implanted device of artificial retina according to the present invention, optionally, the institute that described matrix is covered
The region for stating eyeball is fallen within the scope of a quadrant of the eyeball.Thereby, it is possible to matrix is limited in the proper range of eyeball
It is interior.
Further include being arranged in the thorn optionally in addition, in the implanted device of artificial retina according to the present invention
Swash the loop electrode in the electronic cable of electrode structure.Thereby, it is possible to make the larger loop electrode of area, and will be by
The stimulation circuit that stimulating electrode is formed with loop electrode is limited in the vitreous chamber of specific region such as eyeball.
In addition, in the implanted device of artificial retina according to the present invention, optionally, in the close institute of described matrix
It states on electronic packing body, is additionally provided with stress release portion.In this case, enable the implanted device of artificial retina good
Ground fits in eyeball, and inhibits the accumulation of stress and damaged caused by eyeball.
In addition, another aspect of the present invention also provides a kind of artificial retina comprising：The plant of above-mentioned artificial retina
Enter device；Photographic device is used to capture video image, and the video image is converted into visual signal；Video processing
Device is connect with the photographic device, is had power supply and is handled the visual signal；And transmitting day
Line, by the energy signal provided by the video process apparatus, the visual signal is sent to the reception day with treated
The visual signal received is converted into the electrical stimulation signal by the electronic packing body of line, the implanted device, from
And the gangliocyte of the retina or Beale's ganglion cells are stimulated by the stimulated side of the stimulating electrode structure
And generate light sensation.
In accordance with the invention it is possible to provide it is a kind of can improve implant surgery process and reduce postoperative complications without bandage
Artificial retina implanted device and artificial retina.
Description of the drawings
Fig. 1 shows that the implanted device of the artificial retina involved by embodiments of the present invention is mounted on epibulbar show
It is intended to；
Fig. 2 shows the implanted devices of the artificial retina involved by embodiments of the present invention to be mounted on epibulbar stand
Body schematic diagram；
Fig. 3 shows the schematic top plan view of the matrix involved by embodiments of the present invention；
Fig. 4 is to show that the stereochemical structure including matrix and stimulating electrode structure involved by embodiments of the present invention is shown
It is intended to；
Fig. 5 shows that the stimulating electrode structure involved by embodiments of the present invention fits in the signal of the state of retina
Figure；
Fig. 6 shows the stimulating electrode structure exhibition of the implanted device of the artificial retina involved by embodiments of the present invention
Three-dimensional structure diagram when opening；
Fig. 7 shows the stimulating electrode structure side schematic diagram of the artificial retina involved by embodiments of the present invention；
Fig. 8 shows the signal of the stimulating electrode structure other side of the artificial retina involved by embodiments of the present invention
Figure；
Fig. 9 shows the signal in the section of the stimulating electrode structure of the artificial retina involved by embodiments of the present invention
Figure；
Figure 10 shows that the stimulating electrode structure of the artificial retina involved by embodiments of the present invention is implanted to eyeball
Interior status diagram；And
Figure 11 shows the schematic diagram of the artificial retina involved by embodiments of the present invention.
Label declaration：
The implanted device of 1 ... artificial retina, 2 ... eyeballs, 3 ... external devices, 10 ... matrixes, 10a, 10a1,10a2,
10a3,10a4 ... suturing part, 10b ... stress releases portion, 11 ... electronic packing bodies, 11a ... seal casinghousings, 11b ... substrates, 12 ...
Stimulating electrode structure, 12a ... cardinal extremities, 12b ... electronic cables, the stimulated sides 12c ..., 13 ... reception antennas, 14 ... medical titaniums nail,
21 ... pupils, 22 ... notch, 23 ... vitreums, 120 (121,122,123) ... loop electrode, 124 ... electrod-arrays, stimulation electricity
Pole ... 124a, 126 ... through holes, 125 ... pad arrays, 125a ... pads.
Specific implementation mode
Hereinafter, refer to the attached drawing, explains the preferred embodiment of the present invention in detail.In the following description, for identical
Component assign identical symbol, the repetitive description thereof will be omitted.Scheme in addition, attached drawing is only schematical, the mutual ruler of component
Very little shape of ratio or component etc. can be with actual difference.
Artificial retina involved by embodiments of the present invention can be adapted for retinal pigment degeneration (RP) and old age
Macular degeneration (AMD) visually impaired patient.Specifically, the implantation of the artificial retina involved by embodiments of the present invention
Device 1 is retained by patient intact bipolar by replacing the function of impaired photosensory cell (cone cell, rod cell)
The pathways for vision such as cell, gangliocyte, to generate light sensation in cerebral cortex, the vision of patient is restored in part.In addition, artificial
The implanted device 1 of retina is readily applicable to other retinopathy and leads to the situation blinded, as long as in such view
The pathways for vision such as Beale's ganglion cells, gangliocyte can effectively be retained in film lesion.
Fig. 1 shows that the implanted device 1 of the artificial retina involved by embodiments of the present invention is mounted on eyeball 2
Schematic diagram.Fig. 2 shows the implanted devices 1 of the artificial retina involved by embodiments of the present invention to be mounted on eyeball 2
Stereoscopic schematic diagram.In fig. 2, for convenience of explanation, the perspective view of the Local map and eyeball 2 of reception antenna 13 is depicted.
In the present embodiment, as depicted in figs. 1 and 2, artificial retina implanted device 1 mainly include matrix 10 and
Electronic packing body 11, stimulating electrode structure 12 and the reception antenna 13 being arranged on matrix 10.In addition, the base in implanted device 1
Body 10 can pass through the suture way being for example described later on and be fixed on eyeball 2, and stimulating electrode structure 12 can be via eye
The notch 22 of ball 2 enters in the vitreous chamber of eyeball 2, is close to retina (referring to the Fig. 8 being described later on).
Here, the notch 22 of eyeball 2 can extend along the peripheral direction (corneal limbus) of pupil 21.The length of notch 22 is not
Preferably long, from the point of view of safety, the length of notch 22 is preferably 3mm to 10mm.In addition, between notch 22 and pupil 21
Distance is not particularly limited, such as notch 22 can be with pupil 21 at a distance of 3mm to 8mm.
Under normal circumstances, such as the patients such as retinal pigment degeneration (RP) and age-related macular degeneration (AMD), because
Retinal pigment degeneration (RP) and age-related macular degeneration (AMD) and the decline or death for causing photosensory cell, namely normally regard
Feel that access is hindered because of the lesion of photosensory cell disease, the light for normally entering intraocular can not be transformed into electric signal, caused
Patient blinds.In the implanted device 1 of artificial retina involved by present embodiment, the stimulation of stimulating electrode structure 12
12c (including electrod-array 124) is held to generate electrical stimulation signal (such as providing Bipolar pulse current signal) to ganglia retinae
Cell or Beale's ganglion cells are stimulated (referring to the Fig. 8 being described later on).Due to most of retinal pigment degeneration (RP) and old age
Other pathways for vision of macular degeneration (AMD) patient other than photosensory cell obtain intact reservation, therefore, gangliocyte mostly
Or after Beale's ganglion cells is stimulated, which is transferred to brain skin via intact downstream pathways for vision (optic nerve) is retained
Layer simultaneously generates light sensation, so as to partly restore the vision of patient.
In addition, although above example shows that the stimulated side 12c of stimulating electrode structure 12 is fitted on retina,
It is that the implantation position of the stimulating electrode structure 12 of present embodiment is not limited to the example of above-mentioned " (epiretinal) on retina ".
In other example, the stimulated side 12c of stimulating electrode structure 12 can also be with the side of " (subretinal) under retina "
Formula is arranged namely stimulated side 12c can be arranged between photosensory cell and choroid.In addition, in some other example, stimulation
The stimulated side 12c of electrode structure 12 can also be arranged under choroid, and between choroid and sclera.
Referring again to FIGS. 1, as shown in Figure 1, matrix 10 can be in non-loop-like.In other words, matrix 10 not entirely around
Eyeball 2 and the ring-type being closed, but the only shape of the non-closed loop of a part for covering eyeball 2.Further, matrix 10 is covered in
Eyeball 2 is outer and is fixed on eyeball 2.
In the present embodiment, it as described above, matrix 10 is in non-loop-like, therefore, is filled by the implantation of artificial retina
Setting 1, (including matrix 10 and electronic packing body 11, stimulating electrode structure 12 and reception antenna 13 for being arranged on matrix 10) is fixed
When on eyeball 2, only non-loop-like matrix 10 is covered on eyeball 2 and is bonded with eyeball 2, is not needed at this time as existing
There is technology to need the full conjunctivas and whole 4 internus of suspention of 360 ° of opening eyes like that, therefore, it is possible to substantially reduce pair
The art source of eyeball 2 is damaged.
In the present embodiment, matrix 10 can be fixed on eyeball 2 in a manner of suturing or be bonded.Specifically, one
In a little examples, matrix 10 can be sutured in outside the sclera of eyeball 2 by way of suture by the sewing hole on matrix 10, from
And it is fixed on the outer surface of eyeball 2.In other example, matrix 10 can be by way of bonding for example by matrix
Biogum etc. is coated between 10 and eyeball 2 and is fixed on the outer surface of eyeball 2.
In addition, in some instances, 10 shape of matrix can be about the band-like of quarter circular arc, i.e. matrix 10 is along having in mind
The outer surface of ball 2 is in band-like extension.It in some instances, can be along big with the peripheral direction of pupil 21 in band-like matrix 10
Cause parallel direction be arranged in eyeball 2 outer surface namely band-like matrix 10 it is substantially flat along the peripheral direction with pupil 21
Capable direction extends.
In addition, it is arc-shaped band-like that matrix 10, which can be in both ends,.10 both ends of matrix can be preferably bonded to be arc-shaped
In 2 surface of eyeball, matrix 10 is made to be not susceptible to displacement, dystopy or slippage repulsion etc..
Preferably, matrix 10 can be matched with the outer profile of eyeball 2.Thereby, it is possible to so that 10 seamless unoccupied place of matrix is fitted in
The outer surface of eyeball 2 and the outer surface for being fixed on eyeball 2.Specifically, the matrix 10 for being fixed on the outer surface of eyeball 2 can be with
With the outer profile Curvature Matching of eyeball 2.Here, the curvature for being fixed with the outer profile of eyeball 2 is, for example, close to the maximum straight of eyeball 2
The curvature of path portion.
In addition, the region for the eyeball 2 that matrix 10 is covered can be fallen within the scope of a quadrant of eyeball 2.In this feelings
Under condition, since matrix 10 is limited within the scope of a quadrant of eyeball 2, in the appearance that matrix 10 is fixed on to eyeball 2
It only needs that (such as fixing using suture way) is fixed on the above-mentioned quadrant of eyeball 2 substantially when face, thus, it is possible to
Operating difficulty is substantially reduced, reduces and the art source of eyeball 2 is damaged.In addition, small to the overlay area of eyeball 2 be also beneficial to improve disease
The comfort level of eyeball when people uses implantation equipment.In addition, in some instances, matrix 10 can also cross over several of eyeball 2
Quadrant such as 2 quadrants.
In addition, in the present embodiment, matrix 10 is insulator.The constituent material of matrix 10 is not particularly limited, can be with
It is made of silica gel etc..For example, matrix 10 can be formed by silica gel injection molding.In this case, since silica gel has well
Flexibility and bio-compatibility, therefore, it is possible to make matrix 10 more preferably fit in eyeball 2 and be suitable for being chronically implanted within the eye.
In the present embodiment, as shown in Figure 1, electronic packing body 11 is installed on matrix 10.In some instances, such as
The gum cover for installing electronic packing body 11 is provided on matrix 10, electronic packing body 11 is installed on by being placed in the gum cover
On matrix 10, the gum cover can cover at least a part for electronic packing body 11 at this time.Further, in order to by Electronic Packaging
Body 11 is fixedly mounted on matrix 10, can also be coated between electronic packing body and matrix 10 viscous with bio-compatibility
Connect agent.Here, bonding agent is not particularly limited, and can be silicones, epoxy resin etc..
In addition, the electronic packing body 11 involved by present embodiment at least has the processing circuit for handling electric signal
(not shown).Specifically, electronic packing body 11 may include seal casinghousing 11a and the base that is contained in seal casinghousing 11a
Plate 11b (referring to the Fig. 9 being described later on).In some instances, seal casinghousing 11a by the good metal of bio-compatibility for example
The compositions such as titanium, titanium alloy are consequently formed and have both air-tightness and the good shell of bio-compatibility, to be conducive to seal casinghousing 11a
It is chronically implanted within the eye.
In addition, in some instances, the substrate 11b being contained in seal casinghousing 11a may include printed circuit board (PCB)
And electronic components and application-specific integrated circuit (ASIC), the miniature processing such as resistance, inductance, the capacitance of setting on a printed circuit
Device etc., thus substrate 11b, which is formed with, above-mentioned has processing circuit for handling electric signal.
In the present embodiment, the shape of seal casinghousing 10 is preferably cylindric, but present embodiment is not limited to this,
In some examples, the shape of seal casinghousing 10 can also be in flat column.In addition, the shape of seal casinghousing 10 can also use other
Suitable shape.
In addition, in some instances, the bottom of seal casinghousing 10 has multiple feed-through holes and fills multiple feed-through holes
Multiple feed through pole (not shown).These feed through pole and the cardinal extremity 12a for the stimulating electrode structure 12 being described later on (are specifically welded
Disk array 125) electrical connection.In the present embodiment, the quantity of the feed through pole of electronic packing body 1 includes stimulating electrode structure 12
Stimulated side 12c electrod-array 124 quantity (alternatively referred to as " electrode stimulating channel ") and the loop electrode 120 that is described later on
Quantity.
In the present embodiment, as shown in Fig. 2, reception antenna 13 can be embedded in the inside of matrix 10.That is, receiving day
Line 13 is embedded to the inside of matrix 10, to enable reception antenna 13 and external electrical insulation, it is ensured that reception antenna 13 can
By property.
In addition, reception antenna 13 is 2 D-coil made of being wound by metal wire.In the above example, when matrix 10 is in
When banded structure, reception antenna 13 is arranged along band-like extending direction, thus, it is possible to improve the area coil of reception antenna 13,
Improve the receiving efficiency of reception antenna 13.
In addition, from the point of view of efficiency of transmission and bio-compatibility, the wire coil of reception antenna 13 is preferably by systems such as gold
At.In addition, the winding method of reception antenna 13 is not particularly limited, such as it can be the 2 D-coil wound in the shape of a spiral.
In addition, the reception antenna 13 as 2 D-coil can match with the curvature of matrix 10.That is, in this embodiment party
In formula, matrix 10 is covered in a manner of matching the curvature of eyeball 2 on the outer surface of eyeball 2.In this case, reception antenna
13 also correspondingly follow matrix 10 to be bent.Design in this way, even if being equipped with the implanted device 1 involved by present embodiment
Patient when in use left-right rotation eyes and slightly move the position of matrix 10, reception antenna 13 can also be efficiently received by
The external signal of transmitting antenna 33 (referring to the Figure 11 being described later on) transmission.
In addition, in the present embodiment, reception antenna 13 for example can be from external device (tool by way of wireless coupling
Body is the transmitting antenna 33 being described later on) receive energy signal and data-signal.These energy signals or data-signal (including figure
As information) it is received after antenna 13 receives, it is transferred into electronic packing body 11.In this case, inside electronic packing body 11
Processing circuit obtain above-mentioned energy signal and handled as power supply, and to received data signal, thus produce
Raw electrical stimulation signal (such as the double current impulsing that can be used in stimulating the gangliocyte of retina or Beale's ganglion cells
Signal).
As described above, electronic packing body 11 is electrically connected with stimulating electrode structure 12 and reception antenna 13, form as a result,
From reception antenna 13 to electronic packing body 11 access is electrically connected to stimulating electrode structure 13 again.In some instances, stimulating electrode
Structure 12 (cardinal extremity 12a) and reception antenna 13 can be respectively distributed to the both sides of such as ribbon base 10.By making stimulating electrode
Structure 12 (cardinal extremity 12a) and reception antenna 13 are distributed in the both sides of matrix 10, can inhibit reception antenna 13 and electronic packing body
Interference between 11 (especially internal circuits).
In electronic packing body 11, electronic packing body 11 by the signal received by the reception antenna 13, (such as believe by data
Number) it is converted into electrical stimulation signal.The electrical stimulation signal is transferred into stimulating electrode structure 12 via above-mentioned feed through pole, thorn
Swash electrode structure 12 and electrical stimulation signal is reached into stimulated side 12c from cardinal extremity 12a via electronic cable 12b, passes through fitting as a result,
Gangliocyte or Beale's ganglion cells are stimulated in the stimulated side 12c of retina, to make patient generate light sensation (referring to later
Fig. 5 of description).
Hereinafter, the suture on the matrix 10 and matrix 10 that are more fully described involved by present embodiment with reference to figure 3 and Fig. 4
Portion 10a.Fig. 3 shows the schematic top plan view of the matrix 10 involved by embodiments of the present invention.Fig. 4 shows the present invention
The dimensional structure diagram for including matrix 10 and stimulating electrode structure 12 involved by embodiment.
As shown in Figure 3 and Figure 4, at the edge (surrounding) of matrix 10, it is provided with suturing part 10a.Specifically, matrix 10 wraps
Include multiple suturing part 10a at the edge for being distributed in matrix 10.That is, being provided with suturing part 10a1, suture at the edge of matrix 10
Portion 10a2, suturing part 10a3, suturing part 10a4 and suturing part 10a5.Although there is illustrated above-mentioned 5 suturing part 10a,
Present embodiment is not limited to this, and may be 2 suturing parts, 3 sutures according to the size of matrix 10, implant site etc.
The suturing part of portion or 5 or more.
In addition, in some instances, matrix 10 can be in band-like.In this case, multiple suturing part 10a can be distributed
In the both sides of matrix 10.Thereby, it is possible to inhibit the electronic packing body being arranged on matrix 10 11 to be interfered with each other with reception antenna 13.
In the present embodiment, suturing part 10a can be the protruding portion for having sewing hole.That is, suturing part 10a is that have
Sewing hole 10a and to the outside of matrix 10 protruding portion outstanding.In some instances, matrix 10 is by by multiple suturing parts
10a is seamed to the sclera of eyeball 2 and is fixed on eyeball 2.In other words, pass through above-mentioned suturing part 10a, for example biological sewing needle of use
Matrix 10 is fixed on the sclera of eyeball 2 by line, to make matrix 10 be firmly fixed on eyeball 2.
In addition, in matrix 10, the number close to the suturing part of electronic packing body 11 can be more than close to reception antenna 13
Suturing part number.Specifically, as shown in figure 3, close to 11 position of electronic packing body, it is provided with 4 suturing parts and stitches
Conjunction portion 10a1, suturing part 10a2, suturing part 10a3 and suturing part 10a4 are provided with 1 seam close to the position of reception antenna 13
Conjunction portion 10a5.In this case, since electronic packing body 11 and reception antenna 13 are arranged along the length direction of matrix 10, because
This, matrix 10 is big (center of gravity is more biased towards in electronic packing body 11 in other words) in 11 end weight accounting of close electronic packing body, therefore point
The quantity of suturing part 10a of the cloth in matrix 10 near electronic packing body 11 is more, and thus, it is possible to more securely by matrix
10 are fixed on eyeball 2.
In the present embodiment, as described above, matrix 10 is formed as non-closed loop shape, and matrix 10 is by being distributed in
Suturing part 10a on matrix 10 carries out suture fixation, does not need to need 360 ° to open eyes as prior art at this time
Full conjunctiva, and suspend all 4 eyeball rectus in midair, therefore, it is possible to substantially reduce the art source damage to eyeball 2.In addition, passing through
Above-mentioned suture way fixing base 10 reduces surgical procedure to which matrix 10 is not susceptible to displacement, dystopy or slippage repulsion etc.
Difficulty, and maximally reduced operation wound, patient restores fast.
In addition, around electronic packing body 11, it is disposed with three suturing part 10a of distribution triangular in shape.That is, in base
Around the close electronic packing body 11 of body 10, be disposed with suturing part 10a2, the suturing part 10a3 being distributed in general triangular and
Suturing part 10a4.Wherein, suturing part 10a2 and suturing part 10a3 is arranged in the both sides (ginseng of the cardinal extremity 142 of stimulating electrode structure 12
See Fig. 3).
In this case, three suturing part 10a (suturing part 10a2, suturing part 10a3 and the suture of distribution triangular in shape
Portion 10a4) more stably the end side with electronic packing body 11 can be fixed.In addition, since stimulating electrode structure 12 is from suture
It is drawn between portion 10a2 and suturing part 10a3, therefore, above-mentioned suturing part 10a, which is arranged, also at these positions will inhibit because of operation
It operates stimulating electrode structure in the process and influences the stability of matrix 10.
In addition, being disposed with suturing part 10a5 close to the side of reception antenna 13 in matrix 10.That is, suturing part 10a5 is separate
The side of stimulating electrode structure 12.In matrix 10, what suturing part 10a5 was mainly used for fixing base 10 includes reception antenna 13
Part.In this case, it can reduce to suture matrix 10 and need the suture site being arranged on sclera, thus, it is possible to
Enough reduce damages the art source of sclera.
In addition, in some variations, matrix 10 is in band-like, and multiple suturing part 10a are distributed in the side of matrix 10, and
The other side of matrix 10 is fixed by the rectus of eyeball 2.More specifically, matrix 10 is in band-like, and the wherein side of matrix 10 is by stitching
Conjunction portion 10a is fixed, and the other side is stretched under the rectus of eyeball 2, is fixed by rectus.In this case, the rectus pair of eyeball
The side of matrix 10 is limited and is fixed, and also matrix 10 successfully can be fixed on eyeball 2 as a result,.
In the present embodiment, on the close electronic packing body 11 of matrix 10, it is additionally provided with stress release portion 10b.
In some examples, stress release portion 10b can be the groove for being formed in matrix 10.In this case, even if having on matrix 10
Stress accumulation, since the stress there are the groove, accumulated can be discharged from the groove.Although be described above this implementation
Stress release portion 10b involved by mode is groove, but present embodiment is without being limited thereto, as long as stress release portion 10b can
Mitigate the stress of matrix 10.
Fig. 5 shows the stimulating electrode structure 12 of the implanted device of the artificial retina involved by embodiments of the present invention
Three-dimensional structure diagram when expansion.Fig. 6 shows the stimulating electrode structure of the artificial retina involved by embodiments of the present invention
The schematic diagram of 12 side.Fig. 7 shows the stimulating electrode structure 12 of the artificial retina involved by embodiments of the present invention
The other side schematic diagram.Fig. 8 shows that the stimulating electrode structure 12 involved by embodiments of the present invention fits in retina
State schematic diagram.
In the present embodiment, as shown in Figures 5 to 7, stimulating electrode structure 12 include cardinal extremity 12a, electronic cable 12b and
Stimulated side 12c.Specifically, cardinal extremity 12a and stimulated side 12c are separately positioned on the both ends of stimulating electrode structure 12, electronic cable
12b connections (electrical connection) cardinal extremity 12a and stimulated side 12c.In this case, the electrical stimulation signal energy received by cardinal extremity 12a
It is enough successfully to pass to stimulated side 12c from cardinal extremity 12a along electronic cable 12b, thus the gangliocyte or bipolar to retina
Cell is stimulated.
As shown in figure 5, the cardinal extremity 12a of stimulating electrode structure 12 is connect with electronic packing body 11.Specifically, institute as above
It states, in some instances, the feed through pole of the pad array 125 and electronic packing body 11 of the cardinal extremity 12a of stimulating electrode structure 12
Connection.In addition, the electronic cable 12b and stimulated side 12c of stimulating electrode structure 12 are fixed with electronic packing body 11 from matrix 10
It draws position.
In some instances, stimulating electrode structure 12 can be in strip.Further, in some instances, strip
Stimulating electrode structure 12 can be generally normal with the extending direction of band-like matrix 10.In this case, by by matrix
10 is mutually orthogonal with stimulating electrode structure 12, can not only save implantation space, and the fixation by matrix 10 on eyeball 2
Position can also limit the implantation orientation and position of stimulating electrode structure 12 substantially.
In the present embodiment, after being for example fixed on matrix 10 on the outer surface of eyeball 2 by way of suture,
Stimulating electrode structure 12 can enter the position to be implanted into such as macular area (in retina via the notch 22 on eyeball 2
It entreats recessed).
Here, the pad 125a quantity of the pad array 125 of cardinal extremity 12a is not particularly limited, such as can be in 5 rows 4
Arrange the pad array 125 with 20 pad 125a of arrangement (referring to Fig. 6).Pass through the pad array 125 of cardinal extremity 12a, stimulation
The cardinal extremity 12a of electrode structure 12 can be connect with the feed through pole of electronic packing body 11, and thereby, it is possible to will be by electronic packing body 11
Treated, and signal is successfully transferred to stimulating electrode structure 12.
In addition, the quantity of pad array 125 should include the number of electrodes and loop electrode of above-mentioned electrod-array 124
120 number of electrodes.In other words, the quantity of pad array 125 should be greater than or equal to the number of electrodes of electrod-array 124 and return
The sum of the number of electrodes of path electrode 120.
As described above, in stimulating electrode structure 12, cardinal extremity 12a can be used for receiving electrical stimulation signal.Specifically, such as
Shown in Fig. 6, cardinal extremity 12a can have for receiving the electrical stimulation signal exported by electronic packing body 11 (such as two-way electric current
Pulse signal) pad array 125.That is, the pad array 125 of cardinal extremity 12a is electrically connected with electronic packing body 11, and receive from
The stimulus signal (such as current impulse) that electronic packing body 11 is sent.In some instances, cardinal extremity 12a can be made as rectangle or
The flakes such as circle.
In addition, the stimulated side 12c of stimulating electrode structure 12 may include the electrode array for being placed with multiple stimulating electrode 124a
Row 124 (referring to Fig. 7).Here, the quantity of the stimulating electrode 124a in electrod-array 124 is not particularly limited, such as can be
In 16 stimulating electrode 124a of 4 rows 4 row arrangement.
In the present embodiment, the constituent material of stimulating electrode 124a is not particularly limited, such as electrode 124a can be by
At least one of work as selected from gold, platinum, iridium and its alloy and constitutes.
In addition, as shown in fig. 7, stimulated side 12c is also provided with through hole 126.That is, through hole 126 has run through thorn
Swash end 12c, as a result, using such as medical titanium follow closely by the through hole 126 by stimulating electrode structure 12 (mainly stimulated side
Implantation position such as macular area 12c) being fixed in eyeball 2, and it is close to retina.
In addition, stimulating electrode structure 12 has pliability.In this case, stimulating electrode structure 12 can be easily curved
23 intracavitary of vitreum for rolling over and entering via the notch of eyeball 2 22 eyeball 2, to be close to implantation position such as macular area.
In the present embodiment, electronic cable 12b include the contact conductor being electrically connected with cardinal extremity 12a and stimulated side 12c, with
And cover the flexible insulating layer with bio-compatibility of the contact conductor (referring to Fig. 9).The contact conductor will be for that will stimulate letter
Number it is transmitted to stimulated side 12c from cardinal extremity 12a.On the other hand, contact conductor is wrapped in wherein by flexible insulating layer, and electrode is avoided to draw
Other of line and eyeball location contacts.
In addition, flexible insulating layer is in flexible film-like.In some instances, flexible insulating layer can be used as supporting body, and
And it can also extend to carry the contact conductor in stimulating electrode structure 12, electrod-array 124 and pad array 125.That is, thorn
The main body for swashing electrode structure 12 is made of flexible insulating layer, and contact conductor, electrod-array 124 and pad array 125 are by flexible exhausted
Edge layer covers, and electrod-array 124 and pad array 125 are exposed to flexible insulating layer.
In some instances, the face side in stimulating electrode structure 12 can be arranged (referring to Fig. 5's in electrod-array 124
D1), and the back side in stimulating electrode structure 12 can be arranged in loop electrode 120 (referring to the D2 of Fig. 5).That is, electrod-array
124 and loop electrode 120 be located at two surfaces of stimulating electrode structure 12.However, present embodiment is not limited to this,
In other example, such as electrod-array 124 and loop electrode 120 can also be located at the same side.
In addition, the flexible insulating layer involved by present embodiment can be by being selected from dimethyl silicone polymer (PDMS), polychlorostyrene
For paraxylene (Parylene C), polyimides (Polyimide) when at least one of constitute.
As described above, when the implanted device 1 of the artificial retina of present embodiment is implanted in eyeball, stimulated side 12c
23 intracavitary of vitreum for entering eyeball 2 via the notch 22 on eyeball 2, to which stimulated side 12c is close to the view in eyeball 2
Film (referring to Fig. 8).The electrod-array 124 of stimulated side 12c can be close to the retina in eyeball 2 as a result, and can be to regarding
The gangliocyte of nethike embrane or Beale's ganglion cells provide electrical stimulation signal and are stimulated.
In the present embodiment, as shown in Figure 5 and Figure 6, loop electrode 120 can be disposed with multiple, and multiple circuits
Electrode 120 can be spaced apart along the extending direction of electronic cable 12b.For example, in some instances, in stimulating electrode structure
On 12 electronic cable 12b, there are three loop electrode, that is, loop electrode 121, loop electrode 122 and loop electrodes 123 for setting.Separately
Outside, these three loop electrodes 121,122,123 are spaced apart along the extending direction of electronic cable 12b.
As described above, loop electrode 120 (loop electrode 121, loop electrode 122 and loop electrode 123) is also via electronics
The feed through pole of packaging body 11 and be electrically connected with electronic packing body 11.In this case, when needing the neuromere to retina
When cell or Beale's ganglion cells are stimulated, the stimulating electrode 124a of stimulating electrode structure 12 can be formed with loop electrode 120 to be pierced
Swash circuit.
In the present embodiment, loop electrode 120 is covered by above-mentioned flexible insulating layer, and loop electrode 120 is (in this reality
Apply loop electrode 121,122,123 in mode) it is exposed to flexible insulating layer.
In addition, in some instances, the loop electrode 120 into 23 intracavitary of vitreum of eyeball 2 can be towards eyeball 2
Inside.That is, loop electrode 120 is distributed in the side (back side) far from retina on electronic cable 12b.In such case
Under, the loop electrode 120 far from retina can inhibit logical with stimulating electrode 124a formation stimulations near retina
Road, thus, it is possible to inhibit loop electrode 120 and stimulating electrode 124a to be formed by stimulation access to retina other positions not
Good influence, thereby, it is possible to improve the effect of stimulation to gangliocyte or Beale's ganglion cells.
In addition, the area of loop electrode 120 can be more than the area of stimulating electrode 124a.In this case, circuit electricity
The area of pole 120 is more than the area of stimulating electrode 124a, and thus, it is possible to be formed to stimulate in loop electrode 120 and stimulating electrode 124a
The ability that loop electrode accommodates electronics is improved when access.
In addition, loop electrode 120 can be by gold, platinum, titanium, iridium, titanium nitride, yttrium oxide and their alloy
At least one is constituted.In this case, the service life and bio-compatibility of loop electrode 120 can be improved.
In addition, in some instances, loop electrode 121, loop electrode 122 and the circuit being arranged in electronic cable 12b
Electrode 123 can independently work, that is, be used as mutually independent loop electrode.In addition.In other example, setting exists
Loop electrode 121, loop electrode 122 in electronic cable 12b can connect with loop electrode 123 and form the circuit being connected
Electrode 120.Thereby, it is possible to further increase the electronics carrying capacity of loop electrode 120.
Figure 10 shows the stimulating electrode structure of the implanted device 1 of the artificial retina involved by embodiments of the present invention
12 are implanted to the status diagram in eyeball 2.
In the implanted device 1 of artificial retina involved by present embodiment, as shown in figure 8, by electronic packing body 11
The stimulus signal (such as double current impulsing signal) of generation is thin to ganglia retinae via such as stimulating electrode structure 12
Born of the same parents or Beale's ganglion cells stimulate, and thereby, it is possible to replace causing retina due to retinal pigment degeneration and age-related macular degeneration
The function of the photosensory cell of damage partly restores the vision of patient.
In the present embodiment, on electronic cable 12b, it is disposed with loop electrode 120.It is passed through by electronic cable 12b
Notch 22 on eyeball 2 and when entering in eyeball 2, loop electrode 120 is located at 23 intracavitary of vitreum of eyeball 2 (referring to Figure 10).
Wherein, the symbol S in Figure 10 indicates the approximate location of loop electrode 120.
Specifically, when stimulating electrode structure 12 to be implanted in eyeball 2, it is arranged in the electronics of stimulating electrode structure 12
Loop electrode 120 on cable 12b is located at 23 intracavitary of vitreum of eyeball 2.That is, by the stimulation of stimulating electrode structure 12
When end 12c is fixed on retina and is close to retina, the loop electrode 120 being arranged on electronic cable 12b (specifically includes back
Path electrode 121, loop electrode 122 and loop electrode 123) it is located at 23 intracavitary of vitreum of eyeball 2.Due to stimulating electrode structure 12
Stimulated side 12c also be located in eyeball 2 close to the position of retina, therefore, by the stimulated side 12c (electricity of stimulating electrode structure 12
Pole array 124) the stimulation circuit that is formed with loop electrode 120 is limited in 2 vitreum of eyeball, 23 intracavitary substantially, and by stimulating
Electrode is formed by stimulation circuit with loop electrode and avoids the nerve fiber for being possible to accidentally be stimulated such as face nerve, by
This can inhibit stimulating electrode structure to tissue cause unnecessary nerve electric stimulation, it is ensured that artificial retina it is safe to use.
In the present embodiment, the stimulated side 12c comprising stimulating electrode 124a of stimulating electrode structure 1 is placed on view
The implant site of film is for example close to fovea centralis.
It is generally believed that each receptor of retinal centre recess is connected with an individual Beale's ganglion cells, and it is somebody's turn to do
Beale's ganglion cells is connected with an individual gangliocyte again.Therefore, each cone cell of foveal area has one
The access of brain is directly arrived, this access provides the exact position of input to brain.It therefore, will be involved by present embodiment
The stimulated side 12c of stimulating electrode structure 12 fits in foveal region of retina domain, can more efficiently improve stimulating electrode knot
Stimulation efficiency of the structure to retina.
In addition, the electrod-array 124 being made of multiple stimulating electrode 124a can with the implant site of retina for example regarding
Curvature Matching near nethike embrane central fovea.In this case, multiple stimulating electrode 124a can be made preferably to be pasted with retina
It closes, significantly more efficient stimulation is generated to retina.
In general, before implanted device 1 carries out implant surgery, the vitreum 23 in eyeball 2 is by water white transparency colloid
It constitutes.Vitreum 23 riddles between crystalline lens and retina, has the effects that dioptric, fixed retina.Due to vitreum 23
It is interior there is no blood vessel, needed for nutrition come from aqueous humor and choroid, therefore the metabolism of vitreum 23 is slow, cannot regenerate, if glass
Glass body 23 has defect, then its space will be filled by aqueous humor.Therefore, in some instances, in implant surgery on one side to vitreum
The vitreum of 23 intracavitary is extracted injection substitute such as silicone oil on one side, then intraocular vitreum will be removed at this time, and
It is filled by the substitute injected in the space that the vitreum being removed leaves.It is postoperative soon by be metabolized 23 intracavitary of vitreum will be gradual
It is filled by aqueous humor.
After stimulating electrode structure 12 enters along the notch 22 of eyeball 2 in eyeball 2, the stimulation of stimulating electrode structure 12
End 12c is moved to the macular region of retina (here, surgical procedure omits).It then, will be through for example, by medical titanium nail etc.
It stimulated side 12c is fixed on retina and is close to retina by being arranged the through hole 126 in stimulated side 12c, to stimulate
The electrod-array 124 of end 12c can be close to retina.As shown in Figure 10, the electrod-array 124 of stimulated side 12c is bonded to
Macular region (retinal centre recess).In some instances, stimulating electrode 124a can provide such as Bipolar pulse current letter
Number be used as electrical stimulation signal.Here, there is tissue fluid (such as rooms for the gap between postoperative stimulating electrode 124a and implant site
Water), the electrical stimulation signal provided by stimulating electrode 124a can be conducted via the tissue fluid and gangliocyte to retina or
Electro photoluminescence is carried out with the neighbouring Beale's ganglion cells of gangliocyte.After gangliocyte or Beale's ganglion cells are stimulated, it is formed by
Stimulus signal forms light sensation via pathways for vision in cerebral cortex layer.
In the present embodiment, the loop electrode of the stimulating electrode 124a and electronic cable 12b of one side stimulated side 12c
120 form stimulation circuits, so as to retina gangliocyte or Beale's ganglion cells carry out effective electro photoluminescence；Another party
Face, loop electrode 120 (being specifically loop electrode 121, loop electrode 122 and loop electrode 123) are limited in the glass of eyeball 2
Therefore 23 intracavitary of body is returned by the stimulation that the loop electrode 120 of the stimulating electrode 124a and electronic cable 12b of stimulated side 12c are formed
Roadbed is originally limited in the intracavitary of the glass 23 of eyeball 2, the adverse effect example occurred thus, it is possible to prevent the prior art
Such as face spasm ill-effect.
Hereinafter, with reference to figure 10, the implanted device 1 that artificial retina is briefly described is implanted to typical procedure mistake in eyeball 2
Journey.
First, part bulbar conjunctiva is cut off along corneal limbus, detach fascia bulbi sheath and fully exposes sclera, with hooks such as squint hooks
Abducens and superior rectus are taken, No. 1 silk thread suspention (step S1) is used in combination.
Then, by the matrix 10 of implanted device 1 (including electronic packing body 11, the stimulating electrode knot being arranged on matrix 10
Structure 12 and reception antenna 13) it is implanted to the aponeurosis of investment of eyeball, make the part comprising reception antenna 13 of matrix 10 under musculus rectus lateralis
Across (step S2).
Then, the setting-out for being parallel to corneal limbus at 5mm to 15mm along sclera after temporo upper quadrant corneal limbus marks, and adjusts
Integral basis body 10 and stimulating electrode structure 12 keep its leading edge parallel with corneal limbus and suturing part 10a in the position of 2 outer surface of eyeball
In on previous sclera mark line (step S3).
Then, the sewing hole that suturing part 10a is passed through with biological needlework such as polypropylene suture with needle, is sutured and is fixed on
Scleral surface (step S4).
Finally, restore fascia bulbi sheath and bulbar conjunctiva, be used in combination absorbable thread to be sutured in sclera, and cover implanted device
1 matrix 10 (step S5).
In the surgical procedure of the implanted device of above-mentioned artificial retina, the artificial retina with non-loop-like matrix 10
Implanted device 1 be sutured on eyeball 2 by being distributed in the suturing part 10a of 10 surrounding of matrix.It need to only be beaten in above-mentioned operation
The conjunctiva of required quadrant is opened, suspends 1 to 2 rectus in midair, it is then with biological suture that suprascleral implanted device is (main at required position
If matrix 10) it sutures and is fixed on sclera.It is not only able to reduce the difficulty of surgical procedure as a result, firmly fix
Implanted device 1, and operation wound can be reduced to the maximum extent.
Hereinafter, illustrating that the implanted device 1 of the artificial retina involved by embodiments of the present invention is applied to reference to figure 11
The example of artificial retina.
Figure 11 shows the schematic diagram of the artificial retina involved by embodiments of the present invention.As shown in figure 11, as
Artificial retina (sometimes referred to as " retinal prosthesis system "), in addition to the above-mentioned artificial retina being previously mentioned implanted device 1 it
Outside, further include external part i.e. external device 3.That is, artificial retina (or " retinal prosthesis system ") includes artificial
The implanted device 1 and external device 3 of retina.In artificial retina involved by present embodiment, implanted device 1 with it is external
Equipment 3 can be coupled via wireless mode.That is, the implanted device 1 of artificial retina can be via reception day with external device 3
Line 11 is coupled with transmitting antenna 33.
In the present embodiment, external device 3 includes photographic device 31, video process apparatus 32 and transmitting antenna 33.It takes the photograph
As device 31 is for capturing video image, and video image is converted into visual signal.In some instances, photographic device 31
Can be the equipment with camera function such as video camera, camera.In addition, use for convenience, it can be by small volume
Camera Design on glasses, patient can also be used as photographic device 31 by wearing light glasses with camera function
To capture video image.In addition, photographic device 31 can also use GoogleEtc. realizing.
Video process apparatus 32 is connect with photographic device 31.Video process apparatus 32 has power supply.Such as the power supply
Energy can be transmitted to internal implanted device 1 via the transmitting antenna being described later on by power supply, to which implanted device 1 is supplied
Electricity.In addition, the image captured by photographic device 31 is passed to video process apparatus.Video process apparatus 32 will be by photographic device 31
The visual signal of acquisition is handled.
By the energy signal provided by video process apparatus 32, visual signal (also referred to as " counts transmitting antenna 33 with treated
It is believed that number ") it is sent to the reception antenna 11 of artificial retina implanted device 1.Then, reception antenna 3 again will be by reception antenna 11
The data of reception are transferred to subsequent electronic packing body and are handled, the electrical stimulation signal that will finally be generated by electronic packing body 12
Be transferred to the stimulating electrode 124a of electrod-array 124, so as to retina gangliocyte or Beale's ganglion cells into assassination
Swash.
Although being illustrated to the present invention above in association with drawings and examples, it will be appreciated that above description
The invention is not limited in any way.Those skilled in the art without departing from the true spirit and scope of the present invention may be used
To deform and change to the present invention as needed, these deformations and variation are within the scope of the present invention.
Claims (11)
1. a kind of implanted device of the retinal prosthesis system of no bandage, which is characterized in that
Including：
Matrix is covered on eyeball and is fixed on the eyeball；
Electronic packing body is installed on described matrix, and at least has the processing circuit for handling electric signal；
Stimulating electrode structure has and is connect with the electronic packing body；And
Reception antenna is embedded in described matrix, and is connect with the electronic packing body,
Wherein, described matrix is formed as non-closed loop shape.
2. the implanted device of artificial retina as described in claim 1, which is characterized in that
Described matrix includes multiple suturing parts at the edge for being distributed in described matrix,
Described matrix is fixed on the eyeball by the multiple suturing part to be seamed to the sclera of the eyeball.
3. the implanted device of artificial retina as claimed in claim 2, which is characterized in that
Described matrix is in band-like, and the multiple suturing part is distributed in the both sides of described matrix.
4. the implanted device of artificial retina as claimed in claim 2 or claim 3, which is characterized in that
It is more than of the suturing part close to the reception antenna close to the number of the suturing part of the electronic packing body
Number.
5. the implanted device of artificial retina as claimed in claim 2, which is characterized in that
Around the electronic packing body, three suturing parts of distribution triangular in shape are disposed with, and described in this three
Two in the suturing part both sides for being arranged in the stimulating electrode structure.
6. the implanted device of artificial retina as described in claim 1, which is characterized in that
Described matrix is shaped to and the matched non-closed loop shape of the outer profile of the eyeball.
7. the implanted device of artificial retina as claimed in claim 2, which is characterized in that
For described matrix in band-like, the multiple suturing part is distributed in the side of described matrix, and the other side of described matrix by
The rectus of the eyeball is fixed.
8. the implanted device of artificial retina as described in claim 1, which is characterized in that
The region for the eyeball that described matrix is covered is fallen within the scope of a quadrant of the eyeball.
9. the implanted device of artificial retina as described in claim 1, which is characterized in that
It further include the loop electrode being arranged in the stimulating electrode structure.
10. the implanted device of artificial retina as described in claim 1, which is characterized in that
In described matrix on the electronic packing body, it is provided with stress release portion.
11. a kind of retinal prosthesis system, which is characterized in that
Including：
The implanted device of artificial retina described in any one of claims 1 to 10；
Photographic device is used to capture video image, and the video image is converted into visual signal；
Video process apparatus is connect with the photographic device, is had power supply and is handled the visual signal；
And
Transmitting antenna, by the energy signal provided by the video process apparatus, the visual signal is sent to treated
The reception antenna,
The visual signal received is converted into electrical stimulation signal by the electronic packing body of the implanted device, to logical
Crossing the stimulating electrode structure stimulates retina.
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| CN201810192171.7A CN108310625B (en) | 2016-08-22 | 2016-08-22 | Bandage-free artificial retina system implantation device and artificial retina system |
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| CN201610700140.9A CN106267556B (en) | 2016-08-22 | 2016-08-22 | The implanted device and artificial retina of artificial retina without bandage |
| CN201810192171.7A CN108310625B (en) | 2016-08-22 | 2016-08-22 | Bandage-free artificial retina system implantation device and artificial retina system |
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| CN201610700140.9A Active CN106267556B (en) | 2016-08-22 | 2016-08-22 | The implanted device and artificial retina of artificial retina without bandage |
| CN201710250629.5A Active CN107411875B (en) | 2016-08-22 | 2016-08-22 | Bandage-free artificial retina implantation device |
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|---|---|---|---|---|
| WO2021238415A1 (en) * | 2020-05-27 | 2021-12-02 | 微智医疗器械有限公司 | Implant apparatus, and visual prosthesis having same |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925092A (en) * | 2017-12-18 | 2019-06-25 | 深圳先进技术研究院 | The artificial retina implant of silica gel packaging |
| CN108172553A (en) * | 2018-01-17 | 2018-06-15 | 杭州暖芯迦电子科技有限公司 | A kind of encapsulating structure and its packaging method of retina Using prosthesis chip |
| CN111588984B (en) * | 2020-05-27 | 2021-02-19 | 微智医疗器械有限公司 | Implanted retina electric stimulator and implant thereof |
| CN112569044B (en) * | 2020-12-10 | 2022-09-09 | 北京大学第三医院（北京大学第三临床医学院） | Posterior scleral staphyloma stent |
| CN117839077A (en) * | 2024-03-07 | 2024-04-09 | 超目科技(北京)有限公司 | Nystagmus electrical stimulation device and method of operation thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060235485A1 (en) * | 2001-01-16 | 2006-10-19 | Jerry Ok | Visual prosthesis including enhanced receiving and stimulating portion |
| CN1849993A (en) * | 2006-05-18 | 2006-10-25 | 上海交通大学 | Artificial vision emulation and experiment system |
| EP1772117A1 (en) * | 1997-10-08 | 2007-04-11 | Refocus Ocular, Inc. | Segmented scleral band for treatment of presbyopia and other eye disorders |
| CN1961850A (en) * | 2006-12-07 | 2007-05-16 | 上海交通大学 | Implantable vision prosthesis |
| US20120192416A1 (en) * | 2005-04-28 | 2012-08-02 | Jordan Matthew Neysmith | Flexible Circuit Electrode Array |
| CN104825248A (en) * | 2015-05-25 | 2015-08-12 | 浙江诺尔康神经电子科技股份有限公司 | Artificial retina system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7211103B2 (en) * | 2002-04-11 | 2007-05-01 | Second Sight Medical Products, Inc. | Biocompatible bonding method and electronics package suitable for implantation |
| US8588921B2 (en) * | 2010-11-12 | 2013-11-19 | Second Sight Medical Products, Inc. | Visual prosthesis with an improved electrode array adapted for foveal stimulation |
| CN104013491B (en) * | 2014-05-23 | 2016-03-23 | 浙江诺尔康神经电子科技股份有限公司 | A kind of folding Wicresoft artificial retina microelectrode array |
| CN104873330B (en) * | 2015-06-19 | 2017-06-13 | 浙江诺尔康神经电子科技股份有限公司 | A kind of artificial retina implant |
-
2016
- 2016-08-22 CN CN201810192171.7A patent/CN108310625B/en active Active
- 2016-08-22 CN CN201610700140.9A patent/CN106267556B/en active Active
- 2016-08-22 CN CN201710250629.5A patent/CN107411875B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1772117A1 (en) * | 1997-10-08 | 2007-04-11 | Refocus Ocular, Inc. | Segmented scleral band for treatment of presbyopia and other eye disorders |
| US20060235485A1 (en) * | 2001-01-16 | 2006-10-19 | Jerry Ok | Visual prosthesis including enhanced receiving and stimulating portion |
| US20120192416A1 (en) * | 2005-04-28 | 2012-08-02 | Jordan Matthew Neysmith | Flexible Circuit Electrode Array |
| CN1849993A (en) * | 2006-05-18 | 2006-10-25 | 上海交通大学 | Artificial vision emulation and experiment system |
| CN1961850A (en) * | 2006-12-07 | 2007-05-16 | 上海交通大学 | Implantable vision prosthesis |
| CN104825248A (en) * | 2015-05-25 | 2015-08-12 | 浙江诺尔康神经电子科技股份有限公司 | Artificial retina system |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021238415A1 (en) * | 2020-05-27 | 2021-12-02 | 微智医疗器械有限公司 | Implant apparatus, and visual prosthesis having same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106267556B (en) | 2018-04-10 |
| CN107411875B (en) | 2020-06-02 |
| CN107411875A (en) | 2017-12-01 |
| CN106267556A (en) | 2017-01-04 |
| CN108310625B (en) | 2020-04-03 |
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Address after: 518000 A, 4 building, 3 Ting Wei Industrial Park, 6 Baoan District Road, Xin'an, Shenzhen, Guangdong. Patentee after: Shenzhen Silicon Bionics Technology Co.,Ltd. Address before: 518000 A, 4 building, 3 Ting Wei Industrial Park, 6 Baoan District Road, Xin'an, Shenzhen, Guangdong. Patentee before: SHENZHEN SIBIONICS TECHNOLOGY Co.,Ltd. |