CN206198475U - The stimulating electrode structure and artificial retina of artificial retina - Google Patents
The stimulating electrode structure and artificial retina of artificial retina Download PDFInfo
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- CN206198475U CN206198475U CN201620914790.9U CN201620914790U CN206198475U CN 206198475 U CN206198475 U CN 206198475U CN 201620914790 U CN201620914790 U CN 201620914790U CN 206198475 U CN206198475 U CN 206198475U
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- electrode structure
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Abstract
The utility model provides a kind of stimulating electrode structure of artificial retina, and it includes：Cardinal extremity, it is used to receive electrical stimulation signal；Stimulated side, for being close to intraocular retina, and with the stimulating electrode of multiple output electrical stimulation signal；And electronic cable, its connection cardinal extremity and stimulated side, electrical stimulation signal are transferred to stimulated side, loop electrode are disposed with electronic cable via electronic cable from cardinal extremity, when electronic cable is entered in the vitreous chamber of eyeball through epibulbar otch, loop electrode is located in the vitreous chamber.In the utility model, the stimulation loop that the loop electrode that is arranged in electronic cable is formed with stimulating electrode avoids nerve fiber such as face nerve for being possible to be stimulated by mistake etc., unnecessary nerve electric stimulation is caused to tissue thus, it is possible to suppress stimulating electrode structure, it is ensured that using for artificial retina is safe.
Description
Technical field
The utility model is related to a kind of stimulating electrode structure of artificial retina and artificial retina.
Background technology
In normal vision forming process, the photosensory cell of intraocular retina (including cone cell and retinal rod it is thin
Born of the same parents) outside optical signal is converted into visual signal, visual signal is along the vertical passage of vision successively via the double of retina
Beale's ganglion cell, gangliocyte etc., and be finally collected to optic nerve and pass to the cortex of brain, so as to form light sensation.
In part retinal disease such as retinal pigment degeneration (RP) and age-related macular degeneration (AMD), due to view
Membranochromic pigments denaturation and age-related macular degeneration etc. cause the decline of photosensory cell, and above-mentioned normal pathways for vision is because of the disease of photosensory cell
Become and it is hindered, normally entering the light of intraocular cannot be transformed into visual signal, cause patient to perceive light sensation, and forfeiture is regarded
Feel.Fortunately, Beale's ganglion cells, the god of the retina of the retinal disease patient such as retinal pigment degeneration and age-related macular degeneration
Retained through the function major part such as ganglion cell.At present, artificial retina product by replacing because of retinal pigment degeneration and
The function of the photosensory cell of the retinal damage caused by age-related macular degeneration, for example being produced by using stimulating electrode stimulates letter
Number retinal ganglial cells or Beale's ganglion cells stimulated, and using the intact pathways for vision of other reservations, also can
It is enough to produce light sensation in cerebral cortex such that it is able to recover the vision of patient in part.Just because of artificial retina product is regarded to above-mentioned
The life of Omental lesion patient can bring greatly improvement, and artificial retina is obtained all the more as implantable medical devices in recent years
Pay attention to and develop.
In the implanted device of artificial retina, generally require implanted device set loop electrode so that stimulating electrode with
Loop electrode is formed to stimulate loop and retinal ganglial cells or Beale's ganglion cells is stimulated.In existing artificial retina
Implanted device in, usually loop electrode is arranged on the metal-back of the encapsulating structure of implanted device.
The content of the invention
However, the present inventor etc. has found by long-term practice, in existing artificial retina, encapsulating structure is arranged on
Loop electrode on metal shell is likely to draw unnecessary nerve stimulation, it is possible to which having causes the face of patient to occur taking out
The side effect such as jerk.Although above-mentioned mechanism is not fully apparent from yet at present, the present inventor etc. speculates, in existing artificial retina
Implanted device in, because the loop electrode being arranged on electronic packing body is usually placed in the outside of eyeball and is likely to contact
Or near eye or the muscle of face, therefore, in electro photoluminescence, stimulating electrode is formed with loop electrode and stimulates loop, flows through the thorn
The stimulating current for swashing loop is likely to the nerve stimulated to the facial muscles close with eye, thus causes patient face occur
The side effects such as tic.
The utility model is completed in view of above-mentioned present situation, its object is to provide a kind of suppression face spasm etc. no
The stimulating electrode structure and artificial retina of the artificial retina of necessary neural stimulation.
Therefore, one side of the present utility model provides a kind of stimulating electrode structure of artificial retina, including：Cardinal extremity, its
For receiving electrical stimulation signal；Stimulated side, for being close to intraocular retina, and with the multiple output electro photoluminescence
The stimulating electrode of signal；And electronic cable, its described cardinal extremity of connection and the stimulated side, the electrical stimulation signal is via described
Electronic cable is transferred to the stimulated side from the cardinal extremity, and loop electrode is disposed with the electronic cable, by the electricity
Sub-line cable enters when in the vitreous chamber of the eyeball through the epibulbar otch, and the loop electrode is located at the glass
In glass body cavity.
In the utility model, loop electrode is disposed with electronic cable, and pass through on eyeball by electronic cable
Otch and enter eyeball vitreous chamber in when, loop electrode be located at the eyeball vitreous chamber in, therefore, stimulating electrode
The loop electrode of structure is restricted in the vitreous chamber of eyeball, and is returned by the stimulation that stimulating electrode and loop electrode are formed
Road avoids nerve fiber such as face nerve for being possible to be stimulated by mistake etc., thus, it is possible to suppress stimulating electrode structure to tissue
Cause unnecessary nerve electric stimulation, it is ensured that using for artificial retina is safe.
In addition, in the stimulating electrode structure of the artificial retina involved by the utility model, alternatively, the loop electricity
Pole is towards the inner side of the eyeball.Thereby, it is possible to further ensure that the stimulation formed between stimulating electrode and loop electrode is returned
The nerve of eyeball inner surface is avoided on road, so as to ensure the stimulation safety of the implanted device of artificial retina.
In addition, in the stimulating electrode structure of the artificial retina involved by the utility model, alternatively, the loop electricity
Pole is disposed with multiple, and the plurality of loop electrode is spaced apart along the bearing of trend of the electronic cable.This
In the case of, multiple loop electrodes can be set on the bearing of trend of electronic cable, so as to improve the receiving electronics of loop electrode
Ability.
In addition, in the stimulating electrode structure of the artificial retina involved by the utility model, alternatively, in the stimulation
End, is additionally provided with through hole.The stimulated side of stimulating electrode structure is fixed on view thereby, it is possible to be followed closely for example, by medical titanium etc.
On film and it is close to retina.
In addition, in the stimulating electrode structure of the artificial retina involved by the utility model, alternatively, the electric wire
Cable includes the contact conductor electrically connected with the cardinal extremity and the stimulated side and covers the simultaneous with biology of the contact conductor
The flexible insulating layer of capacitive.In this case, stimulating electrode structure can be made to enter the eye of eyeball along epibulbar otch
In ball.
In addition, in the stimulating electrode structure of the artificial retina involved by the utility model, it is alternatively, described flexible exhausted
Edge layer is in flexible film-like.Thereby, it is possible to facilitate operation of the doctor to stimulating electrode structure, required plant is conveniently implanted to
Enter position.
In addition, in the stimulating electrode structure of the artificial retina involved by the utility model, it is alternatively, described flexible exhausted
Edge layer is constituted by selected from silica gel, at least one gathered in the middle of, polyimides stupid to diformazan, polytetrafluoroethylene (PTFE), polyvinyl alcohol.By
This, can either ensure the flexibility of stimulating electrode structure, it is also possible to ensure the bio-compatibility of stimulating electrode structure.
In addition, in the stimulating electrode structure of the artificial retina involved by the utility model, alternatively, the loop electricity
Area of the area of pole more than the stimulating electrode.Thereby, it is possible to improve the ability that loop electrode accommodates electronics.
Additionally, in the stimulating electrode structure of the artificial retina involved by the utility model, alternatively, the loop electricity
Pole is constituted by selected from least one in the middle of gold, platinum, titanium, iridium, titanium nitride, yttrium oxide and their alloy.Thereby, it is possible to improve
The service life and bio-compatibility of loop electrode.
Another aspect of the present utility model provides a kind of artificial retina, including：Implanted device, it has above-mentioned artificial
The stimulating electrode structure of retina, electronic packing body and reception antenna, the stimulating electrode structure and the reception antenna connect
It is connected to the electronic packing body；Camera head, it is used to capture video image, and the video image is converted into vision letter
Number；Video process apparatus, it is connected with the camera head, is processed with power supply and to the visual signal；
And transmitting antenna, be sent to for the visual signal after the energy signal provided by the video process apparatus and treatment by it
The reception antenna, the visual signal that the electronic packing body of the implanted device will be received is converted into the electricity thorn
Energizing signal, so that gangliocyte or Beale's ganglion cells by the stimulated side of the stimulating electrode structure to the retina
Stimulated and produced light sensation.
According to the utility model, using the teaching of the invention it is possible to provide a kind of artificial view of the unnecessary neural stimulation such as suppression face spasm
The stimulating electrode structure and artificial retina of film.
Brief description of the drawings
Fig. 1 shows that the implanted device of the artificial retina involved by implementation method of the present utility model is arranged on eyeball
Schematic diagram；
Fig. 2 shows that the implanted device of the artificial retina involved by implementation method of the present utility model is arranged on eyeball
Schematic perspective view；
The stimulating electrode structure that Fig. 3 shows involved by implementation method of the present utility model fits in the state of retina
Schematic diagram；
Fig. 4 shows the stimulating electrode knot of the implanted device of the artificial retina involved by implementation method of the present utility model
Three-dimensional structure diagram when structure launches；
Fig. 5 shows that the stimulating electrode structure side of the artificial retina involved by implementation method of the present utility model is illustrated
Figure；
Fig. 6 shows the stimulating electrode structure opposite side of the artificial retina involved by implementation method of the present utility model
Schematic diagram；
Fig. 7 shows the section of the stimulating electrode structure of the artificial retina involved by implementation method of the present utility model
Schematic diagram；
Fig. 8 shows that the stimulating electrode structure of the artificial retina involved by implementation method of the present utility model is implanted to eye
View in ball；
Fig. 9 shows the schematic diagram of the artificial retina involved by implementation method of the present utility model.
Description of reference numerals：
The implanted device of 1 ... artificial retina, 2 ... eyeballs, 3 ... external devices, 10 ... matrixes, 11 ... electronic packing bodies,
11a ... seal casinghousings, 11b ... substrates, 12 ... stimulating electrode structures, 12a ... cardinal extremities, 12b ... electronic cables, 12c ... stimulated sides,
13 ... reception antennas, 14 ... medical titaniums nail, 21 ... pupils, 22 ... otch, 23 ... vitreums, 120 (121,122,123) ... loop
Electrode, 124 ... electrod-arrays, stimulating electrode ... 124a, 126 ... through holes, 125 ... pad arrays, 125a ... pads.
Specific embodiment
Hereinafter, refer to the attached drawing, explains preferred embodiment of the present utility model.In the following description, for
Identical part assigns identical symbol, and the repetitive description thereof will be omitted.In addition, accompanying drawing is schematical figure, part is each other
Size ratio or the shape etc. of part can be with actual difference.
Artificial retina involved by implementation method of the present utility model, go for retinal pigment degeneration (RP) and
Age-related macular degeneration (AMD) visually impaired patient.Specifically, the artificial view involved by implementation method of the present utility model
The implanted device 1 of film has been retained by replacing the function of impaired photosensory cell (cone cell, rod cell) by patient
The pathways for visions such as good Beale's ganglion cells, gangliocyte, so as to produce light sensation in cerebral cortex, the vision of patient is recovered in part.
Additionally, the implanted device 1 of artificial retina is readily adaptable for use in other PVRs and causes the situation of blindness, as long as at this
The pathways for visions such as Beale's ganglion cells, gangliocyte can effectively be retained in the PVR of sample.
Fig. 1 shows that the implanted device 1 of the artificial retina involved by implementation method of the present utility model is arranged on eyeball 2
On schematic diagram.Fig. 2 shows that the implanted device 1 of the artificial retina involved by implementation method of the present utility model is arranged on eye
Schematic perspective view on ball 2.Fig. 3 shows that the stimulating electrode structure 12 involved by implementation method of the present utility model is fitted in and regards
The schematic diagram of the state of nethike embrane.In fig. 2, for convenience of explanation, the Local map of reception antenna 13 and the perspective of eyeball 2 are depicted
Figure.
In the present embodiment, as depicted in figs. 1 and 2, artificial retina implanted device 1 mainly include matrix 10 and
It is arranged on electronic packing body 11 on matrix 10, stimulating electrode structure 12 and reception antenna 13.In addition, the base in implanted device 1
Body 10 can be fixed on eyeball 2 by such as suture way, and stimulating electrode structure 12 can be via the otch 22 of eyeball 2
Into in the vitreous chamber of eyeball 2, and it is close to retina (referring to Fig. 2).
Here, the otch 22 of eyeball 2 can extend along the peripheral direction (corneal limbus) of pupil 21.The length of otch 22 is not
Preferably long, from from the point of view of security, the length of otch 22 is preferably 3mm to 10mm.In addition, between otch 22 and pupil 21
Distance is not particularly limited, and for example otch 22 can be with pupil 21 at a distance of 3mm to 8mm.
In general, for example for the patient such as retinal pigment degeneration (RP) and age-related macular degeneration (AMD), because
Retinal pigment degeneration (RP) and age-related macular degeneration (AMD) and cause the decline or death of photosensory cell, namely normally regard
Feel that path is hindered because of the lesion of photosensory cell disease, it is impossible to which the light that will normally enter intraocular is transformed into electric signal, causes
Patient blinds.In the implanted device 1 of the artificial retina involved by present embodiment, the stimulation of stimulating electrode structure 12
End 12c (electrod-array 124) produces electrical stimulation signal (for example providing Bipolar pulse current signal) to retinal ganglial cells
Or Beale's ganglion cells is stimulated (referring to Fig. 3).Because most of retinal pigment degeneration (RP) and age-related macular degeneration (AMD) are suffered from
Other pathways for visions of person in addition to photosensory cell obtain intact reservation mostly, therefore, gangliocyte or Beale's ganglion cells are pierced
After swashing, the electrical stimulation signal is transferred to cerebral cortex and produces light sensation via intact downstream pathways for vision (optic nerve) is retained,
So as to partly recover the vision of patient.
In addition, although above example shows that the stimulated side 12c of stimulating electrode structure 12 is fitted on retina,
It is that the implantation position of the stimulating electrode structure 12 of present embodiment is not limited to the example of above-mentioned " (epiretinal) on retina ".
In other example, the stimulated side 12c of stimulating electrode structure 12 can also be with the side of " (subretinal) under retina "
Formula is arranged, namely stimulated side 12c can be arranged between photosensory cell and choroid.In addition, in some other example, stimulating
The stimulated side 12c of electrode structure 12 can also be arranged under choroid, and between choroid and sclera.
Fig. 1 is referred again to, as shown in figure 1, matrix 10 can be in non-loop-like.In other words, matrix 10 not entirely around
The ring-type of eyeball 2 and closure, but the only shape of the non-closed loop of a part for covering eyeball 2.It is outer simultaneously that matrix 10 is covered in eyeball 2
It is fixed on eyeball 2.
In the present embodiment, matrix 10 can be fixed on eyeball 2 in the way of suturing or be bonded.Specifically, one
In a little examples, matrix 10 can be to be sutured in outside the sclera of eyeball 2 by the sewing hole on matrix 10 by way of suture, from
And it is fixed on the outer surface of eyeball 2.In other example, matrix 10 can be by way of bonding for example by matrix
Biogum etc. is coated between 10 and eyeball 2 and be fixed on the outer surface of eyeball 2.
In addition, in some instances, the shape of matrix 10 can be about the banding of quarter circular arc, i.e. matrix 10 along having in mind
The outer surface of ball 2 extends in banding.In some instances, can be along big with the peripheral direction of pupil 21 in the matrix 10 of banding
Parallel direction is caused to be arranged in the outer surface of eyeball 2, namely the matrix 10 of banding is substantially put down along the peripheral direction with pupil 21
Capable direction extends.
Preferably, matrix 10 can be matched with the outline of eyeball 2.Thereby, it is possible to be fitted in the seamless unoccupied place of matrix 10
The outer surface of eyeball 2 and it is fixed on the outer surface of eyeball 2.Specifically, the matrix 10 for being fixed on the outer surface of eyeball 2 can be with
With the outline Curvature Matching of eyeball 2.Here, the curvature for being fixed with the outline of eyeball 2 is, for example, straight near the maximum of eyeball 2
The curvature of path portion.
In addition, in the present embodiment, matrix 10 is insulator.The constituent material of matrix 10 is not particularly limited, can be with
It is made up of silica gel etc..For example, matrix 10 can be formed by silica gel injection moulding.In this case, because silica gel has well
Flexibility and bio-compatibility, therefore, it is possible to make matrix 10 more preferably fit in eyeball 2 and be suitable for being chronically implanted within the eye.
In the present embodiment, as shown in figure 1, electronic packing body 11 is installed on matrix 10.In some instances, for example
The gum cover for installing electronic packing body 11 is provided with matrix 10, electronic packing body 11 is installed on by inserting the gum cover
On matrix 10, now the gum cover can covering at least a part for electronic packing body 11.Further, in order to by Electronic Packaging
Body 11 is fixedly mounted on matrix 10, it is also possible to which coating is viscous with bio-compatibility between electronic packing body and matrix 10
Connect agent.Here, bonding agent is not particularly limited, and can be silicones, epoxy resin etc..
In addition, the electronic packing body 11 involved by present embodiment at least has the process circuit for processing electric signal
(not shown).Specifically, electronic packing body 11 can include seal casinghousing 11a and the base being contained in seal casinghousing 11a
Plate 11b (referring to the Fig. 7 being described later on).In some instances, seal casinghousing 11a by the good metal of bio-compatibility for example
Titanium, titanium alloy etc. are constituted, and are consequently formed and are had air-tightness and the good housing of bio-compatibility concurrently, to be conducive to seal casinghousing 11a
It is chronically implanted within the eye.
In addition, in some instances, the substrate 11b being contained in seal casinghousing 11a can include printed circuit board (PCB) (PCB)
And electronic component and application specific integrated circuit (ASIC), the miniature treatment such as resistance, inductance, electric capacity on a printed circuit are set
Device etc., thus substrate 11b be formed with the above-mentioned process circuit with for processing electric signal.
In the present embodiment, the profile of seal casinghousing 10 is preferably cylindric, but present embodiment is not limited to this,
In some examples, the profile of seal casinghousing 10 can also be in flat column.In addition, the profile of seal casinghousing 10 can also use other
Suitable shape.
In addition, in some instances, the bottom of seal casinghousing 10 has multiple feed-through holes and fills multiple feed-through holes
Multiple feed through pole (not shown).These feed through pole (are specifically welded with the cardinal extremity 12a of the stimulating electrode structure 12 being described later on
Disk array 125) electrical connection.In the present embodiment, the quantity of the feed through pole of electronic packing body 1 includes stimulating electrode structure 12
Stimulated side 12c electrod-array 124 quantity (alternatively referred to as " electrode stimulating passage ") and the loop electrode 120 being described later on
Quantity.
In the present embodiment, as shown in Fig. 2 reception antenna 13 can be embedded in the inside of matrix 10.That is, receiving day
Line 13 is embedded to the inside of matrix 10, so that reception antenna 13 can be with external electrical insulation, it is ensured that reception antenna 13 can
By property.
In addition, reception antenna 13 is the 2 D-coil wound by metal wire.In above-mentioned example, when matrix 10 is in
During banded structure, reception antenna 13 is arranged along the bearing of trend of banding, the area coil thus, it is possible to improve reception antenna 13,
Improve the receiving efficiency of reception antenna 13.
In addition, from from the point of view of efficiency of transmission and bio-compatibility, the wire coil of reception antenna 13 is preferably made by gold etc.
Into.In addition, the winding method of reception antenna 16 is not particularly limited, for example can be the 2 D-coil for winding in the shape of a spiral.
In addition, can match with the curvature of matrix 10 as the reception antenna 13 of 2 D-coil.That is, in this embodiment party
In formula, matrix 10 is covered on the outer surface of eyeball 2 in the way of matching the curvature of eyeball 2.In this case, reception antenna
13 also correspondingly follow matrix 10 to bend.By such design, even if the implanted device 1 being provided with involved by present embodiment
Patient when in use left-right rotation eyes and somewhat move the position of matrix 10, reception antenna 13 can also be efficiently received by
The external signal of transmitting antenna 33 (referring to the Fig. 9 being described later on) transmission.
In addition, in the present embodiment, reception antenna 13 for example can be from external device (tool by way of wireless coupling
Body is the transmitting antenna 33 being described later on) receive energy signal and data-signal.These energy signals or data-signal (including figure
As information) received by reception antenna 13 after, be transferred into electronic packing body 11.In this case, inside electronic packing body 11
Process circuit obtain above-mentioned energy signal as power supply, and received data signal is processed, thus produce
Life can be used in the electrical stimulation signal stimulated the gangliocyte of retina or Beale's ganglion cells.
As described above, electronic packing body 11 is electrically connected with stimulating electrode structure 12 and reception antenna 13, thus, form
From reception antenna 13 path is electrically connected to electronic packing body 11 to stimulating electrode structure 13 again.In some instances, stimulating electrode
Structure 12 (cardinal extremity 12a) and reception antenna 13 can be respectively distributed to the both sides of such as ribbon base 10.By making stimulating electrode
Structure 12 (cardinal extremity 12a) and reception antenna 13 are distributed in the both sides of matrix 10, can suppress reception antenna 13 and electronic packing body
Interference between 11 (particularly internal circuits).
In electronic packing body 11, electronic packing body 11 by the signal received by reception antenna 13, (for example believe by data
Number) it is converted into electrical stimulation signal.The electrical stimulation signal is transferred into stimulating electrode structure 12 via above-mentioned feed through pole, thorn
Swash electrode structure 12 and electrical stimulation signal is reached into stimulated side 12c from cardinal extremity 12a via electronic cable 12b, thus, by laminating
Gangliocyte or Beale's ganglion cells are stimulated in the stimulated side 12c of retina, so that patient produces light sensation.
Hereinafter, the stimulating electrode structure 12 involved by present embodiment is illustrated in more detail.Fig. 4 shows this reality
Stereochemical structure when being launched with the stimulating electrode structure 12 of the implanted device 1 of the artificial retina involved by new implementation method
Figure.Fig. 5 shows the stimulating electrode structure side of the artificial retina involved by implementation method of the present utility model (hereinafter referred to as
" rear side ", referring to the D2 of Fig. 4) schematic diagram.Fig. 6 shows the artificial retina involved by implementation method of the present utility model
Stimulating electrode structure opposite side (hereinafter referred to as " face side ", referring to the D1 of Fig. 2) schematic diagram.Fig. 7 shows the utility model
Implementation method involved by artificial retina stimulating electrode structure section schematic diagram.
In fig. 5 and fig., for convenience of explanation, it is illustrated that in eliminate electronic packing body 11.In addition, in this manual,
Make the side including electrod-array 124 of stimulating electrode structure 12 for " face side " i.e. D1, opposite side is (i.e. including loop electrode
120 side) it is " rear side " D2.
In the present embodiment, as shown in Figure 4 and Figure 5, stimulating electrode structure 12 include cardinal extremity 12a, electronic cable 12b and
Stimulated side 12c.Specifically, cardinal extremity 12a and stimulated side 12c are separately positioned on the two ends of stimulating electrode structure 12, electronic cable
12b connects (electrical connection) cardinal extremity 12a and stimulated side 12c.In this case, the electrical stimulation signal energy received by cardinal extremity 12a
It is enough successfully to pass to stimulated side 12c along electronic cable 12b from cardinal extremity 12a, so as to the gangliocyte or bipolar to retina
Cell is stimulated.
As shown in figure 4, the cardinal extremity 12a of stimulating electrode structure 12 is connected with electronic packing body 11.Specifically, as above institute
State, in some instances, the pad array 125 of the cardinal extremity 12a of stimulating electrode structure 12 and the feed through pole of electronic packing body 11
Connection.In addition, the electronic cable 12b and stimulated side 12c of stimulating electrode structure 12 are fixed with electronic packing body 11 from matrix 10
Draw position.
In some instances, stimulating electrode structure 12 can be in strip.Further, in some instances, strip
Stimulating electrode structure 12 can be generally normal with the bearing of trend of the matrix 10 of banding.In this case, by by matrix
10 is mutually orthogonal with stimulating electrode structure 12, can not only save implantation space, and the fixation by matrix 10 on eyeball 2
Position can also limit the implantation orientation and position substantially of stimulating electrode structure 12.
In the present embodiment, after matrix 10 is for example fixed on the outer surface of eyeball 2 by way of suture,
Stimulating electrode structure 12 can enter the position to be implanted into such as macular area (in retina via the otch 22 on eyeball 2
Centre is recessed).
Here, the pad 125a quantity of the pad array 125 of cardinal extremity 12a is not particularly limited, for example, can be in 5 rows 4
Row arrangement with 20 pad arrays of pad 125a 125 (referring to Fig. 5).By the pad array 125 of cardinal extremity 12a, stimulate
The cardinal extremity 12a of electrode structure 12 can be connected with the feed through pole of electronic packing body 11, thereby, it is possible to will be by electronic packing body 11
Signal after treatment is successfully transferred to stimulating electrode structure 12.
In addition, the quantity of pad array 125 should include the number of electrodes and loop electrode of above-mentioned electrod-array 124
120 number of electrodes.In other words, the quantity of pad array 125 should be more than or equal to the number of electrodes of electrod-array 124 and return
The number of electrodes sum of path electrode 120.
As described above, in stimulating electrode structure 12, cardinal extremity 12a can be used for receiving electrical stimulation signal.Specifically, such as
Shown in Fig. 5, cardinal extremity 12a can have for receiving electrical stimulation signal (such as two-way electric current exported by electronic packing body 11
Pulse signal) pad array 125.That is, the pad array 125 of cardinal extremity 12a is electrically connected with electronic packing body 11, and receive from
The stimulus signal (such as current impulse) that electronic packing body 11 sends.In some instances, cardinal extremity 12a can be made as rectangle or
The flakes such as circle.
In addition, the stimulated side 12c of stimulating electrode structure 12 can include being placed with the electrode array of multiple stimulating electrode 124a
Row 124 (referring to Fig. 6).Here, the quantity of the stimulating electrode 124a in electrod-array 124 is not particularly limited, for example, can be
In 16 stimulating electrode 124a of the row arrangement of 4 row 4.
In the present embodiment, the constituent material of stimulating electrode 124a is not particularly limited, and such as electrode 124a can be by
Constituted selected from least one in the middle of gold, platinum, iridium and its alloy.
In addition, as shown in fig. 6, stimulated side 12c is also provided with through hole 126.That is, through hole 126 has run through thorn
End 12c is swashed, thus, using such as medical titanium nail etc. by the through hole 126 by (the mainly stimulated side of stimulating electrode structure 12
Implantation position 12c) being fixed in eyeball 2 such as macular area, and it is close to retina.
In addition, stimulating electrode structure 12 has pliability.In this case, stimulating electrode structure 12 can be easily curved
Roll over and via eyeball 2 otch 22 enter eyeball 2 the chamber of vitreum 23 in, be close to implantation position such as macular area (referring to
Fig. 8 being described later on).
In the present embodiment, electronic cable 12b include electrically connected with cardinal extremity 12a and stimulated side 12c contact conductor, with
And cover the flexible insulating layer (referring to Fig. 7) with bio-compatibility of the contact conductor.The contact conductor is used to stimulate to be believed
Number it is delivered to stimulated side 12c from cardinal extremity 12a.On the other hand, be wrapped in contact conductor wherein by flexible insulating layer, it is to avoid electrode draws
Other location contacts of line and eyeball.
In addition, flexible insulating layer is in flexible film-like.In some instances, flexible insulating layer can as supporting body, and
And can also extend to carry the contact conductor in stimulating electrode structure 12, electrod-array 124 and pad array 125.That is, thorn
The main body for swashing electrode structure 12 is made up of flexible insulating layer, and contact conductor, electrod-array 124 and pad array 125 are by flexible exhausted
Edge layer is covered, and electrod-array 124 and pad array 125 are exposed to flexible insulating layer.
In some instances, electrod-array 124 can be arranged on the face side of stimulating electrode structure 12 (referring to Fig. 4's
D1), and loop electrode 120 can be arranged on the rear side (referring to the D2 of Fig. 4) of stimulating electrode structure 12.That is, electrod-array
124 and loop electrode 120 respectively positioned at stimulating electrode structure 12 two relative surfaces.However, present embodiment is not limited
In this, in other example, such as electrod-array 124 and loop electrode 120 can also be located at the same side.
In addition, the flexible insulating layer involved by present embodiment can be by selected from dimethyl silicone polymer (PDMS), polychlorostyrene
Constituted at least one in the middle of paraxylene (Parylene C), polyimides (Polyimide).
As described above, when the implanted device 1 of the artificial retina of present embodiment is implanted in into eyeball, stimulated side 12c
Enter via the otch 22 on eyeball 2 in the chamber of vitreum 23 of eyeball 2, so that stimulated side 12c is close to the view in eyeball 2
Film (referring to Fig. 3).Thus, the electrod-array 124 of stimulated side 12c can be close to the retina in eyeball 2, and can be to regarding
The gangliocyte of nethike embrane or Beale's ganglion cells provide electrical stimulation signal to be stimulated.
In the present embodiment, as shown in Figure 4 and Figure 5, loop electrode 120 can be disposed with multiple, and multiple loops
Electrode 120 can be spaced apart along the bearing of trend of electronic cable 12b.For example, in some instances, in stimulating electrode structure
On 12 electronic cable 12b, three loop electrodes i.e. loop electrode 121, loop electrode 122 and loop electrode 123 are provided with.Separately
Outward, these three loop electrodes 121,122,123 are spaced apart along the bearing of trend of electronic cable 12b.
As described above, loop electrode 120 (loop electrode 121, loop electrode 122 and loop electrode 123) is also via electronics
The feed through pole of packaging body 11 and electrically connected with electronic packing body 11.In this case, when needing the neuromere to retina
When cell or Beale's ganglion cells are stimulated, the stimulating electrode 124a of stimulating electrode structure 12 can be formed with loop electrode 120 and pierced
Swash loop.
In the present embodiment, loop electrode 120 is covered by above-mentioned flexible insulating layer, and loop electrode 120 is (in this reality
Apply loop electrode 121,122,123 in mode) exposed to flexible insulating layer.
In addition, in some instances, can be towards eyeball 2 into the loop electrode 120 in the chamber of vitreum 23 of eyeball 2
Inner side.That is, loop electrode 120 is distributed on electronic cable 12b the side (rear side) away from retina.In such case
Under, the loop electrode 120 away from retina can suppress stimulating logical with stimulating electrode 124a formation near the vicinity of retina
Road, thus, it is possible to suppress stimulation path that loop electrode 120 and stimulating electrode 124a formed to retina other positions not
Good influence, thereby, it is possible to improve the effect of stimulation to gangliocyte or Beale's ganglion cells.
In addition, the area of loop electrode 120 can be more than the area of stimulating electrode 124a.In this case, loop electricity
Area of the area of pole 120 more than stimulating electrode 124a, stimulates thus, it is possible to be formed in loop electrode 120 and stimulating electrode 124a
The ability that loop electrode accommodates electronics is improved during path.
In addition, loop electrode 120 can be by the middle of selected from gold, platinum, titanium, iridium, titanium nitride, yttrium oxide and their alloy
At least one is constituted.In this case, it is possible to increase the service life and bio-compatibility of loop electrode 120.
In addition, in some instances, loop electrode 121 in electronic cable 12b, loop electrode 122 and loop are arranged on
Electrode 123 can independently work, i.e., as separate loop electrode.In addition.In other example, it is arranged on
Loop electrode 121, loop electrode 122 in electronic cable 12b can connect and be formed the loop being connected with loop electrode 123
Electrode 120.Thereby, it is possible to further improve the electronics carrying capacity of loop electrode 120.
Fig. 8 shows that the stimulating electrode structure 12 of the artificial retina 1 involved by implementation method of the present utility model is implanted into
To the view in eyeball 2.
In the implanted device 1 of the artificial retina involved by present embodiment, as shown in figure 8, by electronic packing body 11
The stimulus signal (such as double current impulsing signal) of generation is thin to ganglia retinae via such as stimulating electrode structure 12
Born of the same parents or Beale's ganglion cells are stimulated, thereby, it is possible to replace causing retina due to retinal pigment degeneration and age-related macular degeneration
The function of the photosensory cell of damage, partly recovers the vision of patient.
In the present embodiment, on electronic cable 12b, it is disposed with loop electrode 120.Passed through by electronic cable 12b
Otch 22 on eyeball 2 and enter when in eyeball 2, loop electrode 120 is located in the chamber of vitreum 23 of eyeball 2.Wherein, in Fig. 8
Symbol S indicate the approximate location of loop electrode 120.
Specifically, when stimulating electrode structure 12 is implanted in eyeball 2, it is arranged in the electronics of stimulating electrode structure 12
Loop electrode 120 on cable 12b is located in the chamber of vitreum 23 of eyeball 2.That is, by the stimulation of stimulating electrode structure 12
When end 12c is fixed on retina and is close to retina, the loop electrode 120 being arranged on electronic cable 12b (is specifically included back
Path electrode 121, loop electrode 122 and loop electrode 123) in the chamber of vitreum 23 of eyeball 2.Due to stimulating electrode structure 12
Stimulated side 12c also be located in eyeball 2 pressing close to the position of retina, therefore, by the stimulated side 12c (electricity of stimulating electrode structure 12
Pole array 124) it is limited in substantially in the chamber of 2 vitreum of eyeball 23 with the stimulation loop of the formation of loop electrode 120, and by stimulating
The stimulation loop that electrode and loop electrode are formed avoids nerve fiber such as face nerve for being possible to be stimulated by mistake etc., by
This can suppress stimulating electrode structure and cause unnecessary nerve electric stimulation to tissue, it is ensured that using for artificial retina is safe.
In the present embodiment, the stimulated side 12c comprising stimulating electrode 124a of stimulating electrode structure 1 is placed on view
The implant site of film is for example near fovea centralis.
It is generally believed that each receptor of retinal centre recess is connected with a single Beale's ganglion cells, and it is somebody's turn to do
Beale's ganglion cells is connected with a single gangliocyte.Therefore, each cone cell of foveal area has one
The path of brain is directly arrived, this path provides the exact position of input to brain.Therefore, by involved by present embodiment
The stimulated side 12c of stimulating electrode structure 12 fits in foveal region of retina domain, can more efficiently improve stimulating electrode knot
Stimulation efficiency of the structure to retina.
In addition, the electrod-array 124 being made up of multiple stimulating electrode 124a can for example be regarded with the implant site of retina
Curvature Matching near nethike embrane central fovea.In this case, multiple stimulating electrode 124a can be made preferably to be pasted with retina
Close, significantly more efficient stimulation is produced to retina.
In general, before implanted device 1 carries out implant surgery, the vitreum 23 in eyeball 2 is by water white transparency colloid
Constitute.Vitreum 23 is riddled between crystalline lens and retina, with effects such as dioptric, fixed retinas.Due to vitreum 23
Interior no blood vessel, the nutrition needed for it comes from aqueous humor and choroid, therefore the metabolism of vitreum 23 is slow, it is impossible to regenerate, if glass
Glass body 23 has defect, then its space will be filled by aqueous humor.Therefore, in some instances, in implant surgery while to vitreum
Vitreum in 23 chambers carries out extraction while injecting substitute such as silicone oil, then now intraocular vitreum will be removed, and
Filled by the substitute injected in the space that the vitreum being removed leaves.It is postoperative soon by the way that be metabolized will gradually in the chamber of vitreum 23
Filled by aqueous humor.
After stimulating electrode structure 12 enters in eyeball 2 along the otch 22 of eyeball 2, the stimulation of stimulating electrode structure 12
End 12c is moved to the macular region (here, surgical procedure is omitted) of retina.Then, will be through for example, by medical titanium nail etc.
Stimulated side 12c is fixed on retina and retina is close to by being arranged on the through hole 126 of stimulated side 12c, so as to stimulate
Holding the electrod-array 124 of 12c can be close to retina.As shown in figure 8, the electrod-array 124 of stimulated side 12c is bonded to Huang
Spot region (retinal centre recess).In some instances, stimulating electrode 124a can provide such as Bipolar pulse current signal
As electrical stimulation signal.Here, the gap between postoperative stimulating electrode 124a and implant site has tissue fluid (such as room
Water), the electrical stimulation signal provided by stimulating electrode 124a can be conducted via the tissue fluid and the gangliocyte to retina or
The Beale's ganglion cells neighbouring with gangliocyte carries out electro photoluminescence.After gangliocyte or Beale's ganglion cells are upset, formed
Stimulus signal forms light sensation via pathways for vision in cerebral cortex layer.
In the present embodiment, the loop electrode of the stimulating electrode 124a and electronic cable 12b of one side stimulated side 12c
120 form stimulation loop such that it is able to which gangliocyte or Beale's ganglion cells to retina carry out effective electro photoluminescence；The opposing party
Face, loop electrode 120 (specifically loop electrode 121, loop electrode 122 and loop electrode 123) is limited in the glass of eyeball 2
In the chamber of body 23, therefore, the stimulation formed by the loop electrode 120 of the stimulating electrode 124a and electronic cable 12b of stimulated side 12c is returned
Roadbed is originally limited in the chamber of glass 23 of eyeball 2, thus, it is possible to prevent the adverse effect example that prior art occurs
Such as face spasm ill-effect.
Hereinafter, the preparation method for easily describing the stimulating electrode structure 12 involved by present embodiment.Retouched in following
In stating, for conventional microelectronics or MEMS manufacturing process, due to belonging to technology well known to those skilled in the art, therefore at this
In repeat no more.
First, formed for example by dimethyl silicone polymer (PDMS), Parylene C by conventional thin-film process
(Parylene C) or polyimides (Polyimide) constitute basalis (step S1).Here thin-film technique for example can be
Chemical vapor deposition etc..In step sl, the thickness of made basalis is, for example, 10 μm to 100 μm.
Then, metal line (step S2) is formed on the base layer.The method for forming metal line in basalis is for example wrapped
Include to form sputtering, plating or electroless plating, evaporation etc., be then etched to form specific wiring pattern.Here, wiring pattern
For example include the distribution patterns of the part of array body.
Then, on the basalis with metal wiring pattern, reuse thin-film technique etc. and formed for example by poly- diformazan
Radical siloxane (PDMS), Parylene C (Parylene C) or polyimides (Polyimide) coating (step S3).
Then, perforate is formed in coating, makes to need the position to form stimulating electrode to expose (step S4).Here, substrate
Layer together forms flexible insulating layer with coating.
Finally, formed with 3D shape in the position for needing to form stimulating electrode by plating or electroless mode
Stimulating electrode (step S5).Here, by controlling plating or electroless time, can control what three-dimensional stimulating electrode was formed
Electrode height.In general, the formation time by being uniformly controlled all stimulating electrodes, can form with roughly the same height
Three-dimensional stimulating electrode.
Hereinafter, illustrate that the stimulating electrode structure 2 involved by implementation method of the present utility model is applied to artificial retina
Example.
Fig. 9 shows the schematic diagram of the artificial retina involved by implementation method of the present utility model.As shown in figure 9, making
It is artificial retina (sometimes referred to as " retinal prosthesis system "), except the implanted device 1 of the above-mentioned artificial retina being previously mentioned
Outside, it is external device 3 also including external part.That is, artificial retina (or " retinal prosthesis system ") includes people
The implanted device 1 and external device 3 of work retina.In the artificial retina involved by present embodiment, implanted device 1 and body
External equipment 3 can be coupled via wireless mode.That is, the implanted device 1 of artificial retina can be via reception with external device 3
Antenna 11 is coupled with transmitting antenna 33.
In the present embodiment, external device 3 includes camera head 31, video process apparatus 32 and transmitting antenna 33.Take the photograph
As device 31 is used to capture video image, and video image is converted into visual signal.In some instances, camera head 31
Can be such as video camera, camera etc. of the equipment with camera function.In addition, use for convenience, can be by small volume
Camera Design on glasses, patient can also be used as camera head 31 by wearing the light glasses with camera function
To capture video image.In addition, camera head 31 can also use GoogleEtc. realizing.
Video process apparatus 32 are connected with camera head 31.Video process apparatus 32 have power supply.Such as power supply
Energy can be transmitted to internal implanted device 1 by power supply via the transmitting antenna being described later on, so that implanted device 1 is supplied
Electricity.In addition, being passed to video process apparatus by the image that camera head 31 is captured.Video process apparatus 32 will be by camera head 31
The visual signal of acquisition is processed.
The energy signal that transmitting antenna 33 will be provided by video process apparatus 32 (also referred to as " is counted with the visual signal after treatment
It is believed that number ") it is sent to the reception antenna 11 of artificial retina implanted device 1.Then, reception antenna 3 again will be by reception antenna 11
The data of reception are transferred to follow-up electronic packing body and are processed, the electrical stimulation signal that will finally be produced by electronic packing body 12
It is transferred to the stimulating electrode 124a of electrod-array 124 such that it is able to which gangliocyte or Beale's ganglion cells to retina enter to assassinate
Swash.
Although being illustrated to the utility model above in association with drawings and Examples, it will be appreciated that above-mentioned
Illustrate not limit the utility model in any form.Those skilled in the art are without departing from connotation of the present utility model and model
The utility model can be deformed and changed as needed in the case of enclosing, these deformations and change are each fallen within this practicality newly
In the range of type.
Claims (10)
1. the stimulating electrode structure of a kind of artificial retina, it is characterised in that
Including：
Cardinal extremity, it is used to receive electrical stimulation signal；
Stimulated side, for being close to intraocular retina, and with the stimulating electrode of the multiple output electrical stimulation signal；
And
Electronic cable, its described cardinal extremity of connection and the stimulated side, the electrical stimulation signal is via the electronic cable from described
Cardinal extremity is transferred to the stimulated side,
In the electronic cable, loop electrode is disposed with, and
When the electronic cable is entered in the vitreous chamber of the eyeball through the epibulbar otch, the loop
Electrode is located in the vitreous chamber.
2. the stimulating electrode structure of artificial retina as claimed in claim 1, it is characterised in that
The loop electrode is towards the inner side of the eyeball.
3. the stimulating electrode structure of artificial retina as claimed in claim 1 or 2, it is characterised in that
The loop electrode is disposed between multiple, and bearing of trend of the plurality of loop electrode along the electronic cable
Every distribution.
4. the stimulating electrode structure of artificial retina as claimed in claim 1, it is characterised in that
In the stimulated side, through hole is additionally provided with.
5. the stimulating electrode structure of artificial retina as claimed in claim 1, it is characterised in that
The electronic cable includes that the contact conductor electrically connected with the cardinal extremity and the stimulated side and the covering electrode draw
The flexible insulating layer with bio-compatibility of line.
6. the stimulating electrode structure of artificial retina as claimed in claim 5, it is characterised in that
The flexible insulating layer is in flexible film-like.
7. the stimulating electrode structure of artificial retina as claimed in claim 6, it is characterised in that
The flexible insulating layer by selected from silica gel, gather, polyimides stupid to diformazan, polytetrafluoroethylene (PTFE), in the middle of polyvinyl alcohol extremely
A kind of few composition.
8. the stimulating electrode structure of artificial retina as claimed in claim 1, it is characterised in that
Area of the area of the loop electrode more than the stimulating electrode.
9. the stimulating electrode structure of artificial retina as claimed in claim 1, it is characterised in that
The loop electrode is constituted by selected from least one in the middle of gold, platinum, titanium, iridium, titanium nitride.
10. a kind of artificial retina, it is characterised in that
Including：
Implanted device, it has stimulating electrode structure, the electronics of the described artificial retina of any one of claim 1 to 9
Packaging body and reception antenna, the stimulating electrode structure and the reception antenna are all connected to the electronic packing body；
Camera head, it is used to capture video image, and the video image is converted into visual signal；
Video process apparatus, it is connected with the camera head, is processed with power supply and to the visual signal；
And
Transmitting antenna, be sent to for the visual signal after the energy signal provided by the video process apparatus and treatment by it
The reception antenna,
The visual signal that the electronic packing body of the implanted device will be received is converted into the electrical stimulation signal, from
And the gangliocyte of the retina or Beale's ganglion cells are stimulated by the stimulated side of the stimulating electrode structure
And produce light sensation.
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| CN201620914790.9U CN206198475U (en) | 2016-08-22 | 2016-08-22 | The stimulating electrode structure and artificial retina of artificial retina |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334258A (en) * | 2016-08-22 | 2017-01-18 | 深圳硅基仿生科技有限公司 | Stimulating electrode structure of artificial retina and artificial retina |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334258A (en) * | 2016-08-22 | 2017-01-18 | 深圳硅基仿生科技有限公司 | Stimulating electrode structure of artificial retina and artificial retina |
| CN106334258B (en) * | 2016-08-22 | 2019-01-18 | 深圳硅基仿生科技有限公司 | The stimulating electrode structure and artificial retina of artificial retina |
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Address after: 518000 A, 4 building, 3 Ting Wei Industrial Park, 6 Baoan District Road, Xin'an, Shenzhen, Guangdong. Patentee after: Shenzhen Silicon Bionics Technology Co.,Ltd. Address before: 518000 A, 4 building, 3 Ting Wei Industrial Park, 6 Baoan District Road, Xin'an, Shenzhen, Guangdong. Patentee before: SHENZHEN SIBIONICS TECHNOLOGY Co.,Ltd. |
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