CN1954835A - Sea-buckthorn plant preparation and its preparation method - Google Patents
Sea-buckthorn plant preparation and its preparation method Download PDFInfo
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- CN1954835A CN1954835A CNA2006101508647A CN200610150864A CN1954835A CN 1954835 A CN1954835 A CN 1954835A CN A2006101508647 A CNA2006101508647 A CN A2006101508647A CN 200610150864 A CN200610150864 A CN 200610150864A CN 1954835 A CN1954835 A CN 1954835A
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Abstract
A medicine for preventing and treating diseases and nourishing human body by promoting micro-circulation and blood circulation, providing 208 bioactive substances, repairing damaged organ and tissue, decreasing fat, etc is proportionally prepared from white gourd, champignon, propolis, liquourice root, seabucklthorn fruit, zinc lactate, oligose, active composite enzymic acid, taurine and auxiliary. Its preparing process is also disclosed.
Description
(1) technical field
The present invention relates to the nutrient and healthcare products field, particularly a kind of seabuckthorn plant preparation that sub-health population takes and preparation method thereof that is suitable for.
(2) background technology
Along with the continuous quickening of rhythm of life, sub-health population is just increasing with the form of advancing by leaps and bounds.People also strengthen day by day to the demand of nutrient and healthcare products simultaneously, and especially to nourishing human body, the demand that has the nutrient and healthcare products of certain prevention and therapeutical effect again strengthens increasingly.And health product in the market are various in style, but can collect prevention, treatment, nourishing is rare for the health product of one, especially at present few especially at the health product of the sub-health population of large contingent, and most health product have only played clear effect in the process of reconciling human body, DeGrain, while Hippophae medicinal and edible plant, though the product of general Fructus Hippophae also contains multiple nutrients composition and active substance, but it can not be transported to the partes corporis humani with these nutritions and active speciality fast, these products can only play the effect of benefit in human body, but do not possess function clearly, therefore, lack very much a kind of can playing simultaneously clearly on the market, transfer, mend the health product of effect.
(3) summary of the invention
The object of the present invention is to provide and a kind ofly collect prevention, treatment, nourish to one and can in the process of adjusting body, reach clearly, transfer, mend and carry out effect simultaneously and have seabuckthorn plant preparation of antitumaous effect and preparation method thereof.
The object of the present invention is achieved like this: the seabuckthorn plant preparation is to be restrained with adjuvant 8-30 by Fructus Benincasae 2-8 gram, Lentinus Edodes 2-8 gram, propolis 1-6 gram, Radix Glycyrrhizae 1-6 gram, Fructus Hippophae stock solution 40-70 gram, zinc lactate 1-5 gram, oligosaccharide 1-5 gram, active compound enzyme acid 2-8 gram, taurine 5-20 gram.
The manufacture method of seabuckthorn plant preparation of the present invention is:
1, Fructus Benincasae 2-8 gram, Lentinus Edodes 2-8 gram and Radix Glycyrrhizae 1-6 gram are cleaned and arrangement, boil with 10-12 times of weight decocting and carried out extraction first time in 1-2 hour and make extracting solution;
2, extracting solution being added again 8-10 weight decocting boils to carry out in 1-2 hour extracting the second time and makes extracting solution;
3, extracting solution is concentrated into magma;
4, magma and propolis 1-6 gram, Fructus Hippophae stock solution 40-70 gram, zinc lactate 1-5 gram, oligosaccharide 1-5 gram, active compound enzyme acid 2-8 gram, taurine 5-20 gram and adjuvant 8-30 gram are mixed and dry;
5, the oven dry back is pulverized and is granulated, and sterilizes after the packing.
The present invention also has some technical characterictics like this:
1, described active compound enzyme acid comprises vitamin B group, vitamin C, vitamin E and calcium, ferrum, zinc, selenium and the aminoacid in the water soluble vitamins.
2, the relative density of described magma is 1: 1.25-2;
3, described oven dry control temperature was dried 4-5 hour at 70-80 ℃.
Elder generation was with Fructus Benincasae when the present invention prepared; Lentinus Edodes and Radix Glycyrrhizae are cleaned and arrangement; decocted 1-2 hour with 10-12 times of water gaging; it is extracted obtain extracting solution; extracting solution is added 8-10 times of water gaging again to be decocted 1-2 hour; it is carried out the second time extracts; extracting solution filtrate is concentrated into magma; the relative density of magma is 1: 1.25-2; from Fructus Hippophae, extract stock solution; will be by the vitamin B group in the water soluble vitamins; vitamin C; natural complex and calcium such as vitamin E; ferrum; zinc; selenium and part aminoacid are made active compound enzyme acid; with magma and propolis; Fructus Hippophae stock solution; zinc lactate; oligosaccharide; active compound enzyme acid; taurine and adjuvant mix; mix the back oven dry; oven dry control temperature is at 70-80 ℃; dry and add adjuvant and the pulverizing of making electuary after 4-5 hour; pulverize the back and cross the granulation of 100 mesh sieves, the sub-packing of 20 mesh sieves is crossed in the back of granulating, and sterilizes after the packing.When preparing, the present invention also magma can be mixed with propolis, Fructus Hippophae stock solution, zinc lactate, oligosaccharide, active compound enzyme acid, taurine and adjuvant; adding the adjuvant of making solvent after the mixing stirs; stir the back allotment and purify bottling; promptly can be made into the solvent packing; therefore, the present invention can add different auxiliary material in the preparation and makes products such as electuary, solvent, potus.
The science and technology prescription of seabuckthorn plant electuary of the present invention is a kind of high-tech product that forms after the basis of biological preparation and the scientific and reasonable proportioning of Fructus Hippophae, it can get through microcirculation fast in moment, 208 kinds of bioactive substances of simultaneously that Fructus Hippophae among the present invention is contained needed by human body are in time delivered to corresponding position, subhealth state people obeys the back also quick dredging vascellum in 5-20 minute, blood circulation promoting, the effect of fat melting, blood fat reducing; But have effects such as the metabolism of enhancing body, the cell debris of repairing impaired internal organs, branch toxolysin, removing organism metabolism rubbish and death, balance endocrine simultaneously again.Common biological formulation products has only played clear effect in the process of reconciling human body, and seabuckthorn plant electuary of the present invention can reach clearly, transfers, mend the effect of carrying out simultaneously in the process of adjusting body.
Be rich in nutritions such as multivitamin, linoleic acid, flavone compound, phospholipids compounds, phytosterin compound, various trace elements and protein in the Fructus Hippophae stock solution.Wherein flavone compound has effects such as bringing high blood pressure down, prevent cholesterol in atherosclerosis, reduction blood viscosity, the reduction blood, raising high density lipoprotein level Pseudobulbus Bletillae (Rhizoma Bletillae) removing blood wall deposit, coronary blood flow increasing and enhancing cardiac function.Fructus Hippophae flavone can also play arrhythmia by removing reactive oxygen free radical, resists myocardial ischemia, allevating angina pectoris and improve the effect of cardiac function.Active ingredient in the Fructus Hippophae also has tangible active anticancer and antitumor action, and the intravital cancerous cell of people is had certain resistancing action, but also can alleviate the toxic and side effects of chemicotherapy by the autoimmune function that improves the cancer patient; The Radix Glycyrrhizae sweet in the mouth is flat, have QI invigorating and in, the effect of heat-clearing and toxic substances removing, expelling phlegm for arresting cough and relieving spasm to stop pain; Active compound enzyme acid is a kind of active compound enzyme acid that multiple sour matter is polymerized, it can promote the blood of human body circulation fast, dredging vascellum, get through microcirculation, and can be transported to the partes corporis humani to the multiple nutrients composition in the product fast, can make health reaction occur significantly adjusting within 5-20 minute; The elite of propolis collection animals and plants has complexity and the unique chemical composition, includes 20 big classes kind of nutrition surplus in the of totally three hundred, and it all has good conciliation effect to diabetes, tumor, multiple inflammation, germ disease etc.; Oligosaccharide is to adjust the flora structure, can keep the intestinal home, reconciles function of intestinal canal, improve the body health level; ) Main Ingredients and Appearance of zinc lactate is zinc, participates in the synthetic of 18 kinds of enzymes of human body, can human activin 80 plurality of enzymes, also participate in the activity of multiple cofactors; Taurine is two carbon unstructuredness sulfur-containing amino acid; claim 2-aminoethyl sulfonic acid again; taurine belongs to semi-dispensable amino acid; participate in the metabolism and the growth promoter of human body; though human body can synthesize, in the body condition anxiety, often lack, can have influence on growth promoter, vision, heart and brain in case lack taurine; taurine lacks it and also the optical fundus retinopathy can take place the original very strong inhibitory action of spinal nerves simultaneously.Taurine has restitution to the damaged cell of liver, can impel the recovery of liver function, also can strengthen the contractility of scheming, helps the output of heart blood, alleviates the damage of scheming ischemia, resists the effect of scheming disorder in addition; The Lentinus Edodes QI invigorating is not hungry, control the wind removing blood stasis, its Main Ingredients and Appearance contains glutamic acid, threonine, L---aspartic acid, serine, alanine, isoleucine, liver dew alcohol etc., have anti-inflammation, strong taste are aid digestion, the effect of vigorate qi and replenish the blood, can get through microcirculation fast, create good interior environment, accelerated the speed of body removing metabolism rubbish simultaneously, it is crucial that Lentinus Edodes extract is that seabuckthorn plant electuary of the present invention takes effect rapidly, its useful effect has: 1, can dredge blood vessels fast, antioxidation is removed rubbish in the blood; But 2 rheumatisms are treated arthromyodynia, anti-hepatitis, cardiovascular diseases; 3, have antitumaous effect, to gastric cancer, cervical cancer; Fructus Benincasae has the diuresis antiinflammatory, asks the effect of thermal detoxification that cough with asthma, dysentery, edema, beriberi, gonorrhea, summer-heat unhappiness, heatstroke etc. are had certain effect, is the body toxin expelling, the part of mediation body; The Main Ingredients and Appearance of active compound enzyme acid is natural complex such as the vitamin B group, vitamin C, vitamin E in the water soluble vitamins and calcium, ferrum, zinc, selenium and aminoacid partly; it mainly act as powerful antioxidation, protection internal organs, decompose toxin in the body and metabolism rubbish, the metabolic ability of enhancing body; cardiovascular and cerebrovascular vessel, liver, digestive system, immune system all there are fabulous curative effect, dyspepsia, arteriosclerosis, hypertension, senile dementia, anemia etc. are all had fabulous auxiliary opsonic action.
Beneficial functional of the present invention has:
1, prevent and treat cardiovascular disease:
Lentinus Edodes extract in the seabuckthorn plant electuary of the present invention, β-sitoesterol, streptokinase, betanin, active compound enzyme acid isoreactivity material, functions for the treatment of hyperlipidemia, hypertension, vessel softening, prevent and treat arteriosclerosis, lower blood viscosity, anticoagulant, improve blood circulation, cholesterol reducing, triglyceride improve high density lipoprotein, reduce low density lipoprotein, LDL, strengthen and improve cardiac function.Seven kinds of flavone compounds-as isorhamnetin, Quercetin, but allevating angina pectoris, coronary blood flow increasing increases scheming nutritional blood flow amount, reduces the scheming oxygen consumption.Suppress platelet aggregation, promote outer flow of calcium ions of myocardial cell and intracellular calcium store to discharge the effect of calcium.
The present invention is particularly remarkable to the ischemic cardiovascular effect, coronary heart disease, angina pectoris, scheming infarction, arrhythmia, scheming ischemia, anoxia, heart failure, atrial fibrillation there is fabulous preventive and therapeutic effect, also scheming inflammation, rheumatic heart disease, chronic cardiac insufficiency are had better curative effect simultaneously, can improve cardiac function: alleviate breast suppress, uncomfortable in chest, breathe hard, cardiopalmus, symptom such as nervous.
2, control cerebrovascular disease:
Fructus Hippophae total flavones in the seabuckthorn plant electuary of the present invention can directly be removed oxygen-derived free radicals and hydroxy radical, can reduce hypertension, hyperlipidemia, reduction blood viscosity, suppress platelet and excessively assemble, and vessel softening promotes brain to support blood supply.Synergism such as its streptokinase, compound sour enzyme, zinc lactate have been accelerated cleaning and the reparation to cardiovascular and cerebrovascular vessel.
The present invention to cerebral ischemia, cerebral thrombosis, cerebral infarction, cerebral arteriosclerosis and the headache, dizziness, slurred speech, the trick that cause thus send out cold, numb, be slow in action, myasthenia of limbs, movable stiff paralysis, aphasia, brain atrophy, dementia etc. all have good rehabilitative action.
3, reconcile metabolism and immune system:
Biological activities such as Fructus Hippophae total flavones all have in various degree conciliation effect to immune too many levels.Anti-allergic effects is arranged, improve the huge function of biting, increase the content of serum lysozyme, strengthen the nonspecific immunity function.Activated T cell, K, L cell, pair cell immunity and humoral immunization too many levels, multilevel conciliation effect are remarkable.Lentinus Edodes in the compound nutrients, the compound sour enzyme of Fructus Benincasae etc. accelerated the reparation and the mediation of nephridial tissue have been promoted the nucleic acid metabolism of Fructus Hippophae flavone to nephridial tissue, thereby accelerated the recovery of renal function, function of five internal organs got recover, and immunologic function is recovered and strengthened.
4, antitumor, anticancer:
Because V
C, V
E, vitamin such as beta-carotene reasonable assembly extremely strong antitumor action is arranged, white anthocyanidin, guassin, coumarin, 5-hydroxy tryptamine ... wait to have tangible antitumaous effect. the biological activity in the Fructus Hippophae not only can suppress, kill and wound cancerous cell, simultaneously can improve cancer patient's autoimmune function, alleviate put, the toxic and side effects of chemotherapy.Directly suppress cell, the carcinogenic disease factor of blocking-up, suppress tumor growth, especially can kill and wound Human Gastric Cancer cell strain and lymphocytic leukemia cell.Mechanism is coumarin, isocoumarin, furocoumarin, guassin, multiple phenols, 5-hydroxy tryptamine, comprehensive anticancer, the tradition cancer therapy drug kills and wounds cancerous cell, also injured simultaneously cell, human immunity function is descended, and 190 various active material synergistic activation human body recognition systems in the Fructus Hippophae, killing cancer cell reaches purpose anticancer, anti-cancer.Take a tonic or nourishing food to build up one's health simultaneously that mill board seabuckthorn plant electuary can be removed in the blood, toxin and drift in the tissue, make faster, better in the performance of anticancer aspect effect of various anti-cancer active matters in the Fructus Hippophae.
5, treatment respiratory system disease:
The synergism of the active compound dark plum in the seabuckthorn plant electuary of the present invention, zinc lactate etc. has more been accelerated the reparation of disappearing of inflammation and lung tissue, because flavone compound has antiinflammatory, promotes the capillary blood Circulation, the present invention has relieving cough and asthma, moistening the lung and resolving phlegm, to chronic pharyngitis, bronchitis, laryngopharynx swelling and pain, asthma, cough ant phlegm etc. have fine effect.
6, treatment digestive system:
Seabuckthorn plant electuary of the present invention is having fabulous effect to dyspepsia, abdominal distention, stomach discomfort, gastritis, gastric and duodenal ulcers, enteritis, chronic constipation under the effect of mediation gastrointestinal fast.Contain a large amount of aminoacid, organic acid, chlorogenic acid, phenolic compound in the Fructus Hippophae, can promote the generation of gastric juice, stimulate the secretion of gastric juice, the reparation of accelerate gastrointestinal mucosa, the synergism of the Fructus Benincasae in the plant electuary, Lentinus Edodes, name month grass, streptokinase, active compound sour enzyme etc. has been accelerated the reparation and the cleaning of wound surface greatly simultaneously, shorten the conditioning time three to four-fold, accelerated the rehabilitation of body.
7, protect the liver, hepatoprotective:
Contain VC, various phenolic compound in the Fructus Hippophae of the present invention, anti inflammatory detoxication function is preferably all arranged, oxalic acid in the organic acid, malic acid etc. have the toxicity of alleviating antibiotic, other drug and various noxious substances, and phospholipids compounds and 190 various active compositions all have the effect that promotes the cell growth.The cell membrane growth has facilitation, so the present invention can promote cellular metabolism, improve liver function, while anti-fatty liver, anti-liver cirrhosis.
8, antiinflammatory life, promotion tissue regeneration:
Oleum Hippophae oral administration and externally in the seabuckthorn plant electuary of the present invention all has fabulous curative effect to radiation damage, burn, scald, decubital ulcer, mucositis, endocervicitis, cervical erosion and gastric and duodenal ulcers, wound, the perforation of ear drum.Under the synergism of Lentinus Edodes, Fructus Benincasae, zinc lactate, bright moon grass, active compound dark plum etc., because Oleum Hippophae viscosity is big, can make wounded tissue cell regeneration, promote wound tissue's liquid, blood oozes out and cellular infiltration, especially beta-carotene, carotenoid, sitosterol, VE, unsaturated fatty acid, can promote body metabolism, be beneficial to the reparation of cell tissue, can strengthen the antiinflammatory action at inflammation center.
9, nourishing the brain and improving intelligence, promotion upgrowth and development of children:
The present invention can improve children's intelligence level and respond, keeps vigorous energy, vigor, makes children ' s healthy growth.The several amino acids that is rich in the Fructus Hippophae, multivitamin, trace element, unsaturated fatty acid, phosphatide cpd are that upgrowth and development of children is essential.
10, defying age, nourishing skin, wrinkle resistant, beauty treatment:
Old and feeble peroxidation with substance in vivo has substantial connection.The flavone compound that contains in the Fructus Hippophae is directly caught superoxide radical.VE, VC, superoxide dismutase (SOD) have fabulous antioxidation.The effect of the free radical of removing is also arranged.Can strengthen immune function of human body, reconcile immunologically competent cell, help improving the human body resistance against diseases.
Therefore, seabuckthorn plant electuary of the present invention all has significant protective effect to heart, liver, spleen, lungs, bone marrow, kidney, nerve, cutaneous circulation, each body of gland of human body; Can improve the human body high density lipoprotein, reduce the human low density lipoprotein cholesterol; Simultaneously, these active substance synergism have produced the curative effect of highly significant, any medicine all is a treating the poisonous disease with poisonous drugs, Fructus Hippophae then is a comprehensively regulating, without any side effects, and it is very fast to take effect, and can obviously experience it in 3-20 minute to get through microcirculatory effect fast, is the once omnidistance maintenance that the human body human body is carried out.
The Hippophae medicinal and edible plant, though the product of general Fructus Hippophae also contains multiple nutrients composition and active substance, but it can not be transported to the partes corporis humani with these nutritions and active speciality fast, these products can only play the effect of benefit in human body, it does not possess function clearly, though the product of general Fructus Hippophae also contains multiple nutrients composition and active substance, but it can not be transported to the partes corporis humani with these nutritions and active speciality fast, these products can only play the effect of benefit in human body, it does not possess function clearly, after inventor's scientific matching, the present invention can be after taking within 5-20 minute, promote the blood of human body circulation fast, dredging vascellum is got through microcirculation, fat melting, the thrombolytic toxin expelling replenishes necessary for human body nutrition and active substance simultaneously fast, can realize clearly, transfer, mend integrated.The inventor specially invites for checking product curative effect of the present invention and has asked numerous professors and well-known doctor that product of the present invention is carried out pharmacological research.
1, the present invention is to the pharmacological research and the exploitation of cardiovascular system:
The Wang Bingwen of Xian Medical Univ etc. studies product of the present invention, the TFH of product of the present invention is tested during to the cardiac function of rat, after intravenous injection, find rat left ventricular pressure peak value, the maximum speed (dp/dtmax) that changes in chamber, a left side obviously raises, left ventricle begins to be retracted to generation, and (the dp/dtmax time is obviously in conjunction with shortening, the easypro last pressure drop in left side chamber diastolic pressure and left chamber is low, isovolumetric index and myocardial oxygen consumption index increase, thereby prompting TFH can strengthen cardiac systolic function and diastolic function, the rising blood pressure, reduce effects such as Peripheral resistance, further research thinks that TFH can make guinea pig in vitro papillary muscles contractility strengthen, and its mechanism of action may be relevant with the effect of outer flow of calcium ions of its promotion myocardial cell and intracellular Ca2+ storage storehouse release calcium.
The Liu Fengming of packet header medical college etc. studies product of the present invention, with the rat heart antiarrhythmic experiment of TFH to exsomatizing, find that TFH can prolong the anoxia arrhythmia time significantly, improve ventricular fibrillation threshold, delay the chamber conduction, decreased heart rate weakens myocardial contraction, TFH can also slightly prolong the Guinea Pig Left room function refractory stage that exsomatizes, and obviously resists aconitine and brings out the not normal effect of Cavia porcellus right atrial rhythm of exsomatizing.
The Chai Qiuyan of Shanxi Prov. Medicine Inst. etc. research adopts the ethanol exudate (SE) of Fructus Hippophae in the product of the present invention to rat experiment, results suggest SE have significantly resist myocardial ischemia, antilipemic raises and reduce the summation of the dirty lipid of liver fat.This product can make hyperlipidemia patient's cholesterol, and triglyceride and beta lipoprotein reduce, and the blood fat that the experimental raising fat feedstuff of animal is caused raises antagonism is arranged.
Through studies confirm that of domestic expert, Fructus Hippophae total flavones in the product of the present invention has booster action to heart, the myocardial contraction of rat is strengthened, the myocardial relaxation function improves, the myocardial ischemia that pituitrin is caused has tangible antagonism, the area of the myocardial infarction that ligation coronary artery in ground causes can obviously dwindle, also can improve the hypoxia-bearing capability of mice under normal pressure and low pressure, to aconitine, epinephrine, the arrhythmia that Barium monoxide etc. cause has tangible antagonism, can also prevent to cause because of high lipid food the rising of animal lipid, these effects show that the Fructus Hippophae total flavones among the present invention can be used for auxiliary treatment coronary heart disease, angina pectoris.
2, product of the present invention is to immune pharmacological research and exploitation:
Immune system is one of mankind defence line of resisting extraneous and self various paathogenic factors injury.Modern medicine thinks that nearly all disease is all got in touch with function of immune system, and this makes people constantly remove to seek to adjust immune normal function and the medicine that improves body resistance against diseases.
The Zhong Fei of Nanjing Railway College of Medicine etc. studies at product of the present invention, with the former liquid extract of Fructus Hippophae wherein (CEH) mice is experimentized, find the existing slight anti-allergic effects of CEH, can improve the huge function of biting of mice again, increase the content and the Cavia porcellus total complement content of serum bacteriolyze, thereby the enhancing non-specific immunity function, and after using CEH, the ability that the level of mice serum hemolysin, hemagglutinin and splenocyte produce hemolysin obviously strengthens; Obviously improve external thin percentage rate of T lymph and SRFC number, the immunosuppressant that the antagonism cyclophosphamide causes; Simultaneously CEH concentration and its direct ratio that acts as to interleukin II (IL-2) DEDE of mice generation; And then proof CEH pair cell is immune and the too many levels of humoral immunization, multilevel regulating action are that significantly this provides breadboard foundation for CEH is widely used in the clinical treatment immune disease.
Shanxi Tumors Inst. appoints power to sough etc. to study at product of the present invention, experimentize by the mouse bone marrow cells micronucleus technique, show that Fructrs Hippophae seed oil has natural killer cell (NK) level under the tangible recovery immunosuppressive condition.
Open the institute of oncology and accompany treasure to wait to have studied Fructrs Hippophae seed oil and juice of Fructus Hippophae that the phagocytic function of mouse macrophage is had facilitation in Gansu Province, and juice of Fructus Hippophae can also strengthen the phagocytic function of lotus B (melanoma) mouse macrophage.This makes Oleum Hippophae and juice of Fructus Hippophae improve immune function of human body, and prophylaxis of tumours generation development aspect has good prospect.
Lee's electricity east of Inst. of Medicinal Biological Technology, Chinese Academy of Medical Sciences etc. is studied at the present invention, and polymerase chain reaction technology and mitogen inducer T lymphocyte factor doubling technology are combined.The research juice of Fructus Hippophae is to the influence of aged mouse splenocyte secreting leukocytes mesonium 2 (IL-2).In aging course, the propagation of splenocyte and the secretion of interleukin II increase with the age and descend.This is owing to the gene expression ability reduces caused along with the increase at age.Experiment is found to take the mice spleen lymphocytes proliferation index of juice of Fructus Hippophae than matched group height of the same age, two groups of difference highly significants (P＜0.01), and the IL-2 activity of measuring is also than higher, two groups of significant differences (P＜0.05), therefore think that juice of Fructus Hippophae can improve immune function of mice, its mechanism may also be that the gene expression by mice realizes.
Therefore, active ingredient among the present invention has the effect of removing human free radical, can improve the content of interleukin II in the aged animal body, influence its gene expression, thereby raising body's immunological function, as a kind of immunomodulator, to improving the resistance against diseases of human body, delaying human body caducity has important function.States such as the former Soviet Union as a kind of famous and precious health medicine, specialize in Oleum Hippophae spaceman and use, and its purpose also may be this.This department's work is carried out very fast at present, as Oleum Hippophae for health care, the dried milk beverage of Fructus Hippophae, Fructus Hippophae cosmetics of everyday use, all production and sales.Go to develop promising from health care medicine, daily cosmetics aspect.
3, antitumor action of the present invention is removed it and can be also had the effect of directly anticancer effect and blocking-up carcinogenic factor by outside immunologic mechanism or other approach role:
The present invention is through researchs such as antitumor institute Zhang Peizhen, with product of the present invention to mice-transplanted tumor: sarcoma (S180), Lymphocytic leukemia (P388) and melanoma (B16) are carried out inhibition test, find no matter be through the lumbar injection Fructrs Hippophae seed oil, still oral juice of Fructus Hippophae all has the effect of obvious suppression tumor growth, and the juice of Fructus Hippophae body outer suppressioning test also shows, it can kill and wound (S180) and (P388) cancerous cell, can suppress human stomach cancer cell line (SGC7901) and Lymphocytic leukemia (L1210) cell again.
Fructus Hippophae stock solution among usefulness the present invention such as the Jianping YANG of Shanxi Tumors Inst. is studied the effect of external antibody leukemia cell line (K562) with the various effective ingredient that extract in this product the life that Fructus Hippophae stock solution can obviously prolong the ehrlich carcinoma mice with tumor of discovering of anti-Emhorn outside of belly water cancer in the experiment mice body, found that its each constituent all has significant cytotoxicity to K562 in cell strain.
The Tang Jing of Shanxi Province medical science branch etc. studies at the present invention, shows the aspergillus flavus-resistance mycin B in this product
1(AF B
1) hepatocarcinogenesis.Liver GGT kitchen range (the liver cell proliferation sexually transmitted disease (STD) becomes, and the is the hepatocarcinoma precancerous lesion) quantity that discovery adds the experimental rat of the juice of Fructus Hippophae of distinguishing the flavor of obviously reduces, and area is also less.The Li Yong of Shanxi Medical College etc. studied with juice of Fructus Hippophae through be diluted to be suitable for the concentration of drinking after, can under in-vitro simulated human gastric juice's condition, block the synthetic of N-nitrous acid morpholine, and compare with ascorbic acid solution matched group with concentration, its blocking-up rate has extremely significantly meaning (P＜0.01), illustrate that juice of Fructus Hippophae is better than ascorbic acid, may also contain other blocking-up material in the prompting juice of Fructus Hippophae.Another experiment, juice of Fructus Hippophae is synthetic and lure the blocking-up and the protective action of cancer in the rat body to carcinogen N-N-nitrosodimethylamine (NDMA), further confirms, and it is synthetic and lure cancer in the rat body that juice of Fructus Hippophae can be blocked the N-nitrous compound effectively.Its anti-cancer effect is better than the ascorbic acid of equivalent.
4, Fructus Hippophae Study of Anti-senility and exploitation:
Antidotal research is the interested problem of current medical science, thinks that the peroxidation of generation, substance in vivo of old and feeble and numerous disease is closely related, so blocking-up peroxidating and eliminate the focus that free radical that vivo oxidation produces becomes research on anti-senescence.
The Jin Yuehua of Shenyang Inst. of Applied Ecology, Chinese Academy of Sciences etc. by to Fructus Hippophae stock solution and seabuckthorn plant among the present invention discover that it contains superoxide dismutase, it is the same with vitamin C, can antioxidation and eliminate the effect of free radical on the cell membrane.
The Rui Lixin of Shanxi Medical College etc. has studied the effect of the present invention to guinea-pig red blood cell, show guinea-pig red blood cell film G-6-PD and Na-K-ATPase activity that Fructus Hippophae stock solution is fed, sulfhydryl content is apparently higher than the Fructus Hippophae line of oils of not feeding, and the product MDA content and the inductive erythrocyte hemolysis rate of MDA of lipid peroxide also significantly is lower than the do not feed group and the vitamin E group of feeding on the erythrocyte membrane.Show that this product has slow down aging, prevents the effect of lipid peroxidation, and the V-E group of dosing such as replacement compares, effect of the present invention is better than V-E.
The sentence Korean pine of Medical Colleges of the Inner Mongol etc. has been studied the effect of the Fructus Hippophae total flavones among the present invention (TFE) to reactive oxygen free radical, find that TFE significantly suppresses the chemiluminescence that PMA stimulates the human polymorphonuclear leukocyte to produce, the reactive oxygen free radical of catching when stimulating the human polymorphonuclear leukocyte to produce respiratory burst to PMA also has (ultra-oxygen anion free radical and hydroxy radical) that tangible scavenging action is arranged; The superoxide radical that the purine oxidase system is produced also has tangible scavenging action, and has confirmed that further TFE has the effect of directly catching superoxide radical and hydroxy radical.
5, the pharmacology of Fructus Hippophae antiinflammatory, Antiradiation injury and other effect and exploitation:
Chronic skin infection (decubital ulcer) is treated in the China Chinese medicine academy Xiyuan Xu Ming of hospital fishing etc. with the present invention research has been done the experiment of system according to three kind new medicines, the test of first kind heat-clearing and toxic substances removing is arranged: comprise that auricle edema test, capillary permeability test, granuloma induced by implantation of cotton pellets form test, bacteriostatic test.Second class is removing the necrotic tissue and promoting granulation test: comprise that the ooze treatment of Mus of experimental scald observes; The treatment of experimental chmice acute radiodermatitis (I) is observed.The 3rd class righting test, analgesic test.Experiment showed, that by eight main pharmacodynamics of this three class Oleum Hippophae has the effect of tangible antiinflammatory suppression pain: good removing the necrotic tissue and promoting granulation effect, and can improve immunologic function, certain centralizing function is arranged, for clinical treatment provides scientific basis.This institute has carried out I phase clinical observation again, and treatment decubital ulcer patient and burn patient be totally 25 examples, obtained curative effect preferably, and this part work is being examined and reported I phase clinical research.
The L.D. Natalya Lebedyevas of chemistry institute of Tajikistan academy of science etc. in 20～30d during use, have suppressed mice subcutaneous tissue development of inflammation, and have strengthened the antiinflammatory action at inflammation center laboratory animal use product of the present invention.
Institute studies confirm that from the former Soviet Union to product of the present invention, contain 180mg/100g above carotene and carotenoid (lycopene and derivant thereof) among the present invention, vitamin E contains 110mg/100g, also contains olein, fatty acid, citric acid and stearic acid.Carotene-VA is former in these compositions.Can form vitamin A in body, the normalization that can enhance metabolism promotes injured tissues to recover; V-E is a kind of antidotal material, and it can block the metabolism of protein and nucleic acid, and then pre-preventing tissue aging, and unsaturated fatty acid also is the important substance that promotes tissue repair.
The researchs such as Jiang Zhenyi of China second medicine and pharmacology institute of medical university of army are strolled the infections model with the rat due to product Dichlorodiphenyl Acetate method of the present invention and the chronic reserpine method and are treated, and finding has good promotion gastric ulcer healing effect and excellent cimetidine.Fructus Hippophae stock solution is further extracted and separated, found that cupreol-β-D-Fructus Vitis viniferae glycoside is the effective ingredient of anti-gastric-ulcer among the present invention.
Xian Medical Univ has carried out research extensively and profoundly at the present invention, and wherein Wu's mist has been studied product treatment chronic cervicitis of the present invention as waiting, and has obtained good result, and total effective rate reaches 97%; Analgesia, the antiinflammatory action of car stannum equality research product of the present invention, after finding that product of the present invention is irritated stomach, white mice acetic acid twisting reaction times obviously reduces (F＜=0.05, woolfe-Macdonald method experiment pain threshold values significantly improves (P＜=0.05, also can cause ear's inflammation to mouse knoting oil has remarkable inhibitory action to make mice acetic acid peritoneum inflammation ooze out obvious minimizing, and certain antiinflammatory, analgesic activity are arranged; Researchs such as Zhang Wen has product of the present invention all has curative effect preferably to chmice acute radiodermatitis and the caused acute radiation dermatitis of tumor patient radiotherapy, mucosal inflammation, inactive scytitis, ulcer, poor wound healing etc.Xu Hanqing etc. use product external of the present invention and for oral administration, and treatment chloasma, brown cyan speckle, chronic skin ulcer also obtain good result; Fan Yulin etc. are applied to clinical treatment traumatic perforation of tympanic membrane patient 56 examples with Oleum Hippophae.Observe to find that product viscosity of the present invention is big, the film butt joint that can make perforated edge with close up, promote wound tissue's liquid, blood oozes out and cellular infiltration, can promote the metabolism of epithelial layer of tympanic membrane and other two-layer cell, helps the healing of tympanum holostrome hypertrophy.And to product of the present invention prevention gentamycin zoopery has been carried out in reaction, with the index of electrocochleogram as the auditory function variation, product of the present invention as a result has preventive effect, can make and listen valve to recover normal, also can name ferrum in the deaf animal perilymph, zinc content to improve, think that the prophylactic function of product of the present invention removes and its antiallergic action, outside the Pass opsonic immunity function, improve nutrition, class acupuncture-moxibustion effect etc. have, more may be relevant with its " effect of class zinc " or " transferring the zinc effect ", thereby safeguard cell membrane stability, it is closely related to suppress effects such as " the ferrum confinement are out of control ".
The Wang Naiwen of Inner Mongol pharmaceuticals general corporation etc. adopts 60CO-gamma-rays and deep x-ray bombardment through four times respectively to 190 parts in Beijing opera spoken in Beijing dialect Mus; compare observation with feed and two kinds of products of the present invention of taking various dose of filling stomach, show that product of the present invention all has obvious protective effect to heart, spleen, liver, lung and bone marrow.
The Lanzhou beautiful grade of medical college journey body is studied at product of the present invention, make liver injury model with rat and mice, inquire into the influence of product of the present invention to hepatic injury, the result shows that product of the present invention has some improvement to indexs such as SGPD, the MDA of the hepatic injury due to CCL4, ethanol, the acetaminophen, GSH, morphological observation also takes an evident turn for the better, and conforms to researchs such as Zhao Tiande.
Shanxi Prov. Medicine Inst.'s time civilization etc. has been carried out chronic toxicity test at product of the present invention, table as a result, when rat is drawn (above nearly 20 times of clinical consumption) under the pre-18mg/kg dosage, can not cause harmful effect to human body, when Marc oil is preserved under good condition, only otherwise lipid peroxidation takes place and consumption loses phenomenon, it is nontoxic and safe in actual applications.Show that through teratology testing this product also all finds no fetal toxicity and teratogenic effect to animal parent and tire son.Thereby think that product of the present invention can be used as medicine, food, is safe.It not only can be used as food but also can be used as medicine.
The seabuckthorn plant preparation of making according to prescription of the present invention is up to the standards through the Harbin City, Heilongjiang Province product quality supervision and testing institute.
(4) specific embodiment
Embodiment 1:
Fructus Benincasae 5 grams, Lentinus Edodes 5 grams, propolis 1 gram, Radix Glycyrrhizae 1 gram, Fructus Hippophae stock solution 50 grams, zinc lactate 1 gram, oligosaccharide 1 gram, active compound enzyme acid 6 grams, taurine 10 grams, adjuvant 10 grams.
The fabrication and processing method is:
1, Fructus Benincasae 5 gram, Lentinus Edodes 5 grams and Radix Glycyrrhizae 1 gram are cleaned and arrangement, boil with 12 times of weight decoctings and carry out the extraction first time after 2 hours and make extracting solution;
2, extracting solution being added again 8 times of weight decoctings boils to carry out in 2 hours extracting the second time again and makes extracting solution;
3, extracting solution is concentrated into magma, the relative density of magma is 1: 2;
4, magma is mixed the back oven dry with propolis 1 gram, Fructus Hippophae stock solution 50 grams, zinc lactate 1 gram, oligosaccharide 1 gram, active compound enzyme acid 6 grams, taurine 10 grams and adjuvant 10 grams, oven dry control temperature was dried 5 hours at 70-80 ℃;
5, add adjuvant and the pulverizing of making electuary after the oven dry, pulverize the back and cross the granulation of 100 mesh sieves, the sub-packing of 20 mesh sieves is crossed in the back of granulating, and sterilizes after the packing.
In manufacturing process; from Fructus Hippophae, extract earlier stock solution; will by natural complex such as the vitamin B group in the water soluble vitamins, vitamin C, vitamin E and calcium, ferrum, zinc, selenium and partly aminoacid make active compound enzyme acid, again magma is mixed with propolis, Fructus Hippophae stock solution, zinc lactate, oligosaccharide, active compound enzyme acid, taurine and adjuvant.
Embodiment 2:
Fructus Benincasae 4 grams, Lentinus Edodes 4 grams, propolis 2 grams, Radix Glycyrrhizae 2 grams, Fructus Hippophae stock solution 45 grams, zinc lactate 2 grams, oligosaccharide 2 grams, active compound enzyme acid 4 grams, taurine 5 grams and adjuvant 30 grams.
The fabrication and processing method is as follows:
1, Fructus Benincasae 4 gram, Lentinus Edodes 4 grams and Radix Glycyrrhizae 2 grams are cleaned and arrangement, boil with 10 times of weight decoctings and carry out extracting for the first time the extracting solution of making after 1.5 hours;
2, extracting solution being added again 8 times of weight decoctings boils to carry out in 1 hour extracting the second time again and makes extracting solution;
3, extracting solution is concentrated into magma, the relative density of magma is 1: 1.5;
4, magma is mixed the back oven dry with propolis 2 grams, Fructus Hippophae stock solution 45 grams, zinc lactate 2 grams, oligosaccharide 2 grams, active compound enzyme acid 4 grams, taurine 5 grams and adjuvant 30 grams, oven dry control temperature was dried 4 hours at 70-80 ℃;
5, add adjuvant and the pulverizing of making electuary after the oven dry, pulverize the back and cross the granulation of 100 mesh sieves, the sub-packing of 20 mesh sieves is crossed in the back of granulating, and sterilizes after the packing.
Embodiment 3:
Fructus Benincasae 5 grams, Lentinus Edodes 5 grams, propolis 1 gram, Radix Glycyrrhizae 1 gram, Fructus Hippophae stock solution 50 grams, zinc lactate 1 gram, oligosaccharide 1 gram, active compound enzyme acid 6 grams, taurine 10 grams, adjuvant 10 grams.
The fabrication and processing method is:
1, Fructus Benincasae 5 gram, Lentinus Edodes 5 grams and Radix Glycyrrhizae 1 gram are cleaned and arrangement, boil with 12 times of weight decoctings and carry out the extraction first time after 2 hours and make extracting solution;
2, extracting solution being added again 8 times of weight decoctings boils to carry out in 2 hours extracting the second time again and makes extracting solution;
3, extracting solution is concentrated into magma, the relative density of magma is 1: 2;
4, magma is mixed with propolis 1 gram, Fructus Hippophae stock solution 50 grams, zinc lactate 1 gram, oligosaccharide 1 gram, active compound enzyme acid 6 grams, taurine 10 grams, adjuvant 10 grams, add the adjuvant of making solvent after the mixing and stir;
5, stir the back allotment and purify bottling.
Embodiment 4:
Fructus Benincasae 4 grams, Lentinus Edodes 4 grams, propolis 2 grams, Radix Glycyrrhizae 2 grams, Fructus Hippophae stock solution 45 grams, zinc lactate 2 grams, oligosaccharide 2 grams, active compound enzyme acid 4 grams, taurine 5 grams and adjuvant 30 grams.
The fabrication and processing method is as follows:
1, Fructus Benincasae 4 gram, Lentinus Edodes 4 grams and Radix Glycyrrhizae 2 grams are cleaned and arrangement, boil with 10 times of weight decoctings and carry out the extraction first time after 1.5 hours and make extracting solution;
2, extracting solution being added again 8 times of weight decoctings boils to carry out in 1 hour extracting the second time again and makes extracting solution;
3, extracting solution is concentrated into magma, the relative density of magma is 1: 1.5;
4, magma is mixed with propolis 2 grams, Fructus Hippophae stock solution 45 grams, zinc lactate 2 grams, oligosaccharide 2 grams, active compound enzyme acid 4 grams, taurine 5 grams and adjuvant 30 grams, add the adjuvant of making solvent after the mixing and stir;
5, stir the back allotment and purify bottling.
Claims (5)
1, a kind of seabuckthorn plant preparation is characterized in that it is to be restrained with adjuvant 8-30 by Fructus Benincasae 2-8 gram, Lentinus Edodes 2-8 gram, propolis 1-6 gram, Radix Glycyrrhizae 1-6 gram, Fructus Hippophae stock solution 40-70 gram, zinc lactate 1-5 gram, oligosaccharide 1-5 gram, active compound enzyme acid 2-8 gram, taurine 5-20 gram.
2, a kind of manufacture method of seabuckthorn plant preparation is characterized in that:
1.1, Fructus Benincasae 2-8 gram, Lentinus Edodes 2-8 gram and Radix Glycyrrhizae 1-6 gram are cleaned and arrangement, boil with 10-12 times of weight decocting and carried out extraction first time in 1-2 hour and make extracting solution;
1.2, extracting solution is added 8-10 weight decocting again boil to carry out in 1-2 hour extracting the second time and make extracting solution;
1.3, extracting solution is concentrated into magma;
1.4, magma and propolis 1-6 gram, Fructus Hippophae stock solution 40-70 gram, zinc lactate 1-5 gram, oligosaccharide 1-5 gram, active compound enzyme acid 2-8 gram, taurine 5-20 gram and adjuvant 8-30 gram mixed and dry;
1.5, pulverize oven dry back and granulate, sterilize after the packing.
3, a kind of seabuckthorn plant preparation according to claim 1 is characterized in that described active compound enzyme acid comprises vitamin B group, vitamin C, vitamin E and calcium, ferrum, zinc, selenium and the aminoacid in the water soluble vitamins.
4, the manufacture method of a kind of seabuckthorn plant preparation according to claim 2, the relative density that it is characterized in that described magma is 1: 1.25-2.
5,, it is characterized in that described oven dry control temperature at 70-80 ℃, dried 4-5 hour according to the manufacture method of claim 2 or 3 described a kind of seabuckthorn plant preparations.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101508647A CN1954835A (en) | 2006-10-11 | 2006-10-11 | Sea-buckthorn plant preparation and its preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106954662A (en) * | 2017-04-14 | 2017-07-18 | 张掖市润星生物科技有限公司 | Sea-buckthorn biscuits and its processing method |
| CN111214642A (en) * | 2018-11-23 | 2020-06-02 | 河南旭仁堂生物科技有限公司 | Traditional Chinese medicine composition for dredging microcirculation |
-
2006
- 2006-10-11 CN CNA2006101508647A patent/CN1954835A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106954662A (en) * | 2017-04-14 | 2017-07-18 | 张掖市润星生物科技有限公司 | Sea-buckthorn biscuits and its processing method |
| CN111214642A (en) * | 2018-11-23 | 2020-06-02 | 河南旭仁堂生物科技有限公司 | Traditional Chinese medicine composition for dredging microcirculation |
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