CN1947524A - Anti-rot agent of traditional Chinese compounding medicine contg. Portulaca oleracea, its prepn. method and use - Google Patents
Anti-rot agent of traditional Chinese compounding medicine contg. Portulaca oleracea, its prepn. method and use Download PDFInfo
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- CN1947524A CN1947524A CN 200610162654 CN200610162654A CN1947524A CN 1947524 A CN1947524 A CN 1947524A CN 200610162654 CN200610162654 CN 200610162654 CN 200610162654 A CN200610162654 A CN 200610162654A CN 1947524 A CN1947524 A CN 1947524A
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Abstract
A composite antiseptic agent for controlling the growth and reproduction of pathogenic microbes is prepared from portulaca, phyllanthus emblica fruit, papaya, seaweed and tea. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of corrosion-resistant Chinese medicine preparation.Be the preservative of feedstock production specifically, the invention still further relates to the preparation method and the purposes of this preservative with the Chinese herbal medicine.
Background technology
Bacterial infection disease is the common frdquently encountered disease of harm humans health.Pathogenic microorganism can cause the disease of the mankind, animal, plant, causes article (paper and goods thereof, food, medicine.) rotten.Winter～2003 year the spring in 2002, the popular many aspects to Chinese national economy and social development of SARS (SevereAcute Respiratory Syndrome) cause tremendous loss and harm.
After pathogenic microorganism is invaded the host, carry out growth and breeding, and discharge toxin, can cause the pathology of the mankind, animal, plant, and article (paper and goods thereof, food, medicine.) go mouldy.
1. " practical Chinese medicine dictionary " (upward volume), Tian Daihua chief editor, Xie Zongwan trial, Beijing: People's Health Publisher, the 1st edition the 2nd printing in May the 1st edition, 2003 September in 2002, three pictures, 075 kitchen garden, the page number: 209; " the clinical new usefulness of Chinese herbal medicine commonly used " Chen Xiaogang chief editor, Guangzhou: Guangdong science and technology publishing house, the 1st edition the 2nd printing in January the 1st edition, 2006 March in 2005, three pictures, 027 kitchen garden, the page number: 51; The herb of Chinese medicinal herbs portulacaceous plant kitchen garden Portulacaoleracea L. is disclosed, medicinal material be called kitchen garden Herba Portulacae extract external to shigella dysenteriae, typhoid bacillus,, Pseudomonas aeruginosa, Escherichia coli all have significant antibacterial action; Various common food pollution bacterium all there is stronger inhibitory action, still have certain bacteriostasis even be diluted to 12.5% concentration, stronger to Escherichia coli, detection of Salmonella, proteus, Shigella, staphylococcus aureus, bacillus subtilis, bacillus cereus bacteriostasis; Also stronger to Mucor racemosus, gibberella, high Neurospora, Aspergillus flavus inhibitory action; Its water decoction has stronger inhibitory action in external to the Pseudomonas aeruginosa growth and breeding.
2. " practical Chinese medicine dictionary " (upward volume), Tian Daihua chief editor, Xie Zongwan trial, Beijing: People's Health Publisher, the 1st edition the 2nd printing in May the 1st edition, 2003 September in 2002, seven pictures, 318 emblics, the page number: 971; " the clinical new usefulness of Chinese herbal medicine commonly used " Chen Xiaogang chief editor, Guangzhou: Guangdong science and technology publishing house, the 1st edition the 2nd printing in January the 1st edition, 2006 March in 2005, seven pictures, 159 emblics, the page number: 231; Disclose the ripening fruits of Chinese medicinal herbs euphorbia plant emblic Phyllanthusemblica L., the fruit leachate that medicinal material is called emblic Fructus Phyllanthi Emblicae reveals bacterium, the redness bacterium of becoming visible to staphylococcus aureus, hay bacillus, salmonella typhimurium, comma bacillus, colon bacillus, saccharomycete, beard and hair and shows and press down (killing) bacterium effect.
3. " practical Chinese medicine dictionary " (upward volume), Tian Daihua chief editor, Xie Zongwan trial, Beijing: People's Health Publisher, the 1st edition the 2nd printing in May the 1st edition, 2003 September in 2002, four pictures, 095 pawpaw, the page number: 269,270; The Chinese medicinal herbs rosaceous plant is disclosed: wrinkled papaya Chaenomeles speciosa (Sweet) Nakai[C.lagenaria (Loisel.) Koidz.]; Or shine skin papaya Chaenomeles sinensis (Thouin) koehne; Perhaps hair leaf pawpaw C.cathayensis (Hemsl.) Schneid.; The perhaps almost ripe fruit of chaenomeles thibetica Yu C.thibetica Yii., medicinal material is called pawpaw Fructus Chaenomelis; Fresh Chinese flowering quince juice and pawpaw decoction have tangible bacteriostasis to intestinal and staphylococcus, and more sensitive bacterium has shigella, shigella flexneri, sonne bacillus and mutation thereof, enteropathogenic E, Bacillus coli communis, proteus, bacillus enteritidis, staphylococcus.
4. " practical Chinese medicine dictionary " (last volume), Tian Daihua chief editor, Xie Zongwan trial, Beijing: People's Health Publisher, the 1st edition the 2nd printing in May the 1st edition, 2003 September in 2002, ten pictures, 559 marine algas, the page number: 1635,1636; Chinese medicinal herbs Sargassaceae plant Sargassum fusiforme (Harv.) Setch Sargassum fusiforme (Harv.) Setch.[Hizikiafusiforme (Harv.) Okam. is disclosed] frond, medicinal material is called leaflet marine alga Sargassum, and it contains chemical composition: the effect that Hijiki polysaccharide A, B, C all have antagonism mouse botulinum toxin to poison.
5. " practical Chinese medicine dictionary " (last volume), Tian Daihua chief editor, Xie Zongwan trial, Beijing: People's Health Publisher, the 1st edition the 2nd printing in May the 1st edition, 2003 September in 2002, nine pictures, 431 tealeaves, the page number: 1290,1292; Chinese medicinal herbs plant of theaceae tea Camellia sinensis (L.) O.Kuntze[Thea sinensis L. is disclosed] tender leaf or tender shoots, medicinal material is called tealeaves Folium Camelliae Sinensis, its decoction and preserved material have remarkable inhibitory action external to various shigella dysenteriae, to staphylococcus, streptococcus, diplococcus meningitidis, streptococcus pneumonia, Escherichia coli, detection of Salmonella, proteus, hay bacillus, Pseudomonas aeruginosa, diphtheria bacillus, bacillus anthracis also has antibacterial action in various degree, and the tea extract has killing action external to comma bacillus.Contain chemical composition in the green tea: contain chemical composition in green tea polyphenols (GTP) and the tealeaves: theaflavin (theaflavin) also has antagonism to the clostridium botulinum exotoxin.
Adopt anticorrosion chemicals [beta naphthal 2-naphthol, Peracetic acid peroxyacetic acid, methyl p-hydroxybenzoate methyl p-hydroxy benzoate, ethyl-para-hydroxybenzoate ethyl p-hydroxy benzoate, six hydrogen-1 at paper and cardboard manufacturing both at home and abroad at present, 3,5-three (a-ethoxy) s-triazine hexahydro-1,3,5-tris (2-hydroxyethyl) triazinane], because of it contains phenol, formaldehyde harmful substance and chemical substance environmental pollution problem in manufacture process in various degree.
Summary of the invention
The present invention is based on a kind of like this discovery and finishes, promptly when using following natural plant crude drugs: 1. kitchen garden HerbaPortulacae; 2. emblic Fructus Phyllanthi Emblicae; Pawpaw Fructus Chaenomelis (wrinkled papaya Chaenomeles speciosa (Sweet) Nakai[C.lagenaria (Loisel.) Koidz.]; Or shine skin papaya Chaenomeles sinensis (Thouin) koehne; Perhaps hair leaf pawpaw C.cathayensis (Hemsl.) Schneid.; Perhaps chaenomeles thibetica Yu C.thibetica Yii.); 4. leaflet marine alga Sargassum; 5. tealeaves FoliumCamelliae Sinensis; For raw material are made with extra care the anticorrosive products that forms through the science compatibility, method according to routine is applied in paper and the cardboard manufacturing field again, unexpectedly demonstrates effective inhibition staphylococcus aureus, shigella dysenteriae, Pseudomonas aeruginosa, detection of Salmonella, the growth of Aspergillus flavus, breeding effect.
Therefore, the object of the present invention is to provide a kind of preservative that can suppress the growth of organic surface microorganism, breeding within the specific limits, this preservative can: 1. control pathogenic microorganism, blocking-up transmission of pathogen; 2. effective controlling microbial stops harmful microorganism to be propagated; 3. controlling microbial is propagated, and can avoid living contaminants and harmful bacterium to propagate.
Another object of the present invention is to provide a kind of method for preparing preservative.
The present invention also aims to provide a kind of preservative to make the application in field at paper and cardboard.
Solution of the present invention is based on understanding and the principle of motherland's traditional Chinese medicine to the pathogenic microorganism prevention, reference is modern in clinical medicine practise, achievement in research to the new purposes of Chinese herbal medicine, and the Chinese herbal medicine that this class has a new purposes further excavated, and put in order and improved, from motherland's pools of traditional Chinese medicine, filter out and have the natural plant crude drugs that suppresses the pathogenic microorganism effect, scientific formula, make every effort to use and play complementary effect with pharmacological research, it is given full play to suppress the pathogenic microorganism effect, effectively avoid living contaminants and harmful bacterium to propagate.
Preparation of the present invention is to be made by the raw material of following consumption:
Kitchen garden 15%～50%; Emblic 10%～40%; Pawpaw 10%～30%; Leaflet marine alga 5%～20%; Tealeaves 5%～20%.
The prescription preferable amount ratio range of preparation of the present invention is:
Kitchen garden 20%～40%; Emblic 15%～30%; Pawpaw 15%～25%; Leaflet marine alga 10%～15%; Tealeaves 10%～15%.
The optimum amount proportioning of preparation of the present invention is:
Kitchen garden 35%; Emblic 25%; Pawpaw 20%; Leaflet marine alga 10%; Tealeaves 10%.
Above-mentioned each component is made the manufacture method 1 of preparation of the present invention:
1. get kitchen garden earlier, water decocts 2 times, merges to concentrate, and it is standby to get purslane extract;
2. get emblic, with 80% methanol extraction 3 times, use extracted with diethyl ether again, reclaim solvent, it is standby promptly to get emblic extract;
3. get pawpaw, water decocts 2 times, merges to concentrate, and it is standby promptly to get papaya extractives;
4. get the leaflet marine alga again, processing algae powder solution, (amount with every gram raw medicinal herbs 10U adds papain to add papain.) at pH6.5, enzymolysis is 2 hours in 60 ℃, through vacuum concentration, uses ethanol (to contain alcohol and reach 50% again.) precipitation and be 4000 times rotations 15 minutes in the per minute rotation number, with sediment with acetone wash-out and freeze drying, the leaflet marine algae extract is standby;
5. get tealeaves again, extracted 3 hours down at 75 ℃ with 60% ethanol of 9 times of amounts, filter (filter residue again with 60% ethanol of 5 times of amounts 70 ℃ of extractions 2 hours down, discard filter residue after the filtration.), reclaim ethanol, centrifugal, get supernatant, last polymeric adsorbent, be washed to colourless, alkaline ethanol wash-out (transferring pH8.5) with ammoniacal liquor, recovery ethanol, it is standby promptly to get tea extract;
6. after above-mentioned whole extract components being mixed in described ratio, promptly obtain the paste of preservative.
Above-mentioned each component is made the manufacture method 2 of preparation of the present invention:
Take by weighing respectively in described ratio: kitchen garden, emblic, pawpaw, leaflet marine alga, tealeaves, dry mixed is crushed to 120～200 order fine powders, promptly obtains the pulvis of preservative.
Preparation of the present invention is made Application for Field method 1 at paper and cardboard:
The preparation of the present invention (paste or pulvis) that directly in the production raw material (paper pulp) of paper and cardboard, adds bone dry fiber amount 5%～20%.
Preparation of the present invention is made Application for Field method 2 at paper and cardboard:
Take by weighing preparation of the present invention (paste), after dissolving with ethanol (or water), directly be applied on paper and the cardboard for the bone dry fiber amount 5%～20% of paper and cardboard.
For showing that preparation of the present invention has the inhibition effect to pathogenic microorganism, preparation of the present invention is tested through in-vitro antibacterial:
Adopt Plating, the concentration that the plating medium that contains medicine contains preparation of the present invention is respectively 0.2,0.1,0.5,0.25,0.125,0.063,0.032,0.016mg/ml; Dip in respectively with oese and to get staphylococcus aureus, shigella dysenteriae, Pseudomonas aeruginosa, detection of Salmonella, the streak inoculation of Aspergillus flavus experimental bacteria liquid, and put into 37 ℃ of incubators and cultivate to take out in 24 hours and observe in the zones of different of each pastille flat board.The in-vitro antibacterial result of the test demonstrates preparation of the present invention has in various degree inhibitory action to 5 kinds of bacteriums being tested, as shown in the table.
The antibacterial action of preparation of the present invention (Plating)
| Bacterial strain | Minimum inhibitory concentration MIC (mg/ml) |
| Staphylococcus aureus | 0.016 |
| Shigella dysenteriae | 0.016 |
| Pseudomonas aeruginosa | 0.016 |
| Detection of Salmonella | 0.016 |
| Aspergillus flavus | 0.063 |
The raw material of preparation of the present invention all adopt the primary raw material (paper pulp) of Chinese herbal medicine and pulvis and paper and cardboard manufacturing to belong to vegetable fiber, can make paper and cardboard constant in the mechanism of recovery, decrement, regeneration and degraded.
Embodiment
Embodiment 1
Take by weighing raw material by following percentage:
Kitchen garden 35%; Emblic 25%; Pawpaw 20%; Leaflet marine alga 10%; Tealeaves 10%.
1. get kitchen garden earlier, water decocts 2 times, merges to concentrate, and gets purslane extract;
2. get emblic,, use extracted with diethyl ether again, reclaim solvent, promptly get emblic extract with 80% methanol extraction 3 times;
3. get pawpaw, water decocts 2 times, merges to concentrate, and promptly gets papaya extractives;
4. get the leaflet marine alga again, processing algae powder solution, (amount with every gram raw medicinal herbs 10U adds papain to add papain.) at pH6.5, enzymolysis is 2 hours in 60 ℃, through vacuum concentration, uses ethanol (to contain alcohol and reach 50% again.) precipitation and be 4000 times rotations 15 minutes in the per minute rotation number, with sediment with acetone wash-out and freeze drying, the leaflet marine algae extract;
5. get tealeaves again, extracted 3 hours down at 75 ℃ with 60% ethanol of 9 times of amounts, filter (filter residue again with 60% ethanol of 5 times of amounts 70 ℃ of extractions 2 hours down, discard filter residue after the filtration.), reclaim ethanol, centrifugal, get supernatant, last polymeric adsorbent, be washed to colourless, alkaline ethanol wash-out (transferring pH8.5) with ammoniacal liquor, recovery ethanol promptly gets tea extract;
6. after above-mentioned whole extract components being mixed in described ratio, promptly obtain the paste of preservative.
Embodiment 2
Take by weighing raw material by following percentage:
Kitchen garden 35%; . emblic 25%; Pawpaw 20%; Leaflet marine alga 10%; Tealeaves 10%.
With kitchen garden, emblic, pawpaw, leaflet marine alga, tealeaves, dry mixed is crushed to 120～200 order fine powders, promptly obtains the pulvis of preservative.
Embodiment 3
Preparation of the present invention is made the Application for Field method at paper and cardboard:
The preparation of the present invention (paste or pulvis) that directly in the production raw material (paper pulp) of paper and cardboard, adds bone dry fiber amount 5%～20%.
Embodiment 4
Preparation of the present invention is made the Application for Field method at paper and cardboard:
Take by weighing preparation of the present invention (paste), after dissolving with ethanol (or water), directly be applied on paper and the cardboard for the bone dry fiber amount 5%～20% of paper and cardboard.
Claims (10)
1. preservative is characterized in that it is the preparation of being made by following raw material:
Kitchen garden; Emblic; Wrinkled papaya or shine skin papaya or hair leaf pawpaw or chaenomeles thibetica Yu; The leaflet marine alga; Tealeaves.
2. preservative according to claim 1, wherein the weight proportion of each raw material is:
Kitchen garden 15%～50%; Emblic 10%～40%; Wrinkled papaya or shine skin papaya or hair leaf pawpaw or chaenomeles thibetica Yu 10%～30%; Leaflet marine alga 5%～20%; Tealeaves 5%～20%.
3. preservative according to claim 1, wherein the weight proportion of each raw material is:
Kitchen garden 20%～40%; Emblic 15%～30%; Wrinkled papaya or shine skin papaya or hair leaf pawpaw or chaenomeles thibetica Yu 15%～25%; Leaflet marine alga 10%～15%; Tealeaves 10%～15%.
4. preservative according to claim 1, wherein the weight proportion of each raw material is:
Kitchen garden 35%; Emblic 25%; Wrinkled papaya or shine skin papaya or hair leaf pawpaw or chaenomeles thibetica Yu 20%; Leaflet marine alga 10%; Tealeaves 10%.
5. according to claim 2,3 or 4 described preservatives, it is characterized in that said preparation is paste or pulvis.
6. the preparation method of preservative according to claim 5 is characterized in that: get kitchen garden earlier, water decocts 2 times, merge to concentrate, purslane extract; Get emblic,, use extracted with diethyl ether again, reclaim solvent, obtain emblic extract with 80% methanol extraction 3 times; Get wrinkled papaya or shine skin papaya or hair leaf pawpaw or chaenomeles thibetica Yu again, water decocts 2 times, merges to concentrate, and promptly gets wrinkled papaya or shine skin papaya or hair leaf pawpaw or chaenomeles thibetica Yu extract; Get the leaflet marine alga again, processing algae powder solution, (amount with every gram raw medicinal herbs 10U adds papain to add papain.) be enzymolysis 2 hours in 6.5,60 ℃ at pH, through vacuum concentration, use ethanol (to contain the alcohol amount and reach 50% again.) precipitation and be 4000 times rotations 15 minutes in the per minute rotation number, with sediment with acetone wash-out and freeze drying, the leaflet marine algae extract; Get tealeaves again, 60% ethanol with 9 times of amounts extracted 3 hours down at 75 ℃, and (filter residue extracted 2 hours down at 70 ℃ with 60% ethanol of 5 times of amounts again, discarded filter residue after the filtration in filtration,) recovery ethanol, centrifugal, get supernatant, last polymeric adsorbent, water is to colourless, alkaline ethanol wash-out (transferring pH8.5 with ammoniacal liquor) reclaims ethanol, gets tea extract; After above-mentioned whole extract components are mixed in described ratio, promptly get the paste of preservative.
7. the preparation method of preservative according to claim 5, it is characterized in that taking by weighing respectively: kitchen garden, emblic, wrinkled papaya or shine skin papaya or hair leaf pawpaw or chaenomeles thibetica Yu, leaflet marine alga, tealeaves in described ratio, dry mixed, be crushed to 120～200 order fine powders, promptly get the pulvis of preservative.
8. the application that the preservative of any one qualification is made as paper and cardboard in the claim 2～5.
9. the application as paper and cardboard manufacturing according to claim 8 is characterized in that the directly preservative of the present invention (paste or pulvis) of adding bone dry fiber amount 5%～20% in the production raw material (paper pulp) of paper and cardboard.
10. the application as paper and cardboard manufacturing according to claim 8 is characterized in that taking by weighing the preservative of the present invention (paste) into the bone dry fiber amount 5%～20% of paper and cardboard, after dissolving with ethanol (or water), directly is applied on paper and the cardboard.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610162654XA CN100544598C (en) | 2006-11-28 | 2006-11-28 | Kitchen garden Chinese medicine compound prescription preservative and preparation thereof and purposes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610162654XA CN100544598C (en) | 2006-11-28 | 2006-11-28 | Kitchen garden Chinese medicine compound prescription preservative and preparation thereof and purposes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1947524A true CN1947524A (en) | 2007-04-18 |
| CN100544598C CN100544598C (en) | 2009-09-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200610162654XA Expired - Fee Related CN100544598C (en) | 2006-11-28 | 2006-11-28 | Kitchen garden Chinese medicine compound prescription preservative and preparation thereof and purposes |
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| Country | Link |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103229827A (en) * | 2013-05-05 | 2013-08-07 | 嘉兴职业技术学院 | Preparation for strawberry corrosion protection and preservation and application of preparation |
| CN103584255A (en) * | 2013-11-23 | 2014-02-19 | 遵义市农林源食品有限公司 | Plant preservative and preparation method thereof |
| CN104783297A (en) * | 2015-04-16 | 2015-07-22 | 浙江师范大学 | Preparation method and application of plant-source food preservative |
| CN105498466A (en) * | 2015-11-24 | 2016-04-20 | 安徽省水磨坊酒业有限公司 | Drying and mildewproof bag for distiller's yeast preservation |
| CN116159091A (en) * | 2023-03-16 | 2023-05-26 | 安徽协和成药业饮片有限公司 | Papaya extract with uric acid reducing activity and preparation method and application thereof |
-
2006
- 2006-11-28 CN CNB200610162654XA patent/CN100544598C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103229827A (en) * | 2013-05-05 | 2013-08-07 | 嘉兴职业技术学院 | Preparation for strawberry corrosion protection and preservation and application of preparation |
| CN103584255A (en) * | 2013-11-23 | 2014-02-19 | 遵义市农林源食品有限公司 | Plant preservative and preparation method thereof |
| CN103584255B (en) * | 2013-11-23 | 2015-01-28 | 遵义市农林源食品有限公司 | Plant preservative and preparation method thereof |
| CN104783297A (en) * | 2015-04-16 | 2015-07-22 | 浙江师范大学 | Preparation method and application of plant-source food preservative |
| CN104783297B (en) * | 2015-04-16 | 2018-08-10 | 浙江师范大学 | A kind of plant derived foods preservative and its preparation method and application |
| CN105498466A (en) * | 2015-11-24 | 2016-04-20 | 安徽省水磨坊酒业有限公司 | Drying and mildewproof bag for distiller's yeast preservation |
| CN116159091A (en) * | 2023-03-16 | 2023-05-26 | 安徽协和成药业饮片有限公司 | Papaya extract with uric acid reducing activity and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN100544598C (en) | 2009-09-30 |
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