CN1943719A - A Chinese traditional medicinal composition for treating diabetes and its preparation method - Google Patents
A Chinese traditional medicinal composition for treating diabetes and its preparation method Download PDFInfo
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Abstract
This invention provides a Chinese traditional medicinal composition. This composition is prepared by using gypsum, common anemarrhena rhizome, fresh radix rehmammiae, radix ophioponis, snakegourd root, fragrant solomonseal rhizome, ningpo figwort root, twotooth achyranehes root, rhizoma chuanxiong, oriental waterplantain rhizome, pilose asiabell root, Japanese cornel dogwood, loquat leaf, orange magnoliavine fruit, etc. It can be clinically used to treat diabetes. This invention also reveals it preparing method.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Diabetes (DM, Diabetes Mellitus) are a kind of metabolic diseases of multi-pathogenesis, and characteristics are chronic hyperglycemias, follow sugar, fat and protein metabolism disorder because of insulin (Insulin) is secreted and the effect defective causes.Diabetes can be divided into insulin dependent diabetes mellitus (IDDM) (IDDM, type 1 diabetes) and non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes mellitus) two classes.Wherein type 2 diabetes mellitus accounts for 90% of total morbidity number, and it mainly is because the insulin secretion level is normal or low slightly, but target tissue causes the amount of insulin secretion relative deficiency to the insulin sensitivity deficiency.The diabetes clinical manifestation is that glucose level raises in the blood, causes carbohydrate metabolism disturbance, secondary albumen and fat metabolic disturbance, and cause cardiovascular and cerebrovascular disease, renal failure, retinopathy etc.Type 2 diabetes mellitus is clinical mainly to show as " three-many-one-little ", and " more than three " refer to polyuria, polydipsia, polyphagia; " one few " refers to that health becomes thin, and has symptoms such as tired, excessive thirst concurrently.
Diabetes spp is in the traditional Chinese medical science " diabetes " " diseases due to endogenous heat of ZANG FU organs " categories such as " three types of diabetes ".Chinese medicine just has the record and the description of " diseases due to endogenous heat of ZANG FU organs " in bimillennial Huangdi's Internal Classics.In the piece of writing of quenching one's thirst of the famous doctor family in Han dynasty Zhang Zhongjing in his " Medical Treasures of the Golden Chamber ", the three-many-one-little symptom of diabetes has been done complete record.Ancient Chinese medicine doctor thinks that the sick position of diabetes is dirty at lung, stomach, kidney three more, pathogenesis is basis, scorching for marking with the deficiency of YIN, clinically it is divided into the upper, middle and lower three types of diabetes, delay with the passing of time then causing impairment of both QI and YIN or deficiency in both YIN and YANG, in the treatment with YIN nourishing, heat clearing away, to moisturize be rule of treatment.The clinical visible multiple pattern of syndrome of diabetes, wherein modal pattern of syndrome is a syndrome of deficiency of both qi and yin.Have between all key elements of this pattern of syndrome of diabetes (deficiency of vital energy, the deficiency of YIN, wet resistance, blood stasis) interact, the relation of reciprocal causation.The initiating agent of most diabetics onsets may accumulate resistance (surfeit fat meat and fine grain, Shengs crossed in excessive consumption of alcohol, nutrition) for damp, and long-term wet accumulateing so that the obstacle that gasify, the smart mistakeization of gas, the mistake of shape gas is foster, thereby gas, essence, shape biochemistry are not normal and deficient.Can cause simultaneously the mechanism of qi retardance again, not promoting the circulation of blood of gas and the hyperamization stasis of blood, the hematogenous blockage internal organs lose and support also disfigurement, feel frustrated.Deficiency of vital energy gasification obstacle hinders dehumidifying again.Therefore, accumulateing in this pattern of syndrome damp is the initiating agent of onset diabetes, and the smart weakened and emaciated body of gas is this, and the deficiency of YIN is when the mark for disease.Because the gasification obstacle, smart mistakeizations of gas, vital essence is lost mutually, cause negative and positive can not from and, and make the touching difficulty of diabetes heal (the reestablishment to yin-yang equilibrium person is healed).
Based on the understanding that above pathology machine changes, the rule of treatment is when being through-supplementation, and removing dampness promptly activates yang.The boosting qi and nourishing yin that activates yang, the ventilation blood stasis dispelling, short its separated the dehumidifying resistance, gas essence (the moon) biochemistry, blood vessels and smooth make reestablishment to yin-yang equilibrium and spontaneous recovery.So there is the person to use Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Radix Codonopsis, Fructus Corni, Folium Eriobotryae, Fructus Schisandrae Sphenantherae etc. to be used for supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid, the Chinese medicine of invigorating the spleen and regulating the stomach makes up, and has invented a kind of pharmaceutical composition that is used for the treatment of diabetes.This medicine can effectively be regulated the homergy effect of function, equilibrium between yin and yang, recovery human pancreatic islet function.After the patient received treatment, sugar, protein, fat three big metabolism disorders were improved, and yang deficiency is scorching to be controlled, and Abwehrkraft des Koepers strengthens, and health status is improved naturally.
The present invention promptly is the research of being done under above background technology, and invention has obtained a kind of Chinese medicine composition of effective treatment diabetes.
Summary of the invention
The present invention relates to a kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof, its objective is provides a kind of clearing away heat and nourishing YIN that has, and the promoting the production of body fluid to quench thirst effect is used for the Chinese medicine composition of type ii diabetes intense heat due to deficiency of YIN disease; The present invention also aims to provide a kind of preparation method of Chinese medicine composition.
The present invention seeks to be achieved through the following technical solutions:
On prescription was formed, the weight proportion of each crude drug was:
45～135 parts of 35～105 parts of Radix Rehmanniae of 65～200 parts of Rhizoma Anemarrhenaes of Gypsum Fibrosum
45～135 parts of 55～160 portions of Rhizoma Polygonati Odorati of 35～105 parts of Radix Trichosanthis Radix Ophiopogonis
45～135 parts of 25～80 parts of Radix Salviae Miltiorrhizaes of 35～105 parts of Radix Achyranthis Bidentataes of Radix Scrophulariae
35～105 parts of 35～105 parts of Fructus Corni of 35～105 parts of Radix Codonopsis of Rhizoma Alismatis
20～60 parts of 25～80 parts of Fructus Schisandrae Sphenantheraes of Folium Eriobotryae
Crude drug weight ratio after preferred is:
89 parts of 71 parts of Radix Rehmanniae of 133 parts of Rhizoma Anemarrhenaes of Gypsum Fibrosum
89 parts of 106 portions of Rhizoma Polygonati Odorati of 71 parts of Radix Trichosanthis Radix Ophiopogonis
89 parts of 53 parts of Radix Salviae Miltiorrhizaes of 71 parts of Radix Achyranthis Bidentataes of Radix Scrophulariae
71 parts of 71 parts of Fructus Corni of 71 parts of Radix Codonopsis of Rhizoma Alismatis
44 parts of 53 parts of Fructus Schisandrae Sphenantheraes of Folium Eriobotryae
Form at this prescription, can make multiple dosage form, comprise granule, capsule, tablet, pill etc. according to clinical needs.The inventor at first studies the preparation method of this Chinese medicine composition, and has determined following preparation method:
A, get Gypsum Fibrosum, the Rhizoma Anemarrhenae, add 8～12 times of water gagings and decoct 2～4 times, each 1～3 hour, collecting decoction filtered, and filtrate is concentrated into about 1000ml, leave standstill, and filtration, filtrate is concentrated into the clear paste of relative density 1.15～1.38 (60～80 ℃), and is standby;
B, get Radix Salviae Miltiorrhizae, Fructus Schisandrae Sphenantherae, Fructus Corni, with 40%～90% alcohol reflux 2～4 times, each 1～3 hour, merge extractive liquid, reclaimed ethanol, filters, and filtrate is concentrated into the clear paste of relative density 1.15～1.38 (60～80 ℃), and is standby;
C, get Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Codonopsis, Folium Eriobotryae, decoct with water each 0.5～2 hour 1～3 time, collecting decoction filters, and filtrate is concentrated into the clear paste of relative density 1.01～1.22 (60～80 ℃), be chilled to room temperature, add ethanol and reach 40%～80%, stir evenly to containing the alcohol amount, left standstill 6～24 hours, draw supernatant, reclaim ethanol, filter, filtrate is concentrated into the clear paste of relative density 1.15～1.38 (60～80 ℃), and is standby;
D, the above three kinds of clear paste of merging are concentrated into the thick paste that relative density is about 1.25～1.45 (60～80 ℃), add suitable adjuvant, make required dosage form.
The inventor optimizes above-mentioned preparation method, has obtained following preparation method:
A, get Gypsum Fibrosum, the Rhizoma Anemarrhenae, add 10 times of amounts of water and decoct three times, each 1.5 hours, collecting decoction filtered, and filtrate is concentrated into about 1000ml, leave standstill, and filtration, filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃), and is standby;
B, get Radix Salviae Miltiorrhizae, Fructus Schisandrae Sphenantherae, Fructus Corni, with 70% alcohol reflux three times, each 2 hours, merge extractive liquid, reclaimed ethanol, filters, and filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃), and is standby;
C, get Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Codonopsis, Folium Eriobotryae, decoct with water secondary, each 1 hour, collecting decoction filters, and filtrate is concentrated into the clear paste of relative density 1.11～1.12 (70 ℃), be chilled to room temperature, add ethanol and reach 60%, stir evenly to containing the alcohol amount, left standstill 12 hours, draw supernatant, reclaim ethanol, filter, filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃), and is standby;
D, the above three kinds of clear paste of merging are concentrated into the thick paste that relative density is about 1.35～1.38 (70 ℃), add suitable adjuvant, make required dosage form.
With above-mentioned resulting thick paste, add galenic pharmacy adjuvant commonly used, by corresponding technology, just can make required dosage form.Add an amount of dextrin and steviosin as thick paste, mixing is made granule; Or, add starch to required total amount with the thick paste drying, and with 90% ethanol system soft material, to granulate, drying is crossed 20 mesh sieves, and mixing is encapsulated.
Chinese medicine composition among the present invention has clearing away heat and nourishing YIN, the effect of promoting the production of body fluid to quench thirst.Be mainly used in type ii diabetes intense heat due to deficiency of YIN type card, improve thirst and liking drink, rapid digestion of food is easily hungry, frequent micturition, and being irritable and getting angry easily, it is vexed that To Be Protected from Heat, diseases such as constipation with dry stool.
The effect of medicine according to the present invention, the inventor tests its pharmacodynamics from improving aspects such as diabetic animal blood glucose.
Concrete enforcement is as follows:
Test one, medicine of the present invention cause the influence of mice hyperglycemia to epinephrine
1, trial drug and reagent
Be subjected to the reagent thing to be the Chinese medicine composition among the present invention.
Epinephrine is produced for Sigma company
2, animal
Kunming mouse, body weight 18～22g, the male and female dual-purpose, the institute of biological products provides by Shandong.
3, grouping and administration
50 of male and female half and half mices are divided 5 groups at random by body weight, are respectively blank group (10ml/kg water), model control group (10ml/kg water), three dosage groups of invention medicine (800,400 and 200mg/kg).In 7 days every day gastric infusion once, irritate the long-pending 10ml/kg that is of body of stomach, after the last administration 2 hours, except that the blank group, all the other respectively organize equal lumbar injection epinephrine 240 μ g/kg, respectively at behind the injection epinephrine 0.5,1 and 2 hour, every treated animal are put to death 10, get blood, survey blood glucose with glucose oxidase method.The results are shown in Table 1.
Table 1 medicine of the present invention causes the influence (x ± s) of mice hyperglycemia to epinephrine
| Group | Dosage (mg/kg) | Mus number (only) | Blood glucose value (mmol/L) | ||
| 0.5h | 1h | 2h | |||
| Normal control | - | 10 | 7.75±1.20 | 7.5±1.38 | 17.81±1.64 |
| The model contrast | - | 10 | 17.1±4.12 | 12.6±1.79 | 49.54±0.86 |
| The invention medicine | 800 | 10 | 10.6±2.31*** | 10.3±1.58** | 8.14±1.18** |
| The invention medicine | 400 | 10 | 11.6±3.38** | 10.5±2.35* | 8.38±1.72 |
| The invention medicine | 200 | 10 | 13.6±2.76* | 10.5±2.18* | 8.44±1.23* |
Compare * P＜0.05, * * P＜0.01 with model control group
Epinephrine is to make blood sugar increasing owing to decomposing hepatic glycogen.This result of the test shows: medicine of the present invention can reduce the blood sugar increasing that epinephrine causes.
Test two, medicine of the present invention are to the influence of rat diabetes disease
1. experimental animal and medicine
The Wistar rat, male, body weight 220～250g at 3～4 monthly ages, is provided by Shandong University's Experimental Animal Center.
Be subjected to the reagent thing:, contain the preparation of 0.4g/kg by the preparation that optimal case of the present invention makes
The glipizide sheet, Hainan Jin Xiao pharmaceutical Co. Ltd product, lot number 030934
2. main agents and instrument
Streptozotocin (STZ), U.S. Sigma company product
The Unicheck test strip for blood-sugar, U.S. Diagnlstic Solutions Inc company product
One Touch blood glucose meter, U.S. Scanlife company product
AL204 type ten thousand/electronic balance.
3. test method
3.1 diabetes rat pathological model preparation
Choose 55 of rats, before the modeling in available light, freely drink water, trained for 1 week under the condition of freely ingesting.Randomly draw 9 and be normal control group (normal group), 9 are prevention administration group (prevention group), and 4d gives medicine of the present invention before the modeling, and 1 time/d is totally 5 weeks.Prepare the diabetes pathological model with 30 of residues behind the 4d.Change the cage tool before the modeling earlier, fasting (can't help water) 12h, STZ is dissolved in the citric acid-sodium citrate buffer solution for preparing then, be made into concentration and be 2% solution, press the capable lumbar injection of dosage of STZ50mg/kg, get tail blood behind the 72h, measure its fasting glucose (FBG) with One touch blood glucose meter, FBG 〉=11.11mmol/L person is defined as the modeling success.Normal control group isopyknic citric acid-sodium citrate buffer under lumbar injection the same terms.
3.2 test method
Randomly drawing 10 rats is normal control group (normal group).10 modelings of administration group (prevention group) in advance are success all.Remain 35,30 of modeling successes are divided into 3 groups of medicine groups of the present invention, model group, western medicine group, every group each 10 at random according to blood sugar level again.
Handle by the following method: normal group: irritate stomach with distilled water, dosage is pressed 20ml/kg again, give simultaneously in model group, and 1 time/d, totally 4 weeks.Model group: irritate stomach with distilled water, dosage is pressed 20ml/kg, gives after the modeling success, and 1 time/d, totally 4 weeks.The prevention group: irritate stomach with the invention medicine, dosage is by 20ml/kg (being equivalent to 30 times of normal adult consumptions), and the preceding 4d of modeling begins administration, and 1 time/d, totally 5 weeks.The invention group: irritate stomach with the invention medicine, dosage press 20ml/kg, modeling success administration afterwards, 1 time/d, totally 4 weeks.The Western medicine group: irritate stomach with glipizide, dosage is pressed 1.8ml/kg, adds 0.5% sodium carboxymethyl cellulose and is mixed with suspension, and dosage is pressed 20ml/kg.The administration of modeling success back, 1 time/d, totally 4 weeks.
3.3 observation index and method
Rat is surveyed body weight weekly 1 time, and record in addition.Respectively at the 0th week, the 4th weekend after the modeling getting blood, water 12h is can't help in fasting, and fasting glucose is surveyed in blood sampling.Method: survey 5min before the blood glucose and rat is placed temperature is set is 40 ℃ the permanent steady air dry oven of electric heating, take out then, place on the rat platform, cut off rat tail point, discard the 1st and bleed, get the 2nd and bleed, measure blood glucose with blood glucose meter with sharp knife blade.
4. result
4.1 respectively organize rat body weight relatively
Table 2 medicine of the present invention is to the influence of rat body weight (g, x ± s)
| Group | n | The 0th week | n | The 4th weekend | Rate of change |
| Normal group | 10 | 238.3852±6.7704 | 7 | 357.8794±13.1247 | 0.5142±0.0476 |
| Model group | 10 | 230.7486±7.0624 | 7 | 336.7145±11.5082 | 0.4436±0.0257 ** |
| The Western medicine group | 10 | 233.3402±7.1034 | 7 | 345.4567±12.0393 | 0.4776±0.0225 * |
| The invention group | 10 | 234.0501±10.5141 | 8 | 325.8472±21.4875 | 0.4813±0.0246 * |
| The prevention group | 10 | 232.5298±16.1015 | 8 | 348.8487±26.4205 | 0.4819±0.0379 * |
Annotate: compare with normal group:
*P＜0.05,
*P＜0.01; Compare with model group,
*P＜0.05
Last table result shows, in the 0th week, the body weight no significant difference of each experimental group rat (P＞0.05) illustrates the random packet balanced and reasonable.The 4th weekend the body weight change rate, more all there were significant differences for each modeling group and normal group (P＜0.05 or P＜0.01), there were significant differences (P＜0.05) for each group of administration and model group comparison.Compare zero difference between each group of administration.
4.2 respectively organize the rat blood sugar level relatively
Table 3 medicine of the present invention is to the influence of rat test blood glucose (x ± s)
| Group | n | The 0th week (mmol/L) | n | The 4th weekend (mmol/L) | Rate of change (%) |
| Normal group | 10 | 4.0807±0.2769 | 7 | 4.2514±0.2763 | 0.0531±0.1083 |
| Model group | 10 | 14.3851±1.4367 | 7 | 20.5414±3.1155 | 0.4496±0.2682 |
| The Western medicine group | 10 | 14.0036±1.2081 | 7 | 5.4843±1.2140 ** | 0.6120±0.0866 ** |
| Multiple spleen group | 10 | 14.0689±0.9602 | 8 | 10.6437±0.8937**▲▲ | 0.2521±0.0519**▲▲ |
| The prevention group | 10 | 13.2052±0.3759*▲△ | 8 | 10.3050±0.7356**▲▲ | 0.2158±0.0529**▲▲ |
Annotate: compare P＜0.05, P＜0.01 with normal group; Compare with model group,
*P＜0.05,
*P＜0.01; Compare with the Western medicine group, ▲ P＜0.05, ▲ ▲ P＜0.01; Compare △ P＜0.05 with the invention group.
Last table result shows, in the 0th week, the prevention group compares with the FBG level of invention group, Western medicine group that there were significant differences (P＜0.05), illustrates that the prevention group has the effect of prevention blood sugar increasing.The FBG level of the model group at the 0th week, the 4th weekend, invention group, prevention group, Western medicine group all is significantly higher than the normal group same period (P＜0.01 or P＜0.05), illustrates that this experiment modeling model stability is reliable.The 4th weekend FBG and rate of change thereof, invention group, prevention group, Western medicine group and model group significant difference (P＜0.01) illustrate that treatment is effectively.
The result shows, Chinese medicine composition among the present invention can improve the trophic level of rat, contain the process of becoming thin gradually that the disease Mus causes because of the metabolic disturbance of muscular tissue, stop the carbohydrate metabolism of the downward trend of disease Mus spleen and stomach function, the fortune function that promotes its taste, the sick Mus of improvement, and can obviously reduce the blood glucose after the rat modeling success.
As seen, the Chinese medicine composition among the present invention improves thirst and liking drink for type ii diabetes intense heat due to deficiency of YIN card, and rapid digestion of food is easily hungry, being irritable and getting angry easily, and To Be Protected from Heat, and vexed grade has curative effect preferably.
The specific embodiment
Illustrate with specific embodiment more below, to the present invention without limits but following this embodiment only is used to the present invention is described.
Embodiment one
[prescription]
Gypsum Fibrosum 133g Rhizoma Anemarrhenae 71g Radix Rehmanniae 89g 71g Radix Ophiopogonis
Radix Trichosanthis 106g Rhizoma Polygonati Odorati 89g Radix Scrophulariae 71g Radix Achyranthis Bidentatae 53g
Radix Salviae Miltiorrhizae 89g Rhizoma Alismatis 71g Radix Codonopsis 71g Fructus Corni 71g
Folium Eriobotryae 53g Fructus Schisandrae Sphenantherae 44g
[method for making]
More than 14 flavors, get Gypsum Fibrosum, the Rhizoma Anemarrhenae and add 10 times of amounts of water and decoct three times, each 1.5 hours, collecting decoction filtered, filtrate is concentrated into about 1000ml, leave standstill, filtration, filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).Other gets Radix Salviae Miltiorrhizae, Fructus Schisandrae Sphenantherae, Fructus Corni with 70% alcohol reflux three times, and each 2 hours, merge extractive liquid, reclaimed ethanol, filters, and filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).All the other Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Codonopsis, Folium Eriobotryae nine flavors decoct with water secondary, and each 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.11～1.12 (70 ℃), is chilled to room temperature, adds ethanol and reaches 60% to containing the alcohol amount, stir evenly, left standstill 12 hours, and drew supernatant, reclaim ethanol, filter, filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).Merge above three kinds of clear paste, be concentrated into the thick paste that relative density is about 1.35～1.38 (70 ℃), add an amount of dextrin and steviosin, mixing is made granule, and drying is made 1000g, promptly.
Embodiment two
[prescription]
Gypsum Fibrosum 266g Rhizoma Anemarrhenae 142g Radix Rehmanniae 198g 142g Radix Ophiopogonis
Radix Trichosanthis 212g Rhizoma Polygonati Odorati 198g Radix Scrophulariae 142g Radix Achyranthis Bidentatae 106g
Radix Salviae Miltiorrhizae 198g Rhizoma Alismatis 142g Radix Codonopsis 142g Fructus Corni 142g
Folium Eriobotryae 106g Fructus Schisandrae Sphenantherae 88g
[method for making]
More than 14 flavors, get Gypsum Fibrosum, the Rhizoma Anemarrhenae and add 10 times of amounts of water and decoct three times, each 1.5 hours, collecting decoction filtered, filtrate is concentrated into about 1000ml, leave standstill, filtration, filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).Other gets Radix Salviae Miltiorrhizae, Fructus Schisandrae Sphenantherae, Fructus Corni with 70% alcohol reflux three times, and each 2 hours, merge extractive liquid, reclaimed ethanol, filters, and filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).All the other Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Codonopsis, Folium Eriobotryae nine flavors decoct with water secondary, and each 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.11～1.12 (70 ℃), is chilled to room temperature, adds ethanol and reaches 60% to containing the alcohol amount, stir evenly, left standstill 12 hours, and drew supernatant, reclaim ethanol, filter, filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).Merge above three kinds of clear paste, be concentrated into the thick paste that relative density is about 1.35～1.38 (70 ℃), add 4% carboxymethylstach sodium and 10% microcrystalline Cellulose again, add starch to total amount 500g, mix homogeneously, with 85% ethanol moistening, cross 20 mesh sieves, dry below 70 ℃, add a small amount of magnesium stearate, granulate is pressed into 1000.
Embodiment three
[prescription]
Gypsum Fibrosum 266g Rhizoma Anemarrhenae 142g Radix Rehmanniae 198g 142g Radix Ophiopogonis
Radix Trichosanthis 212g Rhizoma Polygonati Odorati 198g Radix Scrophulariae 142g Radix Achyranthis Bidentatae 106g
Radix Salviae Miltiorrhizae 198g Rhizoma Alismatis 142g Radix Codonopsis 142g Fructus Corni 142g
Folium Eriobotryae 106g Fructus Schisandrae Sphenantherae 88g
[method for making]
More than 14 flavors, get Gypsum Fibrosum, the Rhizoma Anemarrhenae and add 10 times of amounts of water and decoct three times, each 1.5 hours, collecting decoction filtered, filtrate is concentrated into about 1000ml, leave standstill, filtration, filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).Other gets Radix Salviae Miltiorrhizae, Fructus Schisandrae Sphenantherae, Fructus Corni with 70% alcohol reflux three times, and each 2 hours, merge extractive liquid, reclaimed ethanol, filters, and filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).All the other Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Codonopsis, Folium Eriobotryae nine flavors decoct with water secondary, and each 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.11～1.12 (70 ℃), is chilled to room temperature, adds ethanol and reaches 60% to containing the alcohol amount, stir evenly, left standstill 12 hours, and drew supernatant, reclaim ethanol, filter, filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).Merge above three kinds of clear paste, be concentrated into the thick paste that relative density is about 1.35～1.38 (70 ℃), add microcrystalline Cellulose 200g, add starch to total amount 1000g, mixing, the system soft material is pressed into ball, drying, packing, promptly.
Claims (6)
1. Chinese medicine composition for the treatment of diabetes is characterized in that said composition made by following medicaments in part by weight:
35～105 parts of 35～105 parts of Radix Rehmanniae of 65～200 parts of Rhizoma Anemarrhenaes of Gypsum Fibrosum 45～135 parts of Radix Ophiopogonis
25～80 parts of 35～105 parts of Radix Achyranthis Bidentataes of 45～135 portions of Radix Scrophulariaes of 55～160 portions of Rhizoma Polygonati Odorati of Radix Trichosanthis
35～105 parts of 35～105 parts of Fructus Corni of 35～105 parts of Radix Codonopsis of 45～135 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae
20～60 parts of 25～80 parts of Fructus Schisandrae Sphenantheraes of Folium Eriobotryae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that said composition preferred weight ratio be:
71 parts of 71 parts of Radix Rehmanniae of 133 parts of Rhizoma Anemarrhenaes of Gypsum Fibrosum 89 parts of Radix Ophiopogonis
53 parts of 71 parts of Radix Achyranthis Bidentataes of 89 portions of Radix Scrophulariaes of 106 portions of Rhizoma Polygonati Odorati of Radix Trichosanthis
71 parts of 71 parts of Fructus Corni of 71 parts of Radix Codonopsis of 89 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae
44 parts of 53 parts of Fructus Schisandrae Sphenantheraes of Folium Eriobotryae.
3. Chinese medicine composition as claimed in claim 1 or 2 is characterized in that said composition can make acceptable pharmaceutical dosage form clinically such as granule, tablet, capsule, pill.
4. as the preparation method of Chinese medicine composition as described in the claim 3, it is characterized in that comprising following steps:
A, get Gypsum Fibrosum, the Rhizoma Anemarrhenae, add 8～12 times of water gagings and decoct 2～4 times, each 1～3 hour, collecting decoction filtered, and filtrate is concentrated into about 1000ml, leave standstill, and filtration, filtrate is concentrated into relative density and is determined as 1.15～1.38 clear paste at 60～80 ℃, and is standby;
B, get Radix Salviae Miltiorrhizae, Fructus Schisandrae Sphenantherae, Fructus Corni, with 40%～90% alcohol reflux 2～4 times, each 1～3 hour, merge extractive liquid, reclaimed ethanol, filtered, and filtrate is concentrated into relative density and is determined as 1.15～1.38 clear paste at 60～80 ℃, and is standby;
C, get Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Codonopsis, Folium Eriobotryae, decoct with water each 0.5～2 hour 1～3 time, collecting decoction filters, and filtrate is concentrated into relative density and is determined as 1.01～1.22 clear paste at 60～80 ℃, be chilled to room temperature, add ethanol and reach 40%～80%, stir evenly to containing the alcohol amount, left standstill 6～24 hours, draw supernatant, reclaim ethanol, filter, filtrate is concentrated into relative density and is determined as 1.15～1.38 clear paste at 60～80 ℃, and is standby;
D, merge above three kinds of clear paste, be concentrated into relative density and be determined as 1.25～1.45 thick paste, add conventional adjuvant, make required dosage form at 60～80 ℃.
5. the preparation method of Chinese medicine composition as claimed in claim 4 is characterized in that comprising following steps:
A, get Gypsum Fibrosum, the Rhizoma Anemarrhenae, add 10 times of amounts of water and decoct three times, each 1.5 hours, collecting decoction filtered, and filtrate is concentrated into about 1000ml, leave standstill, and filtration, filtrate is concentrated into relative density and is determined as 1.25～1.28 clear paste at 70 ℃, and is standby;
B, get Radix Salviae Miltiorrhizae, Fructus Schisandrae Sphenantherae, Fructus Corni, with 70% alcohol reflux three times, each 2 hours, merge extractive liquid, reclaimed ethanol, filtered, and filtrate is concentrated into relative density and is determined as 1.25～1.28 clear paste at 70 ℃, and is standby;
C, get Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Codonopsis, Folium Eriobotryae, decoct with water secondary, each 1 hour, collecting decoction filters, and filtrate is concentrated into relative density and is determined as 1.11～1.12 clear paste at 70 ℃, be chilled to room temperature, add ethanol and reach 60%, stir evenly to containing the alcohol amount, left standstill 12 hours, draw supernatant, reclaim ethanol, filter, filtrate is concentrated into relative density and is determined as 1.25～1.28 clear paste at 70 ℃, and is standby;
D, merge above three kinds of clear paste, be concentrated into relative density and be determined as 1.35～1.38 thick paste at 70 ℃; Add suitable adjuvant, make required dosage form.
6. Chinese medicine composition as claimed in claim 1 or 2 is used for the treatment of application in the diabetes medicament in preparation.
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| CN2005101078625A CN1943719B (en) | 2005-10-08 | 2005-10-08 | A Chinese traditional medicinal composition for treating diabetes and its preparation method |
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| CN1943719B CN1943719B (en) | 2010-09-22 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107737234A (en) * | 2017-10-27 | 2018-02-27 | 北京昆达中医医学研究院 | A kind of medicine for preventing and treating diabete peripheral herve pathology |
| CN109908261A (en) * | 2017-12-13 | 2019-06-21 | 河北万邦复临药业有限公司 | A kind of preparation method for treating diabetes medicament |
-
2005
- 2005-10-08 CN CN2005101078625A patent/CN1943719B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107737234A (en) * | 2017-10-27 | 2018-02-27 | 北京昆达中医医学研究院 | A kind of medicine for preventing and treating diabete peripheral herve pathology |
| CN109908261A (en) * | 2017-12-13 | 2019-06-21 | 河北万邦复临药业有限公司 | A kind of preparation method for treating diabetes medicament |
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| Publication number | Publication date |
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| CN1943719B (en) | 2010-09-22 |
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