CN1943657A - A Chinese traditional medicinal composition and its preparation method - Google Patents
A Chinese traditional medicinal composition and its preparation method Download PDFInfo
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- CN1943657A CN1943657A CN 200510105940 CN200510105940A CN1943657A CN 1943657 A CN1943657 A CN 1943657A CN 200510105940 CN200510105940 CN 200510105940 CN 200510105940 A CN200510105940 A CN 200510105940A CN 1943657 A CN1943657 A CN 1943657A
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Abstract
This invention reveals a Chinese traditional medicinal composition treating constipation and its preparation method. This composition is prepared by using radix scutellariae, cape jasmine, peony root bark, garden burnet root, sophora flower, fructus cannabis, liquorice according certain processing technology used for remitting the symptom of anus gall defecating with blood, constipation due to stasis hemorrhoids coursed by wind heat stasis, damp heat stasis, and at the same time revealed its preparing method.
Description
Technical field
The present invention relates to a kind of swelling and pain of anus that stagnation of damp-heat type hemorrhoid cause for the treatment of, bleed in the time of just, Chinese medicine composition of symptoms such as constipation due to dry stool and preparation method thereof belongs to the field of Chinese medicines.
Background technology
Show that according to relevant reconnaissance information the sickness rate of anorectal disease is 59.1%, hemorrhoid account for 87.25% in all anal and intestinal diseases, and wherein common with internal hemorrhoid, account for 52.19% of all anal and intestinal diseases.The men and women all can fall ill, and women's sickness rate is 67%, and male's sickness rate is 53.9%, is height with women's sickness rate; Any age all can fall ill, and wherein the people in 20-40 year comparatively more sees, and can increase the weight of gradually along with the increase at age, so saying of " ten people, nine hemorrhoid " arranged.Its pathogenic factor is a lot of, sitting, station, fatigue etc. for a long time make human body be in a kind of fixation postures for a long time, thereby influence blood circulation, make slow blood flow and the interior internal organs hyperemia of abdomen in the pelvic cavity, cause that haemorrhoidal vein over filling, varicose, protuberance, wall of vein tension force descend and causes that hemorrhoid are one of major reasons of morbidity.If hypomotility, enterokinesia is slowed down, and feces is descending slow or because of habitual constipation, thereby the compressing vein makes contrafluxion and blood backflow obstacle, causes the intrinsic pressure rising of haemorrhoidal vein, and the wall of vein resistance reduces, and also can cause the hemorrhoid sickness rate to increase.According to clinical observation and the analysis of statistics findings of the survey, there were significant differences for the prevalence among the different occupation patient, and government functionary, driver, shop-assistant, teacher's prevalence is obviously higher clinically.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of constipation and preparation method thereof for preparing.
The present invention seeks to be achieved through the following technical solutions:
At first be that prescription is formed, comprise following bulk drugs:
Radix Scutellariae 800～950 weight portion Fructus Gardeniaes 500～700 weight portion Cortex Moutans 200～320 weight portions
Radix Sanguisorbae 200～320 weight portion Flos Sophoraes 200～320 weight portion Fructus Cannabiss 200～320 weight portions
Radix Glycyrrhizae 200～320 weight portions
Further after the research, determine that its best group becomes:
Radix Scutellariae 900 weight portion Fructus Gardeniaes 600 weight portion Cortex Moutans 270 weight portions
Radix Sanguisorbae 270 weight portion Flos Sophoraes 270 weight portion Fructus Cannabiss 270 weight portions
Radix Glycyrrhizae 270 weight portions
Should write out a prescription, invention is thought can make clinical required oral liquid, granule, tablet, capsule.Be directed to this, the inventor has carried out technical study again.Its process is as follows:
Get crude drug, decoct with water secondary, add 10 times of amounts of water at every turn, decocted 1 hour, wherein Radix Scutellariae, Flos Sophorae boiling water feed intake, and decoct with distillation parallel, distillate device is in addition collected, and collecting decoction filters, it is 1.20 that filtrate is concentrated into 70 ℃ of relative densities, is chilled to room temperature, adds ethanol and makes and contain alcohol amount and reach 70%, stir evenly, left standstill 24 hours, filter, filtrate recycling ethanol is made concentrated solution, promptly.
The specific embodiment:
Medicine of the present invention is applicable to the swelling and pain of anus that stagnation of damp-heat type hemorrhoid cause, bleeds symptoms such as constipation due to dry stool in the time of just.The inventor cures mainly according to its function, from heat-clearing and toxic substances removing, loosening bowel to relieve constipation aspect its pharmacodynamics is verified.
The animal Kunming mouse, body weight 18～22g, the male and female dual-purpose is provided by laboratory animal portion of Medical School of Peking University.
Method
Test the experiment of 1 refrigeration function
Method: do prerun earlier, the suitable pyrogenicity dosage that records escherichia coli endotoxin is 150ng/kg.Getting body weight is 18～22kg, 20 of the qualified healthy rabbits of body temperature between 38.6～39.5 ℃, and male and female are not limit.Be divided into 4 groups by the basal body temperature stratified random, survey a body temperature every 30min before the administration, with the meansigma methods of twice body temperature as radix.Press 20ml/kg, irritate stomach respectively and give 500%, 250% compositions (100g/kg, 50g/kg are equivalent to 20 times of clinical consumption respectively, 10 times, below all with), 50% paracetamol distilled water diluting liquid 320mg/kg, be equivalent to 20 times of consumptions, below all with) and normal saline.1h behind the medicine is from auricular vein injection escherichia coli endotoxin 150ng/kg (1ml/kg).Attack back 1h, 2h, 3h, 4h, 5h and 6h in endotoxin and respectively survey body temperature 1 time, calculate the body temperature changing value (Δ T) of each minute, the results are shown in Table 1 according to radix.
Table 1 compositions is to the influence of endotoxin-induced fever in rabbits
| Group | Number of animals (only) | Dosage (g/kg) | Basal body temperature (℃) (X ± S) | ΔT (℃)(X±S) |
| High dose group low dose group paracetamol group NS group | 5 5 5 5 | 100 50 0.32 equal-volumes | 39.1±0.18 39.1±0.15 39.0±0.26 38.9±0.22 | 0.58±0.18** Δ 0.96±0.21** 0.85±0.15** 1.36±0.18 |
Annotate: Δ T compares Δ P＜0.05 by above table 1 as can be seen for heating peak body temperature changing value and NS group * * P＜0.01 relatively with the paracetamol group, and the paracetamol child oral syrup of bringing down a fever has the trivial solution heat effect to the fever in rabbits due to the endotoxin.The heat effect of the equal tool trivial solution of the high low dose group of compositions, and the high dose group refrigeration function is better than paracetamol group, significant difference.
The defecation influence of 2 pairs of normal mouses of test
40 of normal mouses, fasting 6h, be divided into 4 groups at random, every group 10, each group respectively with high (1.5ml/kg), in (3ml/kg), low (6ml/kg) liquid oral dosage (dilution be 10ml respectively, down with) and normal saline filling stomach, observe every animal 7h fecal grains after the administration continuously, stool weight, adopts the relatively difference of each treated animal These parameters of t check at the 1st discharge melena time.
The influence of table 2 pair normal mouse defecation (X ± s)
| Group | Number of animals (only) | Defecation time (min) | Fecal grains | Stool weight (mg) |
| Dosage group high dose group in the normal saline low dose group | 10 10 10 10 | 32.3±4.65 30.5±4.86 22.3±5.12 20.1±4.52 | 3.8±3.25 5.1±1.16 5.4±2.02 7.6±2.25 | 44.6±24.2 55.8±25.8 62.8±22.1 72.5±25.1 |
Annotate: compare P＜0.05 with the normal saline group.
Embodiment one
[prescription] Radix Scutellariae (wine) 900g Fructus Gardeniae (stir-fry) 600g Cortex Moutan 270g Radix Sanguisorbae (stir-fry) 270g
Flos Sophorae (stir-fry) 270g Fructus Cannabis (stir-fry) 270g Radix Glycyrrhizae 270g
[method for making] above seven flavors decoct with water secondary, add 10 times of amounts of water at every turn, decoct 1 hour, wherein Radix Scutellariae, Flos Sophorae boiling water feed intake, and decoct with distillation to walk abreast, and distillate device is in addition collected collecting decoction, filter, it is 1.20 (70 ℃) that filtrate is concentrated into relative density, is chilled to room temperature, adds ethanol and makes and contain the alcohol amount and reach 70%, stir evenly, left standstill 24 hours, filter filtrate recycling ethanol, add distillate, benzoic acid 2g, add water and adjust total amount, stir evenly to 1000ml, filter, embedding, promptly.
Embodiment two
[prescription] Radix Scutellariae (wine) 900g Fructus Gardeniae (stir-fry) 600g Cortex Moutan 270g Radix Sanguisorbae (stir-fry) 270g
Flos Sophorae (stir-fry) 270g Fructus Cannabis (stir-fry) 270g Radix Glycyrrhizae 270g
[method for making] above seven flavors decoct with water secondary, add 10 times of amounts of water at every turn, decoct 1 hour, wherein Radix Scutellariae, Flos Sophorae boiling water feed intake, and decoct with distillation to walk abreast, and distillate device is in addition collected collecting decoction, filter, it is 1.20 (70 ℃) that filtrate is concentrated into relative density, is chilled to room temperature, adds ethanol and makes and contain the alcohol amount and reach 70%, stir evenly, left standstill 24 hours, filter, filtrate recycling ethanol, being concentrated into relative density is 1.10 (60 ℃), spray drying, with sucrose to total amount is 1000g, and dry-pressing is granulated, promptly.
Claims (5)
1. Chinese medicine composition is characterized in that this pharmaceutical composition made by following raw material medicaments:
Radix Scutellariae 800～950 weight portion Fructus Gardeniaes 500～700 weight portion Cortex Moutans 200～320 weight portions
Radix Sanguisorbae 200～320 weight portion Flos Sophoraes 200～320 weight portion Fructus Cannabiss 200～320 weight portions
Radix Glycyrrhizae 200～320 weight portions
2. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following raw materials according:
Radix Scutellariae 900 weight portion Fructus Gardeniaes 600 weight portion Cortex Moutans 270 weight portions
Radix Sanguisorbae 270 weight portion Flos Sophoraes 270 weight portion Fructus Cannabiss 270 weight portions
Radix Glycyrrhizae 270 weight portions
3. Chinese medicine composition as claimed in claim 1 is characterized in that said composition can be made into clinical required oral liquid, granule, tablet, capsule.
4. the preparation method of Chinese medicine composition as claimed in claim 1 is characterized in that preparing as follows: get crude drug, decoct with water 1-3 time, the each decoction 1-3 hour, wherein Radix Scutellariae, Flos Sophorae boiling water feed intake, and decoct with distillation parallel, distillate device is in addition collected, and collecting decoction filters, filtrate is condensed into clear paste, is chilled to room temperature, adds ethanol and makes the alcohol amount of containing reach 60-80%, stir evenly, leave standstill, filter, filtrate recycling ethanol is made concentrated solution, promptly.
5. the preparation method of Chinese medicine composition as claimed in claim 1 is characterized in that preparing as follows: get crude drug, decoct with water secondary, add 10 times of amounts of water at every turn, decocted 1 hour, wherein Radix Scutellariae, Flos Sophorae boiling water feed intake, and decoct with distillation parallel, distillate device is in addition collected, and collecting decoction filters, it is 1.20 that filtrate is concentrated into 70 ℃ of relative densities, is chilled to room temperature, adds ethanol and makes and contain alcohol amount and reach 70%, stir evenly, left standstill 24 hours, filter, filtrate recycling ethanol is made concentrated solution, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2005101059408A CN1943657B (en) | 2005-10-08 | 2005-10-08 | A Chinese traditional medicinal composition and its preparation method |
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| CN2005101059408A CN1943657B (en) | 2005-10-08 | 2005-10-08 | A Chinese traditional medicinal composition and its preparation method |
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| CN1943657A true CN1943657A (en) | 2007-04-11 |
| CN1943657B CN1943657B (en) | 2010-11-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125692A (en) * | 2015-09-29 | 2015-12-09 | 济南邦文医药科技有限公司 | Traditional Chinese medicine composition for treating damp-heat downward flow type constipation after hemorrhoids PPH (Procedure for Prolapse and Hemorrhoids) surgery |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256129C (en) * | 2003-05-27 | 2006-05-17 | 佳木斯市肛肠医院 | Anagetic muscle regenerating paste for pile |
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2005
- 2005-10-08 CN CN2005101059408A patent/CN1943657B/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125692A (en) * | 2015-09-29 | 2015-12-09 | 济南邦文医药科技有限公司 | Traditional Chinese medicine composition for treating damp-heat downward flow type constipation after hemorrhoids PPH (Procedure for Prolapse and Hemorrhoids) surgery |
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| Publication number | Publication date |
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| CN1943657B (en) | 2010-11-10 |
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