CN1943598A - Eye medicine for preventing and curing shortsightedness and relieving sight fatigue and its preparing method - Google Patents
Eye medicine for preventing and curing shortsightedness and relieving sight fatigue and its preparing method Download PDFInfo
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- CN1943598A CN1943598A CNA2005100218163A CN200510021816A CN1943598A CN 1943598 A CN1943598 A CN 1943598A CN A2005100218163 A CNA2005100218163 A CN A2005100218163A CN 200510021816 A CN200510021816 A CN 200510021816A CN 1943598 A CN1943598 A CN 1943598A
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Abstract
The invention provides a medicine of eye use for prevention and cure shortsightedness particularly for youngsters pseudomyopia and reliving eyestrain and its preparation method. Said invention is compound of medicine for eye use comprising effective components such as pearl or pearl powder, borneol, zinc gluconate, and auxiliary component acceptable by medicine for eye use and preparation method thereof. Said invention is made up of several medicines and prepared into liquid or semi-solid medicine for eye use.
Description
Technical field the present invention is a kind of eye medicinal of preventing and treating near-sighted particularly teenage pseudomyopia and alleviating asthenopia and preparation method thereof.Belong to pharmaceutical sanitary field.
The background technology Margarita is that bivalve irriates such as Pteriidae animal Pteria martensii Dunker, Unionidae animal hydriopsis cumingii or pleat hat freshwater mussel form, and takes out cleaning, drying and obtaining in animal body.Sweet in the mouth, salty, cold, GUIXIN, Liver Channel.China's traditional medicine thinks that Margarita has the drug effect of the arresting convulsion of calming the nerves, the removing nebula that makes eye bright, the nourishing the liver that makes eye bright.China's myopia incidence rate is high, particularly in teenager the pseudomyopia incidence rate up to 60-80%.The great cause that the control of myopia involves the interests of the state and the people.Particularly the medicine of teenage pseudomyopia is few to can be used for preventing and treating myopia at present.
We are according to market demand, theory of Chinese medical science and modern medical theory are combined, study and invented a kind of eye medicinal of preventing and treating near-sighted particularly teenage pseudomyopia and alleviating asthenopia, and adopt the eye medicinal liquid preparation and the solid preparation of modern pharmaceutical technology preparation control teenage pseudomyopia and alleviating asthenopia.
Summary of the invention the object of the invention first purpose is to provide a kind of eye medicinal of preventing and treating shortsightedness and relieving sight fatigue.
Another object of the present invention is to the eye medicinal of control shortsightedness and relieving sight fatigue is made the eye liquid preparation.
Another purpose of the present invention is the eye medicinal of control shortsightedness and relieving sight fatigue is made the eye semi-solid preparation.
First purpose of the present invention realizes by following steps.
With Margarita or Margarita layer powder, Borneolum Syntheticum, zinc gluconate is the active drug composition, mixes composition with the auxiliary adding ingredient of eye medicinal preparation acceptable, and the weight portion ratio of each active drug composition is:
Margarita or Margarita layer powder 250-450 Borneolum Syntheticum 0.1-6 zinc gluconate 1-4
The better weight portion ratio of active drug composition of the present invention is:
Margarita or Margarita layer powder 300-400 Borneolum Syntheticum 0.2-0.4 zinc gluconate 2-3
Optimum weight part ratio of active drug composition of the present invention is:
Margarita or Margarita layer powder 320 Borneolum Syntheticums 0.3 zinc gluconate 2.3
Another object of the present invention realizes by following steps.
A: get Margarita or get Margarita layer powder, add the injection water and stir evenly, heating filters, and filtrate concentrates, and puts coldly, filters, and it is standby that filtrate is the Margarita layer powder extracting solution;
B: get sodium chloride, Margarita or Margarita layer powder extracting solution, zinc gluconate mixes, heating is stirred and is made dissolving, boils, and filters, and the filtrate cooling is standby;
C: get Borneolum Syntheticum, polysorbate80 adds ethanol makes dissolving, is added in the described filtrate of B, stirs, and adds the injection water to the 800-1000 weight part ratio, stirs evenly, and filters, embedding promptly gets and makes the clear and bright eye drop body preparation of water solublity.
Its drug effect of eye medicinal liquid preparation that makes as stated above is a nourishing the liver to improve visual acuity with curing mainly function, is used for myopia and alleviating asthenopia, is specially adapted to teenage pseudomyopia and alleviates the asthenopia that causes because of visual TV, computer screen.
Another purpose of the present invention realizes by following steps.
A: get Margarita or get Margarita layer powder, add the injection water and stir evenly, heating filters, and filtrate concentrates, and puts coldly, filters, and it is standby that filtrate is the Margarita layer powder extracting solution;
B: get sodium chloride, Margarita or Margarita layer powder extracting solution, zinc gluconate mixes, heating is stirred and is made dissolving, boils, and filters, and the filtrate cooling is standby;
C: get Borneolum Syntheticum, polysorbate80 adds ethanol makes dissolving, is added in the described filtrate of B, stirs, and makes the aqueous phase solution of semi-solid preparation;
D: getting eye, use semi-solid preparation oil phase substrate, its weight part ratio be 800 to deduct aqueous phase solution weight part ratio or 1000 and deduct the aqueous phase solution weight part ratio, and heating stirs evenly, the described aqueous phase solution of C added, and stirring, fill, promptly.
Above-mentioned eye medicinal semi-solid preparation is ophthalmic ointment, gel for eye.
Margarita of the present invention comprises Margarita, Margarita powder, Margarita hydrolyzed solution, is specially:
A: bivalve irriates such as Pteriidae animal Pteria martensii Dunker, Unionidae animal hydriopsis cumingii or pleat hat freshwater mussel form, and take out cleaning, drying and the material that obtains in animal body.
B: adopt elutriation or pulverizing or other mechanical means to prepare Margarita powder the described material of A.
C: or the Margarita powder that B makes is added water 5-10 doubly measure, boil 20-60 hour, cooling, filtration, filtrate and concentrate, prepare Margarita hydrolyzed solution.
Margarita layer powder of the present invention is the powder that layer segment processes in the pearl shell.
Margarita of making as stated above or Margarita layer powder eye medicinal semi-solid preparation have the drug effect of nourishing the liver to improve visual acuity, are used for myopia and remitting vision fatigue, are specially adapted to teenage pseudomyopia and alleviate the asthenopia that causes because of visual TV, computer screen.
Further elaborate the present invention below in conjunction with embodiment.
Embodiment one
Take by weighing raw material by following proportioning:
Margarita layer powder 3200g Borneolum Syntheticum 3g zinc gluconate 23g
Preparation method is as follows:
A: get Margarita layer powder, add the injection water and stir evenly, heating filters, and filtrate concentrates, and puts coldly, filters, and it is standby that filtrate is the Margarita layer powder extracting solution;
B: get sodium chloride, Margarita layer powder extracting solution, zinc gluconate and mix, heating is stirred dissolving is boiled, and filters, and the filtrate cooling is standby;
C: get Borneolum Syntheticum, polysorbate80 adds ethanol makes dissolving, is added in the described filtrate of B, stirs, and adds the injection water to 10000ml, stirs evenly, and filters, embedding promptly gets and makes the clear and bright eye drop body preparation of water solublity.
Embodiment two
Take by weighing raw material by following proportioning:
Margarita 3200g Borneolum Syntheticum 3g zinc gluconate 23g
Preparation method is as follows:
A: get Margarita, add the injection water and stir evenly, heating filters, and filtrate concentrates, and puts coldly, filters, and it is standby that filtrate is the Margarita extracting solution;
B: get sodium chloride, Margarita extracting solution, zinc gluconate and mix, heating is stirred dissolving is boiled, and filters, and the filtrate cooling is standby;
C: get Borneolum Syntheticum, polysorbate80 adds ethanol makes dissolving, is added in the described filtrate of B, stirs, and adds the injection water to 10000ml, stirs evenly, and filters, embedding promptly gets and makes the clear and bright eye drop body preparation of water solublity.
Embodiment three:
Take by weighing raw material by following proportioning:
Margarita layer powder 3200g Borneolum Syntheticum 3g zinc gluconate 23
Preparation method is as follows:
A: get Margarita layer powder, add injection water 5000g and stir evenly, heating filters, and filtrate is concentrated into 2500g, puts coldly, filters, and it is standby that filtrate is the Margarita layer powder extracting solution;
B: get sodium chloride, Margarita layer powder extracting solution, zinc gluconate and mix, heating is stirred and is made dissolving, boils, and filters, and the filtrate cooling is standby;
C: get Borneolum Syntheticum, polysorbate80 adds ethanol 100g makes dissolving, is added in the described filtrate of B, stirs, and makes the aqueous phase solution of semi-solid preparation;
D: get eye semi-solid preparation oil phase substrate 7400g, heating stirs evenly, and the described aqueous phase solution of C is added, stirs, and fill, promptly.
Embodiment four
Take by weighing raw material by following proportioning:
Margarita 3200g Borneolum Syntheticum 3g zinc gluconate 23
Preparation method is as follows:
A: get Margarita, add injection water 5000g and stir evenly, heating filters, and filtrate is concentrated into 2500g, puts coldly, filters, and it is standby that filtrate is the Margarita extracting solution;
B: get sodium chloride, Margarita extracting solution, zinc gluconate and mix, heating is stirred and is made dissolving, boils, and filters, and the filtrate cooling is standby;
C: get Borneolum Syntheticum, polysorbate80 adds ethanol 100g makes dissolving, is added in the described filtrate of B, stirs, and makes the aqueous phase solution of semi-solid preparation;
D: get eye semi-solid preparation oil phase substrate 7400g, heating stirs evenly, and the described aqueous phase solution of C is added, stirs, and fill, promptly.
Set forth good effect of the present invention below:
Margarita sweet in the mouth, salty, cold, GUIXIN, Liver Channel.Have the arresting convulsion of calming the nerves, removing nebula makes eye bright, the drug effect of nourishing the liver to improve visual acuity; Zinc gluconate can activate multiple important antioxidase, thereby eliminates the damage of free radical, safeguards the normal permeability of eye cell membrane; Keep conjunctiva, the effect of cornea normal function; Borneolum Syntheticum is refrigerant comfortable; Above-mentioned all medicines share, and collaborative performance curative effect is to myopia and remitting vision fatigue, particularly for teenage pseudomyopia and alleviate the asthenopia that causes because of visual TV, computer screen treatment and preventive effect are arranged.
Liquid preparation of the present invention is dripped in eyelid, and one time 1-2 drips, and 3-4 time on the one, closes behind the eye drip order 2-3 minute; Or semi-solid preparation of the present invention is applied in the eyelid, one time 1-2 drips, and 3-4 time on the one, closes behind the eye drip order 2-3 minute; To effectively prevent and treat myopia and remitting vision fatigue, and particularly effectively prevent and treat teenage pseudomyopia and alleviate the asthenopia that causes because of visual TV, computer screen.
Claims (8)
1. eye medicinal that is used to prevent and treat myopia and alleviating asthenopia, it is characterized in that with Margarita or Margarita layer powder, Borneolum Syntheticum, zinc gluconate be the active drug composition, mix composition with the auxiliary adding ingredient of eye medicinal preparation acceptable, the weight portion ratio of each active drug composition is:
Margarita or Margarita layer powder 250-450 Borneolum Syntheticum 0.1-6 zinc gluconate 1-4.
2. eye medicinal as claimed in claim 1 is characterized in that the better weight portion ratio of described each active drug composition is:
Margarita or Margarita layer powder 300-400 Borneolum Syntheticum 0.2-0.4 zinc gluconate 2-3.
3. as claim 1 and 2 described eye medicinals, it is characterized in that optimum weight part ratio of described each active drug composition is:
Margarita or Margarita layer powder 320 Borneolum Syntheticums 0.3 zinc gluconate 2.3.
4. as the preparation method of claim 1 and 2 and 3 described eye medicinal liquid preparations, it is characterized in that
A: get Margarita or get Margarita layer powder, add the injection water and stir evenly, heating filters, and filtrate concentrates, and puts coldly, filters, and it is standby that filtrate is the Margarita layer powder extracting solution;
B: get sodium chloride, Margarita or Margarita layer powder extracting solution, zinc gluconate mixes, heating is stirred dissolving is boiled, and filters, and the filtrate cooling is standby;
C: get Borneolum Syntheticum, polysorbate80 adds ethanol makes dissolving, is added in the described filtrate of B, stirs, and adds the injection water to the 800-1000 weight part ratio, stirs evenly, and filters, embedding promptly gets and makes the clear and bright eye drop body preparation of water solublity.
5. eye medicinal eye drop body preparation as claimed in claim 4 is characterized in that drug effect is a nourishing the liver to improve visual acuity, is used for myopia and remitting vision fatigue, is specially adapted to teenage pseudomyopia and alleviates the asthenopia that causes because of visual TV, computer screen.
6. as the preparation method of eye medicinal semi-solid preparation as described in claim 1 and 2 and 3, it is characterized in that
A: get Margarita or get Margarita layer powder, add the injection water and stir evenly, heating filters, and filtrate concentrates, and puts coldly, filters, and it is standby that filtrate is the Margarita layer powder extracting solution;
B: get sodium chloride, Margarita or Margarita layer powder extracting solution, zinc gluconate mixes, heating is stirred dissolving is boiled, and filters, and the filtrate cooling is standby;
C: get Borneolum Syntheticum, polysorbate80 adds ethanol makes dissolving, is added in the described filtrate of B, stirs, and makes the aqueous phase solution of semi-solid preparation;
D: get eye semi-solid preparation substrate 800-1000 weight part ratio, heating stirs evenly, and the described aqueous phase solution of D is added, and stirs evenly, filters, and embedding, promptly.
7. eye medicinal semi-solid preparation as claimed in claim 6 is ophthalmic ointment, gel for eye.
8. eye medicinal semi-solid preparation as claimed in claim 6 is characterized in that drug effect is a nourishing the liver to improve visual acuity, is used for myopia and remitting vision fatigue, is specially adapted to teenage pseudomyopia and alleviates the asthenopia that causes because of visual TV, computer screen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100218163A CN1943598A (en) | 2005-10-08 | 2005-10-08 | Eye medicine for preventing and curing shortsightedness and relieving sight fatigue and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100218163A CN1943598A (en) | 2005-10-08 | 2005-10-08 | Eye medicine for preventing and curing shortsightedness and relieving sight fatigue and its preparing method |
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| CN1943598A true CN1943598A (en) | 2007-04-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2005100218163A Pending CN1943598A (en) | 2005-10-08 | 2005-10-08 | Eye medicine for preventing and curing shortsightedness and relieving sight fatigue and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961749A (en) * | 2012-11-07 | 2013-03-13 | 温州医学院 | Application of fibrate drugs used as drugs for inhibiting myopia |
| CN109260145A (en) * | 2018-10-09 | 2019-01-25 | 湖北远大天天明制药有限公司 | It can releive eye drop composition, preparation method and the purposes of eye strain containing nacreous layer powder |
-
2005
- 2005-10-08 CN CNA2005100218163A patent/CN1943598A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961749A (en) * | 2012-11-07 | 2013-03-13 | 温州医学院 | Application of fibrate drugs used as drugs for inhibiting myopia |
| CN109260145A (en) * | 2018-10-09 | 2019-01-25 | 湖北远大天天明制药有限公司 | It can releive eye drop composition, preparation method and the purposes of eye strain containing nacreous layer powder |
| CN109260145B (en) * | 2018-10-09 | 2020-12-22 | 湖北远大天天明制药有限公司 | Eye drop composition containing pearl powder and capable of relieving eye fatigue, preparation method and application |
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Open date: 20070411 |