CN1931354A - Arrhythmia treating Chinese medicine prepn and its prepn process - Google Patents
Arrhythmia treating Chinese medicine prepn and its prepn process Download PDFInfo
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- CN1931354A CN1931354A CN 200510018005 CN200510018005A CN1931354A CN 1931354 A CN1931354 A CN 1931354A CN 200510018005 CN200510018005 CN 200510018005 CN 200510018005 A CN200510018005 A CN 200510018005A CN 1931354 A CN1931354 A CN 1931354A
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Abstract
The present invention belongs to the field of Chinese medicine preparation technology, and is especially arrhythmia treating Chinese medicine preparation prepared with flavescent sophora root 3-9 weight portions, red sage 3-12 weight portions, spikenard 2-6 weight portions, Yunnan tuckahoe 3-10 weight portions, prepared licorice 3-8 weight portions, dry ginger 1-6 weight portions and magnet 3-9 weight portions. The preparation process includes the following steps: 1. crushing dry ginger, red sage, spikenard and Yunnan Tuckahoe into meal; 2. decocting magnet for 2-4 times to obtain decoction; 3. soaking flavescent sophora root and prepared licorice in the decoction, decocting for 2-4 times, filtering and concentrating to obtain extractum; 4. mixing the meal and the extractum, drying and grinding into powder; and 5. sterilizing the powder and filling into 0# capsule. The Chinese medicine preparation has high curative effect on arrhythmia.
Description
Affiliated technical field
The invention belongs to the Chinese medicine preparation technical field.Relate generally to ARR Chinese medicine preparation of a kind of treatment and preparation method thereof.
Background technology
Arrhythmia is one of clinical common disease.Not only can occur in the patient that organic heart diseasies such as chronic heart failure, myocardial ischemia, myocardial hypertrophy become, also can concurrently not have obvious structural disease change person in heart, some serious arrhythmia has become human underlying cause of death.
In the clinical multiple arrhythmia, the most common with multiple premature beat except that sinus tachycardia and arrhythmia, secondly be atrial fibrillation.Chamber in various degree or intraventricular conductional block and paroxysmal supraventricular tachycardia are also more to be seen.More rare is ventricular tachycardia, the boundary property rhythm of the heart, atrial flutter and ventricular flutter, vibration etc.The traditional Chinese medical science is with clinical multiple arrhythmia ownership " cardiopalmus " category, and the traditional Chinese medical science thinks that the generation of cardiopalmus is relevant with following factor.1. have a delicate constitution.2. improper diet and overtiredness.3. damaged by excess of seven emotions.Said as " element ask lift pain opinion ": " the frightened then heart does not have institute and leans on, and refreshing do not have institute and return, and considers nothing and decide, so nothing is random." 4. being invaded by exogenous pathogen.5. drug intoxication etc.
Clinical four classes that usually antiarrhythmic drug are divided into.One class is a sodium channel inhibitor, and two classes are the beta receptor antagonist, and three classes are over reach current potential time-histories medicine, and four classes are calcium channel blocker.Discover that though be the arrhythmia of the sodium channel inhibitor may command myocardial infarction patient of representative with flecainide etc., the group of taking medicine mortality rate is higher than the comfort group, shows that the sodium channel blocking medicine is invalid.At present, three class antiarrhythmic drugs of clinical use are mainly based on simple type or compound potassium channel antagonists.Although constantly have three new class antiarrhythmic drugs to come out in recent years, in the research and development process of this type of medicine, also expose great number of issues.First, antiarrhythmic drug has obvious arrhythmogenic effect, another multi-center randomized double clinical trial shows, the three class antiarrhythmic drug groups of using simple type retardance potassium channel are high 1 times than the matched group mortality rate, and its main cause is the ARR generations of lethal such as torsades de pointes chamber speed.The second, the late result of antiarrhythmic drug is still undesirable, generally acknowledges three class antiarrhythmic drug amiodarones preferably at present, and 1, the total effective rate in 2,3 years also has 67%, 59% and 53% respectively.These clinical effectivenesses make the research and development of antiarrhythmic drug be absorbed in predicament, have reflected the deficiency of fundamental research, still can not solve the not good problem of antiarrhythmic drug late result.
Studies show that by multiple under pathological state, the ion channel imbalance is to produce ARR key reason.The simple ion passage inhibitory action of antiarrhythmic drug prolongs action potential duration, APD (APD), and the excited conduction of slowing down reduces the myocardial cell excited type.But the prolonged application of antiarrhythmic drug certainly will further increase the weight of the ion channel function disorder, makes each passage proportional imbalance, causes occurring problem such as ARR side effect and late result be not good.Have only by regulating ion channel function, make unbalance routing restoration normal, improve the channel function disorder, less ARR generation just can be arranged, late result---this should be an antiarrhythmic drug developing direction from now in raising.
Summary of the invention
Task of the present invention promptly produces thus, proposes ARR Chinese medicine preparation of a kind of treatment and preparation method thereof.Make the cardiac ion channel dysfunction be improved significantly, and improve myocardium electric reconstruct after the myocardial infarction, effectively improve late result.
Another object of the present invention provides the preparation method of the ARR Chinese medicine preparation of treatment.
The present invention is to be that the component of weight portion is made by following weight:
Radix Sophorae Flavescentis 3-9 Radix Salviae Miltiorrhizae 3-12 Radix Et Rhizoma Nardostachyos 2-6 Poria 3-10
Radix Glycyrrhizae Preparata 3-8 Rhizoma Zingiberis 1-6 Magnetitum 3-9
The preparation method that above-mentioned each component is made medicine of the present invention is:
1. pulverize Rhizoma Zingiberis, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Nardostachyos, Poria standby;
2. indissoluble matter is heavy Magnetitum decocts with water 2-4 time;
3. Radix Sophorae Flavescentis, Radix Glycyrrhizae Preparata are soaked with the decocting liquid of above-mentioned Magnetitum medicine, decoct 2-4 time, gained solution is condensed into cream after filtering;
4. (1) coarse powder is blended into mixing in the cream, drying is ground into fine powder;
5. the 0# capsule is filled in Chinese medicine fine powder sterilization back.
Chinese medicine preparation of the present invention is the new antiarrhythmic drug that filters out from Chinese medicine, is not only feasiblely, and compares with Western medicine screening, more has screening time short, saves advantages such as human and material resources, financial resources.This product is Chinese medicine preparation sheerly, can obviously improve the cardiac ion channel dysfunction, improves myocardium electric reconstruct after the myocardial infarction, has demonstrated tangible antiarrhythmic activity.Compare with Western medicine, the general toxicity of Chinese medicine is low, few side effects.
The mechanism that the late result of this product is better than Western medicine may be, the molecular weight less of Western medicine has stronger retardation to ion channel " hole ", and is difficult for having the regulating action of ion channel; The Chinese medicine molecular weight is bigger, be difficult for that ion channel " hole " is had stronger retardation, but many target spots action characteristic makes it may act on different ion channels, different subunit or the ion channel stream signal molecules of ion channel, produces the regulating action to the ion channel function disorder.In addition, Chinese medicine is as natural product, and clinical research shows, compares with Western medicine to have lower arrhythmogenic effect and toxic and side effects, makes the prolonged application of medicine become possibility.
Prescription of the present invention is that the composition principle by traditional Chinese medical science monarch carries out prescription.The formation of cardiopalmus often by timidness due to deficiency of the heart, deficiency of heart-blood, deficiency of heart-YANG decline, fluid-retention stagnating in the interior, disturb in burning hot, due to the imbalance of YIN and YANG.The inventor studies for a long period of time and thinks, its mainly be disturb in burning hot, due to the imbalance of YIN and YANG.According to this thinking, the present invention is mainly with clearing heart fire, and coordinating YIN and YANG is an aim.The fire that the Radix Sophorae Flavescentis heat clearing and damp drying is disturbed in can be clearly in the side is monarch drug, shows according to modern pharmacological research: the Chinese medicine matrine, can obviously improve the cardiac ion channel dysfunction, and improve myocardium electric reconstruct after the infarction, shown tangible antiarrhythmic activity.The hot temperature of Rhizoma Zingiberis, warming spleen and stomach for dispelling cold is joined Radix Sophorae Flavescentis, and cold and heat are alternate, and one can prevent the Radix Sophorae Flavescentis damaging the spleen and stomach, but a coordinating YIN and YANG is ministerial drug.Poria, Radix Glycyrrhizae Preparata Qi-benefiting and heart-nourishing, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Nardostachyos blood circulation promoting and blood stasis dispelling, promote qi circulation opening is through being adjuvant drug altogether.The Magnetitum tranquilizing mind is a messenger drug.All medicines share, and can adjust the rhythm of the heart, remedying defects and rectifying errors, tranquilizing mind, coordinating YIN and YANG.Make heart channel logical, heart arteries and veins is multiple and cardiopalmus must be removed.
Chinese medicine preparation of the present invention can obviously improve the cardiac ion channel dysfunction, improves myocardium electric reconstruct after the myocardial infarction, has demonstrated tangible antiarrhythmic activity.Through clinical practice, obtained curative effect preferably.Details are as follows for relevant clinical treatment situation:
Clinical testing data
Case source: clinical observation case 300 examples, male's 121 examples wherein, women's 179 examples, minimum 2 years old of age, maximum 86 years old, average 48.8 years old of age.
Room 99 examples early wherein, the chamber is 162 examples early, atrial fibrillation 39 examples.
Case is selected
Diagnostic check: formulate with reference to " the common disease conventional treatment of the traditional Chinese medical science " (1998).
Diagnosis basis:
Conscious nervous uneasiness can not be autonomous, and heartbeat becomes fast, or slows down, or heart beating is overweight, or neglect to jump to neglect and end, and is paroxysmal or continues more than.
With discomfort uncomfortable in chest, vexed, weak, dizziness etc.
Normal spiritedness stimulation, anxiety, overstrain, the factor such as be satiated with food of drinking of showing effect and bringing out.
As seen pulse condition number, disease, short, knot, generation, heavy, late, variation such as loose.
Electrocardiogram is as seen: artrial premature beat or ventricular premature contraction or atrial fibrillation, or premature nodal contraction.
Treatment clinical efficacy: see the following form
Classification | The example number | Recovery from illness | Produce effects | Good number | Invalid | Total effective rate (%) |
The room early | 99 | 42 | 32 | 21 | 4 | 95.96 |
The chamber early | 162 | 76 | 49 | 29 | 8 | 95 |
Atrial fibrillation | 39 | 15 | 4 | 13 | 7 | 82.05 |
The specific embodiment
Embodiment 1
Take by weighing raw material by following proportioning:
Radix Sophorae Flavescentis 3 Radix Salviae Miltiorrhizaes 3 Radix Et Rhizoma Nardostachyos 2 Poria 3 Radix Glycyrrhizae Preparatas 3 Rhizoma Zingiberiss 1 Magnetitum 3
Production method: 1. pulverize Rhizoma Zingiberis, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Nardostachyos, Poria standby; 2. indissoluble matter is heavy Magnetitum decocts with water 2 times; 3. Radix Sophorae Flavescentis, Radix Glycyrrhizae Preparata (make by traditional handicraft, market can be buied) are soaked with the decocting liquid of above-mentioned Magnetitum medicine, decoct 2 times, gained solution is condensed into cream after filtering; 4. (1) coarse powder is blended into mixing in the cream, drying is ground into fine powder; 5. the 0# capsule is filled in Chinese medicine fine powder sterilization back, pvc aluminium foil pressing plate, and packing gets product.
Embodiment 2
Take by weighing raw material by following proportioning:
Radix Sophorae Flavescentis 6 Radix Salviae Miltiorrhizaes 6 Radix Et Rhizoma Nardostachyos 3 Poria 5 Radix Glycyrrhizae Preparatas 5 Rhizoma Zingiberiss 3 Magnetitums 6
Production method: 1. pulverize Rhizoma Zingiberis, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Nardostachyos, Poria standby; 2. indissoluble matter is heavy Magnetitum decocts with water 3 times; 3. Radix Sophorae Flavescentis, Radix Glycyrrhizae Preparata are soaked with the decocting liquid of above-mentioned Magnetitum medicine, decoct 3 times, gained solution is condensed into cream after filtering; 4. (1) coarse powder is blended into mixing in the cream, drying is ground into fine powder; 5. the 0# capsule is filled in Chinese medicine fine powder sterilization back, pvc aluminium foil pressing plate, and packing gets product.
Embodiment 3
Take by weighing raw material by following proportioning:
Radix Sophorae Flavescentis 9 Radix Salviae Miltiorrhizaes 12 Radix Et Rhizoma Nardostachyos 6 Poria 10 Radix Glycyrrhizae Preparatas 8 Rhizoma Zingiberiss 6 Magnetitums 9
Production method: 1. pulverize Rhizoma Zingiberis, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Nardostachyos, Poria standby; 2. indissoluble matter is heavy Magnetitum decocts with water 4 times; 3. Radix Sophorae Flavescentis, Radix Glycyrrhizae Preparata are soaked with the decocting liquid of above-mentioned Magnetitum medicine, decoct 4 times, gained solution is condensed into cream after filtering; 4. (1) coarse powder is blended into mixing in the cream, drying is ground into fine powder; 5. the 0# capsule is filled in Chinese medicine fine powder sterilization back, pvc aluminium foil pressing plate, and packing gets product.
Claims (3)
1, the ARR Chinese medicine preparation of a kind of treatment is characterized in that: it is the medicament of being made by the following weight proportion raw material:
Radix Sophorae Flavescentis 3-9 Radix Salviae Miltiorrhizae 3-12 Radix Et Rhizoma Nardostachyos 2-6 Poria 3-10
Radix Glycyrrhizae Preparata 3-8 Rhizoma Zingiberis 1-6 Magnetitum 3-9
2, the ARR Chinese medicine preparation of treatment according to claim 1, it is characterized in that: said medicament is a capsule.
3, the preparation method of ARR Chinese medicine preparation is treated in treatment according to claim 2, it is characterized in that: 1. pulverize Rhizoma Zingiberis, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Nardostachyos, Poria standby; 2. indissoluble matter is heavy Magnetitum decocts with water 2-4 time; 3. Radix Sophorae Flavescentis, Radix Glycyrrhizae Preparata are soaked with the decocting liquid of above-mentioned Magnetitum medicine, decoct 2-4 time, gained solution is condensed into cream after filtering; 4. (1) coarse powder is blended into mixing in the cream, drying is ground into fine powder; 5. the 0# capsule is filled in Chinese medicine fine powder sterilization back.
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CNB2005100180058A CN100386112C (en) | 2005-09-16 | 2005-09-16 | Arrhythmia treating Chinese medicine prepn and its prepn process |
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CNB2005100180058A CN100386112C (en) | 2005-09-16 | 2005-09-16 | Arrhythmia treating Chinese medicine prepn and its prepn process |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101199676B (en) * | 2007-12-11 | 2012-04-18 | 周鑫 | Kangxin tea |
CN102836320A (en) * | 2012-10-08 | 2012-12-26 | 河南中医学院 | Chinese medicinal pill for treating tachyarrhythmia |
CN112206279A (en) * | 2020-11-03 | 2021-01-12 | 长春中医药大学附属医院(吉林省中医院) | Traditional Chinese medicine composition for treating ventricular arrhythmia and preparation method and application thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1085082C (en) * | 1993-02-17 | 2002-05-22 | 山海丹企业集团西安中医多学科研究所 | Recipe of Fumailing for curing arrhythmic coronary heart disease and producing method |
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2005
- 2005-09-16 CN CNB2005100180058A patent/CN100386112C/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101199676B (en) * | 2007-12-11 | 2012-04-18 | 周鑫 | Kangxin tea |
CN102836320A (en) * | 2012-10-08 | 2012-12-26 | 河南中医学院 | Chinese medicinal pill for treating tachyarrhythmia |
CN102836320B (en) * | 2012-10-08 | 2013-09-04 | 河南中医学院 | Chinese medicinal pill for treating tachyarrhythmia |
CN112206279A (en) * | 2020-11-03 | 2021-01-12 | 长春中医药大学附属医院(吉林省中医院) | Traditional Chinese medicine composition for treating ventricular arrhythmia and preparation method and application thereof |
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