CN105435026A - Medicine for treating arrhythmia - Google Patents
Medicine for treating arrhythmia Download PDFInfo
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- CN105435026A CN105435026A CN201610048498.8A CN201610048498A CN105435026A CN 105435026 A CN105435026 A CN 105435026A CN 201610048498 A CN201610048498 A CN 201610048498A CN 105435026 A CN105435026 A CN 105435026A
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention relates to a medicine for treating the arrhythmia. The medicine is prepared from, by weight, 10 parts of poria with hostwood, 5 parts of asarum, 18 parts of Chinese pyrola herb, 12 parts of cistanche salsa, 7 parts of rhizoma sparganic, 10 parts of ligustrum lucidum ait, 8 parts of finger citron and 7 parts of dichroae radix. The medicine has the advantages that poria with hostwood quiets heart, soothes nerves and promotes urination; asarum dispels cold and wind, stops pain and dredges orifices, and warms lung and dissipates excessive fluid; Chinese pyrola herb nourishes kidney and strengthens bones, dispels wind and eliminates dampness, and stops coughing and bleeding; cistanche salsa nourishes kidney yang, nourishes body fluid and blood, and lubricates intestines; rhizoma sparganic removes blood stasis and promotes qi circulation, and eliminates stasis and stops pain; ligustrum lucidum ait nourishes liver and kidney, clears away deficiency heat and improves eyesight; finger citron discharges liver and regulates qi, and harmonizes stomach and stops pain; dichroae radix removes phlegm and eliminates dampness; the medicine components are used in cooperation and have functions of nourishing yin and clearing away fever, tranquilizing mind by nourishing heart, promoting blood circulation to remove blood stasis and regulating qi and dredging veins; it is proved through clinical experiments that the medicine can safely and effectively treat the arrhythmia.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to one and be used for the treatment of ARR medicine.
Background technology
Arrhythmia (arrhythmia) refers to that the cardiac impulse that any cause of disease causes is formed and/or conduction abnormalities; because the exciting exception of sinuatrial node or excitement result from beyond sinuatrial node; exciting conduction slowly, retardance or through abnormal passage conduction, namely the origin of cardiomotility and (or) conductive impairment cause frequency and (or) the allorhythmia of heartbeat.Arrhythmia is one group of disease important in cardiovascular disease.Rest sense, uncomfortable in chest, weak, dizzy with cardiopalmus, heart beating, very then faint, electrocardiogram points out various arrhythmia to be main clinical characteristics.All kinds of premature beat, paroxysm supraventricular or ventricular tachycardia, atrial fibrillation, atrioventricular block, sick sinus syndrome etc. are ARR clinical common type.It can be fallen ill separately, also can occur together with other cardiovascular diseasess.Arrhythmia is found in normal person, but is more common in greatly organic heart disease patient, as coronary heart disease, myocarditis, cardiomyopathy, rheumatic heart disease, hypertensive cardiopathy, heart failure etc., and the drug intoxication such as Folium Digitalis Purpureae, quinidine.Bring out ARR reason to comprise the idiomuscular change of the heart, electrolyte disturbance, anoxia, excited, smoking, drink strong tea etc.Its prognosis with the ARR cause of disease, inducement, evolving trend, whether cause serious hemodynamic obstacle relevant, can break out and cause sudden death, also sustainablely involve heart and cause its exhaustion.Arrhythmia belongs to the category such as " palpitation with fear ", " palpitation with a distress feeling ", " faintness ", " asthenia " of the traditional Chinese medical science.
The cause of disease
Heritability arrhythmia mostly is caused by Gene channel sudden change, as long QT syndrome, Short QT syndiome, Brugada syndrome etc.
Acquired arrhythmia will be found in various organic heart disease the day after tomorrow, wherein with coronary atherosclerotic heart disease (abbreviation coronary heart disease), cardiomyopathy, myocarditis and rheumatic heart disease (abbreviation rheumatic heart disease) for common, especially occur heart failure or acute myocardial infarction time.Occur in that arrhythmia in basic healthy person or autonomic nervous dysfunction patient is quite a few sees.Other causes of disease still have electrolyte or endocrine disturbance, anesthesia, low temperature, thoracic cavity or operation on heart, drug effect and central nervous system disease etc., part etiology unknown.
Clinical manifestation
The clinical manifestation of ARR hemodynamic change depends primarily on ARR character, type, cardiac function and the degree to hemodynamic effect, as slight sinus bradycardia, arrhythmia, accidental atrial premature beat, first degree A-V blocks etc. are very little to hemodynamic effect, therefore without obvious clinical manifestation, more serious arrhythmia, as sick sinus syndrome, rapid atrial fibrillation, paroxysmal supraventricular tachycardia, sustained ventricular tachycardia etc., cardiopalmus can be caused, breast is vexed, dizzy, hypotension, perspire, fainting can appear in severe patient, Adams Stokes syndrome, even die suddenly, because ARR type is different, clinical manifestation is different, mainly contain following several performance:
1. the performance of coronary insufficiency
Various arrhythmia all can cause coronary artery blood flow to reduce, although various arrhythmia can cause coronary flow to reduce, but lessly cause myocardial ischemia, but, to the patient having coronary heart disease, various arrhythmia can be brought out or be increased the weight of myocardial ischemia, main manifestations is angina pectoris, breathes hard, peripheral vessels exhaustion, acute heart failure, acute myocardial infarction etc.
2. the performance of cerebral arterial insufficiency
Different arrhythmia is also different on the impact of cerebral blood flow.The normal person of cerebrovascular, above-mentioned hemodynamic obstacle is unlikely causes serious consequence, if during cerebrovascular generation pathological changes, then be enough to cause cerebral blood supply insufficiency, it shows as dizziness, weak, blurred vision, temporary total blindness, the transient or permanent cerebral lesion performance such as aphasia, paralysis, tic, stupor even.
3. the performance of renal artery blood supply insufficiency
After arrhythmia occurs, also there is different minimizings in renal blood flow, clinical manifestation has oliguria, albuminuria, azotemia etc.
4. the performance of Mesenteric artery blood supply insufficiency
During tachy-arrhythmia, blood flow reduces, and Mesenteric artery spasm, can produce the clinical manifestation of gastrointestinal ischemia, and as abdominal distention, stomachache, diarrhoea, even occurs hemorrhage, ulcer or paralysis.
5. the performance of cardiac insufficiency
Be mainly cough, dyspnea, asthenia, weak etc.
Drug therapy
1. I class and sodium channel blocade, I category-A appropriateness block sodium channels, what belong to this type of has the medicines such as quinidine; The slight block sodium channels of I category-B, what belong to this type of has the medicines such as lignocaine; The obvious block sodium channels of I C class, what belong to this type of has the medicines such as Propafenone.2. II class is beta-adrenoceptor blocking drug, and because blocking beta receptor effectively, representative drugs is Propranolol.3. III class is the medicine selectively extending process of repolarization, and what belong to this type of has amiodarone.4. IV class and calcium channel blocker, their block calcium channel and suppress to flow in Ca, and representative medicine has verapamil.Long-term taking anti-arrhythmic all has side effect in various degree, serious caused ventricular arrhythmia or heart block and fatal.5. treatment by Chinese herbs, available traditional Chinese medical herbal treatment, from many aspects relief of symptoms, effectiveness comparison is desirable.
Medical material involved in the present invention is recorded in all as seen " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide one and is used for the treatment of ARR medicine, by selecting suitable medical material and proportioning thereof, reaches the ARR object of safe and effective healing.
In order to achieve the above object, the present invention is by the following technical solutions:
One is used for the treatment of ARR medicine, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Poria cum Radix Pini 10 parts, Herba Asari 5 parts, Herba Pyrolae 18 parts, Herba Cistanches 12 parts, Rhizoma Sparganii 7 parts, Fructus Ligustri Lucidi 10 parts, Fructus Citri Sarcodactylis 8 parts, Radix Dichroae 7 parts.
Below in conjunction with theories of Chinese materia medica, beneficial effect of the present invention is described:
Inventor thinks, the ARR cause of disease is the people of timidness due to deficiency of the heart, suddenly frightened, or element accumulates expectorant heat, is added with depressed rage impairing the liver; Or serious disease prolonged illness, involve heart spleen kidney, undermine negative and positive of qi and blood, all cause the heart and lose peace and support, mind disturbance, or heart arteries and veins stasis blocking and making up one's mind is throbbed with fear.Pathological change is the people of timidness due to deficiency of the heart, suddenly frightened, or emotion rage, large excessive fear impairing the kidney, rage impairing liver, probably then essence but, anger is QI rising in reverse order then, the deficiency of YIN under, fire is inverse in upper, then dynamicly shake the mind and make up one's mind cool.Element accumulates expectorant heat, and be added with disgruntled, stomach-QI being unable to descend normally, phlegm-fire is tied mutually, disturbing the mind upwards, also makes up one's mind and throbs with fear.Prolonged illness serious disease, damage heart spleen kidney, injures negative and positive of qi and blood.Deficiency of both the heart and spleen, deficiency of both QI and blood, the heart is become homeless foster, and the mind is disturbed; Or deficiency of kidney yin, the not good fire of water, heart-fire is solely high, the disturbance mind; Or deficiency of heart-YANG and kidney-YANG, the heart loses replenishing vital QI with drugs of warm nature, and fluid-retention stagnating in the interior, upper Ling Yuxin, all causes cardiopalmus.The stagnation of QI or the deficiency of vital energy, often make stagnation of heart-blood, and the heart is become homeless foster, also makes up one's mind and throb with fear.Therefore treatment then takes removing heat-phlegm, vigorate qi and replenish the blood, tranquilizing the mind.
The present invention uses: Poria cum Radix Pini's mind tranquilizing and the heart calming, diuretic; Herba Asari cold expelling dispels the wind, and pain relieving is sensible, warming the lung to resolve fluid-retention; Herba Pyrolae the kidney invigorating bone strengthening, expelling wind and removing dampness, cough-relieving is stopped blooding; Herba Cistanches kidney-replenishing, benefiting essence-blood, intestine moistening road; The circulation of qi promoting of Rhizoma Sparganii removing blood stasis, removing food stagnancy pain relieving; Fructus Ligustri Lucidi liver and kidney tonifying, clearind deficient heat, improving eyesight; Fructus Citri Sarcodactylis liver-smoothing, qi-regulating, and stomach and alleviating pain; Radix Dichroae robs expectorant removing dampness.All medicines share, and reach nourishing YIN and clearing away fire, tranquilizing by nourishing the heart, blood circulation promoting and blood stasis dispelling, effect of promoting blood circulation of regulating the flow of vital energy.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects 112 routine patients with arrhythmia between in February ,-2015 in March, 2012 altogether.Be divided at random: treatment group 56 example, matched group 56 example.Wherein treatment group man 26 example, female 30 example, 42 ~ 68 years old age, the course of disease 2 months ~ 5 years; Matched group man 22 example, female 34 example, between 43 ~ 65 years old age, the course of disease 4 months ~ 5 years.The data there was no significant differences such as two groups of sexes, age, courses of disease, have comparability.
Diagnostic criteria
1. have ARR medical history more, and/or have cardiopathic diagnosis medical history, and onset patient must do to check further and make a definite diagnosis.
2. clinical main manifestations: cardiopalmus, pareordia are uncomfortable, heart beating rests sense, uncomfortable in chest, weak, dizzy, very then faints.Cardiac auscultation audible and heart rate or rhythm abnormality, several slow or slow, or have premature beat, or have and close a business.Pulse Chang Chengjie, generation, short, disease, slow, several, heavy, puckery etc.
3. lab testing: electrocardiogram or ambulatory electrocardiogram all can show the abnormal indication of cardiac arrhythmia.
1. inclusive criteria meets diagnostic criteria; 2. 18 ~ 70 years old age; 3. compliance is good; 4. Informed Consent Form is signed voluntarily.
1. exclusion standard merges other serious diseases of cardiovascular system patient; 2. severe cardiac, lung, liver, renal disease patient is suffered from; 3. spiritedness systemic disease, can not partner treatment person; 4. through the patient of other drug treatment after falling ill.
2, Therapeutic Method
The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 3 times.Treat 1 month.
The oral propafenon tablet of matched group, each 150mg, every day 3 times.Treat 1 month.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
1. fully recover: cardiopalmus symptom all disappears, electrocardiogram or dynamic ecg recordings examination recover normal, and premature beat disappears;
2. effective: symptom major part disappears, and electrocardiogram or dynamic ecg recordings examination are improved, and premature beat number of times comparatively treats front reduction;
3. invalid: above-mentioned symptom is without improvement or increase the weight of.
3.2 treatment statistical results are in table 1.
Table 1 liang group comparitive study
Visible, the medicine that the present invention obtains can safe and effective treatment arrhythmia, and cure rate is high.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Poria cum Radix Pini 10 grams, Herba Asari 5 grams, Herba Pyrolae 18 grams, Herba Cistanches 12 grams, Rhizoma Sparganii 7 grams, Fructus Ligustri Lucidi 10 grams, Fructus Citri Sarcodactylis 8 grams, Radix Dichroae 7 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of arrhythmia.Oral, daily once.
Embodiment 2
Take: Poria cum Radix Pini 10 grams, Herba Asari 5 grams, Herba Pyrolae 18 grams, Herba Cistanches 12 grams, Rhizoma Sparganii 7 grams, Fructus Ligustri Lucidi 10 grams, Fructus Citri Sarcodactylis 8 grams, Radix Dichroae 7 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of arrhythmia.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Take: Poria cum Radix Pini 10 grams, Herba Asari 5 grams, Herba Pyrolae 18 grams, Herba Cistanches 12 grams, Rhizoma Sparganii 7 grams, Fructus Ligustri Lucidi 10 grams, Fructus Citri Sarcodactylis 8 grams, Radix Dichroae 7 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of arrhythmia.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. one kind is used for the treatment of ARR medicine, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Poria cum Radix Pini 10 parts, Herba Asari 5 parts, Herba Pyrolae 18 parts, Herba Cistanches 12 parts, Rhizoma Sparganii 7 parts, Fructus Ligustri Lucidi 10 parts, Fructus Citri Sarcodactylis 8 parts, Radix Dichroae 7 parts.
2. one as claimed in claim 1 is used for the treatment of ARR medicine, and it is characterized in that, its preparation method is: take: Poria cum Radix Pini 10 parts, Herba Asari 5 parts, Herba Pyrolae 18 parts, Herba Cistanches 12 parts, Rhizoma Sparganii 7 parts, Fructus Ligustri Lucidi 10 parts, Fructus Citri Sarcodactylis 8 parts, Radix Dichroae 7 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. one as claimed in claim 1 is used for the treatment of ARR medicine, and it is characterized in that, its preparation method is: take: Poria cum Radix Pini 10 parts, Herba Asari 5 parts, Herba Pyrolae 18 parts, Herba Cistanches 12 parts, Rhizoma Sparganii 7 parts, Fructus Ligustri Lucidi 10 parts, Fructus Citri Sarcodactylis 8 parts, Radix Dichroae 7 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. one as claimed in claim 1 is used for the treatment of ARR medicine, and it is characterized in that, its preparation method is: take: Poria cum Radix Pini 10 parts, Herba Asari 5 parts, Herba Pyrolae 18 parts, Herba Cistanches 12 parts, Rhizoma Sparganii 7 parts, Fructus Ligustri Lucidi 10 parts, Fructus Citri Sarcodactylis 8 parts, Radix Dichroae 7 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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CN103784865A (en) * | 2012-12-18 | 2014-05-14 | 唐继元 | Chinese herbal medicine for treating palpitation due to insufficiency heart qi, deficiency of yin and stagnation of liver qi |
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CN104984207A (en) * | 2015-07-22 | 2015-10-21 | 王丹丹 | Medicine for treating heart-yang deficiency type arrhythmia |
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CN103784865A (en) * | 2012-12-18 | 2014-05-14 | 唐继元 | Chinese herbal medicine for treating palpitation due to insufficiency heart qi, deficiency of yin and stagnation of liver qi |
CN104758582A (en) * | 2015-03-11 | 2015-07-08 | 兰柳生 | Traditional Chinese medicine composition for treating arrhythmia in the type of fire excess from yin deficiency |
CN104873689A (en) * | 2015-06-17 | 2015-09-02 | 孙宗丽 | Chinese medicinal composition for treating cardiovascular diseases |
CN104984207A (en) * | 2015-07-22 | 2015-10-21 | 王丹丹 | Medicine for treating heart-yang deficiency type arrhythmia |
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