CN1931274B - Pile treating suppository prepared with longan stone and its preparation process - Google Patents
Pile treating suppository prepared with longan stone and its preparation process Download PDFInfo
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- CN1931274B CN1931274B CN200610104631A CN200610104631A CN1931274B CN 1931274 B CN1931274 B CN 1931274B CN 200610104631 A CN200610104631 A CN 200610104631A CN 200610104631 A CN200610104631 A CN 200610104631A CN 1931274 B CN1931274 B CN 1931274B
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- longan
- suppository
- stone
- seed
- arillus longan
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Abstract
The present invention belongs to the field of medicine technology, and is especially one kind of pile treating suppository and its preparation process. The pile treating suppository features that it contains active component of longan stone in 50-900 mg and liposoluble matrix as supplementary material, with the weight ratio of longan stone and liposoluble matrix being 1 to 1-80. The preparation process includes the following steps: peeling longan stone, calcining, crushing and 200 mesh sieving to obtain longan stone powder; heating the liposoluble matrix to smelt, adding longan stone powder with or without coating slow releasing polymer and stirring for homogeneous mixing to obtain mixture; molding the mixture and cooling. The pile treating suppository has obvious effects of arresting bleeding, relieving pain, promoting tissue regeneration and promoting healing of wound.
Description
Technical field:
The invention belongs to technical field of pharmaceuticals, be specifically related to a kind of ZHICHUAN SHUAN for the treatment of anus.
Background technology:
" modern Compendium of Materia Medica " carries: seed of Arillus Longan, and different name Arillus Longan kernel is the seed of Sapindaceae Euphoria plant Arillus Longan, puckery is flat, and the effect of hemostasis, pain relieving, circulation of qi promoting, removing dampness is arranged, and cures mainly traumatic hemorrhage, hernia, scrofula, scabies, eczema.Anal and intestinal disease is common clinical, frequently-occurring disease, mainly contain hemorrhoid, anal fissure, anal sinusitis etc., the method of current these diseases of treatment has therapies such as operation, cover bundle, injection, laser and medicine oral administration and externally, wherein in the medicine external therapy of expectant treatment, existing MAYINGLONG MUSK HEMORRHOID UNGUENTUM (bolt), HUAZHI SHUAN, Jiuhua Zhichuang Shuan, Rongchang County's anus Thailand etc., however its prescription is different, and effect is different, still can not meet clinical needs, and not make the suppository of treatment anus at present with seed of Arillus Longan.
Summary of the invention:
The objective of the invention is to overcome the deficiencies in the prior art, a kind of suppository---pile treating suppository prepared with longan stone and preparation method thereof for the treatment of anal and intestinal diseases such as hemorrhoid, anal fissure is provided.
A kind of pile treating suppository prepared with longan stone of the present invention is characterized in that it contains the active constituents of medicine seed of Arillus Longan, and adjuvant fat-soluble suppository substrate.Adjuvant fat-soluble suppository substrate can be semi-synthetic fatty acid ester, cocoa butter etc.
The content of the active constituents of medicine seed of Arillus Longan of every suppository of the present invention is 50-900mg.
As further prioritization scheme, the weight proportion of product Chinese medicine active component seed of Arillus Longan of the present invention and fat-soluble suppository substrate is 1 part of a seed of Arillus Longan, fat-soluble suppository substrate 1-80 part, more the scheme of You Huaing is that weight ratio is 1 part of a seed of Arillus Longan, fat-soluble suppository substrate 5-40 part.
Product of the present invention can also contain other non-essential components, if need make slow, controlled release bolt, then also may contain the macromolecular material such as ethyl cellulose, beta-schardinger dextrin-of packaging medicine active component.
Pile treating suppository prepared with longan stone of the present invention is a slow release suppository.
The preparation method of product of the present invention is: with seed of Arillus Longan peeling, calcine, pulverizing, cross 200 mesh sieves, make powder.After fat-soluble suppository substrate heat fused, add the seed of Arillus Longan powder or add ethyl cellulose and the beta-schardinger dextrin-parcel after the seed of Arillus Longan powder, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.
The clinical practice and the curative effect of product of the present invention see the following form:
| The sick kind | Cure | Produce effects | Invalid | Total effective rate % |
| The internal hemorrhoid first phase | 20 | 0 | 0 | 100 |
| The internal hemorrhoid second phase | 15 | 0 | 0 | 100 |
| Three phases of internal hemorrhoid | 15 | 10 | 0 | 100 |
| Acute anal fissure | 16 | 14 | 0 | 100 |
| The sick kind | Cure | Produce effects | Invalid | Total effective rate % |
| Old anal fissure | 2 | 10 | 3 | 80 |
| Anal sinusitis | 12 | 5 | 0 | 100 |
Through clinical verification, product of the present invention has significant hemostasis analgesic therapy, promoting tissue regeneration and ulcer healing effect, can promote blood coagulation, quickens the growth of mucosa and epithelial tissue, promotes the wound quickly-healing.
The effect that the present invention is useful has provided a kind of ZHICHUAN SHUAN new drug of treatment anus evident in efficacy, easy to use.
The specific embodiment:
Be embodiments of the invention below, the invention is not restricted to described embodiment.
Embodiment one
Take by weighing raw material seed of Arillus Longan 30g, with the seed of Arillus Longan peeling, the calcine sustainability was pulverized 200 mesh sieves, made powder 25g.After semi-synthetic fatty acid ester 825g heat fused, add the seed of Arillus Longan powder, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.Products obtained therefrom is 500 pieces of supp anals.
Embodiment two
Take by weighing raw material seed of Arillus Longan 120g, with the seed of Arillus Longan peeling, the calcine sustainability was pulverized 200 mesh sieves, made powder 100g.After semi-synthetic fatty acid ester 750g heat fused, add the seed of Arillus Longan powder, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.Products obtained therefrom is 500 pieces of supp anals.
Embodiment three
Take by weighing raw material seed of Arillus Longan 360g, with the seed of Arillus Longan peeling, the calcine sustainability was pulverized 200 mesh sieves, made powder 300g.After semi-synthetic fatty acid ester 550g heat fused, add seed of Arillus Longan powder 300g, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.Products obtained therefrom is 500 pieces of supp anals.
Claims (4)
1. a pile treating suppository prepared with longan stone is characterized in that, with the weight portion note, is made up of for 825 parts 30 parts of seed of Arillus Longan, fat-soluble suppository substrate; Perhaps form for 750 parts by 120 parts of seed of Arillus Longan, fat-soluble suppository substrate; Perhaps form for 550 parts by 360 parts of seed of Arillus Longan, fat-soluble suppository substrate.
2. a pile treating suppository prepared with longan stone as claimed in claim 1 is characterized in that, pile treating suppository prepared with longan stone is a slow release suppository.
3. the preparation method of a pile treating suppository prepared with longan stone as claimed in claim 1, it is characterized in that, with seed of Arillus Longan peeling, calcine, pulverizing, cross 200 mesh sieves, make powder, after fat-soluble suppository substrate heat fused, add the seed of Arillus Longan powder, stirring makes its mix homogeneously, is poured in the bolt mould after cold slightly, and take out promptly the cooling back.
4. the preparation method of a pile treating suppository prepared with longan stone as claimed in claim 2, it is characterized in that, with seed of Arillus Longan peeling, calcine, pulverizing, cross 200 mesh sieves, make powder, after fat-soluble suppository substrate heat fused, add the seed of Arillus Longan powder after ethyl cellulose and beta-schardinger dextrin-wrap up, stirring makes its mix homogeneously, is poured in the bolt mould after cold slightly, and take out promptly the cooling back.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610104631A CN1931274B (en) | 2006-09-14 | 2006-09-14 | Pile treating suppository prepared with longan stone and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610104631A CN1931274B (en) | 2006-09-14 | 2006-09-14 | Pile treating suppository prepared with longan stone and its preparation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1931274A CN1931274A (en) | 2007-03-21 |
| CN1931274B true CN1931274B (en) | 2010-05-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200610104631A Expired - Fee Related CN1931274B (en) | 2006-09-14 | 2006-09-14 | Pile treating suppository prepared with longan stone and its preparation process |
Country Status (1)
| Country | Link |
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| CN (1) | CN1931274B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383078A (en) * | 2014-12-15 | 2015-03-04 | 天津商业大学 | Compound longan seed oral liquid, and preparation method and application thereof |
| CN107441232B (en) * | 2017-08-04 | 2020-07-28 | 马应龙药业集团股份有限公司 | Musk hemorrhoid suppository and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066594A (en) * | 1991-05-16 | 1992-12-02 | 朱集文 | " Llaemorrhoids pills " and production method thereof |
-
2006
- 2006-09-14 CN CN200610104631A patent/CN1931274B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066594A (en) * | 1991-05-16 | 1992-12-02 | 朱集文 | " Llaemorrhoids pills " and production method thereof |
Non-Patent Citations (12)
| Title |
|---|
| .龙眼核的营养成分.食品科技 1.2004,(1),93-94. |
| 刘学铭 |
| 南京中医药大学.中药大辞典 15 2.上海科学技术出版社,2006,882. * |
| 南京中医药大学.中药大辞典15 2.上海科学技术出版社,2006,882. |
| 曾庆孝 |
| 肖更生 |
| 肖更生;黄儒强;曾庆孝;陈卫东;刘学铭;芮汉明;.龙眼核的营养成分.食品科技 1.2004,(1),93-94. * |
| 芮汉明 |
| 陈卫东 |
| 黄儒强 |
| 黎海妮 等.超声波乙醇浸提法提取龙眼核总黄酮方法的探讨.右江民族医学院学报28 2.2006,28(2),168-169. |
| 黎海妮 等.超声波乙醇浸提法提取龙眼核总黄酮方法的探讨.右江民族医学院学报28 2.2006,28(2),168-169. * |
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| Publication number | Publication date |
|---|---|
| CN1931274A (en) | 2007-03-21 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Yunlei Inventor after: Jing Rong Inventor after: Cao Dongmei Inventor after: Liu Yunlei, Jing Rong, Cao Dongmei, Zong Qiaomei Inventor before: Liu Yunlei Inventor before: Jing Rong |
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| COR | Change of bibliographic data | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100512 Termination date: 20160914 |