CN1927350A - Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases - Google Patents
Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases Download PDFInfo
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- CN1927350A CN1927350A CNA2006101128775A CN200610112877A CN1927350A CN 1927350 A CN1927350 A CN 1927350A CN A2006101128775 A CNA2006101128775 A CN A2006101128775A CN 200610112877 A CN200610112877 A CN 200610112877A CN 1927350 A CN1927350 A CN 1927350A
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Abstract
The invention relates to a Chinese medicinal composition and preparing process thereof, wherein the composition can be used for treating megrims, hear irritation, insomnia, amnesia, languidness and numbness of limbs caused by hypertension and cerebral arteriosclerosis. The medicament can be prepared into any of the clinically usable dosage forms.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind ofly be used for the vertigo, vexedly sleep less, palpitation and amnesia, limbs are weak, numb limbs and tense tendons etc. is clinical prescription and the preparation technology thereof who sees disease due to hypertension, the cerebral arteriosclerosis.
Background technology:
The vertigo, vexedly sleep less, palpitation and amnesia, limbs are weak, numb limbs and tense tendons etc. is clinically due to hypertension, the cerebral arteriosclerosis to see that disease is the clinical symptom of seeing more, the means that the traditional Chinese medical science often takes suppressing the hyperactive liver and subsiding YANG, endogenous wind stopping to decide convulsion, saturating key refreshment are treated it, and evident in efficacy.But shortcomings such as in the practice, onset is slow because many Chinese medicines have, the course of treatment is long have a strong impact on its clinical practice.
Chinese medicine composition of the present invention can collect the elite and thick the putting of medicine, is easy to dissolving and absorption, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide and a kind ofly be used for the vertigo, vexedly sleep less, palpitation and amnesia, limbs are weak, numb limbs and tense tendons etc. is clinical pure Chinese medicine composition and multiple appropriate formulation thereof of seeing disease due to hypertension, the cerebral arteriosclerosis, said preparation is rapid-action, evident in efficacy, is worthy of popularization.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units in basic side is prepared from by following proportion raw material:
150～600 parts of 100～400 parts of Rhizoma Acori Graminei of 150～600 parts of Pheretimas of Rhizoma Gastrodiae
15～60 parts of 25～100 parts of Benzoinumes of 100～400 parts of succinums of Radix Polygalae.
Preferably:
300 parts of 200 parts of Rhizoma Acori Graminei of 300 parts of Pheretimas of Rhizoma Gastrodiae
30 parts of 50 parts of Benzoinumes of 200 parts of succinums of Radix Polygalae.
The preparation of per 1000 dosage units of the present invention side of deriving a is prepared from by following proportion raw material:
150～600 parts of 100～400 parts of Rhizoma Acori Graminei of 150～600 parts of Pheretimas of Rhizoma Gastrodiae
15～60 parts of 25～100 parts of Benzoinumes of 100～400 parts of succinums of Radix Polygalae
60～240 parts of 100～400 parts of Semen Trigonellae of 150～600 parts of Fructus Ligustri Lucidi of Radix Polygoni Multiflori.
Preferably:
300 parts of 200 parts of Rhizoma Acori Graminei of 300 parts of Pheretimas of Rhizoma Gastrodiae
30 parts of 50 parts of Benzoinumes of 200 parts of succinums of Radix Polygalae
120 parts of 200 parts of Semen Trigonellae of 300 parts of Fructus Ligustri Lucidi of Radix Polygoni Multiflori.
The preparation of per 1000 dosage units of the present invention side of deriving b is prepared from by following proportion raw material:
150～600 parts of 100～400 parts of Rhizoma Acori Graminei of 150～600 parts of Pheretimas of Rhizoma Gastrodiae
15～60 parts of 25～100 parts of Benzoinumes of 100～400 parts of succinums of Radix Polygalae
100～400 parts of 55.5～222 parts of Fructus Lycii of 300～1200 parts of Semen Allii Tuberosi of Colla Corii Asini.
Preferably:
300 parts of 200 parts of Rhizoma Acori Graminei of 300 parts of Pheretimas of Rhizoma Gastrodiae
30 parts of 50 parts of Benzoinumes of 200 parts of succinums of Radix Polygalae
200 parts of 111 parts of Fructus Lycii of 600 parts of Semen Allii Tuberosi of Colla Corii Asini.
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be multiple suitable dosage forms such as capsule, granule, tablet, powder.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of granule of the present invention:
Prescription:
Rhizoma Gastrodiae 450g Pheretima 300g Rhizoma Acori Graminei 450g
Radix Polygalae 300g succinum 75g Benzoinum 45g
Make 1000g
Preparation method:
(1) get Rhizoma Gastrodiae, succinum, Benzoinum medical material and directly be ground into fine powder, standby;
(2) get the residue medical material, extracting in water 2 times, amount of water are 8 times, each extraction time is 1.5 hours, and merge extractive liquid, filters, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(3) above active component is merged mixing, add aspartame 5.0g, dextrin 200.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 2:
The preparation method of capsule of the present invention:
Prescription:
Rhizoma Gastrodiae 300g Pheretima 200g Rhizoma Acori Graminei 300g
Radix Polygalae 200g succinum 50g Benzoinum 30g
Make 1000
Preparation method:
(1) get Rhizoma Gastrodiae, succinum, Benzoinum medical material and directly be ground into fine powder, standby;
(2) get the residue medical material, extracting in water 2 times, amount of water are 8 times, each extraction time is 1.5 hours, and merge extractive liquid, filters, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(3) above active component is merged mixing, dry, be made into 1000 of capsules according to the pharmaceutics routine techniques.
Embodiment 3:
The preparation method of tablet of the present invention:
Prescription:
Rhizoma Gastrodiae 300g Pheretima 200g Rhizoma Acori Graminei 300g
Radix Polygalae 200g succinum 50g Benzoinum 30g
Make 1000
Preparation method:
(1) get Rhizoma Gastrodiae, succinum, Benzoinum medical material and directly be ground into fine powder, standby;
(2) get the residue medical material, extracting in water 2 times, amount of water are 8 times, each extraction time is 1.5 hours, and merge extractive liquid, filters, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(3) above active component is merged mixing, dry, be made into 1000 in tablet according to the pharmaceutics routine techniques.
Claims (8)
1, a kind of Chinese medicine preparation that is used for cardiovascular and cerebrovascular disease, it is characterized in that: according to weight proportion, it is by Rhizoma Gastrodiae 150～600, Pheretima 100～400, Rhizoma Acori Graminei 150～600, Radix Polygalae 100～400, succinum 25～100, Benzoinum 15～60 are for basic side or be equipped with other Chinese medicines and generate the sides of deriving and be made.
2, the Chinese medicine preparation of claim 1 is characterized in that, described basic side's proportioning is: 300 parts in Rhizoma Gastrodiae, 200 parts of Pheretimas, 300 parts of Rhizoma Acori Graminei, 200 parts of Radix Polygalaes, 50 parts of succinums, 30 parts of Benzoinumes.
3, the Chinese medicine preparation of claim 1 is characterized in that, the proportioning of the described side of deriving is:
The basic side of A adds 300 parts of Radix Polygoni Multiflori, 200 parts of Fructus Ligustri Lucidi, 120 parts of Semen Trigonellae;
The basic side of B adds 600 parts in Colla Corii Asini, 111 parts of Semen Allii Tuberosi, 200 parts of Fructus Lycii.
4, the Chinese medicine preparation of claim 1 is characterized in that, is described raw material of Chinese medicine is extracted processing, obtains active component, adds suitable adjuvant as required, makes clinical needed dosage form with the galenic pharmacy routine techniques.
5, the Chinese medicine preparation of claim 4 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, disintegrating agent, granulates, and drying, tabletting promptly gets tablet.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
7, the preparation method of claim 6 is characterized in that: the prescription of the preparation of making is respectively:
The a Rhizoma Gastrodiae, Pheretima, Rhizoma Acori Graminei, Radix Polygalae, succinum, Benzoinum;
The b Rhizoma Gastrodiae, Pheretima, Rhizoma Acori Graminei, Radix Polygalae, succinum, Benzoinum, Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Semen Trigonellae;
The c Rhizoma Gastrodiae, Pheretima, Rhizoma Acori Graminei, Radix Polygalae, succinum, Benzoinum, Colla Corii Asini, Semen Allii Tuberosi, Fructus Lycii.
8, the Chinese medicine preparation of claim 1 in the preparation treatment vertigo, vexedly sleep less, palpitation and amnesia, limbs are weak, numb limbs and tense tendons etc. is the application in the clinical medicine of seeing disease due to hypertension, the cerebral arteriosclerosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101128775A CN1927350A (en) | 2006-09-06 | 2006-09-06 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101128775A CN1927350A (en) | 2006-09-06 | 2006-09-06 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases |
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| Publication Number | Publication Date |
|---|---|
| CN1927350A true CN1927350A (en) | 2007-03-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2006101128775A Pending CN1927350A (en) | 2006-09-06 | 2006-09-06 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112773867A (en) * | 2021-03-24 | 2021-05-11 | 黔西南民族职业技术学院 | Preparation of Chinese medicinal composition, decoction and granule for preventing and treating cardiovascular and cerebrovascular diseases |
-
2006
- 2006-09-06 CN CNA2006101128775A patent/CN1927350A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112773867A (en) * | 2021-03-24 | 2021-05-11 | 黔西南民族职业技术学院 | Preparation of Chinese medicinal composition, decoction and granule for preventing and treating cardiovascular and cerebrovascular diseases |
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Application publication date: 20070314 |