CN1923169A - Water aqua containing clindamycin for treating acne - Google Patents
Water aqua containing clindamycin for treating acne Download PDFInfo
- Publication number
- CN1923169A CN1923169A CN 200610122134 CN200610122134A CN1923169A CN 1923169 A CN1923169 A CN 1923169A CN 200610122134 CN200610122134 CN 200610122134 CN 200610122134 A CN200610122134 A CN 200610122134A CN 1923169 A CN1923169 A CN 1923169A
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- clindamycin
- skin ulcer
- azoles
- treatment
- water preparation
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a water solution containing chlorolincomycin for treating acne which comprises the following ingredients (by weight portion): clindamycin hydrochloride 1-3.55, ethanol 22-25%, glycerin 0.1-2%, methyl glycol 0.25-1%, methyl-p-hydroxybenzoate 0.1-0.22%, propyl-p-hydroxybenzoate 0.01-1.14%, and balancing pure water.
Description
Technical field
The present invention designs a kind of liquor that contains clindamycin that is used for the treatment of the azoles skin ulcer.
Background technology
The azoles skin ulcer is a kind of common skin disease, and some serious patients can have a strong impact on attractive in appearance.Think that at present the cause of disease and the pathogeny of azoles skin ulcer have 4 points: 1. skin gland secretion is vigorous; Find that after deliberation the androgen precursor obviously increases in the serious azoles skin ulcer patient blood, causes the sebum hyperfunctioning, generates too much sebum.2. hair follicle ductal epithelium hypertrophy forms excessive horn cell, adds the change of intercellular substance, makes horn cell secure adhesion each other, with sebum and mixing with cells, is blocked in follicular orifice again, forms " acne ".3. infected by microbes: mainly being azoles skin ulcer corynebacterium (propionibacterium), is oval bran Pi pityrosporion ovale secondly, Staphylococcus albus.4. inflammatory reaction: azoles skin ulcer propionibacterium is an anaerobe, be suitable in the hair follicle that stops up, growing, cause body in partial immunoreation, and this bacterium can decomposite free fatty with triglyceride, the hair follicle stimulating surrounding tissue, cause the nonspecific inflammation reaction, form red little pimple, papilla, and may be further development of cyst, the inflammation tuberosity, abscess etc.Therefore, the data of azoles skin ulcer should be started with from above aspect, preferably can be directly effective to everyway.
Think that at present clindamycin is best for the fungistatic effect of azoles skin ulcer propionibacterium.So, some have occurred and contained the composition medicine of the treatment azoles skin ulcer of clindamycin.What these pharmaceutical compositions had is unguentum, this unguentum often contains a large amount of oil substances, be used for the patient and very easily produce uncomfortable feeling on the face, and the composition of these unguentum is various, cause complex manufacturingization, and often in order to prevent that precipitation from appearring in clindamycin, need the pH value of control combination thing, otherwise stability is not high.In addition, for female patient, generally can when going out, put at least a skin care item on the skin on the face, if these treatment azoles skin ulcers are to make unguentum, will allow the people feel very greasy, if the employing water preparation, also can not influence attractive in appearancely after convenient the absorption, can not influence women's makeup especially.But some clindamycin detergents then just are dissolved in clindamycin in the solvent simply, and the azoles skin ulcer curative effect that causes for above-mentioned the 1st, 2 kind of reason is not high.In addition, clindamycin produces intensive stink usually through after a while, and the local application's medicine that is used for patient face can not have this abnormal smells from the patient.Above-mentioned these shortcomings are that azoles skin ulcer patient can not adhere to medication.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, a kind of water preparation that contains clindamycin that is used for the treatment of the azoles skin ulcer is provided, it can effectively treat the azoles skin ulcer that a variety of causes causes.
Another object of the present invention provides a kind of water preparation that contains clindamycin that is used for the treatment of the azoles skin ulcer with faint scent.
In order to achieve the above object, the water preparation that contains clindamycin that is used for the treatment of the azoles skin ulcer of the present invention comprises following components in weight percentage: clindamycin hydrochloride 1-3.5%, ethanol 22-25%, glycerol 0.1-2%, propylene glycol 0.25-1%, methyl parahydroxybenzoate 0.1-0.22%, propyl p-hydroxybenzoate 0.01-1.14%, surplus is a pure water.
Further, the water preparation that contains clindamycin that is used for the treatment of the azoles skin ulcer of the present invention also contains the plant extract with faint scent of 0.1-0.45%.
The above-mentioned plant extract with faint scent can select to Flos Jasmini Sambac or lavandula angustifolia or Flos Rosae Rugosae extract, preferred Flos Rosae Rugosae extract.
The water preparation composition that contains clindamycin that is used for the treatment of the azoles skin ulcer of the present invention is simple, need not to add the pH regulator agent, and patient's use feeling is comfortable, can effectively treat the azoles skin ulcer that a variety of causes causes.And easy to use, can anytime anywhere use.
Below will describe further the present invention with specific embodiment.
The specific embodiment
Embodiment 1
Be used for the treatment of the water preparation that contains clindamycin of azoles skin ulcer, comprise following composition:
Clindamycin hydrochloride (Clindamycin Hydrochloride) 3%
Ethanol 25%
Glycerol 0.21%
Propylene glycol (Propylene Glycol) 0.75%
Methyl parahydroxybenzoate (Methylparaben) 0.15%
Propyl p-hydroxybenzoate (Propylparaben) 0.05%
Water surplus
Above-mentioned clindamycin hydrochloride has the azoles of killing skin ulcer corynebacterium and antiinflammation.
Ethanol dissolves various components as primary solvent, and need not to add the pH regulator agent, and can keep the stability of clindamycin hydrochloride; Ethanol can also clean the sebum of skin surface, makes hydrochloric acid chlorine woods can mouldly penetrate into hair follicle ductal epithelium inside; In addition, the present invention has used the ethanol of higher concentration, and it yet has certain antiinflammatory disinfectant effect.
Glycerol makes the main component dissolving fully; Preserve moisture, Glycerin; Reduce the infringement of ethanol to skin.
Propylene glycol is to skin moisture-keeping; Reduce the infringement of ethanol to skin; Make the main component uniform distribution.
Pure water plays the primary solvent effect.
Methyl parahydroxybenzoate and propyl p-hydroxybenzoate are antiseptic, and these two kinds of components matching are used, and strengthen antiseptic effect.
Using method, wash one's face finishes at every turn, wipes thinly in the affected part, and every day, sooner or later respectively once if severe patient, then morning every day, noon, evening were respectively once.
The described product of present embodiment places shady and cool place, can preserve more than 1 year.
Adopt the described product of present embodiment, 100 azoles skin ulcer patients treated, made for 1 week after, have 82 patients obvious curative effects to occur, made for 2 weeks after, have 94 patients to cure, cure rate reaches 94%.In the medication process, there are 7 patients sensitivity or erythema to occur, after the drug withdrawal 3 days, all Lock-outs.
Embodiment 2
Be used for the treatment of the water preparation that contains clindamycin of azoles skin ulcer, comprise following composition:
Clindamycin hydrochloride (Clindamycin Hydrochloride) 1%
Ethanol 22%
Liquor Rosae Rugosae Distillata 0.1%
Glycerol 0.1%
Propylene glycol (Propylene Glycol) 0.25%
Methyl parahydroxybenzoate (Methylparaben) 0.1%
Propyl p-hydroxybenzoate (Propylparaben) 0.14%
Distilled water surplus
Rose extract makes product that fragrance is arranged, and have preserve moisture, wrinkle resistant, whiten, soften, Rose Extract, anti-ageing, Rose Extract, prevent xerosis cutis, promote the excretory effect of estrogen.Flos Jasmini Sambac or the alternative rose extract of Garden lavender extract.
The effect of all the other compositions is identical with embodiment 1.
The described water preparation that contains clindamycin that is used for the treatment of the azoles skin ulcer of present embodiment has faint scent, both can be used for treating the azoles skin ulcer, also allows the patient experience pure and fresh fragrance, can make the spraying water preparation, makes things convenient for the patient to use.
Occupation mode is identical with embodiment 1.
Adopt the described product of present embodiment, 100 azoles skin ulcer patients treated, made for 1 week after, have 78 patients obvious curative effects to occur, made for 2 weeks after, have 88 patients to cure, cure rate reaches 88%.In the medication process, there are 5 patients sensitivity or erythema to occur, after the drug withdrawal 3 days, all Lock-outs.
Embodiment 3
Be used for the treatment of the water preparation that contains clindamycin of azoles skin ulcer, comprise following composition:
Clindamycin hydrochloride (Clindamycin Hydrochloride) 3.5%
Ethanol 25%
Liquor Rosae Rugosae Distillata 0.45%
Glycerol 2%
Propylene glycol (Propylene Glycol) 1%
Methyl parahydroxybenzoate (Methylparaben) 0.22%
Propyl p-hydroxybenzoate (Propylparaben) 0.01%
Distilled water surplus
Occupation mode is identical with embodiment 1.
Adopt the described product of present embodiment, 100 azoles skin ulcer patients treated, made for 1 week after, have 85 patients obvious curative effects to occur, made for 2 weeks after, have 95 patients to cure, cure rate reaches 95%.In the medication process, there are 11 patients sensitivity or erythema to occur, after the drug withdrawal 3 days, all Lock-outs.
Claims (3)
1. the water preparation that contains clindamycin that is used for the treatment of the azoles skin ulcer comprises following components in weight percentage: clindamycin hydrochloride 1-3.5%, ethanol 22-25%, glycerol 0.1-2%, propylene glycol 0.25-1%, methyl parahydroxybenzoate 0.1-0.22%, propyl p-hydroxybenzoate 0.01-1.14%, surplus is a pure water.
2. by the described water preparation that contains clindamycin that is used for the treatment of the azoles skin ulcer of claim 1, it is characterized in that: the plant extract that also contains 0.1-0.45% with faint scent.
3. by the described water preparation that contains clindamycin that is used for the treatment of the azoles skin ulcer of claim 2, it is characterized in that: described plant extract with faint scent is Flos Jasmini Sambac or lavandula angustifolia or Flos Rosae Rugosae extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101221346A CN100448429C (en) | 2006-09-14 | 2006-09-14 | Water aqua containing clindamycin for treating acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101221346A CN100448429C (en) | 2006-09-14 | 2006-09-14 | Water aqua containing clindamycin for treating acne |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1923169A true CN1923169A (en) | 2007-03-07 |
| CN100448429C CN100448429C (en) | 2009-01-07 |
Family
ID=37816113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101221346A Expired - Fee Related CN100448429C (en) | 2006-09-14 | 2006-09-14 | Water aqua containing clindamycin for treating acne |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100448429C (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW203552B (en) * | 1992-02-18 | 1993-04-11 | J Baroody Lloyd | Compositions of clindamycin and benzoyl peroxide for acne treatment |
-
2006
- 2006-09-14 CN CNB2006101221346A patent/CN100448429C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN100448429C (en) | 2009-01-07 |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090107 Termination date: 20200914 |
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| CF01 | Termination of patent right due to non-payment of annual fee |