CN1917889A - 镓在治疗炎性关节炎中的用途 - Google Patents

镓在治疗炎性关节炎中的用途 Download PDF

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Publication number
CN1917889A
CN1917889A CNA2004800417601A CN200480041760A CN1917889A CN 1917889 A CN1917889 A CN 1917889A CN A2004800417601 A CNA2004800417601 A CN A2004800417601A CN 200480041760 A CN200480041760 A CN 200480041760A CN 1917889 A CN1917889 A CN 1917889A
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CN
China
Prior art keywords
gallium
arthritis
disease
effective dose
described method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800417601A
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English (en)
Chinese (zh)
Inventor
L·R·布卡骆
S·斯里达兰
K·阿拉奈尼
L·R·伯恩斯坦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Titan Pharmaceuticals Inc
Original Assignee
Titan Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Titan Pharmaceuticals Inc filed Critical Titan Pharmaceuticals Inc
Publication of CN1917889A publication Critical patent/CN1917889A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2004800417601A 2003-12-17 2004-12-17 镓在治疗炎性关节炎中的用途 Pending CN1917889A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53035303P 2003-12-17 2003-12-17
US60/530,353 2003-12-17

Publications (1)

Publication Number Publication Date
CN1917889A true CN1917889A (zh) 2007-02-21

Family

ID=34700126

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800417601A Pending CN1917889A (zh) 2003-12-17 2004-12-17 镓在治疗炎性关节炎中的用途

Country Status (9)

Country Link
US (1) US20050220895A1 (enExample)
EP (1) EP1694341A1 (enExample)
JP (1) JP2007514754A (enExample)
CN (1) CN1917889A (enExample)
AU (1) AU2004299126A1 (enExample)
CA (1) CA2550119A1 (enExample)
MX (1) MXPA06006801A (enExample)
WO (1) WO2005058331A1 (enExample)
ZA (1) ZA200605583B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102665421A (zh) * 2009-03-30 2012-09-12 尼基制药公司 治疗骨质疏松的方法

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AU2003279067A1 (en) * 2002-09-23 2004-04-08 Genta Inc. Tri(alkylcarboxylato) gallium (iii) products and pharmaceutical compositions containing them
WO2007100382A2 (en) * 2005-10-27 2007-09-07 Bernstein Lawrence R Orally administrable gallium compositions and method of use
US20110038809A1 (en) * 2005-11-01 2011-02-17 Perl Daniel P Growth control of oral and superficial microorganisms using gallium compounds
CN101300033A (zh) * 2005-11-07 2008-11-05 泰坦医药品公司 用镓对不良肝脏病症的治疗和预防
US7993675B2 (en) 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7976873B2 (en) 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US7959943B2 (en) 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
EP2099464B1 (en) 2006-11-09 2016-05-25 BERNSTEIN, Lawrence Richard Local administration of gallium compositions to treat pain
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
EP2526773A1 (en) * 2007-04-02 2012-11-28 Mount Sinai School Of Medicine Methods for preventing or treating infectious diseases using gallium compounds
EP2262509A4 (en) * 2008-03-07 2012-02-22 Lawrence Bernstein GALLIUM COMPOUNDS AND METHOD OF USE FOR THE TREATMENT OF INFLAMMATORY ENDURANCE
CA2727432C (en) 2008-06-12 2016-10-11 Medtronic Xomed, Inc. Method for treating chronic wounds with an extracellular polymeric substance solvating system
US20100086576A1 (en) * 2008-10-06 2010-04-08 Myntti Matthew F Antimicrobial composition and methods of making and using same
EP2706845B1 (en) 2011-05-10 2021-06-23 Next Science IP Holdings Pty Ltd Antimicrobial solid and methods of making and using same
US10889556B2 (en) 2016-03-08 2021-01-12 The Regents Of The University Of California Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease
WO2017156194A1 (en) * 2016-03-08 2017-09-14 The Regents Of The University Of California Compositions and methods for inhibiting influenza rna polymerase pa endonuclease
CN110381945A (zh) * 2017-02-10 2019-10-25 阿尔图姆制药股份有限公司 口服给予的镓（iii）配合物的组合物
US10537661B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same
US10537658B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same
WO2019226519A1 (en) 2018-05-24 2019-11-28 Celanese EVA Performance Polymers Corporation Implantable device for sustained release of a macromolecular drug compound
EP3801462A4 (en) 2018-05-24 2022-03-16 Celanese EVA Performance Polymers LLC Implantable device for sustained release of a macromolecular drug compound
WO2019222856A1 (en) 2018-05-24 2019-11-28 Nureva Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
JP2024515220A (ja) 2021-04-26 2024-04-05 セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー 高分子薬剤化合物の持続放出用の埋め込み型デバイス

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3519361A1 (de) * 1985-05-30 1986-12-04 Boehringer Ingelheim International GmbH, 6507 Ingelheim (gamma)-ifn als wirkstoff zur hemmung (verhinderung) von abbauprozessen im knochen
EP0330799A1 (en) * 1988-03-03 1989-09-06 Schering Aktiengesellschaft A method for the treatment of arthritis and inflammatory joint diseases
US5258376A (en) * 1989-11-22 1993-11-02 Bernstein Lawrence R Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
US6004951A (en) * 1989-11-22 1999-12-21 Bernstein; Lawrence Richard Administration of gallium complexes of 3-hydroxy-4-pyrones to provide physiologically active gallium levels in a mammalian individual
US5175006A (en) * 1990-09-21 1992-12-29 The Ohio State University Method of treating arthritis using gallium compounds
EP0599881B1 (en) * 1991-07-25 1998-05-13 Philippe Collery Gallium (iii) complexes, process for their obtention and pharmaceutical compositions containing them
ES2151486T3 (es) * 1991-11-12 2001-01-01 Lawrence Richard Bernstein Composiciones farmaceuticas que contienen complejos de 3-hidroxi-4-pironas.
US5902825A (en) * 1997-01-07 1999-05-11 Mitreoak, Ltd. Composition and method for the palliation of pain associated with diseases of the bone and bone joints
US6303804B1 (en) * 1999-05-07 2001-10-16 Raytheon Company Environmentally benign bismuth-containing spin-on precursor materials
US6054600A (en) * 1999-05-07 2000-04-25 Raytheon Company Non-toxic solvent soluble group IV and V metal acid salt complexes using polyether acid anhydrides
JP2003510362A (ja) * 1999-10-04 2003-03-18 ローレンス・アール・バーンスタイン 細胞内原核生物、ｄｎａウイルス及びレトロウイルスによる感染を治療するための、３−ヒドロキシ−４−ピロンのガリウム錯体
US20020068761A1 (en) * 1999-10-04 2002-06-06 Bernstein Lawrence R. Gallium complexes of 3-hydroxy-4-pyrones to treat mycobacterial infections

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102665421A (zh) * 2009-03-30 2012-09-12 尼基制药公司 治疗骨质疏松的方法

Also Published As

Publication number Publication date
ZA200605583B (en) 2009-06-24
CA2550119A1 (en) 2005-06-30
MXPA06006801A (es) 2007-01-26
US20050220895A1 (en) 2005-10-06
WO2005058331A1 (en) 2005-06-30
AU2004299126A1 (en) 2005-06-30
EP1694341A1 (en) 2006-08-30
JP2007514754A (ja) 2007-06-07

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Open date: 20070221