CN1911293A - Gel agent-Guzhining for treating osteoporosis and its prepn. method - Google Patents
Gel agent-Guzhining for treating osteoporosis and its prepn. method Download PDFInfo
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- CN1911293A CN1911293A CN 200610047563 CN200610047563A CN1911293A CN 1911293 A CN1911293 A CN 1911293A CN 200610047563 CN200610047563 CN 200610047563 CN 200610047563 A CN200610047563 A CN 200610047563A CN 1911293 A CN1911293 A CN 1911293A
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Abstract
An exterior-applied Chinese medicine 'Guzhining gel' for treating hyperosteoplasia, rheumatic arthritis, rheumatoid arthritis, periomethritis, soft tissue injury, etc is prepared from muscovite, coptis root, baked alum, sodium carbonate, aqueous gel matrix, solvent, humactant, antiseptic and medical auxiliary. Its preparing process is also disclosed.
Description
One, technical field: the invention belongs to technical field of Chinese medicines, specifically a kind of Chinese medicine compound gel for the treatment of diseases such as swollen tissue, the acid that hyperosteogeny, rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis, soft tissue injury etc. cause is expanded, numbness, pain and preparation method thereof.
Two, background technology: joint disease has a strong impact on human health, reduces quality of life, and general Therapeutic Method is difficult to cure, so World Health Organization (WHO) is defined as the global health subject of 2000-2010 " B﹠J 10 years " especially.Arthritis is a kind of chronic disease, and the title of " No.1 disabling disease " is arranged.Arthritic kind surpasses 100 kinds, and modal arthritis is osteoarthritis and rheumatoid arthritis.There are 3.55 hundred million arthritics in the whole world, and wherein 1.9 hundred million people suffer from osteoarthritis.Updated statistics shows that the arthritic of China has surpassed 100,000,000 people.
Existing treatment osteoarthritis method, doctor trained in Western medicine often adopts oral non-steroidal anti-inflammatory class antipyretic analgesic or operative therapy.The oral drugs side effect is many; The operative treatment cycle is long, and the expense height is painful big, and should recur.Chinese medicine is aspect the treatment joint disease, and unique advantage, is processed treatment etc. positive effect is all arranged at extract oral, external application, fumigation and wash method, acupuncture.But oral preparation of Chinese traditional medicinal contains hypertoxic medicines such as Radix Aconiti, Rhizoma Arisaematis, Semen Strychni more, and dosage is difficult to grasp, and sees that from the biopharmaceutics angle being difficult in diseased region reaches effective blood drug concentration, has influenced the performance of curative effect of medication.Chinese medicine " inner disease outer treat " is theoretical with a long history, a large amount of good recipes, proved recipe have been accumulated, but external therapy of Chinese herb medicine ubiquity dosage form falls behind, dosage is big, uses shortcomings such as inconvenience, as using the plaster of the traditional Chinese medical science, because it is airtight, also untoward reaction such as stimulation, allergy can be arranged to skin, therefore utilize modern preparation technique exploitation evident in efficacy lasting, Chinese medicine for outer use easy to use becomes an important topic of the modernization of Chinese medicine.
Three, summary of the invention:
1, goal of the invention: the invention provides a kind of Chinese medicine compound gel that can treat diseases such as swollen tissue, the acid that hyperosteogeny, rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis, soft tissue injury etc. cause is expanded, numbness, pain and preparation method thereof, its purpose be to solve provide a kind of fill a prescription reasonable, toxic and side effects is little, good effect, Chinese medicine compound gel easy to use and preparation method thereof.
2, technical scheme: the present invention is achieved through the following technical solutions:
A kind of GUZHINING gel, it is characterized in that: this gel mainly is made up of substrate, solvent, wetting agent and antiseptic and the pharmaceutic adjuvant of Muscovitum, Rhizoma Coptidis, dried Alumen, sodium carbonate, aqueous gel, and each component is by weight: the substrate 10～25 of Muscovitum 900～1200, Rhizoma Coptidis 8～15, dried Alumen 10～30, sodium carbonate 30～50, aqueous gel, solvent 30～55, wetting agent 30～55 and antiseptic 1～2; This gel treats mainly that swollen tissue, the acid that hyperosteogeny, rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis, soft tissue injury cause is expanded, numb, pain symptom.
The substrate of aqueous gel is selected a kind of in tragakanta, gelatin, starch, cellulose derivative, carbopol, the carbomer series for use.
When the substrate of aqueous gel is selected carbomer series for use, must add nertralizer, nertralizer is selected from inorganic base or organic base; Carbomer series is selected carbomer 934,940,941 specifications for use; Inorganic base or organic base are selected sodium hydroxide or triethanolamine for use.
When the substrate of aqueous gel is selected cellulose derivative for use, select hypromellose for use, methylcellulose, carboxymethyl cellulose, carboxyethyl cellulose.
Wetting agent is selected glycerol for use; Antiseptic is selected ethylparaben for use.
Solvent is water, distilled water or ethanol, is used for making the abundant swollen purpose of water-soluable gel substrate in the process of preparation.
A kind of preparation method of GUZHINING gel is characterized in that: this method is undertaken by following processing step:
1) extracts: prepare each component in right 1 described ratio; Get Muscovitum and decoct with water the extraction secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered filtrate for later use; Get Rhizoma Coptidis and decoct with water the extraction secondary, each 45 minutes, collecting decoction filtered filtrate for later use;
2) concentrate: two kinds of filtrates merging of gained in the step 1) is concentrated, add corresponding dried Alumen and sodium carbonate, stir evenly, standing over night is got supernatant, and is standby;
3) stir: the substrate of water intaking property gel after adding wetting agent and making its abundant moistening, adds solvent and stirs; Supernatant is added in the mixed liquor of substrate of aqueous gel, the limit edged stirs;
4) antiseptic dissolving back is added wherein, add distilled water at last to full dose, stir evenly, placement is spent the night, and swelling is complete, promptly.
The substrate of aqueous gel is selected carbomer when series for use in step 3), gets inorganic base or organic base adds gradually, stirs evenly, and the control pH value is between 6.0～8.0; Inorganic base or organic base are selected sodium hydroxide or triethanolamine for use.
Get Muscovitum and decoct with water extraction twice in step 1), add 6 times of water gagings for the first time, extracted 3 hours, add 5 times of water gagings for the second time, extracted 2 hours, collecting decoction filters filtrate for later use; Get Rhizoma Coptidis and decoct with water extraction twice, add 8 times of water gagings for the first time, add 6 times of water gagings for the second time, each 45 minutes, collecting decoction filtered filtrate for later use.
Prescription by the proportioning of the concrete enforcement of each component is: Muscovitum 1000g, and Rhizoma Coptidis 10g, dried Alumen 20g, sodium carbonate 40g, Acritamer 940 17g, ethanol 45g, glycerol 45g, polyoxyethylene sorbitan monoleate 2g, ethylparaben 1g, distilled water adds to 1000g.
3, advantage and effect: the present invention has carried out further optimization to its prescription and dosage form thereof when keeping original treatment by Chinese herbs effect, be made into the gel dosage form.Gel is a kind of exterior-applied formulation that is applicable to skin, mucosa and cavity/canal drug administration, can alleviate the toxic and side effects of medicine, meets the theory of the traditional Chinese medical science " inner disease outer treat ", adapts to the production status of compound Chinese medicinal preparation, is the comparatively ideal dosage form of Chinese medicine tradition medicine for external use.Carbomer and skin coupling effect are good, and granularity is little and even, good dispersion, and room temperature storage is stable.Have no greasy, easily be coated with exhibition, release is fast, to skin and mucosa nonirritant, can closely stick with agents area in the long time.Have especially in addition the effect of orthopaedics osmotic therapeutic obvious, longer duration, preparation technology is simple, good hand touch, easily eluting, not pollution clothes, good characteristic such as easy to use.
In addition, some sclerotin treatment liniment in the past adopts the thin layer fluorescence scanning method to measure the content of berberine hydrochloride, and operation is trouble, and evaluated error is bigger.And GUZHINING gel of the present invention can have been set up the content of berberine hydrochloride in the high effective liquid chromatography for measuring Rhizoma Coptidis that a kind of separating degree is good, highly sensitive, specificity is strong on quality control, and this can access reliable assurance on the quality control of product.
Four, the specific embodiment: the following specific embodiment that provides is for further describing the present invention for example, and is not limited to only following these several modes.
Example 1. preparation gels:
Prescription and proportioning:
Muscovitum 1000g Rhizoma Coptidis 10g
Dried Alumen 20g sodium carbonate 40g
Acritamer 940 17g glycerol 45g
Ethanol 45g polyoxyethylene sorbitan monoleate 2g
All the other are distilled water for triethanolamine 60g
Preparation method is: get Muscovitum and decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered filtrate for later use; Get Rhizoma Coptidis and decoct with water secondary, each 45 minutes, collecting decoction filtered, and filtrate merges, and is concentrated in right amount, adds dried Alumen and sodium carbonate, stirs evenly, and standing over night is got supernatant, and is standby; Get carbomer series and select carbomer 934,940,941 specifications for use, must add antalkali, generally can select sodium hydroxide or triethanolamine for use.After adding polyoxyethylene sorbitan monoleate and glycerol and making its abundant moistening, add an amount of distilled water mixing and stirring.Above-mentioned supernatant is added wherein, and the limit edged stirs.After other gets ethylparaben and is dissolved in ethanol, add gradually, add distilled water at last to 1000g, stir evenly, placement is spent the night, promptly.
By analysis: owing to have a large amount of hydroxy-acid groups in the carbomer molecule, can be in water swelling rapidly, but do not dissolve.Hydroxy-acid group in its molecular structure makes its aqueous dispersions be acid, and the pH value of 1% aqueous dispersions is about 3.11, and viscosity is lower.When with in the alkali and the time, dissolve gradually with macromole, viscosity also rises gradually.The effect of nertralizer mainly is to regulate suitable viscosity, reduces the zest to skin simultaneously.The present invention adopts Acritamer 940 especially, because semi-solid external preparation must keep viscosity in processes such as production, the rheological equationm of state of neutral Acritamer 940 gel is subjected to, and influence centrifugal, that grind, heat or place for a long time is little.And for neutral Carbopol 941 gel, grinding can make its structural deterioration, and viscosity reduces.
Example 2. preparation gels
Prescription and proportioning:
Muscovitum 1000g Rhizoma Coptidis 10g
Dried Alumen 20g sodium carbonate 40g
Hypromellose 15g ethylparaben 1g
All the other are distilled water for glycerol 20g
Preparation method is: get Muscovitum and decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered filtrate for later use; Get Rhizoma Coptidis and decoct with water secondary, each 45 minutes, collecting decoction filtered, and filtrate merges, and is concentrated in right amount, adds dried Alumen and sodium carbonate, stirs evenly, and standing over night is got supernatant, and is standby; Hypromellose is added the abundant swelling of an amount of distilled water, add glycerol by said ratio, ethylparaben and standby supernatant, adding distil water stirs to 1000g, promptly.Wherein hypromellose also can adopt methylcellulose, carboxymethyl cellulose, any replacement in the carboxyethyl cellulose.
Example 3. preparation gels
Prescription and proportioning:
Muscovitum 1000g Rhizoma Coptidis 10g
Dried Alumen 20g sodium carbonate 40g
Gelatin 20g benzalkonium bromide 0.5g
Glycerol 30g distilled water adds to 1000g
Preparation method is: get Muscovitum and decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered filtrate for later use; Get Rhizoma Coptidis and decoct with water secondary, each 45 minutes, collecting decoction filtered, and filtrate merges, and is concentrated in right amount, adds dried Alumen and sodium carbonate, stirs evenly, and standing over night is got supernatant, and is standby; Gelatin is added the abundant swelling of an amount of distilled water, add glycerol by said ratio, benzalkonium bromide and standby supernatant, adding distil water stirs to 1000g, promptly.Wherein gelatin can adopt any replacement of tragakanta, starch.
Example 4. stability tests relatively
Get GUZHINING liniment 5g, add an amount of dissolve with ethanol, add water 95ml and fully stir into solution, placing had medicine to separate out in 15 days.Get above-mentioned 3 routine gels, place and not see more than 6 months that medicine separates out.
Example 5. Intradermal distribution test
Rat ear hair is removed, apply above-mentioned 3 routine gels respectively, once a day, shared three days, remove the skin surface left drug with normal saline on the 4th day, and put to death rat, take the skin at medicine position, extract with organic solvent, measure drug level in the skin, be respectively 18,13,21 μ g/g.
Claims (10)
1, a kind of GUZHINING gel, it is characterized in that: this gel mainly is made up of substrate, solvent, wetting agent and antiseptic and the pharmaceutic adjuvant of Muscovitum, Rhizoma Coptidis, dried Alumen, sodium carbonate, aqueous gel, and each component is by weight: the substrate 10～25 of Muscovitum 900～1200, Rhizoma Coptidis 8～15, dried Alumen 10～30, sodium carbonate 30～50, aqueous gel, solvent 30～55, wetting agent 30～55 and antiseptic 1～2; This gel treats mainly that swollen tissue, the acid that hyperosteogeny, rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis, soft tissue injury cause is expanded, numb, pain symptom.
2, GUZHINING gel according to claim 1 is characterized in that: the substrate of aqueous gel is selected a kind of in tragakanta, gelatin, starch, cellulose derivative, carbopol, the carbomer series for use.
3, GUZHINING gel according to claim 2 is characterized in that: when the substrate of aqueous gel is selected carbomer series for use, must add nertralizer, nertralizer is selected from inorganic base or organic base; Carbomer series is selected carbomer 934,940,941 specifications for use; Inorganic base or organic base are selected sodium hydroxide or triethanolamine for use.
4, GUZHINING gel according to claim 2 is characterized in that: when the substrate of aqueous gel is selected cellulose derivative for use, select hypromellose for use, methylcellulose, carboxymethyl cellulose, carboxyethyl cellulose.
5, GUZHINING gel according to claim 1, it is characterized in that: wetting agent is selected glycerol for use; Antiseptic is selected ethylparaben for use.
6, GUZHINING gel according to claim 1, it is characterized in that: solvent is water, distilled water or ethanol, is used for making the abundant swollen purpose of water-soluable gel substrate in the process of preparation.
7, a kind of preparation method of GUZHINING gel is characterized in that: this method is undertaken by following processing step:
1) extracts: prepare each component in right 1 described ratio; Get Muscovitum and decoct with water the extraction secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered filtrate for later use; Get Rhizoma Coptidis and decoct with water the extraction secondary, each 45 minutes, collecting decoction filtered filtrate for later use;
2) concentrate: two kinds of filtrates merging of gained in the step 1) is concentrated, add corresponding dried Alumen and sodium carbonate, stir evenly, standing over night is got supernatant, and is standby;
3) stir: the substrate of water intaking property gel after adding wetting agent and making its abundant moistening, adds solvent and stirs; Supernatant is added in the mixed liquor of substrate of aqueous gel, the limit edged stirs;
4) antiseptic dissolving back is added wherein, add distilled water at last to full dose, stir evenly, placement is spent the night, and swelling is complete, promptly.
8. the preparation method of GUZHINING gel according to claim 7 is characterized in that: the substrate of aqueous gel is selected carbomer when series for use in step 3), gets inorganic base or organic base adds gradually, stirs evenly, and the control pH value is between 6.0～8.0; Inorganic base or organic base are selected sodium hydroxide or triethanolamine for use.
9, the preparation method of GUZHINING gel according to claim 7 is characterized in that: get Muscovitum and decoct with water extraction twice in step 1), add 6 times of water gagings for the first time, extracted 3 hours, and added 5 times of water gagings for the second time, extracted 2 hours, collecting decoction filters filtrate for later use; Get Rhizoma Coptidis and decoct with water extraction twice, add 8 times of water gagings for the first time, add 6 times of water gagings for the second time, each 45 minutes, collecting decoction filtered filtrate for later use.
10, the preparation method of GUZHINING gel according to claim 7, the proportioning that it is characterized in that filling a prescription by the concrete enforcement of each component is: Muscovitum 1000g, Rhizoma Coptidis 10g, dried Alumen 20g, sodium carbonate 40g, Acritamer 940 17g, ethanol 45g, glycerol 45g, polyoxyethylene sorbitan monoleate 2g, ethylparaben 1g, distilled water adds to 1000g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200610047563A CN1911293B (en) | 2006-08-28 | 2006-08-28 | Gel agent-Guzhining for treating osteoporosis and its preparation method |
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| CN200610047563A CN1911293B (en) | 2006-08-28 | 2006-08-28 | Gel agent-Guzhining for treating osteoporosis and its preparation method |
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| CN1911293A true CN1911293A (en) | 2007-02-14 |
| CN1911293B CN1911293B (en) | 2010-05-12 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188512A (en) * | 2010-03-01 | 2011-09-21 | 保定市金钟制药有限公司 | Hyperosteogeny plaster |
| CN104288253A (en) * | 2014-09-30 | 2015-01-21 | 江苏奇力康皮肤药业有限公司 | Method for preparing emulsifiable paste for treating soft tissue injury |
| CN112245482A (en) * | 2020-10-29 | 2021-01-22 | 吉林大学 | Application of composition containing active mica in preparing medicine for improving activity of intracellular superoxide dismutase |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091021A (en) * | 1993-02-11 | 1994-08-24 | 沈阳飞龙保健品有限公司 | Guzhining liniment product and preparation method |
| CN1557418A (en) * | 2004-02-10 | 2004-12-29 | 清 顾 | Composite Chinese medicine gelling agent for treating osteo arthropathy and preparing method thereof |
-
2006
- 2006-08-28 CN CN200610047563A patent/CN1911293B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188512A (en) * | 2010-03-01 | 2011-09-21 | 保定市金钟制药有限公司 | Hyperosteogeny plaster |
| CN104288253A (en) * | 2014-09-30 | 2015-01-21 | 江苏奇力康皮肤药业有限公司 | Method for preparing emulsifiable paste for treating soft tissue injury |
| CN112245482A (en) * | 2020-10-29 | 2021-01-22 | 吉林大学 | Application of composition containing active mica in preparing medicine for improving activity of intracellular superoxide dismutase |
| CN112245482B (en) * | 2020-10-29 | 2023-10-27 | 吉林大学 | Application of composition containing active mica in preparation of medicine for improving activity of superoxide dismutase in cells |
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| Publication number | Publication date |
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| CN1911293B (en) | 2010-05-12 |
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