CN1911103A - Health-care food for improving human body physical agility and endurance - Google Patents
Health-care food for improving human body physical agility and endurance Download PDFInfo
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- CN1911103A CN1911103A CNA2005100147242A CN200510014724A CN1911103A CN 1911103 A CN1911103 A CN 1911103A CN A2005100147242 A CNA2005100147242 A CN A2005100147242A CN 200510014724 A CN200510014724 A CN 200510014724A CN 1911103 A CN1911103 A CN 1911103A
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Abstract
A health-care food for improving human physical fitness and endurance and relaxing fatigue and iron-deficiency anemia is suitable for sportsman or sportswoman, and the cancer patient suffering from chemicotherapy or radiotherapy. It is proportionally prepared from porphyrin iron, donkey-hide gelatin, epimedium, rhodiola root, VB1, VB6 and folic acid.
Description
Technical field:
The invention belongs to a kind of health food, particularly a kind of health food that is used for improving human body physical agility and endurance of alleviating human physical power's fatigue and improving hypoferric anemia that relies on.
Background technology:
The crowd that it is suitable for comprises the physical fatigue that causes because of various factors and the crowd of hypoferric anemia, and especially blood loss anemia and the fatigue that the sportsman and the heavy physical labourer one of high strength, highdensity training and match crossed property is more suitable.Weary to the hemogram abnormity and the refreshing tired power of putting, chemotherapy causes, anorexia, the cancer patient that body's immunity descends also can be used as auxiliary health food.
Summary of the invention:
Purpose of the present invention just is to provide a kind of health food that improves human body physical agility, endurance, and this food is that the human physical power is tired to reach this function with the effect that improves hypoferric anemia by alleviating.
Technical scheme of the present invention is: a kind of health food that improves human body physical agility, endurance is characterized in that: made according to following weight proportion by following raw materials according:
20～100 parts of PORPHYRIN IRON
Donkey-hide gelatin 100-500 part
100～500 parts of Shorthorned Epimedium P.Es
50～100 parts of gadol extracts
VB
15～100 parts
VB
60.1～2 parts
0.01～1 part in folic acid
Above-mentionedly can make the various formulations of hard shell capsules, soft capsule, liquid-filling capsule, powder and tablet.
Preparation method of the present invention is: at first preparation contains the Shorthorned Epimedium P.E and the gadol extract that contains rhodioside 1-40% of icariin 5-40%, then Shorthorned Epimedium P.E, gadol extract is mixed with other above-mentioned raw materials, gets final product.
The above-mentioned extracting method that contains the Shorthorned Epimedium P.E of icariin 5-40% is: the barrenwort water extracts, the water yield is a 3-10 times of medicinal material, extract 1-5 time, each 0.5-3 hour, alcohol precipitation concentration is 40-80%, and supernatant reclaims, and concentrates, vacuum drying or spray-drying, the gained Shorthorned Epimedium P.E contains icariin 5-40%.
The above-mentioned extracting method that contains the Shorthorned Epimedium P.E of icariin 5-40% is: barrenwort 30-70% alcohol extract, be recycled to and do not have the alcohol flavor, separate with macroporous absorbent resin or polyamide, resolve with 40-80% ethanol, desorbed solution reclaims, concentrate, vacuum drying or spray-drying, the gained Shorthorned Epimedium P.E contains icariin 5-40%.
The above-mentioned extracting method that contains the gadol extract of rhodioside 1-4% is: rhodiola root 40-90% alcohol extract, consumption are 2-12 times of medicinal material, extract 1-6 time, each 0.5-4 hour, reclaim, concentrate, vacuum drying or spray-drying, the gained gadol extract contains rhodioside 1-4%.
The above-mentioned extracting method that contains the gadol extract of rhodioside 1-4% is: rhodiola root 30-70% alcohol extract, be recycled to and do not have the alcohol flavor, separate with macroporous absorbent resin, resolve with 40-80% ethanol, desorbed solution reclaims, concentrate, vacuum drying or spray-drying, the gained gadol extract contains rhodioside 1-4%.
The above-mentioned extracting method that contains the gadol extract of rhodioside 1-4% is: rhodiola root 30-90% ethanol Microwave Extraction, consumption is a 2-12 times of medicinal material, extract 1-5 time, each 10-40 minute, extract reclaims, concentrate, vacuum drying or spray-drying, the gained gadol extract contains rhodioside 1-4%.
Experimental result of the present invention is: mouse invented food (0.4g, 0.8g, 1.2g/Kg) every day 1 time, 30 days, in the swimming with a load attached to the body test, middle dosage treated animal swimming time very obviously was longer than control group (P＜0.01); Hepatic glycogen content is higher than control group (P＜0.01) very much; High dose group blood lactic acid area under a curve is starkly lower than control group (P＜0.05); Each dosage group urea nitrogen content and control group no significant difference (P＞0.05).Show that this product has the effect of alleviating physical fatigue.
Each dosage group of rat body weight and control group be there was no significant difference (P＞0.05) relatively.
Rat invented food (200,400,1200mg) every day 1 time, detect after 33 days, make the hypoferric anemia rat very significantly increase the content of hemoglobin, and reach normal range (NR).Equal P＜0.01 before and after each dosage group experiment; Relatively has notable difference (P＜0.01) with control group; Free protoporphyrin content is starkly lower than control group (P＜0.05) at 1200mg/Kg in the rat red blood cell.
Human trial:
Anaemia human feeding trial: test-meal group 53 examples (man 2, woman 51), control group (placebo) 50 examples (man 1, woman 49), day takes 2 times, each 3 (0.4g/ grain), took continuously 30 days, result of the test shows: the 104.96 ± 10.77g/L of test-meal group hemoglobin before by test-meal, rise to 119.70 ± 12.99g/L after the test-meal, significant differences (P＜0.001) is arranged, test-meal group and control group comparing difference highly significant (P＜0.001), the test-meal group is improved hypoferric anemia and is better than control group very significantly.20.56 ± the 29.85ng/ml of test-meal group serum ferritin before by test-meal rises to 29.96 ± 35.67ng/ml after the test-meal, very evident difference (P＜0.01) is arranged, serum ferritin after the test-meal of test-meal group give birth to high value (9.41 ± 25.15ng/ml) apparently higher than control group (0.32 ± 15.43ng/ml), difference has conspicuousness (P＜0.05).504.38 ± 254.35 μ g/Ls of free protoporphyrin before by test-meal drop to 456.09 ± 215.79 μ g/L in the test-meal group red blood cell, notable difference (P＜0.05) is arranged, the protoporphyrin that dissociates in the red blood cell after the test-meal of test-meal group is starkly lower than control group (P＜0.05), and drop-out value is also obviously greater than control group (P＜0.05).The integration of clinical symptoms before than test-meal obviously descends (P＜0.01) after the test-meal of test-meal group, especially breathe hard to nervous, and poor appetite, the improvement of symptom such as weak is outstanding.With control group significant difference (P＜0.05) is arranged more all.Show that this product has the obvious effect that improves hypoferric anemia.The dehematize red eggs have significant difference for white two groups after the test-meal, belong to outside effect improves, and other index is all in normal range (NR), illustrate that this product is not to human body blood, urine, just routine and liver, renal function produce harmful effect.
This product shows stimulant, anesthetic, beta blocker, diuretics and the hormone medicine of not finding International Olympic Committee's regulation forbidding in 2004 through national excitant and the detection of sport nutrition testing research center, is applicable to that the sportsman is edible in training and competition.
Rat and acute toxicity test in mice be LD as a result
50＞15.0g/Kg, BW, according to the acute toxicity classification, this product is a non-poisonous material.
Salmonella reversion test shows that this product do not have mutagenesis; The PCEMNR micronucleus test shows that this product does not exert an influence to the PCEMNR micronucleus; The mouse testis chromosomal aberration test shows this product, and chromosome aberration does not exert an influence to mouse testis, and genetic toxicity test is all negative.
Rat was fed 30 days, 1.00g, 2.00g, 4.00g/Kg, and BW fed 30 days; Each organizes body weight, weightening finish and food utilization and control group compares, difference that there are no significant (P＞0.05); Hematology detects each index all in this detection unit range of normal value, but low, the middle dosage group of buck hemoglobin, middle dosage group red blood cell count(RBC) all are higher than control group, and the high dose group neutrophil leucocyte is lower than control group (P＜0.05); Jenny low dose group hemoglobin is higher than control group, but the equal abiology meaning of above-mentioned project.
Biochemical indicator: experiment latter stage every biochemical indicator all in this detection anteposition range of normal value, buck high dose BUN, GLU are lower than control group (P＜0.05); In the jenny, middle dosage CHO is higher than control group, and low dosage CRE is lower than control group (P＜0.05), the equal abiology meaning of above-mentioned project.There are no significant (P＞0.05) for all the other every index differences.
Check substantially and the internal organs system that gross examination of skeletal muscle is no abnormal, when dissected is not also found bladder, the ductuli hepaticus communis calculus, and each treated animal organ weights and dirty body ratio are compared difference with control group do not have conspicuousness (P＞0.05).
Histopathologic examination finds no that typical Histopathology changes and specificity is damaged, and shows that this product do not see tangible toxic action through 30 days feeding trials.
Advantage of the present invention is: have alleviating physical fatigue and the effect that improves hypoferric anemia, the crowd that it is suitable for comprises the physical fatigue that causes because of various factors and the crowd of hypoferric anemia, and especially blood loss anemia and the fatigue that the sportsman and the heavy physical labourer one of high strength, highdensity training and match crossed property is more suitable.Weary to the hemogram abnormity and the refreshing tired power of putting, chemotherapy causes, anorexia, the cancer patient that body's immunity descends also can be used as auxiliary health food.
The specific embodiment:
Embodiment 1---capsule
The preparation Shorthorned Epimedium P.E: get barrenwort 1875 grams, water extracts, and the water yield is a 3-10 times of medicinal material, extracts 1-5 time, each 0.5-3 hour, alcohol precipitation concentration was 40-80%, and supernatant reclaims, concentrate, vacuum drying or spray-drying, the gained Shorthorned Epimedium P.E contains icariin 5-40%.
The preparation gadol extract: get rhodiola root 550 grams, use the 40-90% alcohol extract, consumption is a 2-12 times of medicinal material, extracts 1-6 time, and each 0.5-4 hour, reclaim, concentrate, vacuum drying or spray-drying, the gained gadol extract contains rhodioside 1-4%.
Get PORPHYRIN IRON 40g, donkey-hide gelatin 375g, Shorthorned Epimedium P.E 375g, gadol extract 82.5g, VB according to above-mentioned weight proportion
120g, VB
60.4g, folic acid 0.1g, get auxiliary material 107g again.Described auxiliary material is starch-containing, a kind of or several mixtures of silica, dextrin, and the ratio of its mixture is not limit.
At last, with PORPHYRIN IRON, donkey-hide gelatin, Shorthorned Epimedium P.E, gadol extract, VB
1, VB
6, folic acid and auxiliary material be mixed and made into the present invention's 1000 grams, wherein, the 0.4g/ grain.
Embodiment 2---soft capsule
Preparation Shorthorned Epimedium P.E: get barrenwort 1875 grams, with barrenwort 30-70% alcohol extract, be recycled to and do not have the alcohol flavor, separate with macroporous absorbent resin or polyamide, resolve with 40-80% ethanol, desorbed solution reclaims, and concentrates, vacuum drying or spray-drying, the gained Shorthorned Epimedium P.E contains icariin 5-40%.
Extract gadol extract: get rhodiola root 550 grams, use the 30-70% alcohol extract, being recycled to does not have the alcohol flavor, separate with macroporous absorbent resin, resolve with 40-80% ethanol, desorbed solution reclaims, concentrate, vacuum drying or spray-drying, the gained gadol extract contains rhodioside 1-4%.
Get PORPHYRIN IRON 40g, donkey-hide gelatin 375g, Shorthorned Epimedium P.E 375g, gadol extract 82.5g, VB according to above-mentioned weight proportion
120g, VB
60.4g, folic acid 0.1g, get auxiliary material 107g again.Described auxiliary material contains a kind of or several mixtures of vegetable oil, salad oil, PEG400, cetomacrogol 1000, polyethylene glycol 1500, atoleine, and the component ratio in the mixture is not limit.
At last, with PORPHYRIN IRON, donkey-hide gelatin, Shorthorned Epimedium P.E, gadol extract, VB
1, VB
6, folic acid and auxiliary material be mixed and made into 1000 of the present invention, wherein, the 0.4g/ grain.
Embodiment 3---tablet
The preparation of Shorthorned Epimedium P.E: get barrenwort 1875 grams, the barrenwort water is extracted, the water yield is a 3-10 times of medicinal material, extract 1-5 time, each 0.5-3 hour, alcohol precipitation concentration was 40-80%, supernatant reclaims, concentrate, vacuum drying or spray-drying, the gained Shorthorned Epimedium P.E contains icariin 5-40%.
The preparation of gadol extract: get rhodiola root 550 grams, with 30-90% ethanol Microwave Extraction, consumption is a 2-12 times of medicinal material, extract 1-5 time, each 10-40 minute, extract reclaimed, concentrate, vacuum drying or spray-drying, the gained gadol extract contains rhodioside 1-4%.
Get PORPHYRIN IRON 40g, donkey-hide gelatin 375g, Shorthorned Epimedium P.E 375g, gadol extract 82.5g, VB according to above-mentioned weight proportion
120g, VB
60.4g, folic acid 0.1g, get auxiliary material 107g again.Described auxiliary material is starch-containing, a kind of or several mixtures of microcrystalline cellulose, lactose, dextrin, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, and the component ratio in the mixture is not limit.Thin film coating material contain polyacrylic resin II, polyacrylic resin III, hydroxypropyl methylcellulose, PVA, AEA, glycerine, PEG400～6000, titanium dioxide, talcous two kinds several mixtures are water-soluble or ethanol in.
At last, with PORPHYRIN IRON, donkey-hide gelatin, Shorthorned Epimedium P.E, gadol extract, VB
1, VB
6, folic acid and auxiliary material be mixed and made into 1000 of the present invention, wherein, the 0.5g/ sheet.
Claims (8)
1, a kind of health food that improves human body physical agility, endurance is characterized in that: made according to following weight proportion by following raw materials according:
20～100 parts of PORPHYRIN IRON
Donkey-hide gelatin 100-500 part
100～500 parts of Shorthorned Epimedium P.Es
50～100 parts of gadol extracts
VB
15～100 parts
VB
60.1～2 parts
0.01～1 part in folic acid.
2, a kind of health food that improves human body physical agility, endurance according to claim 1, it is characterized in that: above-mentioned health food can be made the various formulations of hard shell capsules, soft capsule, liquid-filling capsule, powder and tablet.
3, the preparation method of the health food of a kind of raising human body physical agility according to claim 1, endurance, it is characterized in that: at first preparation contains the Shorthorned Epimedium P.E and the gadol extract that contains rhodioside 1-4% of icariin 5-40%, then Shorthorned Epimedium P.E, gadol extract are mixed with other above-mentioned raw materials, get final product.
4, a kind of preparation method who improves the health food of human body physical agility, endurance according to claim 3, it is characterized in that: the above-mentioned extracting method that contains the Shorthorned Epimedium P.E of icariin 5-40% is: the barrenwort water extracts, the water yield is a 3-10 times of medicinal material, extract 1-5 time, each 0.5-3 hour, alcohol precipitation concentration was 40-80%, supernatant reclaims, concentrate, vacuum drying or spray-drying, the gained Shorthorned Epimedium P.E contains icariin 5-40%.
5, a kind of preparation method who improves the health food of human body physical agility, endurance according to claim 3, it is characterized in that: the above-mentioned extracting method that contains the Shorthorned Epimedium P.E of icariin 5-40% is: barrenwort 30-70% alcohol extract, be recycled to and do not have the alcohol flavor, separate with macroporous absorbent resin or polyamide, resolve with 40-80% ethanol, desorbed solution reclaims, and concentrates, vacuum drying or spray-drying, the gained Shorthorned Epimedium P.E contains icariin 5-40%.
6, a kind of preparation method who improves the health food of human body physical agility, endurance according to claim 3, it is characterized in that: the above-mentioned extracting method that contains the gadol extract of rhodioside 1-4% is: rhodiola root 40-90% alcohol extract, consumption is a 2-12 times of medicinal material, extract 1-6 time, each 0.5-4 hour, reclaim, concentrate, vacuum drying or spray-drying, the gained gadol extract contains rhodioside 1-4%.
7, a kind of preparation method who improves the health food of human body physical agility, endurance according to claim 3, it is characterized in that: the above-mentioned extracting method that contains the gadol extract of rhodioside 1-4% is: rhodiola root 30-70% alcohol extract, be recycled to and do not have the alcohol flavor, separate with macroporous absorbent resin, resolve with 4080% ethanol, desorbed solution reclaims, and concentrates, vacuum drying or spray-drying, the gained gadol extract contains rhodioside 1-4%.
8, a kind of preparation method who improves the health food of human body physical agility, endurance according to claim 3, it is characterized in that: the above-mentioned extracting method that contains the gadol extract of rhodioside 1-4% is: rhodiola root 30-90% ethanol Microwave Extraction, consumption is a 2-12 times of medicinal material, extract 1-5 time, each 10-40 minute, extract reclaimed, and concentrated, vacuum drying or spray-drying, the gained gadol extract contains rhodioside 1-4%.
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| CN2005100147242A CN1911103B (en) | 2005-08-08 | 2005-08-08 | Health-care food for improving human body physical agility and endurance |
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| CN2005100147242A CN1911103B (en) | 2005-08-08 | 2005-08-08 | Health-care food for improving human body physical agility and endurance |
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| CN1911103A true CN1911103A (en) | 2007-02-14 |
| CN1911103B CN1911103B (en) | 2011-07-27 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652856A (en) * | 2013-11-01 | 2014-03-26 | 安军 | Anti-fatigue, anti-hypoxic and anti-aging health care product and preparation method thereof |
| CN107496490A (en) * | 2017-09-25 | 2017-12-22 | 安徽金源药业有限公司 | One kind extraction glycoside substance method |
| CN107997123A (en) * | 2017-11-28 | 2018-05-08 | 北京康比特体育科技股份有限公司 | A kind of composition for promoting lactic acid to remove |
| CN113425759A (en) * | 2020-03-19 | 2021-09-24 | 东阿生力源阿胶股份有限公司 | Donkey-hide gelatin, epimedium and rhodiola rosea capsules |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077638A (en) * | 1992-04-14 | 1993-10-27 | 郝超焰 | Preparation method of oral nutritional medicine for pregnant women |
| CN1079216C (en) * | 1997-03-25 | 2002-02-20 | 刘杰龙 | Health glacial water |
| CN1539427A (en) * | 2003-04-23 | 2004-10-27 | 山东绿叶天然药物研究开发有限公司 | Icariin in application of preparing medication for treating and preventing osteoporosis |
-
2005
- 2005-08-08 CN CN2005100147242A patent/CN1911103B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652856A (en) * | 2013-11-01 | 2014-03-26 | 安军 | Anti-fatigue, anti-hypoxic and anti-aging health care product and preparation method thereof |
| CN107496490A (en) * | 2017-09-25 | 2017-12-22 | 安徽金源药业有限公司 | One kind extraction glycoside substance method |
| CN108976264A (en) * | 2017-09-25 | 2018-12-11 | 安徽金源药业有限公司 | A kind of kidney tonifying, benefiting essence-blood, radiation protection saussurea involucrata Herba Epimedii root of kirilow rhodiola Chinese medicine composition |
| CN107997123A (en) * | 2017-11-28 | 2018-05-08 | 北京康比特体育科技股份有限公司 | A kind of composition for promoting lactic acid to remove |
| CN113425759A (en) * | 2020-03-19 | 2021-09-24 | 东阿生力源阿胶股份有限公司 | Donkey-hide gelatin, epimedium and rhodiola rosea capsules |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1911103B (en) | 2011-07-27 |
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Effective date of registration: 20161221 Address after: 510620 Tianhe District Sports Road, Guangdong, No. 3605, No. 103, Guangzhou Patentee after: Guangzhou City Star Health Food Co.,Ltd. Address before: 300061 Tianjin city Hexi District heiniucheng Road friendship road housing station Patentee before: TIANJIN DANXI TRADITIONAL CHINESE MEDICINE Research Institute |
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