CN1909885A - Skin whitening composition having synergic whitening effect - Google Patents

Skin whitening composition having synergic whitening effect Download PDF

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Publication number
CN1909885A
CN1909885A CNA2005800023623A CN200580002362A CN1909885A CN 1909885 A CN1909885 A CN 1909885A CN A2005800023623 A CNA2005800023623 A CN A2005800023623A CN 200580002362 A CN200580002362 A CN 200580002362A CN 1909885 A CN1909885 A CN 1909885A
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extract
skin
whitening
papain
ginseng rubra
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CN100459970C (en
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朴昶埙
姜炳永
金汉坤
韩相勋
黄在晟
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Amorepacific Corp
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Amorepacific Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B35/00—Screw-bolts; Stay-bolts; Screw-threaded studs; Screws; Set screws
    • F16B35/04—Screw-bolts; Stay-bolts; Screw-threaded studs; Screws; Set screws with specially-shaped head or shaft in order to fix the bolt on or in an object
    • F16B35/06—Specially-shaped heads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B23/00—Specially shaped nuts or heads of bolts or screws for rotations by a tool
    • F16B23/0007—Specially shaped nuts or heads of bolts or screws for rotations by a tool characterised by the shape of the recess or the protrusion engaging the tool
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B37/00—Nuts or like thread-engaging members
    • F16B37/14—Cap nuts; Nut caps or bolt caps

Abstract

The present invention relates to a skin-whitening cosmetic composition, that prevents melanin hypersynthesis and promotes exhaustion of systhesized melanin from the skin. More particularily, the skin-whitening cosmetic composition of the prevent invention comprises licorice extract with red ginseng extract, white birch extract and papain, and thus has an excellent skin-whitening effect by improving that of the licorice extract, which is the whitening component.

Description

Skin whitening composition with synergic whitening effect
Technical field
The present invention relates to the skin-whitening cosmetic compositions, said composition can prevent melanin excessively synthetic (hypersynthesis), and promotes the melanin that is generated to be discharged by skin.More specifically, skin-whitening cosmetic compositions of the present invention contains Radix Glycyrrhizae extract (licorice extract) and Radix Ginseng Rubra extract (redginseng extract), Betula platyphylla Suk. extract (white birch extract) and papain (papain), so said composition has excellent skin whitening effect by improving as the effect of brightening the Radix Glycyrrhizae extract of component.
Background technology
When people's skin during by ultraviolet radiation, will produce and discharge the melanin of decider's skin color, thereby cause hyperpigmentation, as melasma, freckle and speckle, they all produce bad influence to beauty treatment.
Melanic building-up process is as follows: the tryrosinase in the cell forms DOPA quinone (dopaquinone) to the tyrosine effect, thereby produces melanin.Therefore, in order to prevent skin darkening, research worker is devoted to research and is suppressed melanic partial synthesis process, thereby reduces the synthetic of melanin self.This brightening agent example of exploitation is kojic acid (kojic acid), arbutin, Radix Glycyrrhizae extract, vitamin A and vitamin C.
In addition, except the decision skin color, melanin such as by forming around the medicated cap spline structure of nucleon and protecting group because of avoiding uv damage, and protect in the albumen in the cell by the elimination free radical and also to play an important role.As a result, the synthetic of melanin self may be excessively suppressed, thereby its minimum must acting in skin can not be finished.
Therefore, the best way is optionally rapidly to eliminate excessive synthetic melanin and the colour of skin is brightened.
Summary of the invention
For addressing these problems, the present inventor has carried out the research of three aspects, is intended to improve the skin whitening effect relevant with skin texture.
As a result, the present inventor finds, can promote the skin whitening effect by making skin renewal mechanism reach maximization, and this mechanism has adopted 1. papain, is intended to improve the separation of the outermost layer cell of keratin layer; 2. Radix Ginseng Rubra extract is intended to stimulating cellular growth; 3. the Betula platyphylla Suk. extract is intended to make rough skin soft and smooth, thereby has finished the present invention.
Therefore, the purpose of this invention is to provide a kind of method that makes the skin whitening maximum effect that brightens component.For realizing purpose of the present invention, provide the cosmetic composition that contains Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and papain.
Another object of the present invention provides the skin-whitening cosmetic compositions that contains as Radix Glycyrrhizae extract and Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and the papain of brightening agent.
The specific embodiment
The invention provides the skin-whitening cosmetic compositions that contains Radix Glycyrrhizae extract, Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and papain.
Compositions of the present invention can promote the skin whitening effect, and this is because to have suppressed melanin excessively synthetic and promoted to get rid of excessive synthetic melanin.And then by promoting that cell peels off, cell forms and skin is soft and smooth, compositions can be carried out the skin renewal cycle rapidly.
The present inventor finds, compares with the single component of independent employing, and when compositions comprised Radix Glycyrrhizae extract, Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and papain mixture, the skin whitening effect of compositions had unexpectedly improved.That is to say that when compositions contained by blended each component, it had maximized skin whitening effect.Below, the skin whitening composition that will contain Radix Glycyrrhizae extract, Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and papain is called " the energy complex of whitening (WhiteEnergy Complex) ".
Be used for described Radix Glycyrrhizae extract of the present invention for suppressing the key component that melanin forms.The content of Radix Glycyrrhizae extract is preferably the 0.001-2.0 weight % of composition total weight.If its content is lower than 0.001 weight %, then can not obtain the skin whitening effect, and, if surpass 2.0 weight %, may cause skin irritation.
The effect of papain mainly is to promote that Skin Cell peels off.The content of papain is preferably the 0.01-0.1 weight % of composition total weight.If its content is lower than 0.01 weight %, then can not obtain the skin whitening effect, and, if surpass 0.1 weight %, may cause skin irritation.
The effect of Radix Ginseng Rubra extract mainly is a stimulating cellular growth.Consider cost and effect, preferably adopt 6 years living Radix Ginseng Rubra extracts.The content of Radix Ginseng Rubra extract is preferably 0.01-5.0 weight %.If its content is lower than 0.01 weight %, then can not obtain the skin whitening effect, and if surpass 5.0 weight %, the cost of product can increase.
The Betula platyphylla Suk. extract then helps skin soft and smooth.The content of Betula platyphylla Suk. extract is preferably the 0.01-5.0 weight % of composition total weight.If its content is lower than 0.01 weight %, then can not obtain the skin whitening effect, and, if surpass 5.0 weight %, may cause skin irritation.
By described each component is mixed, will demonstrate synergy, and aforesaid effect.
In addition, the present invention can adopt kojic acid, arbutin, vitamin A or vitamin C to replace Radix Glycyrrhizae extract as the active key component of skin whitening.
The present invention is below described in more detail.
The skin whitener of having developed up till now can be suppressed in the melanin generation and play the activity of the tryrosinase of most important effect, thereby reduces melanic amount.But the problem of this skin whitener is that they can cause skin irritant side effect, so consumption is limited.Therefore, compositions of the present invention promotes the active system of skin renewal to promote the skin whitening effect of the skin whitener of exploitation at present owing to having adopted, thereby excellent skin whitening effect is provided.
Skin is made up of epidermis and corium, and epidermis is shallow top layer, and corium is subepidermal more deep layer.Be different connective tissue layers (subcutaneous tissue (hypodermic tissue)) below corium, be referred to as " subcutaneous tissue (subcutaneous tissue) ".The skin of the skin that epidermis is made up of epithelial tissue, and constitute by five layers.Specifically, from the inboard, epidermis is by basic unit, spinous layer (spinous layer), granular layer (granular layer), clear layer (clear layer) and horny layer (homy layer); Epidermis forms new cell in the bottom, then, new cell stretches out continuously, separates with cornified dead cell gradually.Aforesaid circulation is called as " upgrade (turnover) ", and wherein, synthetic new cell upwards is pushed into old cell the skin of health in the bottom, with in this separation.By promoting renewal, compositions of the present invention is expelled to the melanin that forms in the epidermis external rapidly.
By following embodiment, comparative example and experimental example the present invention is described in more detail.But those skilled in the art know that clearly these examples only are used for explanation, are not considered as limiting the scope of the invention.
＜embodiment 1 and 2〉preparation skin whitening composition (the energy complex 1 and 2 of whitening)
Buy " polyhydric alcohol solubility Radix Glycyrrhizae extract P-T (40) " as described Radix Glycyrrhizae extract, it comprises and surpasses 35% glabridin, is produced by Maruzen Pharmaceuticals Co.Ltd (Japan).
Radix Ginseng Rubra extract prepares according to following process, and 6 years living Radix Ginseng Rubra extracts being produced by Bioland (Korea S) are carried out enzymolysis.
" enzymolysis process "
10 gram Radix Ginseng Rubra extracts are dissolved in 100 milliliters of citrate buffers (pH 5.5), add the naringinase of 1 gram from penicillium (Penicillium sp.), then, with mixture 40 ℃ stirred in water bath 48 hours.When regularly determining, mixture is carried out 10 minutes hot water heat (hydrothermally heated), then, carry out three extractions and concentrated with identical ether with cessation reaction when the material disappearance and by thin layer chromatography.(chloroform: assay products methanol=9: 1) obtains Radix Ginseng Rubra extract (10.5% yield) with silica gel column chromatography.
The Betula platyphylla Suk. extract is available from " the Betula platyphylla Suk. extract " produced by Arch Personal Care Products (U.S.).
Papain is available from " the refining papain powder (Refined papain powder) " produced by CPC Wolfgang Muhlbauer GmbH (Germany).
With Radix Glycyrrhizae extract, Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and papain with 5: 5: 10: 0.3 mixed, make 203 the gram skin whitening compositions 1 (energy complex 1: embodiment 1 whitens).
In addition, with Radix Glycyrrhizae extract, Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and papain with 5: 10: 20: 0.6 mixed, the preparation 356 the gram skin whitening compositions 2 (energy complex 2: embodiment 2 whitens).
＜experimental example 1〉measure and suppress the effect that melanin forms
Will be as the HM3KO cell (Y.Funasaka of people's melanoma cell, Department ofDermatology, Kobe University School of Medicine, 5-1 Kusunoki-cho7-chrome, Chuo-ku, Kobe 650, Japan) place contain 10% N of embryo's serum minimum essential medium (Minimum Essential Medium) (MEM), and at 37 ℃ and 5% CO 2Condition under cultivate.Cultured cells is applied in the bottom of 75 hole flasks, and cell number is 3 * 10 5/ hole, placement is spent the night, thereby makes cell adhesion on wall.After the affirmation, each culture medium is become the new culture medium that contains the 10ppm laboratory sample.
The laboratory sample that adopts is as shown in table 1 below.
Matched group adopts the culture medium that contains DMSO (dimethyl sulfoxide).
For comparing the effect of each component, adopting each component separately is that Radix Glycyrrhizae extract, kojic acid, arbutin, vitamin A, vitamin C, Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and papain experimentize, and, adopt the mixture that some components in these components is mixed with the form of combination and form to experimentize.
In the above described manner, once every kind of culture medium was become the new culture medium that contains laboratory sample, and be enough to be full of flask in per 2 days until cultured cells.Then, take out culture fluid, with PBS (phosphate buffer) washing, be dissolved among the NaOH of 1N again, (opticaldensity OD), calculates the suppression ratio that melanin forms with following formula 1 to the optical density of measurement under 500 nanometers.The result is as shown in table 1.
General formula 1
Melanin forms suppression ratio (%)={ 1-(OD of the OD/ matched group of each laboratory sample) } * 100
Table 1
Laboratory sample (concentration) Melanin forms suppression ratio (%)
Radix Glycyrrhizae extract (1ppm) 23.1
Kojic acid (1ppm) 20.2
Arbutin (1ppm) 20.5
Vitamin A (1ppm) 19.7
Vitamin C (1ppm) 20.3
Papain (3ppm) 0.5
Radix Ginseng Rubra extract (5ppm) 1.1
Betula platyphylla Suk. extract (10ppm) 1.6
Radix Glycyrrhizae extract (1ppm)+papain (3ppm) 24.2
Radix Glycyrrhizae extract (1ppm)+Radix Ginseng Rubra extract (5ppm) 24.8
Radix Glycyrrhizae extract (1ppm)+Betula platyphylla Suk. extract (10ppm) 24.5
Radix Glycyrrhizae extract (1ppm)+papain (3ppm)+Radix Ginseng Rubra extract (5ppm) 25.2
Radix Glycyrrhizae extract (1ppm)+Radix Ginseng Rubra extract (5ppm)+Betula platyphylla Suk. extract (10ppm) 26.3
Radix Glycyrrhizae extract (1ppm)+papain (3ppm)+Betula platyphylla Suk. extract (10ppm) 26.9
Kojic acid (1ppm)+papain (3ppm)+Radix Ginseng Rubra extract (5ppm) 25.4
Arbutin (1ppm)+Radix Ginseng Rubra extract (5ppm)+Betula platyphylla Suk. extract (10ppm) 24.9
Vitamin A (1ppm)+Radix Ginseng Rubra extract (5ppm)+Betula platyphylla Suk. extract (10ppm) 22.4
Vitamin C (1ppm)+papain (3ppm)+Betula platyphylla Suk. extract (10ppm) 25.8
Embodiment 1 (the energy complex 1 of whitening) 35.6
Embodiment 2 (the energy complex 2 of whitening) 37.2
Shown in table 1 result, can confirm, the described papain, Radix Ginseng Rubra extract and the Betula platyphylla Suk. extract that constitute the energy complex of whitening only have lower melanin and form suppression ratio when using separately, and when one or both of described component are used in combination with Radix Glycyrrhizae extract, has higher skin whitening effect, and, when three kinds of described components are mixed use, demonstrate the highest skin whitening effect.
In addition, when known skin whitener kojic acid, arbutin, vitamin A and vitamin C and papain, Radix Ginseng Rubra extract and Betula platyphylla Suk. extract combination are used, confirm that the skin whitening effect of compositions is enhanced.
＜experimental example 2〉to the skin whitening effect of human body skin
The opaque adhesive tape that will have 6 diameters and be a hole of 1.5 centimetres adheres on 10 healthy men's everyone upper arm, with intensity is 1.5-2 ultraviolet light beam (the UV beam doubly of the minimum Erythema Dose of each subject (Minimal Erythema Dose), UVB) shine, to induce the dermal melanin deposition.Smear laboratory sample then, after 2 months, use the chromatmetry instrument to measure the degree of depth (darkness) of skin.
According to the composition preparation experiment sample in the table 2, smeared the preparation of embodiment in twice table 2 and comparative formulations (sooner or later each once) in one day.
＜preparation 1-5 and comparative formulations 1-4 〉
Preparation is O/W (oil-in-water) lotion, and unit is weight %.The viscosity of the preparation of preparation is the 7000-11000 centipoise, the 2nd day measurement of described viscosity after each preparation places 30 ℃ of constant temperature baths, and pH (10% solution is the basis) is 6.5-7.5.
" preparation method "
(1) makes oil-soluble (oily) composition 1 uniform mixing by heating down at 70-75 ℃.
(2) make water solublity (aqueous) composition 1 dissolving and uniform mixing by heating down at 70-75 ℃.
(3) stir water soluble mixt (2) down at 70-75 ℃, add described oil-soluble mixture (1), make emulsion, add oil-soluble composition 2 and water soluble ingredient 2 then continuously, the mixture that forms is cooled to 28-30 ℃.
Table 2
Composition Component (weight %) Preparation 1 Preparation 2 Preparation 3 Preparation 4 Preparation 5 Comparative formulations 1 Comparative formulations 2 Comparative formulations 3 Comparative formulations 4
Oil-soluble composition 1 Stearic acid 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
Spermol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
Hydrogenated oil and fat 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7 0.7
The lipotropy tristerin 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
Polyglyceryl-3 methyl glucoside distearate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
Antiseptic 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3
Hydrogenated polydecene 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0
Bai Manghua seed oil 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0
Oleum Helianthi 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
Dimethicone 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
Octanoic acid, hexadecyl ester 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0
Cupu oil ester in the last of the ten Heavenly stems (Decylcocoate) 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
Ring first silicon fat (Cyclomethicone) 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0
Tocopherol acetas 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Water soluble ingredient 1 Purified Water To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100 To 100
Glycerol 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0
Butanediol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0
Disodiumedetate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02
Triethanolamine (TEA) 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15
Antiseptic 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
Trehalose 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
Hyaluronic acid 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0
Radix Glycyrrhizae extract - - 0.05 0.05 0.05 0.05 0.05 0.05 0.05
The Betula platyphylla Suk. extract - - 0.1 0.1 - - 0.1 - -
Papain - - 0.003 - 0.003 - - 0.003 -
Radix Ginseng Rubra extract - - - 0.05 0.05 - - - 0.05
Embodiment 1 (the energy complex 1 of whitening) 0.153 - - - - - - - -
Embodiment 2 (the energy complex 2 of whitening) - 0.306 - - - - - - -
Water soluble ingredient 2 1% carbomer (carbomer) solution 12.0 12.0 12.0 12.0 12.0 12.0 12.0 12.0 12.0
Oil-soluble composition 2 Spice Quantity of stimulus (q.s.) Quantity of stimulus Quantity of stimulus Quantity of stimulus Quantity of stimulus Quantity of stimulus Quantity of stimulus Quantity of stimulus Quantity of stimulus
" L " value that adopt to show the skin Lightening degree is come determine effect (" L " value of the Korean who is burnt by the sun is not generally 50-70).If produced effect by smearing laboratory sample, then L-value can increase.Come the comparative experiments sample by value Δ L (L-value before last L-value-the smear laboratory sample).The Δ L-value is big more, and then the skin whitening effect is big more.Δ L is as shown in table 3 below.
Table 3
Laboratory sample Skin whitening effect (Δ L)
Preparation 1 3.36
Preparation 2 3.72
Preparation 3 3.10
Preparation 4 3.11
Preparation 5 3.07
Comparative formulations 1 2.02
Comparative formulations 2 2.21
Comparative formulations 3 2.32
Comparative formulations 4 2.45
Result shown in the table 3 confirms, the Δ L-value that contains Radix Glycyrrhizae extract and be selected from the group of being made up of papain, Betula platyphylla Suk. extract and Radix Ginseng Rubra extract at least two kinds preparation 1-5 will be higher than the Δ L-value of the comparative formulations 1 that only contains Radix Glycyrrhizae extract, also be higher than and contain Radix Glycyrrhizae extract and Betula platyphylla Suk. extract respectively, Radix Glycyrrhizae extract and papain, the comparative formulations 2-4 of Radix Glycyrrhizae extract and Radix Ginseng Rubra extract.Particularly, it is the highest containing the preparation 1 of the energy complex of whitening of three kinds of components and 2 Δ L-value, thereby preparation 1 demonstrates relative higher skin whitening effect with 2 than other preparation.
In addition, confirm also that if the amount of the energy complex of whitening increases, then preparation can increase the skin whitening effect relatively.
As mentioned above, verified, the cosmetic composition of adopting the O/w emulsion of the energy complex preparation of whitening of the present invention has improved the skin whitening effect.

Claims (4)

1, a kind of active skin whitening supplement composition of skin whitener that improves, said composition contains at least two kinds of components that are selected from the group of being made up of Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and papain.
2, compositions according to claim 1, wherein, described skin whitener be selected from the group of forming by kojic acid, arbutin, Radix Glycyrrhizae extract, vitamin A and vitamin C at least a.
3, a kind of skin-whitening cosmetic compositions, said composition contain Radix Glycyrrhizae extract as brightening component, it is characterized in that said composition also contains at least two kinds of components that are selected from the group of being made up of Radix Ginseng Rubra extract, Betula platyphylla Suk. extract and papain.
4, compositions according to claim 3, wherein, in the gross weight of compositions, described components contents is: Radix Glycyrrhizae extract 0.001-2.0 weight %, papain 0.01-0.1 weight %, Radix Ginseng Rubra extract 0.01-5.0 weight % and Betula platyphylla Suk. extract 0.01-5.0 weight %.
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