CN1895384A - Compound medicine for treating diarrheal irritable bowl syndrome - Google Patents
Compound medicine for treating diarrheal irritable bowl syndrome Download PDFInfo
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- CN1895384A CN1895384A CN 200610044954 CN200610044954A CN1895384A CN 1895384 A CN1895384 A CN 1895384A CN 200610044954 CN200610044954 CN 200610044954 CN 200610044954 A CN200610044954 A CN 200610044954A CN 1895384 A CN1895384 A CN 1895384A
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Abstract
A compound medicine in the form of capsule for treating diarrhea-type irritability syndrome is prepared from 7 Chinese-medicinal materials including pilose asiabell root, tuckahoe, white peony root, coptis root, etc, vimicon, VB and thiaminogen through respective grinding, proportional mixing, sieving, and filling it in capsules.
Description
Affiliated technical field
The present invention relates to the compound medicine that a kind of clinical medicine is used, specifically a kind of bonded compound medicine of Chinese medicine and western medicine for the treatment of diarrhea type irritable bowel syndrome.
Background technology
Irritable bowel syndrome is a kind of commonly encountered diseases, frequently-occurring disease of serious harm human health.Epidemiological study about irritable bowel syndrome both at home and abroad shows that China's sickness rate is at 5.6-10.1%, and the sickness rate that Gastroenterology Clinic meets irritable bowel syndrome reaches 34.3%, and western countries' sickness rate reaches 10-22%.Age is being the high-incidence season between 18-30 year, and the woman is more than the man, about 1.5-1.9: 1, and student, cadre, intellectual are more than workman, peasant, and the city patient is more than the rural area.The diarrhea type irritable bowel syndrome patient suffers from diarrhoea for several times every day or ten several do not wait, what have is more violent, patient's life, working and learning have been had a strong impact on, increased the weight of financial burden such as patient's direct medical cost and indirect social consumption costs, people's health and mental health caused great influence.At present, a lot of both at home and abroad to the method for treatment irritable bowel syndrome, but majority is effective to the single symptom of alleviating some patient, is unsatisfied to patient's general curative effect and toleration.Domestic scholars utilizes Chinese medicine, Western medicine in conjunction with aggregate measures such as diet, psychotherapys, and the course of treatment is long, easily recurrence, poor effect.Abroad then based on Drug therapy, medicament categories is various, but therapeutic effect is limited, as analgesic anticholinergic agent once extensive use, now thinks that the disadvantages outweigh the advantages more.Toleration to the antidiarrheal effect because may take place, so can not prolonged application in diphenoxylate or loperamide.5-hydroxytryptamine receptor antagonist alosetrons etc. improve the Encelialgia threshold value at the small intestinal that can slow down, colon duration of runs, reduce intestinal secretion, but because it can cause ischemic enteritis and serious constipation, clinical practice are very limited.
Summary of the invention
Purpose of the present invention just be to provide a kind of to the patient have no side effect, safe and reliable, taking convenience, with low cost, and the bonded compound medicine of Chinese medicine and western medicine of good effect, treatment diarrhea type irritable bowel syndrome that relapse rate is low.
The object of the present invention is achieved like this:
The compound medicine of this invention treatment diarrhea type irritable bowel syndrome is that the various medicines by the following weight proportioning are raw material, earlier raw material of Chinese medicine is made micropowder powder, and 5 with behind the Western medicine raw material, is mixed with the compound medicine of capsule, wherein:
Radix Codonopsis 90-300 part, Fu Ling 100-300 part, Rhizoma Atractylodis Macrocephalae 120-300 part, Radix Paeoniae Alba 100-300 part, Rhizoma Coptidis 50-300 part, Rhizoma Corydalis 50-150 part, Radix Glycyrrhizae 30-90 part, Cyproheptadine 0.1-0.5 part, vitamin B
11.2-3.6 part, oryzanol 1.2-5 part.
Solution of the present invention is based on modern medicine study and combines with the dialectical improvement opinion of executing of Chinese medicine, at diarrhea type irritable bowel syndrome and unusual (the intestinal sensory disturbance of function of intestinal canal, the compliance damage, 5-hydroxy tryptamine effect and spiritual mental pressure etc.) relevant pathogeny, selected to contain the medicine of various active ingredients, form compound medicine according to a certain weight ratio jointly, comprehensively play and regulate the gastrointestinal vegetative nerve function, the visceral sense function, stablize the cental system function, alleviate or elimination mental symptom or simultaneous phenomenon, improve patients ' life quality, reach the purpose of control and treatment diarrhea type irritable bowel syndrome.
Chinese medicine and pharmacy thinks, diarrhea type irritable bowel syndrome belongs to motherland's medical science " stomachache, diarrhoea " category, though diseased region is relevant, clinical many with stagnation of liver-QI with deficiency of the spleen, retention of damp-heat in the interior, deficiency of spleen-YANG and kidneyYANG etc. with functional disorder such as liver spleen kidney at large intestine, dialectical executing controlled.Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, the invigorating the spleen and benefiting QI of volt Siberian cocklebur, eliminating dampness by diuresis antidiarrheal in the side; The Rhizoma Coptidis clearing away heat-damp and promoting diuresis; The then soothing liver-QI circulation of qi promoting of Rhizoma Corydalis, the Radix Paeoniae Alba, Radix Glycyrrhizae, invigorating the spleen and replenishing QI, relieving spasm to stop pain, Rhizoma Corydalis is joined the power that the Radix Paeoniae Alba can be strengthened pain relieving simultaneously; Radix Glycyrrhizae then can coordinating the actions of various ingredients in a prescription, has the merit of invigorating the spleen and benefiting QI jointly, and the absorption function that improves intestinal is had good effect.Modern medicine study confirms that Radix Codonopsis has dual regulation to gastrointestinal movement, can regulate the disorder of rat stomach electrical activity basic electrical rhythm under the stress state, and it is hyperfunction to suppress gastric peristalsis; The Rhizoma Atractylodis Macrocephalae can suppress intestinal tube and be subjected to acetylcholine esterase and the barium chloride intestinal tube spasm due to stimulating, and has immunoloregulation function; The Radix Paeoniae Alba can reduce the spontaneity of guinea pig in vitro intestinal tube and shrink and tension force, the intestinal tube spasm due to the opposing barium chloride; Rhizoma Corydalis then has the effect of maincenter sedation and analgesia.Medical research proves that irritable bowel syndrome may be that too much calcium ion flows into the intestinal wall smooth muscle cell, causes due to the smooth muscle excess shrinkage.The active ingredient berberine of Rhizoma Coptidis is a kind of sure calcium-channel antagonists that acts on, and the retardance calcium ion enters in the cell and removes the intestinal smooth muscle spasm, reduces enteric cavity pressure, and favourable alleviation abdominal distention particularly has better effect to alleviating symptoms such as diarrhoea Mucous Stool; Cyproheptadine selective exclusion 5-hydroxytryptamine receptor suppresses the release action of 5-hydroxy tryptamine, thereby causes that enterokinesia slows down, and H capable of blocking
1Receptor and have a more weak cholinolytic effect is played a role to alleviating stomachache; Vitamin B
1Cut much ice to keeping neural normal function; Oryzanol can improve and regulate the intestinal vegetative nerve function, reduces the incretion balance imbalance, improves spiritual nervous disorder symptom, helps stablizing patient's spirit emotion, and relieving stress is to guarantee sleep.
In sum, medicine of the present invention is multifactorial comprehensive function to the therapeutical effect of diarrhea type irritable bowel syndrome, pathogeny at irritable bowel syndrome, different action pathway by Chinese and western drugs, the length of the active ingredient of the various medicines of comprehensive performance, reach treating both the principal and secondary aspects of a disease, effectively alleviate or eliminate the purpose of irritable bowel syndrome outbreak.
Clinical drug of the present invention uses the result to show to have following advantage:
1, to select clinical Chinese herbal medicine commonly used and Western medicine single-dose thing for use be raw material in the present invention, do not have incompatibility each other, scientific formulation.Animal experiment pours into to rabbit with 3,5,10 times of doses of used drug dose, does not see that untoward reaction occurs, and shows safe in utilization.Chinese and western drugs is united use, and useful effect is coordinated complementary, and non-evident effect, and with low cost.
2, the present invention has avoided single medicine when treatment, and dosage is big, side effect is big, to the prejudicial shortcoming of human body, has reduced dosage and side effect, and is safe and reliable.
3, medicine of the present invention can use separately, also can cooperate psychotherapy, dietetic regulation at conditions of patients, can effectively increase the power of medicine of the present invention, improves patient's mental symptom, improves the quality of living.
4, symptom of irritable bowel syndrome disappearance person is followed up a case by regular visits to 1.5-5, do not have recurrence substantially, the small part recidivist is arranged, behind the oral medicine of the present invention of short-term, very fast diarrhoea stops.
5, total effective rate of the present invention reaches more than 92%.
For showing the therapeutic effect of medicine of the present invention to diarrhea type irritable bowel syndrome, medicine of the present invention has been carried out following clinical observation comparative experimental research, its curative effect is reported as follows:
1, test grouping:
Choose and treat front and back complete data person 918 examples, all meet Rome II diagnostic criteria, whole case fecal occult blood feminine genders, barium coloclysis perspective there is no unusual, and whole per rectum spectroscopy, no pathologic anomaly.
Selected case age 16-64 year, 39.6 ± 9.1 years old mean age, medical history 2-25, average medical history 5.6 ± 2.3 years.Be divided into medicine I group of the present invention and placebo (starch) contrast II group at random according to age, sex, medical history, the state of an illness.What take medicine of the present invention is 486 examples, wherein: male 218 examples, women 268 examples; What take placebo is 432 examples, wherein: male 201 examples, women 231 examples.Two groups of above observation index compare there was no significant difference (P＞0.05).
2, Therapeutic Method:
All patients all adopt double-blind treatment, and two groups of beyond the region of objective existence shapes of taking medicine, quantity are the same, are capsule, and each 3, every day 3 times, two weeks were a course of treatment, did not take other drug in the course of treatment.To the placebo group nonresponder, adopt medicine of the present invention to carry out own control and observe, method of administration, the course of treatment are the same.
3, curative effect determinate standard:
Produce effects: cardinal symptom disappears, and observes through the 3-6 month, does not have recurrence substantially;
Effectively: cardinal symptom is alleviated or is obviously alleviated, and observes through the 3-6 month, and the recidivist obviously reduces than treatment is preceding.
Invalid: symptom does not have the improver.
4, result:
I organizes in 486 examples, and produce effects 207 examples account for 42.59%, and effective 241 examples account for 49.59%, and invalid 38 examples account for 7.82%.Comprehensive produce effects, effectively calculating, total effective rate reaches 92.18%.II organizes in 432 examples, no produce effects person, and effective 47 examples account for 10.88%, and invalid 385 examples account for 89.12%.Comprehensive produce effects, effectively calculating, total effective rate reaches 10.88%.The I group is compared with II group total effective rate, learns by statistics and handles x
2=608.83, there is the utmost point significant difference P＜0.001, proves that medicine of the present invention has specially good effect to the treatment diarrhea type irritable bowel syndrome.
In self-controlled group 385 examples, produce effects 152 examples account for 39.48%, and effective 201 examples account for 52.21%, and invalid 32 examples account for 8.31%.Comprehensive produce effects, effectively calculating, total effective rate reaches 91.69%.The I group is compared with the self-controlled group total effective rate, learns by statistics and handles x
2=0.07, there was no significant difference between P＞0.05, two group proves that medicine of the present invention to treatment diarrhea type irritable bowel syndrome effect certainly.
All cases only I group and self-controlled group patient to have 12 examples slight head to occur heavy, drowsiness, do not influence the continuation medication, do not have other untoward reaction.
The specific embodiment
Below, in conjunction with the embodiments medicine of the present invention is further described.
It is raw material that the compound medicine of this invention treatment diarrhea type irritable bowel syndrome is selected various medicines for use by following weight proportion, Radix Codonopsis 150g, Fu Ling 200g, Rhizoma Atractylodis Macrocephalae 150g, Radix Paeoniae Alba 200g, Rhizoma Coptidis 200g, Rhizoma Corydalis 100g, Radix Glycyrrhizae 80g, Cyproheptadine 0.24g, vitamin B
12.4g, oryzanol 3.12g.Earlier raw material of Chinese medicine is made micropowder powder, 5 with behind the Western medicine raw material, grinds foam and fully mixing, through 200 mesh sieves filter packing, makes capsule, every 3.016g, and each 3, every day 3 times, two weeks were a course of treatment, can effectively treat diarrhea type irritable bowel syndrome.From above-mentioned clinical treatment contrast test, picked at random 4 examples are further to show the therapeutic effect of medicine of the present invention.
Embodiment 1, Zhang, woman, 27 years old, civil servant.Outbreak stomachache repeatedly, diarrhoea 11 years, increase the weight of to examine nearly half a year.Play i.e. outbreak morning, the diarrhoea back does not have uncomfortable, feed is given birth to cool or is felt bad and also can show effect, sometimes every day diarrhoea reach 10 surplus time, have a strong impact on working and learning, once took antiinflammatory antidiarrheal and multiple Chinese patent medicine, sometimes take a turn for the better, but promptly send out soon, take medicine of the present invention after 1 course of treatment, diarrhoea disappears, and follows up a case by regular visits to and does not see recurrence in 3 years.
Embodiment 2, Wang, man, 20 years old, high school student.Outbreak stomachache repeatedly, diarrhoea 3 years increase the weight of January and examine.Rise morning early and all defecate once after meal, before study anxiety sometimes or the examination, the increase of diarrhoea number of times, do not influence feed and growth promoter, it is invalid to take digester, antibiotic and diarrhea, takes medicine of the present invention after 1 course of treatment, transference cure was followed up a case by regular visits to 1.5 years, did not see recurrence.
Embodiment 3, Zhao, man, 36 years old, cadre.Suffered from abdominal pain repeatedly, suffer from diarrhoea 6 years, and increased the weight of March and examine.The diarrhoea of getting up at dawn, early after meal stool once, feed promptly has outbreak accidentally, does not have discomfort after an action of the bowels, many persons every day 5-8 time, body weight does not subtract, and it is invalid to obey multiple medicine, once takes alosetron, but stop using because of serious constipation, take medicine of the present invention after 1 course of treatment, transference cure is followed up a case by regular visits to and was not seen recurrence in 2 years.
Embodiment 4, discriminate certain, woman, 38 years old, peasant.Outbreak stomachache repeatedly, diarrhoea 5 years increase the weight of February and examine.Rise morning and take food give birth to cool, outbreak is arranged when feeling bad, take diarrhea and antibiotic, effective in short-term, recurrence is taken medicine of the present invention after 1 course of treatment soon, transference cure was followed up a case by regular visits to 2 years, did not see recurrence.
Below in conjunction with most preferred embodiment compound medicine of the present invention is described in further details.
Selecting various medicines for use by following weight proportion is raw material, Radix Codonopsis 150g, Fu Ling 200g, Rhizoma Atractylodis Macrocephalae 150g, Radix Paeoniae Alba 200g, Rhizoma Coptidis 200g, Rhizoma Corydalis 100g, Radix Glycyrrhizae 80g, Cyproheptadine 0.24g, vitamin B
12.4g, oryzanol 3.12g.Earlier raw material of Chinese medicine is made micropowder powder, 5 with behind the Western medicine raw material, grinds foam and fully mixing, through 200 mesh sieves filter packing, makes capsule, every 3.016g, and each 3, every day 3 times, two weeks were a course of treatment, can effectively treat diarrhea type irritable bowel syndrome.
Claims (2)
1, a kind of compound medicine for the treatment of diarrhea type irritable bowel syndrome is characterized in that it is that various medicines by the following weight proportioning are the capsule that preparation of raw material becomes:
Radix Codonopsis 90-300 part, Fu Ling 100-300 part, Rhizoma Atractylodis Macrocephalae 120-300 part, Radix Paeoniae Alba 100-300 part, Rhizoma Coptidis 50-300 part, Rhizoma Corydalis 50-150 part, Radix Glycyrrhizae 30-90 part, Cyproheptadine 0.1-0.5 part, vitamin B
11.2-3.6 part, oryzanol 1.2-5 part.
2, the compound medicine of treatment diarrhea type irritable bowel syndrome as claimed in claim 1 is characterized in that wherein the weight proportion of various medicine materials is: Radix Codonopsis 150g, Fu Ling 200g, Rhizoma Atractylodis Macrocephalae 150g, Radix Paeoniae Alba 200g, Rhizoma Coptidis 200g, Rhizoma Corydalis 100g, Radix Glycyrrhizae 80g, Cyproheptadine 0.24g, vitamin B
12.4g, oryzanol 3.12g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100449548A CN100479835C (en) | 2006-06-22 | 2006-06-22 | Compound medicine for treating diarrheal irritable bowl syndrome |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100449548A CN100479835C (en) | 2006-06-22 | 2006-06-22 | Compound medicine for treating diarrheal irritable bowl syndrome |
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| CN1895384A true CN1895384A (en) | 2007-01-17 |
| CN100479835C CN100479835C (en) | 2009-04-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2006100449548A Expired - Fee Related CN100479835C (en) | 2006-06-22 | 2006-06-22 | Compound medicine for treating diarrheal irritable bowl syndrome |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199639B (en) * | 2007-12-20 | 2011-12-14 | 北京天力正元医药技术开发有限公司 | Chinese medicine for treating irritable |
| EP3263114A4 (en) * | 2015-02-26 | 2018-09-05 | Zuoguang Zhang | Use of albiflorin or pharmaceutically acceptable salt for prevention and/or treatment of irritable bowel syndrome |
-
2006
- 2006-06-22 CN CNB2006100449548A patent/CN100479835C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199639B (en) * | 2007-12-20 | 2011-12-14 | 北京天力正元医药技术开发有限公司 | Chinese medicine for treating irritable |
| EP3263114A4 (en) * | 2015-02-26 | 2018-09-05 | Zuoguang Zhang | Use of albiflorin or pharmaceutically acceptable salt for prevention and/or treatment of irritable bowel syndrome |
| US10350230B2 (en) | 2015-02-26 | 2019-07-16 | Zuoguang Zhang | Use of albiflorin or pharmaceutically acceptable salt for prevention and/or treatment of irritable bowel syndrome |
| AU2015384083B2 (en) * | 2015-02-26 | 2021-02-18 | Zuoguang Zhang | Use of albiflorin or pharmaceutically acceptable salt for prevention and/or treatment of irritable bowel syndrome |
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| Publication number | Publication date |
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| CN100479835C (en) | 2009-04-22 |
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Granted publication date: 20090422 |