CN1891310A - Implanted intracranial administration intubate suitable for neuroscience research - Google Patents
Implanted intracranial administration intubate suitable for neuroscience research Download PDFInfo
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- CN1891310A CN1891310A CN 200510080374 CN200510080374A CN1891310A CN 1891310 A CN1891310 A CN 1891310A CN 200510080374 CN200510080374 CN 200510080374 CN 200510080374 A CN200510080374 A CN 200510080374A CN 1891310 A CN1891310 A CN 1891310A
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Abstract
This invention relates to an interpolation encephalic medicine-feeding canula for nerve scientific research including an integral structure canula and a fixed base, an integral structural airproof cap and a canula filling core, in which, said base is a staged revolving body and screw thread is lathed on the outer wall of a tube part of the staged revolving body, said sealing cap and the core are like a capsule, a rod extending from the inside of the top of the capsule and screwed on the fixed base is set in the inside wall of the capsule as the filling core of the canula to form an integral structure and the outside diameter of the core is a bit smaller than that of the internal diameter, the length of the core is the same with that of the canula and medical stainless steel or polyurethane are materials of the components.
Description
Technical field
The present invention relates to a kind of intracranial intubate that is used for Neuroscience Research, particularly relate to a kind of implantable brain interpolation pipe of administration in the brain when can be used for Neuroscience Research.
Background technology
The method that many Neuroscience Research field need utilize administration in the animal brain or give some biological preparation is inquired into the mechanism of some physiology, pathological phenomenon or some disease.One of the method is to be widely used since neurobiology develops, and significant basic skills.Physician and neurobiologist utilize this method, through the administration of intracranial intubate, can improve or reduce the irritability of certain position neurocyte in the brain, perhaps damage certain purpose brain district or nerve nucleus, infer the new function in these unknown brain districts or known brain district with this by the neural malicious excited aminoacid of intubate injection.And determined the function in a lot of significant points He Nao districts in the brain with the method.But because idiophrenic complexity, these work are still being carried out.
The at present still untapped intracranial intubate that goes out to be applied to brain science research of China.Each university or research institution all carry out scientific research with homemade intracranial intubate.The shortcoming that now will make intubate by oneself is described below: (1) intubate material does not reach the medical implant requirement: use steel pipe as implanting tubing with general industry, can't reach medical, biological physical and chemical stability requirement with implant, it discharges poisonous metal or nonmetallic ion in brain, cause neurocyte operation irregularity or pathological changes necrosis; (2) stationarity is poor: homemade intracranial intubate does not have the fixed pedestal structure, from the mechanics angle, fixed comparatively fragile between intubate and the skull, in cycle of carrying out during long chronic experiment, because the distortion of fixing glue or dentistry cement is aging, make intubate be easy to be shifted or directly come off from skull surface.(3) seal is poor: the self-control intubate does not have the sealing cap structure substantially, can not fine intracranial and the strictness of cranium external environment be kept apart effectively, and it is the critical defect that the self-control intubate is difficult to overcome that microorganism enters intracranial initiation intracranial infection.(4) intubate inner core operability is poor: because the filling inner core of self-control intubate is the thin metal tube of ratio cannula inner diameter that experimenter oneself seeks, not only also have the problem of physical and chemical stability, cause toxic reaction or degraded to be got rusty; And be difficult to more fully up to expectations be, its diameter is difficult to reach desirable requirement, after causing intubate to be implanted, cerebrospinal fluid in the brain can be present between inner core and the intubate tube wall in a large number because of capillarity, and in a single day rich in protein and inorganic salt separate out in the cerebrospinal fluid, and the then as easy as rolling off a log effect of playing adhesive is glued together intubate and inner core, cause inner core to be difficult to take out, this phenomenon is comparatively general in the self-control intubate.(5) problem of entry needle or syringe.At present domesticly be difficult to find than the thinner entry needle of general intracranial intubate tube wall or syringe (as external diameter less than 0.4mm); Therefore most of scientific research institutions utilize minimum number sword-shaped needle as entry needle, and comparatively speaking, the internal diameter of intubate just must cause the syringe bore bigger greater than the external diameter of entry needle, are difficult to reach nervelet nuclear group injection requirement in the brain.(6) poor accuracy.The difficult control of the specification of homemade intracranial intubate, size is artificially held, and than inaccuracy, is difficult to reach the brain kernel and rolls into a ball pinpoint strict demand.In a word, there is above shortcoming in homemade intracranial intubate, and these shortcomings all can cause the failure of an experiment, bring loss.Make the intracranial intubate by oneself even if utilize the brain of external import to be implanted into formula intubate tubing, also exist fixing, airtight, operate and problem that accuracy is difficult to hold.
Summary of the invention
The objective of the invention is in order to solve the relatively poor problem of stability, stationarity, seal, operability and accuracy that above-mentioned existing homemade intracranial intubate material exists, thereby provide a kind of implanted intracranial intubate of utilizing the stable medical stainless steel material of physicochemical property to make, and have hermetically-sealed construction, rock-steady structure, be applied to the cranium brain medicine-feeding canula of brain science research.
The present invention also aims to provide intracranial medicine-feeding canula a kind of and of the present invention matching used syringe.
A kind of implanted intracranial medicine-feeding canula that is applicable to Neuroscience Research provided by the invention comprises intubate, intubate filling inner core; It is characterized in that: also comprise fixed pedestal and intubate sealing cap; Described intubate is a pipe, one end of circular tube external wall is provided with and the incorporate intubate fixed pedestal of intubate, this intubate fixed pedestal is the step revolving body, the outer wall of the tube part of the step revolving body screw thread of having got on the bus (is the carnival hat shape, the medicated cap drum outer wall external screw thread of having got on the bus, the female thread of itself and sealing cap is supporting); Described intubate sealing cap and intubate filling inner core are a bottle cap shape, its bottle cap inwall is provided with the intubate fixed pedestal and is screwed, (its section is the font of falling the mountain as intubate filling inner core composition integral structure to extend a bar in the bottle cap top, the intermediary one long perpendicular intubate filling inner core that is, two of the word of falling mountain both sides are erected and are cylinder sealing cap wall, the sealing cap inwall is provided with the female thread that is screwed with the intubate fixed pedestal, as Fig. 2 b); Intubate filling inner core external diameter is slightly less than cannula inner diameter, reaches adaptation ground insertion intubate and is advisable, and its length of inner core is identical with intubation length.
In technique scheme, with the matching used syringe of this intubate be a pipe, the external diameter of this pipe is slightly less than cannula inner diameter, reaches adaptation ground and inserts intubate and be advisable, its length is identical with intubation length, sees Fig. 2 c.During application, the one end connects syringe, and the other end inserts intubate, carries out administration in the brain.The syringe inner diameter of the present invention's design is more small, can cooperate implanted intracranial medicine-feeding canula of the present invention to use, and can reach nervelet nuclear group injection requirement in the brain.
In technique scheme, described intubate and fixed pedestal, intubate sealing cap and intubate filling inner core are the coefficient of expansion identical stainless steel material of the same race or polyurethane material and make.
In technique scheme, described sealing cap outer wall is provided with flour milling, ridge design shape structure or the thin prismatic surface structure of being convenient to staff and screwing.
In technique scheme, (depend primarily on the kind of laboratory animal, toy then size is little, and large animal relative size is big because of experiment needs for the size of each several part.) and different.Described cannula outer diameter scope is 0.7～3.0mm, and inside diameter ranges is 0.5～2.8mm, and length is made generally in 2.0～20.0cm according to the scientific research needs; Described fixed pedestal radius is generally at 4.0mm～20.0mm scope, thickness 1.0～2.0mm.
The design sketch that parts such as intubate and sealing cap matching used with it are implanted behind the intracranial is seen Fig. 1.
The present invention is applicable to that the implanted intracranial medicine-feeding canula work process of Neuroscience Research is as follows:
At first need prepare the skull hole with brain surgery instruments according to researcher, the skull aperture is slightly larger than this cannula outer diameter.Utilize the stereotaxic instrument technology, (the sterilization: before the art of will sterilizing, the intubate and the sealing cap of cleaning were soaked 2 hours with 0.1% bromo geramine, the reuse distilled water flushing for several times, then sealing cap and intubate are screwed, it is standby to immerse physiological saline solution) after intubate insert intracranial through meninges and cerebral tissue, the three-dimensional elements of a fix of the purpose of cannula port are positioned at scientific research person's the purpose ventricles of the brain, brain district or certain nerve nucleus.Use dentistry cement or biogum then, intubate fixed pedestal and skull surface is bonding, securely intubate is fixed in skull.After treating that dentistry cement thoroughly condenses, in the time of need carrying out scientific experiments, the sealing cap of can outwarding winding inserts the medical stainless steel syringe (annotate: the length that syringe inserts intubate should equate with intubation length) that links to each other with syringe, carries out the intracranial administration.
The present invention has following advantage:
(1) be raw material owing to the present invention adopts medical stainless steel, it is tough and tensile durable, and intensity is 2 times of carbon steel pipe, is 4 times of copper pipe, is 8 times of PP-R pipe, and under reasonably using, almost be hard-core its service life.In addition, the medical stainless steel pipe is nontoxic, and histocompatibility is good, and the intubate material reaches the medical implant requirement.Experiment showed, at liquid phase environment, few as the harmful substance of separating out in tissue liquid, the blood; Can not cause toxic effect to organism.
(2) the medical stainless steel material is easy to processing, and at present domestic main each medical apparatus and instruments factory all has sophisticated rustless steel process technology basically.
(3) compare with titanium alloy, medical stainless steel has low-cost characteristics, and the implanted intracranial medicine-feeding canula price that the present invention makes is lower, is suitable for carrying out under China's national situation scientific research.
(4) the implanted intracranial medicine-feeding canula of the present invention's making has the fixed pedestal structure, from the mechanics angle, the chronic experiment test fixed comparatively firm between intubate and the skull, that the cycle of standing is long is difficult for being shifted because of the distortion of fixing glue or dentistry cement is aging or coming off from skull surface.
(5) this intubate is provided with the sealing cap structure, can fine intracranial and the strictness of cranium external environment be kept apart effectively, and microorganism is difficult for entering intracranial and causes intracranial infection, reaches good leak tightness.
(6) the filling inner core and the sealing cap of implanted intracranial medicine-feeding canula of the present invention are integrated, as long as screw off sealing cap, and the then related taking-up of inner core; And the inner core physicochemical property is stable, can not cause toxic reaction or degraded to be got rusty; And because comparatively driving fit dimensionally between inner core and the intubate inwall, being difficult for cerebrospinal fluid is present between inner core and the intubate tube wall because of the hair suction phenomenon, the bonding phenomenon that makes inner core be difficult to take out of intubate of avoiding cerebrospinal fluid protein matter to separate out causing and inner core takes place, so the intubate inner core has good operability.
(7) problem of entry needle or syringe is resolved.The syringe inner diameter of the present invention's design is less, can cooperate implanted intracranial medicine-feeding canula of the present invention to use, and can reach nervelet nuclear group injection requirement in the brain.
(8) has higher accuracy, because implanted intracranial medicine-feeding canula specification unanimity of the present invention can reach the brain kernel and roll into a ball pinpoint strict demand.
(9) this implanted intracranial medicine-feeding canula can be used for the brain science experimentation of scientific experiments animal (monkey, rat, cat, rabbit, Canis familiaris L. etc.), and application promise in clinical practice is arranged.
Description of drawings
Fig. 1 is the application sketch map of implanted intracranial medicine-feeding canula of the present invention
Fig. 2 a is the structure cutaway view of implanted intracranial medicine-feeding canula of the present invention and fixed pedestal one
Fig. 2 b is intubate sealing cap of the present invention and filling inner core cutaway view
Fig. 2 c is of the present invention and the supporting syringe cutaway view of implanted intracranial medicine-feeding canula
(size among the figure is with scientific research rat cranium brain plug-in type intubate data instance)
The drawing explanation;
1-intubate 2-fixed pedestal 3-intubate
4-sealing cap 5-intubate filling inner core 6-injection purpose brain district
7-intubate cranium outer end 8-syringe
The specific embodiment
Below in conjunction with drawings and Examples the present invention is described in detail: now introduce an implanted rustless steel intracranial medicine-feeding canula that is suitable for rat: implant rat intracranial injection purpose brain district 6 back ideographs and see Fig. 1.
With reference to figure 2a, with the medical stainless steel pipe make an external diameter be 0.7 or 2.0mm X internal diameter be 0.6 or the intubate 1 of 1.8mm, its intracranial length is 2.0mm～10.0mm, total length is 4.0mm～15.0mm (intracranial length can determine that the intubate intracranial length numerical value that this patent provides is the approximate range value according to the experiment needs).One end of circular tube external wall is provided with and the incorporate fixed pedestal 2 of intubate, this fixed pedestal 2 is the step revolving body, the tube part of step revolving body is intubate cranium outer end 7, the outer wall of this intubate cranium outer end 7 screw thread of having got on the bus (is the carnival hat shape, the medicated cap drum outer wall external screw thread of having got on the bus, the female thread of itself and sealing cap is supporting); Wherein the step of intubate fixed pedestal 2 (the annular shade of carnival hat) diameter is 8.0mm or 10.0mm, and step thicknesses is 1.0 or 2.0mm, and intubate cranium outer end 7 length are 2.0mm～5.0mm, and external diameter is 2.2mm～3.0mm; The outer wall external screw thread of having got on the bus, external thread length is 2.0mm～5.0mm, can with the internal screw-thread screw of sealing cap inwall.
With reference to figure 2b, make an incorporate cylinder sealing cap 3 and intubate filling inner core 5 with the medical stainless steel pipe, the profile of this integral structure is the font of falling the mountain, the bottle cap inwall of its sealing cap 3 is provided with and the intubate fixed pedestal 2 fixed female thread that is screwed, the extended bar in bottle cap center is an intubate filling inner core 5, and the length of filling inner core 4 and intubation length are mutually; Wherein sealing cap 3 inwall length are 1.0mm or 3.0mm, and the sealing cap external diameter is 3.0mm or 5.0mm, and internal diameter is 2.2mm or 3.0mm, and the sealing cap outer wall is provided with is convenient to flour milling or the thin prismatic surface structure that staff is screwed; The total length of intubate filling inner core 4 is identical with the intubate total length, is 4.0mm or 16.0mm, and diameter is 0.4mm or 1.5mm, and external diameter is slightly less than cannula inner diameter, reaches adaptation ground insertion intubate and is advisable, and sealing cap and intubate inner core total length are 4.1mm or 16.5mm.
With reference to figure 2c, with making one of medical stainless steel pipe and the supporting syringe 8 of implanted rustless steel intracranial medicine-feeding canula, these syringe 8 external diameters are 0.4mm～1.5mm; Internal diameter is 0.1mm～0.3mm; Its application length equates with intubation length.
With reference to figure 2a-c, make one for the intracranial medicine-feeding canula of experiment with the implanted medical polyurethane material making of rabbit, cat, its structure is with embodiment 1, just intubate and parts such as fixed pedestal, sealing cap and intubate filling inner core is in different size, its concrete data within following scope all can:
Cannula outer diameter is 0.7～3.0mm; Cannula inner diameter is 0.6～2.8mm;
Fixed pedestal thickness is 1.0～2.0mm; The fixed pedestal diameter is 8.0mm～15.0mm;
Intubate cranium outer end length is 2.0mm～5.0mm; External thread length is 2.0mm～5.0mm;
Intubate cranium outer end external diameter is 3.2mm～4.0mm; The outer wall external screw thread of having got on the bus, can with the internal screw-thread screw of sealing cap inwall;
Intubate intracranial length 2.0mm～80.0mm (intracranial length can be determined according to the experiment needs); The intubate total length is 4.0mm～86.0mm;
The sealing cap external diameter is 5.0mm～6.5mm; The sealing cap internal diameter is 3.2mm～4.0mm;
Sealing cap inwall length is 1.0mm～5.0mm; Sealing cap inwall female thread length is 1.0mm～5.0mm; Sealing cap outer wall length is 2.0mm～5.0mm;
Inner core diameter is 0.4mm～2.7mm; The inner core total length is 4.0mm～86.0mm;
Sealing cap and intubate inner core total length are 4.1mm～88.0mm.
The syringe external diameter is 0.4mm～2.7mm; Syringe inner diameter is 0.1mm～0.3mm.
Embodiment 3
With reference to figure 2a-c, make one for the implanted rustless steel intracranial medicine-feeding canula of experiment with Canis familiaris L., monkey, its structure is with embodiment 1, and just intubate and parts such as fixed pedestal, sealing cap and intubate filling inner core is in different size, and its concrete data are as follows:
Cannula outer diameter is 1.6mm; Cannula inner diameter is 1.4mm;
Fixed pedestal thickness is 1.5mm; The fixed pedestal diameter is 20.0mm;
Intubate cranium outer end length is 3.5mm; External thread length is 3.5mm;
Intubate cranium outer end external diameter is 5.5mm, intubate intracranial length 4.0～100.0mm (intracranial length can be determined according to the experiment needs);
The intubate total length is 7.5～103.5mm.
The sealing cap external diameter is 6.5mm; The sealing cap internal diameter is 5.5mm.
Sealing cap inwall length is 3.0mm; Sealing cap inwall female thread length is 3.0mm;
Sealing cap outer wall length is 4.0mm; Inner core diameter is 1.35mm;
The inner core total length is identical with the intubate total length, is 7.5mm～103.5mm; Sealing cap and intubate inner core total length are 4.1mm～108.5mm.
The syringe external diameter is 1.35mm; Syringe inner diameter is 0.1mm～0.3mm; Data within the above-mentioned scope all can be according to the kind decision of laboratory animal.
It should be noted that at last: above embodiment is the unrestricted technical scheme of the present invention in order to explanation only, although the present invention is had been described in detail with reference to the foregoing description, those of ordinary skill in the art is to be understood that: still can make amendment or be equal to replacement the present invention, and not breaking away from any modification or partial replacement of the spirit and scope of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (5)
1. an implanted intracranial medicine-feeding canula that is applicable to Neuroscience Research comprises intubate, intubate filling inner core; It is characterized in that: also comprise fixed pedestal and intubate sealing cap; Described intubate is a pipe, and an end of circular tube external wall is provided with and the incorporate intubate fixed pedestal of intubate, and this intubate fixed pedestal is the step revolving body, the outer wall of the tube part of the step revolving body screw thread of having got on the bus; Described intubate sealing cap and intubate filling inner core are a bottle cap shape, its bottle cap inwall is provided with the intubate fixed pedestal and is screwed, extend a bar in the bottle cap top and form integral structure as intubate filling inner core, the sealing cap inwall is provided with the female thread that is screwed with the intubate fixed pedestal; Intubate filling inner core external diameter is slightly less than cannula inner diameter, reaches adaptation ground insertion intubate and is advisable, and its length of inner core is identical with intubation length.
2. by the described implanted intracranial medicine-feeding canula that is applicable to Neuroscience Research of claim 1, it is characterized in that: also comprise one with the matching used syringe of this intubate, described syringe is a pipe, and the external diameter of this pipe and cannula inner diameter are inserted driving fit, and its length is identical with intubation length.
3. by the described implanted intracranial medicine-feeding canula that is applicable to Neuroscience Research of claim 1, it is characterized in that: described intubate and fixed pedestal, intubate sealing cap and intubate filling inner core are the coefficient of expansion identical stainless steel material of the same race or polyurethane material and make.
4. by the described implanted intracranial medicine-feeding canula that is applicable to Neuroscience Research of claim 1, it is characterized in that: described sealing cap outer wall is provided with flour milling, ridge design shape structure or the thin prismatic surface structure of being convenient to staff and screwing.
5. by the described implanted intracranial medicine-feeding canula that is applicable to Neuroscience Research of claim 1, it is characterized in that: described cannula outer diameter scope is 0.7～3.0mm, and inside diameter ranges is 0.5～2.8mm, and length is 2.0～20.0cm; Described fixed pedestal radius is at 4.0mm～20.0mm scope, thickness 1.0～2.0mm.
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| CNB200510080374XA CN100506314C (en) | 2005-07-04 | 2005-07-04 | Implanted intracranial administration intubate suitable for neuroscience research |
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| CNB200510080374XA CN100506314C (en) | 2005-07-04 | 2005-07-04 | Implanted intracranial administration intubate suitable for neuroscience research |
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| CN1891310A true CN1891310A (en) | 2007-01-10 |
| CN100506314C CN100506314C (en) | 2009-07-01 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101951989A (en) * | 2008-02-13 | 2011-01-19 | 瑞尼斯豪(爱尔兰)有限公司 | Catheter |
| CN105435358A (en) * | 2015-11-25 | 2016-03-30 | 菏泽医学专科学校 | Implantable intracranial drug delivery cannula suitable for neurosciences research |
| CN108245771A (en) * | 2018-02-02 | 2018-07-06 | 南方医科大学南方医院 | Orthopaedics implantable drug delivery system |
| WO2021027192A1 (en) * | 2019-08-14 | 2021-02-18 | 中国科学院深圳先进技术研究院 | Administration tube, administration apparatus and neuropsychiatric disorder treatment system |
| WO2021097963A1 (en) * | 2019-11-18 | 2021-05-27 | 中国科学院深圳先进技术研究院 | Disposable impermeable intracranial drug administration device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2172095Y (en) * | 1993-11-15 | 1994-07-20 | 首都医学院附属北京红十字朝阳医院 | Inner skull haematoma smashing puncture needle |
| WO1999024097A1 (en) * | 1997-11-12 | 1999-05-20 | Stereotaxis, Inc. | Intracranial bolt and method of placing and using an intracranial bolt to position a medical device |
| CN2689965Y (en) * | 2004-03-09 | 2005-04-06 | 庞爱华 | Air wetting filter for artificial airway catheter |
| CN2836836Y (en) * | 2005-07-06 | 2006-11-15 | 中国科学院心理研究所 | An implanted encephalic drug-delivery cannula for MRI technology research |
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2005
- 2005-07-04 CN CNB200510080374XA patent/CN100506314C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101951989A (en) * | 2008-02-13 | 2011-01-19 | 瑞尼斯豪(爱尔兰)有限公司 | Catheter |
| CN101951989B (en) * | 2008-02-13 | 2013-06-12 | 瑞尼斯豪(爱尔兰)有限公司 | Catheter |
| CN105435358A (en) * | 2015-11-25 | 2016-03-30 | 菏泽医学专科学校 | Implantable intracranial drug delivery cannula suitable for neurosciences research |
| CN108245771A (en) * | 2018-02-02 | 2018-07-06 | 南方医科大学南方医院 | Orthopaedics implantable drug delivery system |
| WO2021027192A1 (en) * | 2019-08-14 | 2021-02-18 | 中国科学院深圳先进技术研究院 | Administration tube, administration apparatus and neuropsychiatric disorder treatment system |
| WO2021097963A1 (en) * | 2019-11-18 | 2021-05-27 | 中国科学院深圳先进技术研究院 | Disposable impermeable intracranial drug administration device |
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|---|---|
| CN100506314C (en) | 2009-07-01 |
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Granted publication date: 20090701 Termination date: 20120704 |