CN2836836Y - An implanted encephalic drug-delivery cannula for MRI technology research - Google Patents
An implanted encephalic drug-delivery cannula for MRI technology research Download PDFInfo
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- CN2836836Y CN2836836Y CN 200520112444 CN200520112444U CN2836836Y CN 2836836 Y CN2836836 Y CN 2836836Y CN 200520112444 CN200520112444 CN 200520112444 CN 200520112444 U CN200520112444 U CN 200520112444U CN 2836836 Y CN2836836 Y CN 2836836Y
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- intubate
- cannula
- inner core
- sealing cap
- fixed pedestal
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Abstract
The utility model relates to an implanted encephalic drug-supply cannula for neuroscience research, which comprises a cannula and a fixed base in an integrated structure and a sealing cap and a filling inner core of the cannula in an integrated structure, wherein the fixed base of the cannula is a step-shaped revolving body, and an outer wall of a cylinder part of the step-shaped revolving body is provided with screw threads. The sealing cap and the filling inner core of the cannula are of bottle cap shape; an inner wall of the bottle cap is provided with inner screw threads spirally connected with the fixed base of the cannula; a rod extends out of the inner part of a bottle cap top and forms an integrated structure with the filling inner core of the cannula. The outside diameter of the filling inner core of the cannula is slightly smaller than the inside diameter of the cannula, and preferably the cannula can be inserted tightly. The components of the utility model all adopt medical polyurethane as the raw material; the utility model has the advantages of high strength, long service life, asepsis of the medical raw material and good histocompatibility, and the material of the cannula can achieve the requirement of medical implant.
Description
Technical field
This utility model relates to a kind of intracranial intubate that is used for Neuroscience Research, particularly relates to a kind of implanted intracranial medicine-feeding canula that is applicable to nmr imaging technique research.
Background technology
The method that many Neuroscience Research field need utilize administration in the animal brain or give some biological preparation is inquired into the mechanism of some physiology, pathological phenomenon or some disease.One of the method is to be widely used since neurobiology develops, and significant basic skills.Physician and neurobiologist utilize this method, through the administration of intracranial intubate, can improve or reduce the irritability of certain position neurocyte in the brain, perhaps damage certain purpose brain district or nerve nucleus, infer the new function in these unknown brain districts or known brain district with this by the neural malicious excited aminoacid of intubate injection.And determined the function in a lot of significant points He Nao districts in the brain with the method.But because idiophrenic complexity, these work are still being carried out.
The at present still untapped intracranial intubate that goes out to be applied to brain science research of China.Each university or research institution all carry out scientific research with homemade intracranial intubate.The shortcoming that now will make intubate by oneself is described below: (1) intubate material does not reach the medical implant requirement: use steel pipe as implanting tubing with general industry, can't reach medical, biological physical and chemical stability requirement with implant, it discharges poisonous metal or nonmetallic ion in brain, cause neurocyte operation irregularity or pathological changes necrosis; (2) stationarity is poor: homemade intracranial intubate does not have the fixed pedestal structure, from the mechanics angle, fixed comparatively fragile between intubate and the skull, in cycle of carrying out during long chronic experiment, because the distortion of fixing glue or dentistry cement is aging, make intubate be easy to be shifted or directly come off from skull surface.(3) seal is poor: the self-control intubate does not have the sealing cap structure substantially, can not fine intracranial and the strictness of cranium external environment be kept apart effectively, and it is the critical defect that the self-control intubate is difficult to overcome that microorganism enters intracranial initiation intracranial infection.(4) intubate inner core operability is poor: because the filling inner core of self-control intubate is the thin metal tube of ratio cannula inner diameter that experimenter oneself seeks, not only also have the problem of physical and chemical stability, cause toxic reaction or degraded to be got rusty; And be difficult to more fully up to expectations be, its diameter is difficult to reach desirable requirement, after causing intubate to be implanted, cerebrospinal fluid in the brain can be present between inner core and the intubate tube wall in a large number because of capillarity, and in a single day rich in protein and inorganic salt separate out in the cerebrospinal fluid, and the then as easy as rolling off a log effect of playing adhesive is glued together intubate and inner core, cause inner core to be difficult to take out, this phenomenon is comparatively general in the self-control intubate.(5) problem of entry needle or syringe.At present domesticly be difficult to find than the thinner entry needle of general intracranial intubate tube wall or syringe (as external diameter less than 0.4mm); Therefore most of scientific research institutions utilize minimum number sword-shaped needle as entry needle, and comparatively speaking, the internal diameter of intubate just must cause the syringe bore bigger greater than the external diameter of entry needle, are difficult to reach nervelet nuclear group injection requirement in the brain.(6) poor accuracy.The difficult control of the specification of homemade intracranial intubate, size is artificially held, and than inaccuracy, is difficult to reach the brain kernel and rolls into a ball pinpoint strict demand.In a word, there is above shortcoming in homemade intracranial intubate, and these shortcomings all can cause the failure of an experiment, bring loss.Make the intracranial intubate by oneself even if utilize the brain of external import to be implanted into formula intubate tubing, also exist fixing, airtight, operate and problem that accuracy is difficult to hold.
Summary of the invention
The purpose of this utility model is in order to solve the relatively poor problem of stability, stationarity, seal, operability and accuracy that above-mentioned existing homemade intracranial intubate material exists, thereby a kind of implanted intracranial intubate of utilizing the stable medical polyurethane material of physicochemical property to make is provided, and has a kind of implanted intracranial medicine-feeding canula that is applicable to nmr imaging technique research of hermetically-sealed construction, rock-steady structure.
The purpose of this utility model also is to provide intracranial medicine-feeding canula a kind of and of the present utility model matching used syringe.
A kind of implanted intracranial medicine-feeding canula that is applicable to nmr imaging technique research that this utility model provides comprises intubate, intubate filling inner core; It is characterized in that: also comprise fixed pedestal and intubate sealing cap; Described intubate is a pipe, one end of circular tube external wall is provided with and the incorporate intubate fixed pedestal of intubate, this intubate fixed pedestal is the step revolving body, the outer wall of the tube part of the step revolving body screw thread of having got on the bus (is the carnival hat shape, the medicated cap drum outer wall external screw thread of having got on the bus, the female thread of itself and sealing cap is supporting); Described intubate sealing cap and intubate filling inner core are a bottle cap shape, its bottle cap inwall is provided with the intubate fixed pedestal and is screwed, (its section is the font of falling the mountain as intubate filling inner core composition integral structure to extend a bar in the bottle cap top, the intermediary one long perpendicular intubate filling inner core that is, two of the word of falling mountain both sides are erected and are cylinder sealing cap wall, the sealing cap inwall is provided with the female thread that is screwed with the intubate fixed pedestal, as Fig. 2 b); Intubate filling inner core external diameter is slightly less than cannula inner diameter, reaches adaptation ground insertion intubate and is advisable, and its length of inner core is identical with intubation length.
In technique scheme, with the matching used syringe of this intubate be a pipe, the external diameter of this pipe is slightly less than cannula inner diameter, reaches adaptation ground and inserts intubate and be advisable, its length is identical with intubation length, sees Fig. 2 c.During application, the one end connects syringe, and the other end inserts intubate, carries out administration in the brain.
In technique scheme, described intubate and fixed pedestal, intubate sealing cap and intubate filling inner core are the coefficient of expansion identical polyurethane material of the same race or polyurethane material and make.
In technique scheme, described sealing cap outer wall is provided with flour milling, ridge design shape structure or the thin prismatic surface structure of being convenient to staff and screwing.
In technique scheme, (depend primarily on the kind of laboratory animal, toy then size is little, and large animal relative size is big because of experiment needs for the size of each several part.) and different.Described cannula outer diameter scope is 0.7～3.0mm, and inside diameter ranges is 0.5～2.8mm, and length is made generally in 2.0～20.0cm according to the scientific research needs; Described fixed pedestal radius is generally at 4.0mm～20.0mm scope, thickness 1.0～2.0mm.
The design sketch that parts such as intubate and sealing cap matching used with it are implanted behind the intracranial is seen Fig. 1.
This utility model is a kind of to be applicable to that the work process of the implanted intracranial medicine-feeding canula that nmr imaging technique is studied is as follows:
At first need prepare the skull hole with brain surgery instruments according to researcher, the skull aperture is slightly larger than this cannula outer diameter.Utilize the stereotaxic instrument technology, (the sterilization: before the art of will sterilizing, the intubate and the sealing cap of cleaning were soaked 2 hours with 0.1% bromo geramine, the reuse distilled water flushing for several times, then sealing cap and intubate are screwed, it is standby to immerse physiological saline solution) after intubate insert intracranial through meninges and cerebral tissue, the three-dimensional elements of a fix of the purpose of cannula port are positioned at scientific research person's the purpose ventricles of the brain, brain district or certain nerve nucleus.Use dentistry cement or biogum then, intubate fixed pedestal and skull surface is bonding, securely intubate is fixed in skull.After treating that dentistry cement thoroughly condenses, in the time of need carrying out scientific experiments, the sealing cap of can outwarding winding inserts the medical polyurethane syringe (annotate: the length that syringe inserts intubate should equate with intubation length) that links to each other with syringe, carries out the intracranial administration.
The utlity model has following advantage:
(1) because the implanted intracranial medicine-feeding canula employing medical polyurethane that is applicable to that nmr imaging technique is studied of the present utility model is a raw material, and it is tough and tensile durable, intensity is higher.In addition, the medical polyurethane pipe is nontoxic, and histocompatibility is good, and the intubate material reaches the medical implant requirement.Experiment showed, at liquid phase environment, few as the harmful substance of separating out in tissue liquid, the blood; Can not cause toxic effect to organism.
(2) medical polyurethane material is easy to processing, and at present domestic main each medical apparatus and instruments factory all has sophisticated polyurethane process technology basically.
(3) medical polyurethane has low-cost characteristics, and the implanted intracranial medicine-feeding canula price that this utility model is made is lower, is suitable for carrying out under China's national situation scientific research.
(4) the implanted intracranial medicine-feeding canula of this utility model making has the fixed pedestal structure, from the mechanics angle, fixed comparatively firm between intubate and the skull, the chronic experiment test that the cycle of standing is long is difficult for being shifted because of the distortion of fixing glue or dentistry cement is aging or coming off from skull surface.
(5) this intubate is provided with the sealing cap structure, can fine intracranial and the strictness of cranium external environment be kept apart effectively, and microorganism is difficult for entering intracranial and causes intracranial infection, reaches good leak tightness.
(6) the filling inner core and the sealing cap of implanted intracranial medicine-feeding canula of the present utility model are integrated, as long as screw off sealing cap, and the then related taking-up of inner core; And the inner core physicochemical property is stable, can not cause toxic reaction or degraded to be got rusty; And because comparatively driving fit dimensionally between inner core and the intubate inwall, being difficult for cerebrospinal fluid is present between inner core and the intubate tube wall because of the hair suction phenomenon, the bonding phenomenon that makes inner core be difficult to take out of intubate of avoiding cerebrospinal fluid protein matter to separate out causing and inner core takes place, so the intubate inner core has good operability.
(7) problem of entry needle or syringe is resolved.The syringe external diameter of this utility model design is less, can cooperate implanted intracranial medicine-feeding canula of the present utility model to use, and can reach nervelet nuclear group injection requirement in the brain.
(8) has higher accuracy, because implanted intracranial medicine-feeding canula specification unanimity of the present utility model can reach the brain kernel and roll into a ball pinpoint strict demand.
(9) this implanted intracranial medicine-feeding canula can be used for the brain science experimentation of scientific experiments animal (monkey, rat, cat, rabbit, Canis familiaris L. etc.), and application promise in clinical practice is arranged.
Description of drawings
Fig. 1 is the application sketch map of implanted intracranial medicine-feeding canula of the present utility model
Fig. 2 a is the structure cutaway view of implanted intracranial medicine-feeding canula of the present utility model and fixed pedestal one
Fig. 2 b is intubate sealing cap of the present utility model and filling inner core cutaway view
Fig. 2 c is of the present utility model and the supporting syringe cutaway view of implanted intracranial medicine-feeding canula
(size among the figure is with scientific research rat cranium brain plug-in type intubate data instance)
The drawing explanation;
1-intubate 2-fixed pedestal 3-intubate
4-sealing cap 5-intubate filling inner core 6-injection purpose brain district
7-intubate cranium outer end 8-syringe
The specific embodiment
Below in conjunction with drawings and Examples the present invention is described in detail: now introduce an implanted polyurethane intracranial medicine-feeding canula that is suitable for rat: implant rat intracranial injection purpose brain district 6 back ideographs and see Fig. 1.
With reference to figure 2a, with the medical polyurethane pipe make an external diameter be 0.7 or 2.0mm X internal diameter be 0.6 or the intubate 1 of 1.8mm, its intracranial length is 2.0mm～10.0mm, total length be 4.0mm～15.0mm (intracranial length can determine according to the size of laboratory animal, the intubate intracranial length numerical value that present embodiment provides as long as within this value range all can).One end of circular tube external wall is provided with and the incorporate fixed pedestal 2 of intubate, this fixed pedestal 2 is the step revolving body, the tube part of step revolving body is intubate cranium outer end 7, the outer wall of this intubate cranium outer end 7 screw thread of having got on the bus (is the carnival hat shape, the medicated cap drum outer wall external screw thread of having got on the bus, the female thread of itself and sealing cap is supporting); Wherein the step of intubate fixed pedestal 2 (the annular shade of carnival hat) diameter is 8.0mm or 10.0mm, and step thicknesses is 1.0 or 2.0mm, and intubate cranium outer end 7 length are 2.0mm～5.0mm, and external diameter is 2.2mm～3.0mm; The outer wall external screw thread of having got on the bus, external thread length is 2.0mm～5.0mm, can with the internal screw-thread screw of sealing cap inwall.
With reference to figure 2b, make an incorporate cylinder sealing cap 3 and intubate filling inner core 5 with the medical polyurethane pipe, the profile of this integral structure is the font of falling the mountain, the bottle cap inwall of its sealing cap 3 is provided with and the intubate fixed pedestal 2 fixed female thread that is screwed, the extended bar in bottle cap center is an intubate filling inner core 5, and the length of filling inner core 4 and intubation length are mutually; Wherein sealing cap 3 inwall length are 1.0mm or 3.0mm, and the sealing cap external diameter is 3.0mm or 5.0mm, and internal diameter is 2.2mm or 3.0mm, and the sealing cap outer wall is provided with is convenient to flour milling or the thin prismatic surface structure that staff is screwed; The total length of intubate filling inner core 4 is identical with the intubate total length, is 4.0mm or 16.0mm, and diameter is 0.4mm or 1.5mm, and external diameter is slightly less than cannula inner diameter, reaches adaptation ground insertion intubate and is advisable, and sealing cap and intubate inner core total length are 4.1mm or 16.5mm.
With reference to figure 2c, with making one of medical polyurethane pipe and the supporting syringe 8 of implanted polyurethane intracranial medicine-feeding canula, these syringe 8 external diameters are 0.4mm～1.5mm; Internal diameter is 0.1mm～0.3mm; Its application length equates with intubation length.
Embodiment 2
With reference to figure 2a-c, make one for the intracranial medicine-feeding canula of experiment with the implanted medical polyurethane material making of rabbit, cat, its structure is with embodiment 1, just intubate and parts such as fixed pedestal, sealing cap and intubate filling inner core is in different size, its concrete data within following scope all can:
Cannula outer diameter is 0.7～3.0mm; Cannula inner diameter is 0.6～2.8mm;
Fixed pedestal thickness is 1.0～2.0mm; The fixed pedestal diameter is 8.0mm～15.0mm;
Intubate cranium outer end length is 2.0mm～5.0mm; External thread length is 2.0mm～5.0mm;
Intubate cranium outer end external diameter is 3.2mm～4.0mm; The outer wall external screw thread of having got on the bus, can with the internal screw-thread screw of sealing cap inwall;
Intubate intracranial length 2.0mm～80.0mm (intracranial length can according to the experiment needs determine, the data based different animal that bottom provides come again value all can); The intubate total length is 4.0mm～86.0mm;
The sealing cap external diameter is 5.0mm～6.5mm; The sealing cap internal diameter is 3.2mm～4.0mm; Sealing cap inwall length is 1.0mm～5.0mm; Sealing cap inwall female thread length is 1.0mm～5.0mm; Sealing cap outer wall length is 2.0mm～5.0mm;
Inner core diameter is 0.4mm～2.7mm; The inner core total length is 4.0mm～86.0mm;
Sealing cap and intubate inner core total length are 4.1mm～88.0mm.
The syringe external diameter is 0.4mm～2.7mm; Syringe inner diameter is 0.1mm～0.3mm.
With reference to figure 2a-c, make one for the implanted polyurethane intracranial medicine-feeding canula of experiment with Canis familiaris L., monkey, its structure is with embodiment 1, and just intubate and parts such as fixed pedestal, sealing cap and intubate filling inner core is in different size, and its concrete data are as follows:
Cannula outer diameter is 1.6mm; Cannula inner diameter is 1.4mm;
Fixed pedestal thickness is 1.5mm; The fixed pedestal diameter is 20.0mm;
Intubate cranium outer end length is 3.5mm; External thread length is 3.5mm;
Intubate cranium outer end external diameter is 5.5mm, intubate intracranial length 4.0～100.0mm (intracranial length can be determined according to the experiment needs);
The intubate total length is 7.5～103.5mm.
The sealing cap external diameter is 6.5mm; The sealing cap internal diameter is 5.5mm.
Sealing cap inwall length is 3.0mm; Sealing cap inwall female thread length is 3.0mm;
Sealing cap outer wall length is 4.0mm; Inner core diameter is 1.35mm;
The inner core total length is identical with the intubate total length, is 7.5mm～103.5mm; Sealing cap and intubate inner core total length are 4.1mm～108.5mm.
The syringe external diameter is 1.35mm; Syringe inner diameter is 0.1mm～0.3mm.
It should be noted that at last: above embodiment is the unrestricted the technical solution of the utility model in order to explanation only, although this utility model is had been described in detail with reference to the foregoing description, those of ordinary skill in the art is to be understood that: still can make amendment or be equal to replacement this utility model, and not breaking away from any modification or partial replacement of spirit and scope of the present utility model, it all should be encompassed in the middle of the claim scope of the present utility model.
Claims (5)
1. an implanted intracranial medicine-feeding canula that is applicable to nmr imaging technique research comprises intubate, intubate filling inner core; It is characterized in that: also comprise fixed pedestal and intubate sealing cap; Described intubate is a pipe, and an end of circular tube external wall is provided with and the incorporate intubate fixed pedestal of intubate, and this intubate fixed pedestal is the step revolving body, the outer wall of the tube part of the step revolving body screw thread of having got on the bus; Described intubate sealing cap and intubate filling inner core are a bottle cap shape, its bottle cap inwall is provided with the intubate fixed pedestal and is screwed, extend a bar in the bottle cap top and form integral structure as intubate filling inner core, the sealing cap inwall is provided with the female thread that is screwed with the intubate fixed pedestal; Intubate filling inner core external diameter is slightly less than cannula inner diameter, reaches adaptation ground insertion intubate and is advisable, and its length of inner core is identical with intubation length.
2. by the described implanted intracranial medicine-feeding canula that is applicable to nmr imaging technique research of claim 1, it is characterized in that: also comprise one with the matching used syringe of this intubate, described syringe is a pipe, the external diameter of this pipe and cannula inner diameter are inserted driving fit, and its length is identical with intubation length.
3. by the described implanted intracranial medicine-feeding canula that is applicable to nmr imaging technique research of claim 1, it is characterized in that: described intubate and fixed pedestal, intubate sealing cap and intubate filling inner core are the identical polyurethane material of the same race of the coefficient of expansion and make.
4. by the described implanted intracranial medicine-feeding canula that is applicable to nmr imaging technique research of claim 1, it is characterized in that: described sealing cap outer wall is provided with flour milling, ridge design shape structure or the thin prismatic surface structure of being convenient to staff and screwing.
5. by the described implanted intracranial medicine-feeding canula that is applicable to nmr imaging technique research of claim 1, it is characterized in that: described cannula outer diameter scope is 0.7～3.0mm, and inside diameter ranges is 0.5～2.8mm, and length is 2.0～20.0cm; Described fixed pedestal radius is at 4.0mm～20.0mm scope, thickness 1.0～2.0mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520112444 CN2836836Y (en) | 2005-07-06 | 2005-07-06 | An implanted encephalic drug-delivery cannula for MRI technology research |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520112444 CN2836836Y (en) | 2005-07-06 | 2005-07-06 | An implanted encephalic drug-delivery cannula for MRI technology research |
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| Publication Number | Publication Date |
|---|---|
| CN2836836Y true CN2836836Y (en) | 2006-11-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200520112444 Expired - Lifetime CN2836836Y (en) | 2005-07-06 | 2005-07-06 | An implanted encephalic drug-delivery cannula for MRI technology research |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100506314C (en) * | 2005-07-04 | 2009-07-01 | 中国科学院心理研究所 | Implanted intracranial administration intubate suitable for neuroscience research |
-
2005
- 2005-07-06 CN CN 200520112444 patent/CN2836836Y/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100506314C (en) * | 2005-07-04 | 2009-07-01 | 中国科学院心理研究所 | Implanted intracranial administration intubate suitable for neuroscience research |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Effective date of abandoning: 20090701 |
|
| AV01 | Patent right actively abandoned |
Effective date of abandoning: 20090701 |
|
| C25 | Abandonment of patent right or utility model to avoid double patenting |