CN108245771A - Orthopaedics implantable drug delivery system - Google Patents
Orthopaedics implantable drug delivery system Download PDFInfo
- Publication number
- CN108245771A CN108245771A CN201810114572.0A CN201810114572A CN108245771A CN 108245771 A CN108245771 A CN 108245771A CN 201810114572 A CN201810114572 A CN 201810114572A CN 108245771 A CN108245771 A CN 108245771A
- Authority
- CN
- China
- Prior art keywords
- administration
- needle
- sleeve
- drug delivery
- delivery system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses orthopaedics implantable drug delivery systems, and including administration sleeve and the administration needle being inserted into administering cover, administration needle connects administration pump by woven hose, and administration needle includes the gland of needle tubing and fixed needle tubing, and gland is fixed with the inner wall of sleeve is administered.Present invention design administration needle is inserted into administration sleeve, administration sleeve is implanted into subchondral bone, pass through feeding drug of the administration pump through the lasting slow constant speed of administration needle, achievable subchondral bone is administered at regular time and quantity, simultaneously avoid traditional subchondral bone disposably injection or embedment drug when drug release can not quantify and unstability, the composite can be widely applied to medical instruments field.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to orthopaedics implantable drug delivery system.
Background technology
Clinical practice shows that subchondral bone lesion is the key factor that osteoarthritis and other orthopaedic diseases generate,
The research majority of such disease is completed by zoopery.But it is still at present one about the administering mode of subchondral bone
A difficult point, so as to affect the development of subchondral bone experiment.It carries out being directed to subchondral bone administering mode still during basic research at present
Based on so disposably being injected with syringe needle, which can not ensure absorption of the subchondral bone to drug, not account for topically effective
The maintenance problem of drug concentration, if single administration can not meet experiment carry out, need carry out multiple dosing, convenient administration mode into
The infection probability of subchondral bone is increased while row multiple dosing, while syringe repeatedly enters subchondral bone, under cartilage
The structure of bone will also result in destruction.
Invention content
The technical problems to be solved by the invention are to provide orthopaedics implantable drug delivery system, by the way that the drug delivery device is fixed
At administering position, realization continues quantitative subchondral bone administration.
Used technical solution to solve above-mentioned technical problem：
Orthopaedics implantable drug delivery system, including administration sleeve and the administration needle being inserted into the administration sleeve, the administration
Needle connects administration pump by woven hose, and the administration needle includes the gland of needle tubing and fixed needle tubing, the gland with it is described
The inner wall of administration sleeve is fixed.
Further, the gland and the inner wall of the administration sleeve are threadably secured.
Further, the outer wall of the administration sleeve is disposed with screw thread.
Further, the outer wall of the administration sleeve is taper, what the administration needle was relatively large in diameter from the administration sleeve
One end is inserted into.
Further, the administration pump is flat.
Further, the length of the administration sleeve is more than the length of the needle tubing.
Further, the gland and the bearing of the administration sleeve are disposed with sealing ring.
Advantageous effect：Present invention design administration needle is inserted into administration sleeve, by administration sleeve implantation subchondral bone, passes through administration
The feeding drug through the lasting slow constant speed of administration needle is pumped, replaces the mode disposably injected, can avoid because syringe is multiple
The structure of subchondral bone is caused to be destroyed into subchondral bone, the input drug of sustainable slow constant speed.The present invention
Medical instruments field be can be widely applied to, it can be achieved that subchondral bone is administered at regular time and quantity, while avoids traditional subchondral bone primary
Property injection or embedment drug when drug release can not quantify and unstability.At present in the animal experiment study of Osteoarthritis
In, it can be achieved that the administration at regular time and quantity of subchondral bone；Future detects subchondral bone for premature arthritis patient and magnetic resonance
There is the patient of early stage cystic lesion, can be at regular time and quantity administered in patient's subchondral bone by this device, to reach treatment early stage bone
The arthritic purpose of property.Meanwhile the device is not limited to the administration of Osteoarthritis subchondral bone, for long bone of limbs tumour, bone
Small-molecule drug, protein medicine-feeding and the stem-cell therapies of diseases such as matter is loose, infection etc., similarly achievable local timing determines
Amount administration.
Description of the drawings
Fig. 1 is the sectional view that sleeve is administered；
Fig. 2 is the structure chart of administration needle.
Reference numeral：1st, administration needle；2nd, sleeve is administered.
Specific embodiment
With reference to Fig. 1 and Fig. 2, the present invention is described further.
Orthopaedics implantable drug delivery system, it is described to give including administration sleeve 2 and the administration needle 1 being inserted into the administration sleeve 2
Medicine needle 1 connects administration pump by woven hose, and the administration pump is flat miniature administration pump.Administration sleeve 2 is implanted into cartilage
Sending down the fishbone installs required dose in advance in administration pump, and administration pump is implanted into lateral of tibia edge and fixation.Therefore, administration pump passes through
Administration needle 1 is sustainable to be slowly sent into drug in subchondral bone by certain flow rate, and subchondral bone is maintained within the medical time
Constant dosage and administration concentration, reaches good administering effect.By the drug delivery device, the administration of a period of time can be met
Demand avoids repeatedly carrying out needle injection administration, reduces to subchondral bone structural damage, will not influence skeletal structure
Normal growth restores.
The administration needle 1 includes the gland of needle tubing and fixed needle tubing, the gland and the inner wall of the administration sleeve 2
Fixed, the gland and the inner wall of the administration sleeve 2 are threadably secured.The gland and the administration sleeve 2
Bearing is disposed with sealing ring, can prevent drug leakage.
The outer wall of the administration sleeve 2 is disposed with screw thread, the convenient position that administration sleeve 2 is fixed in implantation.For ease of
Administration sleeve 2 is implanted into, the outer wall of the administration sleeve 2 for taper, and the administration needle 1 from diameter on the administration sleeve 2 compared with
Big one end is inserted into.
The length of the administration sleeve 2 is more than the length of the needle tubing, and the needle tubing will not be from the end of the administration sleeve 2
End protrusion is exposed in subchondral bone, can not only prevent needle tubing from being blocked by tissue, but also can prevent needle tubing prick into human body from organizing.
In the present embodiment, used administration pump is common administration pump in medical treatment.Concrete operating principle is as follows：The administration
Pump is divided into two side rooms and a middle room, and room is disposed with elastic membrane in administration pump, during infusion of medicine administration pump, elastic membrane
It is extruded and opens.After drug fills, by the elastic recovery force of elastic membrane, the drug injected is exported outward.Pass through administration
Circuit design inside pump can fix the administration flow velocity of the administration pump, such as monthly 50 microlitres of administration flow velocity.
Embodiments of the present invention are explained in detail above in association with attached drawing, but the present invention is not limited to above-mentioned embodiment party
Formula, can also be before present inventive concept not be departed from the knowledge having in the technical field those of ordinary skill
Put that various changes can be made.
Claims (7)
1. orthopaedics implantable drug delivery system, it is characterised in that：Including administration sleeve (2) and it is inserted into the administration sleeve (2)
Administration needle (1), the administration needle (1) connect administration pump by woven hose, and the administration needle (1) is including needle tubing and fixes needle tubing
Gland, the gland and the inner wall of the administration sleeve (2) are fixed.
2. orthopaedics implantable drug delivery system according to claim 1, it is characterised in that：The gland and the administering cover
The inner wall of cylinder (2) is threadably secured.
3. orthopaedics implantable drug delivery system according to claim 1, it is characterised in that：The outer wall of the administration sleeve (2)
It is disposed with screw thread.
4. orthopaedics implantable drug delivery system according to claim 1, it is characterised in that：The outer wall of the administration sleeve (2)
For taper, one end that the administration needle (1) is relatively large in diameter from the administration sleeve (2) is inserted into.
5. orthopaedics implantable drug delivery system according to claim 1, it is characterised in that：The administration pump is flat.
6. orthopaedics implantable drug delivery system according to claim 1, it is characterised in that：The length of the administration sleeve (2)
More than the length of the needle tubing.
7. orthopaedics implantable drug delivery system according to claim 1, it is characterised in that：The gland and the administering cover
The bearing of cylinder (2) is disposed with sealing ring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810114572.0A CN108245771A (en) | 2018-02-02 | 2018-02-02 | Orthopaedics implantable drug delivery system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810114572.0A CN108245771A (en) | 2018-02-02 | 2018-02-02 | Orthopaedics implantable drug delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108245771A true CN108245771A (en) | 2018-07-06 |
Family
ID=62744720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810114572.0A Pending CN108245771A (en) | 2018-02-02 | 2018-02-02 | Orthopaedics implantable drug delivery system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108245771A (en) |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214012B1 (en) * | 1998-11-13 | 2001-04-10 | Harrington Arthritis Research Center | Method and apparatus for delivering material to a desired location |
| JP2003180699A (en) * | 2001-12-20 | 2003-07-02 | Kyocera Corp | Implant for treating articular cartilage |
| US20060235410A1 (en) * | 2005-04-15 | 2006-10-19 | Ralph James D | Surgical expansion fasteners |
| CN1891310A (en) * | 2005-07-04 | 2007-01-10 | 中国科学院心理研究所 | Implanted intracranial administration intubate suitable for neuroscience research |
| US20080188931A1 (en) * | 2006-11-01 | 2008-08-07 | Seoul National University Hospital | Cricoid wedge implant |
| US20080257412A1 (en) * | 2007-04-18 | 2008-10-23 | John Howard Gordon | Fluid Delivery Device With Flow Rate Control |
| CN101502695A (en) * | 2009-01-15 | 2009-08-12 | 徐泱 | Embedded type chargeable sustained-release administration pump |
| US20100222750A1 (en) * | 2009-02-27 | 2010-09-02 | Vanderbilt University | Replenishable drug delivery implant for bone and cartilage |
| US20110097377A1 (en) * | 2009-10-23 | 2011-04-28 | Hassan Serhan | Methods and Devices for Correcting Spinal Deformity With Pharmaceutical-Eluting Pedicle Screws |
| US20110125272A1 (en) * | 2009-11-20 | 2011-05-26 | Knee Creations, Llc | Bone-derived implantable devices for subchondral treatment of joint pain |
| CN104254352A (en) * | 2012-02-16 | 2014-12-31 | 宽塔流体解决方案有限公司 | Blood pump |
| US20170027628A1 (en) * | 2015-07-28 | 2017-02-02 | University-Industry Cooperation Group Of Kyung Hee University | Drug delivery implant implanted into bone |
| CN209270606U (en) * | 2018-02-02 | 2019-08-20 | 南方医科大学南方医院 | Orthopaedics implantable drug delivery system |
-
2018
- 2018-02-02 CN CN201810114572.0A patent/CN108245771A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214012B1 (en) * | 1998-11-13 | 2001-04-10 | Harrington Arthritis Research Center | Method and apparatus for delivering material to a desired location |
| JP2003180699A (en) * | 2001-12-20 | 2003-07-02 | Kyocera Corp | Implant for treating articular cartilage |
| US20060235410A1 (en) * | 2005-04-15 | 2006-10-19 | Ralph James D | Surgical expansion fasteners |
| CN1891310A (en) * | 2005-07-04 | 2007-01-10 | 中国科学院心理研究所 | Implanted intracranial administration intubate suitable for neuroscience research |
| US20080188931A1 (en) * | 2006-11-01 | 2008-08-07 | Seoul National University Hospital | Cricoid wedge implant |
| US20080257412A1 (en) * | 2007-04-18 | 2008-10-23 | John Howard Gordon | Fluid Delivery Device With Flow Rate Control |
| CN101502695A (en) * | 2009-01-15 | 2009-08-12 | 徐泱 | Embedded type chargeable sustained-release administration pump |
| US20100222750A1 (en) * | 2009-02-27 | 2010-09-02 | Vanderbilt University | Replenishable drug delivery implant for bone and cartilage |
| US20110097377A1 (en) * | 2009-10-23 | 2011-04-28 | Hassan Serhan | Methods and Devices for Correcting Spinal Deformity With Pharmaceutical-Eluting Pedicle Screws |
| US20110125272A1 (en) * | 2009-11-20 | 2011-05-26 | Knee Creations, Llc | Bone-derived implantable devices for subchondral treatment of joint pain |
| CN104254352A (en) * | 2012-02-16 | 2014-12-31 | 宽塔流体解决方案有限公司 | Blood pump |
| US20170027628A1 (en) * | 2015-07-28 | 2017-02-02 | University-Industry Cooperation Group Of Kyung Hee University | Drug delivery implant implanted into bone |
| CN209270606U (en) * | 2018-02-02 | 2019-08-20 | 南方医科大学南方医院 | Orthopaedics implantable drug delivery system |
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