CN1891289A - Chinese medicine for treating by-reaction disease caused by anti-psychosis medicine, and its preparing method - Google Patents
Chinese medicine for treating by-reaction disease caused by anti-psychosis medicine, and its preparing method Download PDFInfo
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- CN1891289A CN1891289A CN 200610044503 CN200610044503A CN1891289A CN 1891289 A CN1891289 A CN 1891289A CN 200610044503 CN200610044503 CN 200610044503 CN 200610044503 A CN200610044503 A CN 200610044503A CN 1891289 A CN1891289 A CN 1891289A
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Abstract
The present invention relates to a Chinese medicine for curing side reaction diseases due to medicine for resisting psychosis. Said Chinese medicine is made up by using 9 Chinese medicinal materials of earthworm, Sichuan fritillaria bulb, ground pine, curcuma tuber and others through a certain preparation process. Said invention also provides its preparation process and its quality control method.
Description
Technical field
The present invention relates to a kind of medicine of medicine side reaction disease, particularly relate to a kind of Chinese medicine for the treatment of the side reaction disease that antipsychotic drug causes, the invention still further relates to its preparation method.
Background technology
The side effect of psychosis is a lot of.Psychosis commonly used at present has: sulpiride, clozapine etc.Wherein EPS is the most common, and this is this class medicine to due to the blocking-up of the dopamine path of cerebrum base section part.The The extrapyramidal symptoms at treatment initial stage shows as the property reversed motion, as turn on the eyeball, the reversing etc. of torticollis, trunk or extremity, symptom is rather peculiar.Mid-term then with medicine source property parkinson for seeing more, show as tremble, muscular hypertonia, the dull and behavior of moving is slow, heavier person's dysarthria, dysphagia.Long-term prescription can cause the EPS of so-called tardive dyskinesia, shows as the involuntary movement of mouth, face, chin portion, as frowns, wrinkle volume, the tooth of grinding one's teeth in sleep, grin, sucks, licks tongue, the drum cheek and pout one's lips etc., and some patient also has can the body involuntary action.Other side effect has asthenia, drowsy, dizzy, drug eruption, sight allergic dermatitis, xerostomia, sialorrhea, blurred vision, constipation, edema, obesity, the non-specific change of Electrocardiographic ST-T section and changes of liver function etc.Accidental blood leukocytes reduces and epilepsy.In a word, the mental patient occurs tangible extrapyramidal system side reaction such as sialorrhea easily, trembles, stiff (be slow in action, have a dull expression on one's face, bradyphrenia) etc. after taking psychosis, have a strong impact on mental patient's quality of life and external image, cause very big mental burden to the mental patient.
The medicine that is used for the treatment of at present psychosis side reaction disease clinically is the Anticholinergics medicine, as trihexyphenidyl, promethazine etc., such medicine is not only invalid to serious symptom side reaction patient, and also have multiple side effect: several kind of smooth muscle cells is lax, heart rate acceleration, platycoria, blood pressure lowering, xerostomia, blurred vision, dysuria etc.
Summary of the invention
The objective of the invention is to overcome the above-mentioned defective of prior art, provide a kind of and have no side effect, and the Chinese medicine of the side reaction disease that causes of the treatment antipsychotic drug of determined curative effect.
For achieving the above object, the present invention's crude drug for the treatment of the Chinese medicine of the side reaction disease that antipsychotic drug causes comprises: Pheretima, Bulbus Fritillariae Cirrhosae, Herba Lycopodii, Radix Curcumae, Flos Albiziae, Fructus Lycii, Rhizoma Curcumae, Arillus Longan, Radix Glycyrrhizae.
The composition principle of medicine of the present invention is:
Monarch drug has: daughter-in-law's wind medicine " Pheretima ", expectorant " Bulbus Fritillariae Cirrhosae ", the medicine that dispels the wind " Herba Lycopodii ".Wherein " Pheretima " is used for heat clearing away, collateral dredging, releasing striped muscle spasm; " Bulbus Fritillariae Cirrhosae " is used to reduce phlegm, eliminating stagnation, releasing smooth muscle spasm; " Herba Lycopodii " is used to dispel the wind, collateral dredging, spasmolytic, stretch muscle, get round by bribery;
Ministerial drug has: sedative " Flos Albiziae ", blood circulation promoting medicine " Radix Curcumae ".Wherein " Flos Albiziae " be used to calm the nerves, resolving depression; " Radix Curcumae " is used to invigorate blood circulation, circulation of qi promoting, refreshment.
Adjuvant drug has: refreshing beneficial medicine " Arillus Longan " and " Fructus Lycii ", blood circulation promoting medicine " Rhizoma Curcumae ".Wherein " Arillus Longan " be used to enrich blood, calm the nerves, QI invigorating, improve cognitive function; " Fructus Lycii " is used for replenishing YIN and removing heat; " Rhizoma Curcumae " is used for the removing blood stasis circulation of qi promoting.
Messenger drug has: " Radix Glycyrrhizae " is used for detoxifcation, coordinating the actions of various ingredients in a prescription.
More than each medicine share, have the spasmolytic clearing away phlegm, invigorate blood circulation that it is strongly fragrant to dispel, the replenishing vital essence and invigorating vital QI effect, thus realize sialorrhea that the anti-psychotropic drugs of treatment causes, tremble, side effect disease such as stiff, improve the target of mental patient's external image.
As optimization, the weight proportion of crude drug is preferred: Pheretima 8-12, Bulbus Fritillariae Cirrhosae 2-4, Herba Lycopodii 7-10, Radix Curcumae 4-6, Flos Albiziae 5-9, Fructus Lycii 6-9, Rhizoma Curcumae 8-10, Arillus Longan 8-12, Radix Glycyrrhizae 9-14.This ratio range curative effect excellence.
As optimization, the weight proportion of crude drug more preferably: Pheretima 9, Bulbus Fritillariae Cirrhosae 3, Herba Lycopodii 8, Radix Curcumae 5, Flos Albiziae 7, Fructus Lycii 8, Rhizoma Curcumae 9, Arillus Longan 10, Radix Glycyrrhizae 10.This proportioning curative effect is best.
As optimization, make: assort in proportion, add water boil, after medicinal liquid concentrates, add adjuvant and make granule by following method.
As optimization, described adjuvant is a sucrose.Sucrose is that adjuvant can improve mouthfeel on the one hand, also helps giving full play to drug effect on the other hand.
As optimization, its dosage form comprises granule, capsule and decoction.Certainly, medically other dosage form of acceptable can adopt, and is granule, and capsule and decoction are preferred dosage form.
The preparation method of medicine of the present invention comprises the steps: to assort in proportion, adds water boil, after medicinal liquid concentrates, adds sucrose and makes granule, every bag 10 grams.This preparation method has workable, and convenient enforcement helps guaranteeing the advantage of drug effect.
Administrated method: each 1-2 bag, every day 2 times.
Prove through long-term clinical application: the psychotic is when taking antipsychotic drug, cooperate and to take medicine of the present invention and can solve multiple side reaction problems such as effectively to solve sialorrhea, tremble, be stiff effectively, not only counterweight reaction disease person is effective for it, and have no side effect, can eliminate the side reaction disease of mental patient after with antipsychotic drug, can fundamentally improve mental patient's external image again, improve self-confidence, help the smooth rehabilitation of mental patient.
Now lift wherein two routine model cases:
Case one: the XX of the patient Qin, the man, 40 years old, because of Mental Subnormality was repeatedly moved in Yulin City demobilized military personnel hospital in 14 years.Be diagnosed as after being admitted to hospital: schizophrenia (psychosis).With treatment in clozapine 50-400mg/ days, mental symptom disappeared after 3 months, but sialorrhea soaks whole medicated pillow in bed in noon, evening.With trihexyphenidyl, promethazine treatment, effect is undesirable, uses medicine granule of the present invention instead, and sialorrhea obviously reduced in 5 days, 3 months no sialorrhea phenomenons.
Case two: old XX, the man weighs 9 years old, and Yulin famous mountain people from town is many because of occurring words repeatedly, and it is surplus to be suspected to have people's evil 2 years, moves in Yulin City demobilized military personnel hospital in February, 2003.Be diagnosed as after being admitted to hospital: schizophrenia---intolerance style.Take clozapine 50-150mg, Bid share sulpiride 0.1-0.4g, and Bid takes a turn for the better after treating 2 months and leaves hospital.The back mental symptom of leaving hospital disappears, but the patient occurs that trick is trembled, sialorrhea, symptom such as stiff.The back cooperates took medicine granule of the present invention after 3 months, no sialorrhea and trick chattering, and stiff obvious improvement can be participated in various social activity.
Therefore, the present invention treats the Chinese medicine of the side reaction disease that antipsychotic drug causes and is made by pure Chinese medicine, not only counterweight reaction disease patient is effective, and have and have no side effect, determined curative effect, to sialorrhea, tremble, multiple side reaction disease curative effect excellence such as stiff, improve mental patient's quality of life and external image effectively, improve self-confidence, help the advantage of the smooth rehabilitation of mental patient.
The specific embodiment
Do further explanation below in conjunction with instantiation:
The present invention treats the Chinese medicine of the side reaction disease that antipsychotic drug causes and is made by following Chinese medicine raw materials by weight proportion: (unit of weight is gram)
Pheretima 8, Bulbus Fritillariae Cirrhosae 2, Herba Lycopodii 7, Radix Curcumae 4, Flos Albiziae 5, Fructus Lycii 6, Rhizoma Curcumae 8, Arillus Longan 8, Radix Glycyrrhizae 9.
Pheretima 12, Bulbus Fritillariae Cirrhosae 4, Herba Lycopodii 10, Radix Curcumae 6, Flos Albiziae 9, Fructus Lycii 9, Rhizoma Curcumae 10, Arillus Longan 12, Radix Glycyrrhizae 14.
Pheretima 8, Bulbus Fritillariae Cirrhosae 4, Herba Lycopodii 7, Radix Curcumae 6, Flos Albiziae 5, Fructus Lycii 9, Rhizoma Curcumae 8, Arillus Longan 12, Radix Glycyrrhizae 9.
Pheretima 12, Bulbus Fritillariae Cirrhosae 2, Herba Lycopodii 10, Radix Curcumae 4, Flos Albiziae 9, Fructus Lycii 6, Rhizoma Curcumae 10, Arillus Longan 8, Radix Glycyrrhizae 14.
Pheretima 9, Bulbus Fritillariae Cirrhosae 3, Herba Lycopodii 8, Radix Curcumae 5, Flos Albiziae 7, Fructus Lycii 8, Rhizoma Curcumae 9, Arillus Longan 10, Radix Glycyrrhizae 10.
The preparation method of its granule is: assort according to the above ratio, add water boil, medicinal liquid adds sucrose and makes granule after being concentrated into (proportion 1.28W/W, heat is surveyed).Amount of water is 3 times of crude drug gross weight.Boiling time is 1-2 hour.
Claims (7)
1, a kind of Chinese medicine for the treatment of the side reaction disease that antipsychotic drug causes is characterized in that its crude drug comprises:
Pheretima, Bulbus Fritillariae Cirrhosae, Herba Lycopodii, Radix Curcumae, Flos Albiziae, Fructus Lycii, Rhizoma Curcumae, Arillus Longan, Radix Glycyrrhizae.
2, the Chinese medicine of the side reaction disease that causes of treatment antipsychotic drug according to claim 1 is characterized in that the weight proportion of crude drug is preferred: Pheretima 8-12, Bulbus Fritillariae Cirrhosae 2-4, Herba Lycopodii 7-10, Radix Curcumae 4-6, Flos Albiziae 5-9, Fructus Lycii 6-9, Rhizoma Curcumae 8-10, Arillus Longan 8-12, Radix Glycyrrhizae 9-14.
3, the Chinese medicine of the side reaction disease that causes of treatment antipsychotic drug according to claim 2, the weight proportion that it is characterized in that crude drug is more preferably: Pheretima 9, Bulbus Fritillariae Cirrhosae 3, Herba Lycopodii 8, Radix Curcumae 5, Flos Albiziae 7, Fructus Lycii 8, Rhizoma Curcumae 9, Arillus Longan 10, Radix Glycyrrhizae 10.
4, the Chinese medicine of the side reaction disease that causes according to claim 1,2 or 3 described treatment antipsychotic drug is characterized in that being made by following method: assort in proportion, add water boil, after medicinal liquid concentrates, add adjuvant and make granule.
5, the Chinese medicine of the side reaction disease that causes of treatment antipsychotic drug according to claim 4 is characterized in that described adjuvant is a sucrose.
6, the Chinese medicine of the side reaction disease that causes according to claim 1,2 or 3 described treatment antipsychotic drug is characterized in that its dosage form comprises granule, capsule and decoction.
7, the preparation method of medicine of the present invention is characterized in that comprising the steps: to assort in proportion, adds water boil, after medicinal liquid concentrates, adds adjuvant and makes granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610044503 CN1891289A (en) | 2006-05-26 | 2006-05-26 | Chinese medicine for treating by-reaction disease caused by anti-psychosis medicine, and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610044503 CN1891289A (en) | 2006-05-26 | 2006-05-26 | Chinese medicine for treating by-reaction disease caused by anti-psychosis medicine, and its preparing method |
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| CN1891289A true CN1891289A (en) | 2007-01-10 |
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| CN 200610044503 Withdrawn CN1891289A (en) | 2006-05-26 | 2006-05-26 | Chinese medicine for treating by-reaction disease caused by anti-psychosis medicine, and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008688A (en) * | 2010-12-09 | 2011-04-13 | 上海市精神卫生中心 | Medicament for treating periodic psychosis |
| CN102526397A (en) * | 2012-01-12 | 2012-07-04 | 高新华 | Medicament for treating salivation |
| CN104740319A (en) * | 2015-03-31 | 2015-07-01 | 惠志强 | Traditional Chinese medicine preparation for preventing side reactions caused by antipsychotics |
-
2006
- 2006-05-26 CN CN 200610044503 patent/CN1891289A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008688A (en) * | 2010-12-09 | 2011-04-13 | 上海市精神卫生中心 | Medicament for treating periodic psychosis |
| CN102008688B (en) * | 2010-12-09 | 2012-04-18 | 上海市精神卫生中心 | Medicament for treating periodic psychosis |
| CN102526397A (en) * | 2012-01-12 | 2012-07-04 | 高新华 | Medicament for treating salivation |
| CN102526397B (en) * | 2012-01-12 | 2013-06-05 | 高新华 | Medicament for treating salivation |
| CN104740319A (en) * | 2015-03-31 | 2015-07-01 | 惠志强 | Traditional Chinese medicine preparation for preventing side reactions caused by antipsychotics |
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