CN1879702A - A medicine for preventing and treating diabetes, preparation method and application thereof - Google Patents
A medicine for preventing and treating diabetes, preparation method and application thereof Download PDFInfo
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- CN1879702A CN1879702A CN 200510046684 CN200510046684A CN1879702A CN 1879702 A CN1879702 A CN 1879702A CN 200510046684 CN200510046684 CN 200510046684 CN 200510046684 A CN200510046684 A CN 200510046684A CN 1879702 A CN1879702 A CN 1879702A
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Abstract
The invention discloses a pharmaceutical composition for the prevention and treatment of diabetes, its preparing process and use, wherein the composition is prepared from cloves as raw material through the steps of drying, disintegrating, water or alcohol extracting, the product may take the forms of tablets, granules, capsules, electuary, pills, mixture or injections.
Description
Technical field
The present invention relates to medical technical field, refer in particular to and a kind of diabetes are had the medicine of preventive and therapeutic effect, and relate to the preparation of this medicine and preventing and treating the new purposes of diabetes.
Background technology
Along with the aging and the growth in the living standard of world population, diabetes have become a kind of commonly encountered diseases, frequently-occurring disease, and its sickness rate is in rising trend.The whole world has 1.6 hundred million diabeticss approximately, and 80% is non-insulin-dependent diabetes mellitus (2 type), and wherein China has surpassed 4,000 ten thousand people.And because diabetes are a kind of chronic diseases, the course of disease is long and complicated, is difficult to radical cure.Because its pathogenesis is still not fully aware of, mainly be to utilize the rising of medicine blood sugar control and prevent and treat complication at present.Now existing many Chinese herbal medicine or compound preparation have all shown multiple blood sugar lowering mechanism, as: have the islet cells of stimulation excreting insulin, suppress pancreas and rise the plain secretion of sugar, increase the sensitivity of Insulin receptor INSR, suppress the intestinal absorption of glucose, improve fatty acid metabolism etc.
The Oleaceae genus syringa has 40 kinds in the world approximately, is distributed in Europe and Asia, and China has 23 kinds, from the extremely southwestern each province in China northeast distribution is arranged all.Genus syringa is based on cultivating and growing at present, and wild is auxilliary.Be mainly derived from Korea Flos Caryophylli, Syringa oblata Lindl., foreign Flos Caryophylli, other still have Syringa pubescens, close Flos Caryophylli, Faeces Passeris, polyphyll Flos Caryophylli, east area of the Liao River, coextensive with eastern and southern Liaoning Province Flos Caryophylli, syringa reticulata var mandshurica etc.The decocting liquid of China's its leaf of usefulness among the people is controlled dysentery and ophthalmic, is the Chinese medicine preparation＜anti-inflammation medicine sheet of raw material with leaf of Syringa oblata Lindl., Korean Folium Caryophylli and leaf of Syringa vulgaris L.〉and＜YANLIXIAO JIAONANG 〉, in the existing approved production of China.This medical instrument has heat-clearing and toxic substances removing, antiinflammation, is used for the bacillary dysentery of heat syndrome, acute tonsillitis, acute/chronic bronchitis, acute gastroenteritis, infectious disease such as acute mastitis.But do not find that as yet Folium Caryophylli has the report of preventing and treating the diabetes effect significantly at present.
Summary of the invention
The object of the present invention is to provide a kind of is that raw material is prevented and treated the medicine and the preparation method of diabetes and prevented and treated the new purposes of diabetes with the genus syringa.
To achieve these goals, technical solution of the present invention is as follows:
Prevent and treat the medicine of diabetes: be that feedstock production gets mainly by genus syringa; The genus syringa medical material is the kind of Oleaceae genus syringa and/or root, stem, leaf, flower, fruit and/or the seed of mutation;
Described Oleaceae genus syringa can be Syringa oblata Lindl. (Syringa oblata lindl), Korea Flos Caryophylli (Syringa diatata Nakai), foreign Flos Caryophylli (Syringa vulgaris L, four seasons Flos Caryophyllis (Syringamicrophylla), Syringa pubescens (Syringa pubescens, Off East Flos Caryophylli (Syringa velutina), flower Leaf Flos Caryophylli (Syringa persica) or Japanese Flos Caryophylli (Syringa reticulate L);
The preparation method of described treatment diabetes medicament is with the genus syringa cleaning, drying, pulverizes and makes medicinal tea; Also can carry or the alcohol extraction preparation through water, specifically: clean genus syringa is added 5～10 times of water gagings, and water or alcohol decoct 1～3 time, and each time was respectively 0.5～2 hour, and filtrate is condensed into extractum;
Described filtrate is extraordinarily gone into adjuvant by 0.5～500 of raw material after being condensed into extractum, and drying is pulverized, and technology pelletize routinely is prepared into tablet, granule, capsule, unguentum, pill, mixture, the multiple dosage form of injection;
Described adjuvant is that forming agent, filler, disintegrating agent, bag are according to agent, correctives and/or toner; Described treatment diabetes medicament can be used for treating diabetes; Be used for health product; Be used for triglyceride reducing.
The present invention has following advantage:
1. medicine of the present invention is used for the treatment of diabetes, and tangible blood sugar lowering effect is arranged, and can effectively reduce the dependency of diabetes patient to insulin, removes diabetic symptom, and sugar tolerance is good, better tolerance, and effect is continual and steady.
2. medicine of the present invention is a Chinese herbal medicine, has no side effect, and is safe and reliable.
3. it is simple to adopt the present invention to prevent and treat the preparation method of diabetes medicament, the genus syringa pulverizing medicinal materials can be made medicinal tea, also genus syringa medical material water can be carried or alcohol extraction, and be prepared into multiple dosage forms such as tablet, granule, capsule, unguentum, pill, mixture, injection.
4. medicine of the present invention has the triglyceride reducing effect, can be used for triglyceride reducing.
5. medicine of the present invention not only is used for the treatment of diabetes, also has prevention effects concurrently, also can be used as health product and takes.
The specific embodiment
Below in conjunction with embodiment this explanation is further elaborated.
The following example only is used to illustrate the present invention, rather than limits the present invention by any way.
Embodiment 1, the preparation medicinal tea:
Manufacture method: Folium Caryophylli 1000g to be cleaned with clear water, is natural drying pulverized, with every bag? the weight packing of gram, the people storehouse promptly makes the medicine of treatment diabetes of the present invention, and this is a medicinal tea.Drink: but every day three times, each one bag.
Present embodiment adopts Oleaceae genus syringa Syringa oblata Lindl. (Syringa oblata lindl); In addition, described medicinal tea can be without pulverizing, dry back packing.
Embodiment 2, the preparation granule:
Manufacture method: with clean Folium Caryophylli 1000g, water decocts 2 times, adds 7 times of water gagings at every turn, and the time was respectively 2 hours and 1 hour, and filtrate is condensed into extractum.Press 1 times of raw material amount and add adjuvant, drying is pulverized, technology pelletize routinely, and packing, the people storehouse promptly makes the medicine of treatment diabetes of the present invention, and this is a granule.
Present embodiment adopts Korea Flos Caryophylli (Syringa diatata Nakai), and described adjuvant is starch 500g, lactose, methylcellulose 200g, carmine 100g.
The Chinese herbal medicine composition that the present invention prevents and treats diabetes is a kind of Oleaceae genus syringa, discovers that it has tangible blood sugar reducing function, and the Chinese medicine preparation with its folk prescription is made by test of animal diabetes model and clinical observation, all obtains satisfied effect.
Now the water extract extractum dosage form with Folium Caryophylli preparation of the present invention provides test report.
One, the influence of alloxan induced hyperglycemia rat blood sugar is tested
Method: body weight 170-240g male rat, under laboratory condition, raise after three days, can't help water after 4 hours in fasting, get blood by the eye socket venous plexus, press enzymatic assays serum blood glucose value, get the rat of blood glucose value 70-100mg/dL and use for experiment.Above-mentioned rat fasting be can't help water after 20 hours, by tail vein injection alloxan 40mg/kg, can't help water 4 hours when prohibiting after 72 hours, the socket of the eye venous plexus is got blood, the same method is measured blood glucose value, getting the rat of blood glucose value more than 150mg/dL uses for experiment, divide five groups at random by blood glucose value and body weight, every group 10, model group gavages the co-content normal saline, positive controls gavages diabetes pill 1.5g/kg, trial drug big, in, small dose group gavages Folium Caryophylli 3.0g/kg respectively, 2.25g/kg, 1.50g/kg, every day gastric infusion once, successive administration 15 days, per 5 days fasting can't help water after 4 hours the same method measure blood glucose value once, weigh once, and adjust dosage by body weight; Measured one time 24 hours amount of drinking water and food-intake in per 5 days.
The result is as follows:
1. to the influence of blood glucose, the model group blood glucose value significantly raises, blood glucose value continues between 193.72-181.73mg/dL in 15 days, large, medium and small three the dosage groups of diabetes pill and Folium Caryophylli (3.0g/kg, 2.25g/kg, 1.50g/kg) are in administration 15 days, blood glucose value significantly reduces, more all there were significant differences that (P＜0.05-0.01), wherein the heavy dose of group effect of Folium Caryophylli slightly is better than diabetes pill, and sees that Folium Caryophylli is along with the enhanced dose-effect relationship of dosage increase effect with model group.
2. to the influence of body weight, body weight reduced after the model group rat was annotated alloxan, and body weight reduces 50-86g in 15 days after causing hyperglycemia model; Body weight is respectively organized in administration also reduction, but the reduction degree is less than model group, with the model group comparison behind medicine 5-15 days except that low dose other each group significant difference (P＜0.05) is all arranged.As seen this medicine reduces the hyperglycemia model rat body weight certain improvement effect.
3. to the influence of amount of drinking water, anxious gathering of model group rat amount of drinking water after annotating alloxan increases, and amount of drinking water is increased in 179.69%-261.4% in 15 days; Diabetes pill group amount of drinking water also is significantly increased, and recruitment is 103.07-237.4%; The large, medium and small dosage group of Folium Caryophylli (3.0g/kg, 2.25g/kg, 1.50g/kg) amount of drinking water increases obviously and reduces, and increasing only is between the 55%-196.9%.Show that this medicine increases symptom to hyperglycemia model rat amount of drinking water and has clear improvement.
4. to the influence of food-intake, model group increases considerably in the laggard appetite of notes alloxan, relatively increases 81.46%-124.39% in 15 days with before the modeling type; Administration is respectively organized the food-intake increase and is obviously alleviated, and increases 10.34%-92.7% in 15 days, shows that this medicine increases symptom to hyperglycemia model rats eating amount and has clear improvement.
Originally experimental results show that, alloxan induced hyperglycemia rat model blood glucose significantly increases, amount of drinking water, food-intake obviously increase, body weight obviously reduces, this is close with clinical diabetes patient " three-many-one-little " symptom, this medicine can make above-mentioned hyperglycemic rat blood glucose significantly reduce, and symptoms such as amount of drinking water, food-intake increase and body weight reduction are also had clear improvement, and shows that this medical instrument has the pharmacological action of obvious treatment diabetes.
1. the influence of alloxan induced hyperglycemia mice carbohydrate tolerance is tested
Method: body weight 22-30g male mice, fasting be can't help water after 24 hours, by tail vein injection alloxan 80mg/kg, fasting be can't help water 3 hours after 72 hours, get blood by the eye socket venous plexus, press enzyme process and survey blood glucose value, divide five groups at random by blood glucose value and body weight, every group 13, gavage co-content normal saline (model group), diabetes pill 2.0g/kg, Folium Caryophylli 4.5g/kg, 3.0g/kg and 1.5g/kg respectively, 1 hour lumbar injection glucose 2g/kg behind the medicine is in annotating back 60 minutes, 120 minutes the same measuring blood sugar of blood extracting values of sugar.
Result: before annotating glucose, respectively organize the mouse blood sugar value between 128-132mg/dL, all belong to the hyperglycemia model mice, annotate sugar back model group blood glucose value and raise and be 225.06mg/dL, blood glucose value is respectively organized in administration and model group significantly reduces, and is 160.30-191.44mg/dL (P＜0.01-0.05); Blood glucose value fell after rise slowly after model group was annotated glucose, annotate sugar after 2 hours blood glucose still be 189.50mg/dL, administration is respectively organized blood glucose value and is fallen after rise obviously and accelerate, and shows that Folium Caryophylli can make the dosis tolerata of hyperglycemia model mice increase glucose load.
2. to the effect of triglyceride reducing
Experiment showed, that Folium Caryophylli extract can significantly reduce the blood lipid level of high blood lipid model rat, show that this medicine in blood sugar lowering, has the pharmacological action of blood fat reducing.
3. acute toxicity test in mice
Through giving test, give mice one twice-daily gastric infusion with this medicine with Cmax (20%), maximum volume (0.4ml/10g), do not see obvious poisoning symptom, there is not death, so can not survey LD
50Give mice one twice-daily gastric infusion with this medicine with Cmax, maximum volume, recording maximum dosage-feeding is 16g/kg, is equivalent to 106.7 times of clinical day for human beings kilogram dosage.Only appearance activity minimizing, loose stool etc. of animal do not have other poisoning symptoms after the administration, do not have dead, observe female mice weight increase 25.51% after 7 days, male mice weight increase 33.16% is not found macroscopic pathological change through the gross anatomy inspection, and as seen this poison of drug is less.
Embodiment 3, the preparation tablet:
Manufacture method: with clean Folium Caryophylli 1000g, water decocts 2 times, adds 7 times of water gagings at every turn, and the time was respectively 2 hours and 1 hour, and filtrate concentrates, and vacuum drying is pulverized.Technology is aided with additive of tablet and adds as starch, lactose, methylcellulose, bag according to pelletizes such as agent by 80 times of raw material amounts routinely, and tabletting is packed, and the people storehouse promptly makes the medicine of treatment diabetes of the present invention, and this is a tablet.Present embodiment adopts foreign Flos Caryophylli (Syringa vulgaris L).
Embodiment 4, the preparation capsule preparations:
Manufacture method: with clean Folium Caryophylli 1000g, put in the alcohol reaction still, extract with the ethanol circulation, concentrate, vacuum drying is pulverized.Technology is aided with capsule adjuvant such as pelletizes such as starch, microcrystalline Cellulose routinely, and is encapsulated, packing, and the people storehouse promptly makes the medicine of treatment diabetes of the present invention, and this is a capsule.Present embodiment adopts four seasons Flos Caryophyllis (Syringa microphylla).
Embodiment 5, preparation Chinese medicine concentrated pill:
Manufacture method: with clean Folium Caryophylli and root 1000g, be that 50% ethanol decocts 2 times with concentration, add 7 times of amount ethanol at every turn, the time was respectively 2 hours and 1 hour, and filtrate concentrates, vacuum drying, pulverizing.Be aided with pill adjuvant pill with routine techniques by 200 times of amounts of raw material, packing, the people storehouse promptly makes the medicine of treatment diabetes of the present invention, and this is a concentrated pill.Present embodiment adopts Syringa pubescens (Syringa pubescens).
Embodiment 6
Manufacture method: with clean Folium Caryophylli and flower 1000g, water decocts 3 times, adds 5 times of water gagings at every turn, and the time was respectively 1 hour, 0.5 hour and 1 hour, and filtrate is condensed into extractum.Press 300 times of raw material amounts and add adjuvants, drying is pulverized, technology pelletize routinely, and packing, the people storehouse promptly makes the medicine of treatment diabetes of the present invention, and this is a granule.Present embodiment Cai Yong Off East Flos Caryophylli (Syringa velutina).
Embodiment 7
Manufacture method: with clean Folium Caryophylli and fruit 1000g, be that 90% ethanol decocts 1 time with concentration, add 10 times and measure ethanol that the time is 3 hours, filtrate is condensed into extractum.Press 400 times of raw material amounts and add adjuvants, drying is pulverized, technology pelletize routinely, and packing, the people storehouse promptly makes the medicine of treatment diabetes of the present invention, and this is a tablet.Present embodiment adopts Hua Leaf Flos Caryophylli (Syringa persica).
Embodiment 8
Manufacture method: with clean Flos Caryophylli seed 1000g, be that 70% ethanol decocts 3 times with concentration, add 8 times of amount ethanol at every turn, the time was respectively 1 hour, and filtrate concentrates, and vacuum drying is pulverized.Be aided with pill adjuvant pill with routine techniques by 500 times of amounts of raw material, packing, the people storehouse promptly makes the medicine of treatment diabetes of the present invention, and this is a concentrated pill.Present embodiment adopts the seed of Oleaceae genus syringa Japan Flos Caryophylli (Syringa reticulate L).
Claims (10)
1, a kind of control diabetes medicament is characterized in that: be raw material with the genus syringa.
2, by the described medicine of preventing and treating diabetes of claim 1, it is characterized in that: genus syringa is the kind of Oleaceae genus syringa and/or root, stem, leaf, flower, fruit and/or the seed of mutation.
3, by the described medicine of preventing and treating diabetes of claim 1, it is characterized in that: described Oleaceae genus syringa can be Syringa oblata Lindl., Korea Flos Caryophylli, foreign Flos Caryophylli, four seasons Flos Caryophylli, Syringa pubescens, Off East Flos Caryophylli, flower Leaf Flos Caryophylli or Japanese Flos Caryophylli.
4, a kind of preparation method by the described control diabetes medicament of claim 1 is characterized in that: with the genus syringa cleaning, drying, pulverize and make medicinal tea.
5, a kind of preparation method by the described control diabetes medicament of claim 1, it is characterized in that: carry or the alcohol extraction preparation through water, specifically: clean genus syringa is added 5～10 times of water gagings, and water or alcohol decoct 1～3 time, each time was respectively 0.5～2 hour, and filtrate is condensed into extractum.
6, press the preparation method of the described control diabetes medicament of claim 5, it is characterized in that: filtrate is extraordinarily gone into adjuvant by 0.5～500 of raw material after being condensed into extractum, dry, pulverize, technology pelletize routinely is prepared into tablet, granule, capsule, unguentum, pill, mixture, the multiple dosage form of injection.
7, by the preparation method of the described control diabetes medicament of claim 6, it is characterized in that: described adjuvant is that forming agent, filler, disintegrating agent, bag are according to agent, correctives and/or toner.
8, a kind of purposes by the described control diabetes medicament of claim 1 is characterized in that: be used to prevent and treat diabetes.
9, a kind of purposes by the described control diabetes medicament of claim 1 is characterized in that: be used for health product.
10, a kind of by the described purposes of preventing and treating the medicine of diabetes of claim 1, it is characterized in that: be used for triglyceride reducing.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB200510046684XA CN100551391C (en) | 2005-06-15 | 2005-06-15 | A kind of control diabetes medicament and preparation method and application |
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| CNB200510046684XA CN100551391C (en) | 2005-06-15 | 2005-06-15 | A kind of control diabetes medicament and preparation method and application |
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| CN1879702A true CN1879702A (en) | 2006-12-20 |
| CN100551391C CN100551391C (en) | 2009-10-21 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664463B (en) * | 2008-09-04 | 2012-07-25 | 河南大学 | Hypoglycemic active part and hypoglycemic effective component of luculia pinceana, preparation method and application thereof |
| CN104257761A (en) * | 2014-09-30 | 2015-01-07 | 青岛申达高新技术开发有限公司 | Pharmaceutical composition capable of decreasing blood sugar and pharmaceutical applications of pharmaceutical composition |
| CN108056337A (en) * | 2018-01-10 | 2018-05-22 | 广东日可威食品原料有限公司 | A kind of beverage of suitable juvenile healthy weight-reducing |
-
2005
- 2005-06-15 CN CNB200510046684XA patent/CN100551391C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664463B (en) * | 2008-09-04 | 2012-07-25 | 河南大学 | Hypoglycemic active part and hypoglycemic effective component of luculia pinceana, preparation method and application thereof |
| CN104257761A (en) * | 2014-09-30 | 2015-01-07 | 青岛申达高新技术开发有限公司 | Pharmaceutical composition capable of decreasing blood sugar and pharmaceutical applications of pharmaceutical composition |
| CN108056337A (en) * | 2018-01-10 | 2018-05-22 | 广东日可威食品原料有限公司 | A kind of beverage of suitable juvenile healthy weight-reducing |
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| Publication number | Publication date |
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| CN100551391C (en) | 2009-10-21 |
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