CN1872232A - Composition of medication for curing cerebrovascular disease, and preparation method - Google Patents
Composition of medication for curing cerebrovascular disease, and preparation method Download PDFInfo
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- CN1872232A CN1872232A CN 200510013641 CN200510013641A CN1872232A CN 1872232 A CN1872232 A CN 1872232A CN 200510013641 CN200510013641 CN 200510013641 CN 200510013641 A CN200510013641 A CN 200510013641A CN 1872232 A CN1872232 A CN 1872232A
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Abstract
A medicine for coronary heart disease and angina pectoris is disclosed. Its advantages are high natural level and safety and low toxic by-effect.
Description
Technical field
The present invention relates to traditional Chinese compound medicine of a kind of oral administration and preparation method thereof.More particularly, the present invention relates to a kind of is the compound medicine of principal agent with the Chinese medicine Radix Notoginseng, and it is used for the treatment of vascular lesions and hemorrhage thereof, is meant cerebrovascular disease, retinopathy, diabetic angiopathy etc. particularly.
Background technology
Cerebrovascular is one of three big diseases that threaten human health, and its sickness rate is about 2/1000ths, and mortality rate is up to one thousandth point three, and with advancing age, its sickness rate and mortality rate all rise.Control cerebrovascular and sequela thereof are the problems of society.And along with the prolongation of human longevity, the diseases such as visual disorder due to circulatory disturbance, the ophthalmology central retinal vein occlusion such as the hypertension relevant with blood vessel and function thereof, arteriosclerosis become the key factor that has a strong impact on human life quality.Retinopathy (central retinal vein occlusion, diabetic renal papillary necrosis, senile degeneration of macula, central authorities' property retinopathy, retinal vasculitis etc.) is one of commonly encountered diseases of harm humans health, along with China's population senescence, this type of patient will increase year by year.Therefore, press for a kind of applied widely, determined curative effect, Drug therapy vascular lesions and hemorrhage thereof that safety is big.
Developed the medicine of a lot of treatment cerebrovascular abroad, but owing to be chemosynthesis, so side effect is very big.Domestic except chemosynthesis, also have Chinese herbal and crude drugs preparations.Especially over past ten years, form of Chinese drug has obtained develop rapidly, nowadays traditional ball is not only arranged, looses, dosage forms such as pellet, cream, also has dosage forms such as capsule, injection, bag bubble, oral liquid, drop pill.But the Chinese patent medicine of existing treatment cerebrovascular disease mostly is pill and capsule, a kind of treatment cardiovascular and cerebrovascular diseases medicament compositions is disclosed such as CN125 381 3A, this pharmaceutical composition is a capsule formulation, and it is to be prepared from by certain proportioning by the Radix Astragali, Radix Apioris Fortunei (Radix Lespedezae Buergeri), the Cortex Eucommiae, Radix Polygalae fallacis, Herba Capsellae, Radix Polygoni Multiflori Preparata, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, Radix Notoginseng.This medicine be with apoplexy at acute stage and convalescent period syndrome of blood stasis due to qi deficiency serve as the pharmaceutical composition that adapts to the treatment cardiovascular and cerebrovascular disease of disease.CN1 308955A discloses a kind of natural composition of preventing and treating cardiovascular and cerebrovascular disease, this pharmaceutical composition is liquid preparation or capsule etc., and it is to be prepared from according to a certain ratio by nattokinase, Herb Gynostemmae Pentaphylli, Radix Notoginseng, Radix Salviae Miltiorrhizae, Folium Ginkgo, Radix Puerariae, Rhizoma Chuanxiong, Flos Carthami, Fructus Crataegi, sugar tolerance factor.CN1 319404A discloses a kind of medicine for the treatment of coronary heart disease, and it is enough to the medicament that Radix Ginseng, Radix Notoginseng, the Radix Astragali, Pollen Typhae, Radix Salviae Miltiorrhizae, Radix Curcumae are prepared into by certain proportioning, and the dosage form of this medicine is tablet, powder, nine doses, capsule, granule, oral liquid.This medicine be to coronary heart disease, angina pectoris, the heart moon infraction good efficacy is arranged.These Chinese herbal medicine dosage forms of prior art make trouble, and oral dose is big, the patient with after easily cause gastrointestinal upset, absorb slowly, produce effects is slow, stability of drug is poor simultaneously, bioavailability is low.Therefore, people still in the continuous new Chinese herbal medicine dosage form of more effective treatment vascular lesions of research and hemorrhage thereof, solve prior art problems, give clinical quick-acting, the medicine efficiently that many kinds are provided.Application number is 02103920.8, publication number is CN1436549A, denomination of invention is: the patent documentation of a kind of Chinese medicine compound notoginseng dripping pills and preparation method thereof provides a kind of preparation method of drop pill, though having overcome, this method absorbs slowly, produce effects is slow, stability of drug is poor simultaneously, the shortcoming that bioavailability is low, but the used adjuvant of this medicine mostly is chemosynthesis, and people thirst for back to nature more at present, utilize the high Drug therapy of pure natural degree, prevent some chemical synthetic drugs cann't be solved problem, so the application of natural plant exceeds the background of its original traditional national culture.Seeking the little and inexpensive medicine of side effect from natural drug becomes the target that countries in the world pharmaceutical manufacturer is chased, and numerous products that China Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of treatment cerebrovascular disease with new type natural substrate adjuvant preparation.
Another object of the present invention provides a kind of preparation method for the treatment of cerebrovascular drug.
The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
Drug component of the present invention, the selection of consumption and adjuvant thereof also gropes to sum up to draw through the inventor in a large number, this medicine comprises following materials of weight proportions medicine: Radix Notoginseng 200-300 part, Radix Astragali 70-90 part, Radix Salviae Miltiorrhizae 40-60 part, Radix Scrophulariae 70-90 part, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
Preferred medicine of the present invention comprises following materials of weight proportions medicine: Radix Notoginseng 240-260 part, Radix Astragali 75-85 part, Radix Salviae Miltiorrhizae 45-55 part, Radix Scrophulariae 75-85 part, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose.
Best medicine of the present invention comprises following materials of weight proportions medicine: 250 parts of Radix Notoginseng, 80 parts of the Radixs Astragali, 50 parts of Radix Salviae Miltiorrhizaes, 80 parts of Radix Scrophulariaes, appropriate amount of auxiliary materials, filler adjuvant wherein are selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
Best medicine of the present invention comprises following materials of weight proportions medicine: Radix Notoginseng 250, the Radix Astragali 80, Radix Salviae Miltiorrhizae 50, Radix Scrophulariae 80, appropriate amount of auxiliary materials, adjuvant wherein are xylitol and starch mixture or xylitol and arabic gum mixture or are lactose and starch mixture.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
Ratio of adjuvant to the combination that becomes xylitol and starch, lactose and starch, xylitol and arabic gum in, low melting point substrate adjuvant is 1: 0～1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1～1: 0.9, more preferably 1: 0.1～1: 0.5; The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Medicine mesostroma adjuvant of the present invention and amount of drug are than being the scope that allows on the galenic pharmacy, and medicine described here can be that crude drug also can be the effective ingredient extract.
The present invention can make tablet, granule, capsule, pill, oral liquid, disintegrating tablet, micropill, drop pill.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, make dropping pill formulation, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine bring into play drug effect better.
The preparation method of medicine of the present invention is as follows:
(1) take off column weight amount proportion raw material medicine: Radix Notoginseng 200-300 part, Radix Astragali 70-90 part, Radix Salviae Miltiorrhizae 40-60 part, 7090 parts of Radix Scrophulariaes are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50-60% alcohol dipping twice, 4-6 days for the first time, 1-2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50-60% alcohol heating reflux, 2-3 hour for the first time, 1-2 hour for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) get above-mentioned thick paste and suitably adjuvant mixed evenly after, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～115 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred process for preparing medicine of the present invention comprises the following steps:
(1) take off column weight amount proportion raw material medicine: Radix Notoginseng 240-260 part, Radix Astragali 75-85 part, Radix Salviae Miltiorrhizae 45-55 part, Radix Scrophulariae 75-85 part are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50-60% alcohol dipping twice, 4-6 days for the first time, 1-2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50-60% alcohol heating reflux, 2-3 hour for the first time, 1-2 hour for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) getting above-mentioned thick paste mixes with suitable adjuvant, fully mix, mixture stirs at 60～85 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore, splashes in 0～18 ℃ the liquid paraffin, methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
Best process for preparing medicine of the present invention comprises the following steps:
(1) take off column weight amount proportion raw material medicine: 250 parts of Radix Notoginseng, 80 parts of the Radixs Astragali, 50 parts of Radix Salviae Miltiorrhizaes, 80 parts of Radix Scrophulariaes are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50-60% alcohol dipping twice, 4-6 days for the first time, 1-2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50-60% alcohol heating reflux, 2-3 hour for the first time, 1-2 hour for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) get above-mentioned thick paste and suitable adjuvant, fully mix, mixture stirs at 60～68 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 60～68 ℃ of temperature following system, dropper bore, splashes in 0～8 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis substrate adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of drop pill taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that cerebrovascular disease is treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill that this adjuvant is made can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
In order to understand the present invention better, be that (according to application number is 02103920.8 to the substrate adjuvant with medicine of the present invention (according to the preparation of embodiment 5 methods) and with the Polyethylene Glycol below, publication number is CN1436549A, and denomination of invention is: embodiment 1 preparation in the literature method of a kind of Chinese medicine compound notoginseng dripping pills and preparation method thereof) test explanation advantages of the present invention such as different, the drop pill soft durometer of dissolve scattered time limit, the ball method of double differences of the compound recipe notoginseng dripping pills of making, the sticking ball of drop pill, animal experiment study.
Test example 1: dissolve scattered time limit, the different contrast experiment's example of the ball method of double differences
In vitro tests
Medicine of the present invention be that the compound recipe notoginseng dripping pills that adjuvant is made compares with the Polyethylene Glycol, by measuring dissolve scattered time limit, investigate its good releasing effect; By measuring indexs such as the ball method of double differences is different, investigate whether it ripe in preparation technology, whether be fit to suitability for industrialized production.
1. test medication: medicine of the present invention (newly) is the compound recipe notoginseng dripping pills (old) that adjuvant is made with the Polyethylene Glycol.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
The medicine of the present invention (newly) that three batches in table 1 is made with the new medium adjuvant with the Polyethylene Glycol be compound recipe notoginseng dripping pills (old) dissolve scattered time limit made of adjuvant, weight differential relatively
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | |
| Dissolve scattered time limit (newly) (old) | 3′58″ 4′30″ | 3′58″ 4′30″ | 3′59″ 4′31″ | 4′0″ 4′34″ | 4′1″ 4′38″ | 4′3″ 4′39″ | 4′5″ 4′41″ | |
| 2 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (old) | 3′58″ 4′30″ | 3′58″ 4′32″ | 3′58″ 4′32″ | 4′1″ 4′33″ | 4′3″ 4′37″ | 4′5″ 4′39″ | 4′5″ 4′40″ | |
| 3 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (old) | 3′56″ 4′30″ | 3′57″ 4′33″ | 3′58″ 4′32″ | 3′57″ 4′35″ | 4′2″ 4′37″ | 4′3″ 4′40″ | 4′6″ 4′42″ | |
Test data shows, the dissolve scattered time limit of medicine of the present invention is that the compound recipe notoginseng dripping pills made of adjuvant is few with the Polyethylene Glycol, and the ball method of double differences of the two is different all to be controlled in the pharmacopeia prescribed limit.The result of the test explanation, the molten diffusing speed of medicine of the present invention is faster, is more conducive to medicine and plays a role in the shortest time, and the ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
Test example 2: the present invention with the Polyethylene Glycol be the sticking ball comparative observation of compound recipe notoginseng dripping pills soft durometer, drop pill that adjuvant is made
Medicine of the present invention be that the compound recipe notoginseng dripping pills that adjuvant is made compares with the Polyethylene Glycol, by measuring indexs such as above-mentioned, investigate its effect.
1. test medication: medicine of the present invention (newly) is the compound recipe notoginseng dripping pills that adjuvant is made with the Polyethylene Glycol.
2. method and result:
Get medicine of the present invention (newly), be three batches of the compound recipe notoginseng dripping pills made of adjuvant with the Polyethylene Glycol, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the compound recipe notoginseng dripping pills reserved sample observing that adjuvant is made compares with the Polyethylene Glycol
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly | |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 2 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 3 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
Table 2.2: three batches of medicines of the present invention (newly) with the Polyethylene Glycol be compound recipe notoginseng dripping pills (old) character observation made of adjuvant relatively
| 0 month | January | February | March | June | December | 18 months | ||
| Criterion | The result | |||||||
| 1 batch | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | Hard slightly (old) be hard (newly) slightly | |
| 2 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
| 3 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
Above test data shows, the soft durometer that medicine of the present invention is made drop pill changes and be that the compound recipe notoginseng dripping pills made of adjuvant is similar, strong slightly with the Polyethylene Glycol; Drop pill of the present invention glues ball variation, firmness change and is the similar of the compound recipe notoginseng dripping pills made of adjuvant with the Polyethylene Glycol.Presentation of results, medicine of the present invention and Polyethylene Glycol are that the sticking ball of the compound recipe notoginseng dripping pills made of adjuvant changes, firmness change is similar, the alternative present chemosynthesis adjuvant of this natural substrates adjuvant, but suitability for industrialized production.
The specific embodiment
Below in conjunction with embodiment the present invention is done step explanation, following each embodiment only is used to the present invention is described and is not limitation of the present invention.
Embodiment 1
(1) get Radix Notoginseng 250g, Radix Astragali 80g, Radix Salviae Miltiorrhizae 50g, Radix Scrophulariae 50g, xylitol 35g, starch 15g are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 60% alcohol dipping twice, 5 days for the first time, 2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 60% alcohol heating reflux, 3 hours for the first time, 2 hours for the second time, filter, merging filtrate, reclaim ethanol, be condensed into thick paste, standby;
(3) get the xylitol and the starch mixture of above-mentioned thick paste and 2.5 times, fully mix, mixture is at 62～66 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, above-mentioned preparation is moved in the drop pill machine insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～6 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make 1000 drop pill, promptly.
Embodiment 2
(1) get Radix Notoginseng 200g, Radix Astragali 70g, Radix Salviae Miltiorrhizae 40g, Radix Scrophulariae 70g, lactose 23g, starch 7g are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50% alcohol dipping twice, 5 days for the first time, 2 days for the second time, filter, merging filtrate reclaims ethanol, is condensed into thick paste, and is standby; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with 50% alcohol heating reflux twice, are filtered 3 hours first time 2 hours second time, and merging filtrate reclaims ethanol, is condensed into thick paste, and is standby;
(3) get above-mentioned thick paste and adjuvant mixed evenly after, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ the liquid paraffin, make 1000 drop pill, promptly.
Embodiment 3
(1) get Radix Notoginseng 100g, Radix Astragali 50g, Radix Salviae Miltiorrhizae 50g, Radix Scrophulariae 40g, xylitol 20g, arabic gum 8g are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50% alcohol dipping twice, 4 days for the first time, 1 day for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50% alcohol heating reflux, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) get above-mentioned thick paste and adjuvant mixed evenly after, mixture stirs at 115 ℃ of heating and meltings, mixing time is 1～120 minute, and insulation is 1.25～1.5 millimeters at 45～55 ℃ of temperature following system, dropper bore, splash in 5～8 ℃ the vegetable oil, make 1000 drop pill, promptly.
Embodiment 4
(1) get Radix Notoginseng 240g, Radix Astragali 75g, Radix Salviae Miltiorrhizae 45g, Radix Scrophulariae 75g, xylitol 20.8g, xanthan gum 4.2g are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 55% alcohol dipping twice, 5 days for the first time, 2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 60% alcohol heating reflux, 2 hours for the first time, 2 hours for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) getting above-mentioned thick paste and lactose and xanthan gum fully mixes, mixture is at 110～115 ℃ of heating and meltings, stir, mixing time is 5 minutes, insulation, at 85 ℃ of temperature following system, dropper bore is 1.2 millimeters, splash in 0～2 ℃ the liquid paraffin, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make 1000 drop pill, promptly.
Embodiment 5
(1) get Radix Notoginseng 260g, Radix Astragali 85g, Radix Salviae Miltiorrhizae 55g, Radix Scrophulariae 85g, xylitol 45g, starch 15g are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 60% alcohol dipping twice, 4 days for the first time, 1.5 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 55% alcohol heating reflux, 2.5 hours for the first time, 1.5 hours for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) getting above-mentioned thick paste and lactose and starch fully mixes, mixture is at 90～95 ℃ of heating and meltings, stir, mixing time is 30 minutes, insulation, at 55～64 ℃ of temperature following system, dropper bore is 1.8 millimeters, splash in 0～5 ℃ the vegetable oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make 1000 drop pill, promptly.
Embodiment 6
(1) get Radix Notoginseng 80g, Radix Astragali 40g, Radix Salviae Miltiorrhizae 30g, Radix Scrophulariae 30g, sorbitol 18.5g, Furcellaran 3.5g are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 60% alcohol dipping twice, 6 days for the first time, 1 day for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 60% alcohol heating reflux, 3 hours for the first time, 2 hours for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) getting above-mentioned thick paste and adjuvant mixes, fully mix, mixture stirs at 60～85 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore, splashes in 0～18 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made 1000 drop pill, promptly.
Embodiment 7
(1) get Radix Notoginseng 250g, Radix Astragali 80g, Radix Salviae Miltiorrhizae 50g, Radix Scrophulariae 80g, erythritol 20.6g, starch 5.4g are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 60% alcohol dipping twice, 6 days for the first time, 2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50% alcohol heating reflux, 3 hours for the first time, 2 hours for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) get above-mentioned thick paste and adjuvant, fully mix, mixture stirs at 45～95 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 60～68 ℃ of temperature following system, dropper bore, splashes in 0～8 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made 1000 drop pill, promptly.
Embodiment 8
(1) get Radix Notoginseng 25g, Radix Astragali 18g, Radix Salviae Miltiorrhizae 15g, Radix Scrophulariae 10g, lactose 26.4g, granulose 6.4g are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50% alcohol dipping twice, 5 days for the first time, 2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50% alcohol heating reflux, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) get above-mentioned thick paste and and lactose and starch fully mix, mixture is at 55～60 ℃ of heating and meltings, stir, mixing time is 120 minutes, insulation, at 48～55 ℃ of temperature following system, dropper bore is 3.5 millimeters, splash in 2～7 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make 1000 drop pill, promptly.
Embodiment 9
(1) get Radix Notoginseng 50g, Radix Astragali 40g, Radix Salviae Miltiorrhizae 30g, Radix Scrophulariae 30g, xylitol 26.9g, starch 8.1g are standby;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50% alcohol dipping twice, 4 days for the first time, 1 day for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50% alcohol heating reflux, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) getting above-mentioned thick paste and xylitol and starch fully mixes, mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make 1000 drop pill, promptly.
Embodiment 10
It is standby to get thick paste 15g, the xylitol 20.5g, chitin 6.2g, the xanthan gum 4.3g that obtain according to embodiment 1 method;
Xylitol, chitin, xanthan gum are mixed evenly, place in the container, add above-mentioned thick paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 11
It is standby to get thick paste 10g, the Furcellaran 5g, sorbitol 15g, the carboxymethyl starch 3.5g that obtain according to embodiment 2 methods;
Furcellaran, sorbitol, carboxymethyl starch are mixed evenly, place in the container, add above-mentioned thick paste, fully mix, mixture stirs at 58～64 ℃ of heating and meltings, and mixing time is 30～50 minutes, insulation, at 58～64 ℃ of temperature following system, dropper bore is 1.25～2.5 millimeters, splashes in 10 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 12
Get thick paste 8.5g, the xylitol 20.4g, starch 4.1g, the tragakanta 2g that obtain according to embodiment 1 method;
Xylitol, starch, tragakanta are mixed evenly, place in the container, add above-mentioned thick paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 13
It is standby to get thick paste 10g, the xylitol 13.5g, the starch 6g that obtain according to embodiment 2 methods;
In xylitol and starch mixture, add above-mentioned thick paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 14
Get thick paste 8g, the lactose 13.5g, the starch 9g, standby that obtain according to embodiment 3 methods;
In lactose and starch mixture, add above-mentioned thick paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 15
Get 6.75 parts of Radix Angelicae Sinensis in proportion, 6.75 parts of Rhizoma Chuanxiongs, 5.4 parts of the Radix Paeoniae Albas, 5.4 parts in Radix Rehmanniae Preparata, 13.5 parts of Ramulus Uncariae Cum Unciss, 13.5 parts of Caulis Spatholobis, 13.5 parts of Spica Prunellaes, 13.5 parts of Semen Cassiaes, 13.5 parts of Concha Margaritiferas, 6.75 parts of Rhizoma Corydalis, 1.34 parts of Herba Asaris, above medicine adds decocting in water 3 times, each 1 hour, collecting decoction, concentrate an amount of, the ethanol that adds 2 times of amounts, leave standstill 24 hours precipitations, get supernatant concentration and become cream, relative density is 1.3～1.4, paste-forming rate 10%, qinghuo reagent again, sucrose, dextrin mixed oven dry by 1: 3: 1 and makes granule, and the method for preparing disintegrating tablet according to routine is made disintegrating tablet.
Embodiment 16
It is standby to get thick paste 28g, the xylitol 83.3g, the chitin 16.7g that obtain according to embodiment 6 methods;
Get xylitol and chitin mix homogeneously, adding above-mentioned thick paste mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 17
It is standby to get thick paste 18g, the lactose 76.9g, the carrageenan 23.1g that obtain according to embodiment 6 methods;
Get lactose and carrageenan mix homogeneously, adding above-mentioned thick paste fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 18
It is standby to get thick paste 40g, the xylitol 71.4g, the agar 28.6g that obtain according to embodiment 3 methods;
Get xylitol and agar mix homogeneously, adding above-mentioned thick paste fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 19
It is standby to get thick paste 55g, the xylitol 80g, the hydroxypropyl starch 20g that obtain according to embodiment 3 methods;
Get xylitol and hydroxypropyl starch mix homogeneously, adding above-mentioned thick paste fully mixes, mixture stirs at 45～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～70 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in-10～10 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 20
It is standby to get thick paste 25g, the xylitol 62.5g, the cross-linking sodium carboxymethyl cellulose 37.5g that obtain according to embodiment 5 methods;
Get xylitol and cross-linking sodium carboxymethyl cellulose mix homogeneously, add above-mentioned thick paste, mixture stirs at 45～115 ℃ of heating and meltings, and mixing time is 1～30 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 21
It is standby to get thick paste 15g, the trehalose 100g, the hydroxypropyl starch 20g that obtain according to embodiment 1 method;
Get trehalose, hydroxypropyl starch mix homogeneously, add above-mentioned thick paste, mixture stirs at 55～75 ℃ of heating and meltings, and mixing time is 5～12 minutes, insulation, at 55～75 ℃ of temperature following system, dropper bore is 1.20～3.0 millimeters, splashes in 0～15 ℃ the liquid paraffin, makes 1000 balls, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly
Embodiment 22
It is standby to get thick paste 20g, the xylitol 80g, the microcrystalline Cellulose 20g that obtain according to embodiment 1 method;
Get xylitol and microcrystalline Cellulose mixing mixing, add above-mentioned thick paste, mixture stirs at 45～115 ℃ of heating and meltings, mixing time is 5～20 minutes, and insulation is dripped system 58～70 ℃ of insulations, splash in 12 ℃ of liquid paraffin, make drop pill 1000 balls, promptly.
Embodiment 23
It is standby to get thick paste 30g, the xylitol 99g, the pregelatinized Starch 1g that obtain according to embodiment 3 methods;
Get xylitol and pregelatinized Starch mix homogeneously, add above-mentioned thick paste, mixture stirs at 60～755 ℃ of heating and meltings, and mixing time is 10～60 minutes, insulation, at 55～65 ℃ of temperature following system, dropper bore is 1.0～3.5 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 24
It is standby to get thick paste 35g, the trehalose 66g, the starch 34g that obtain according to embodiment 5 methods;
Get mixing of trehalose and starch, add above-mentioned thick paste, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～75 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 25
It is standby to get thick paste 40g, the xylitol 62.5g, the hydroxyethyl-cellulose 37.5g that obtain according to embodiment 1 method;
Get xylitol and hydroxyethyl-cellulose mixing mixing, add above-mentioned thick paste, mixture stirs at 60～80 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the liquid paraffin, makes 1000 balls, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 26
It is standby to get thick paste 45g, the xylitol 80g, the alginic acid 20g that obtain according to embodiment 1 method;
Get xylitol and alginic acid mixing mixing, add above-mentioned thick paste, mixture stirs at 70～75 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～75 ℃ of temperature following system, dropper bore is 1.21～3.5 millimeters, splashes in 0～15 ℃ the methyl-silicone oil, makes 1000 balls, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 27
It is standby to get thick paste 50g, the xylitol 166g, the sodium carboxymethyl cellulose 34g that obtain according to embodiment 1 method;
Get xylitol and sodium carboxymethyl cellulose mix homogeneously, add above-mentioned thick paste, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～20 minutes, insulation, at 60～75 ℃ of temperature following system, dropper bore is 1.5～3.5 millimeters, splashes in 10～18 ℃ the liquid paraffin, makes 1000 balls, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 28
It is standby to get thick paste 35g, the lactose 40g, the agar 10g that obtain according to embodiment 7 methods;
Get lactose and agar mix homogeneously, add above-mentioned thick paste, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 63～67 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 4 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 29
It is standby to get thick paste 55g, the xylitol 85g, the methylcellulose 15g that obtain according to embodiment 8 methods;
Get xylitol and methylcellulose mix homogeneously, add above-mentioned thick paste, mixture stirs at 55～85 ℃ of heating and meltings, and mixing time is 5～30 minutes, insulation, at 58～68 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 30
It is standby to get thick paste 60g, the lactose 70g, the hydroxypropyl emthylcellulose 20g that obtain according to embodiment 3 methods;
Getting lactose and hydroxypropyl emthylcellulose mixes, add above-mentioned thick paste, fully mix, mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, and insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splash in 0 ℃ the methyl-silicone oil, make 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 31
It is standby to get thick paste 70g, the xylitol 60g, the methylcellulose 40g that obtain according to embodiment 1 method;
Get xylitol and methylcellulose mixing, adding above-mentioned thick paste fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, asks to be 10～30 minutes during stirring, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 32
It is standby to get thick paste 150g, the sorbitol 150g, the crospolyvinylpyrrolidone 50g that obtain according to embodiment 9 methods;
Get sorbitol and crospolyvinylpyrrolidone mixing, adding above-mentioned thick paste fully mixes, mixture stirs at 58～78 ℃ of heating and meltings, and mixing time is 20～50 minutes, insulation, at 58～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0～10 ℃ the methyl-silicone oil, makes 10000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 33
It is standby to get thick paste 55g, the xylitol 55g, the sodium stearate 5g that obtain according to embodiment 1 method;
Get xylitol and sodium stearate mixing, adding above-mentioned thick paste fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 15～25 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0～15 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 34
It is standby to get thick paste 10g, the sodium stearate 83.3g, the carbomer 16.7g that obtain according to embodiment 1 method;
Get carbomer and carbomer mix homogeneously, adding above-mentioned thick paste fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 35
It is standby to get thick paste 20g, the tristerin 76.9g, the acrylic resin 23.1g that obtain according to embodiment 1 method;
Get tristerin and acrylic resin mix homogeneously, adding the above-mentioned thick paste that obtains according to embodiment 1 method fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Claims (10)
1, a kind of pharmaceutical composition for the treatment of cerebrovascular disease, its feature is comprising following materials of weight proportions medicine: Radix Notoginseng 200-300 part, Radix Astragali 70-90 part, Radix Salviae Miltiorrhizae 40-60 part, Radix Scrophulariae 70-90 part, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
2, pharmaceutical composition as claimed in claim 1, its feature is comprising following materials of weight proportions medicine: Radix Notoginseng 240-260 part, Radix Astragali 75-85 part, Radix Salviae Miltiorrhizae 45-55 part, Radix Scrophulariae 75-85 part, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose.
3, pharmaceutical composition as claimed in claim 2, its feature is comprising following materials of weight proportions medicine: Radix Notoginseng 250, the Radix Astragali 80, Radix Salviae Miltiorrhizae 50, Radix Scrophulariae 80, appropriate amount of auxiliary materials, adjuvant wherein are xylitol and starch mixture or xylitol and arabic gum mixture or are lactose and starch mixture.
4, as each described pharmaceutical composition in the claim 1～3, it is characterized in that described adjuvant is xylitol and starch, xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Perhaps be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Perhaps be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
5, the pharmaceutical composition as controlling as described in the claim 1,2 or 3 is characterized in that the substrate adjuvant and the ratio of the weight of drug extract are 1: 0.1～1: 1.
6, pharmaceutical composition as claimed in claim 5 is characterized in that the substrate adjuvant and the ratio of the weight of drug extract are 1: 0.1～1: 0.6.
7, pharmaceutical composition as claimed in claim 6 is characterized in that the substrate adjuvant and the ratio of the weight of drug extract are 1: 0.2～1: 0.4.
8, a kind of preparation of drug combination method for the treatment of cerebrovascular disease comprises the following steps:
(1) it is standby to get Radix Notoginseng 200-300 part, Radix Astragali 70-90 part, Radix Salviae Miltiorrhizae 40-60 part, Radix Scrophulariae 70-90 part;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50-60% alcohol dipping twice, 4-6 days for the first time, 1-2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50-60% alcohol heating reflux, 2-3 hour for the first time, 1-2 hour for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) get above-mentioned thick paste and suitably adjuvant mixed evenly after, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～115 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
9, preparation of drug combination method as claimed in claim 7 comprises the following steps:
(1) it is standby to get Radix Notoginseng 240-260 part, Radix Astragali 75-85 part, Radix Salviae Miltiorrhizae 45-55 part, Radix Scrophulariae 75-85 part;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50-60% alcohol dipping twice, 4-6 days for the first time, 1-2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50-60% alcohol heating reflux, 2-3 hour for the first time, 1-2 hour for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) getting above-mentioned thick paste mixes with suitable adjuvant, fully mix, mixture stirs at 60～85 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore, splashes in 0～18 ℃ the liquid paraffin, methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
10, preparation of drug combination method as claimed in claim 9, it comprises the following steps:
(1) it is standby to get 250 parts of Radix Notoginseng, 80 parts of the Radixs Astragali, 50 parts of Radix Salviae Miltiorrhizaes, 80 parts of Radix Scrophulariaes;
(2) Radix Notoginseng in the above-mentioned four Chinese medicine is pulverized, with 50-60% alcohol dipping twice, 4-6 days for the first time, 1-2 days for the second time, filter merging filtrate, be condensed into thick paste, standby, with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavors with twice of 50-60% alcohol heating reflux, 2-3 hour for the first time, 1-2 hour for the second time, filter merging filtrate, be condensed into thick paste, standby;
(3) get above-mentioned thick paste and suitable adjuvant, fully mix, mixture stirs at 60～68 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 60～68 ℃ of temperature following system, dropper bore, splashes in 0～8 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2005100136411A CN1872232B (en) | 2005-06-01 | 2005-06-01 | Composition of medication for curing cerebrovascular disease, and preparation method |
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| CN2005100136411A CN1872232B (en) | 2005-06-01 | 2005-06-01 | Composition of medication for curing cerebrovascular disease, and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406923A (en) * | 2010-09-26 | 2012-04-11 | 湖北国力生物技术开发有限公司 | Three Chinese medicaments capable of improving activity of nattokinase |
| CN108404048A (en) * | 2018-04-28 | 2018-08-17 | 李太平 | A kind of formula of hypoglycemic body health ball |
| CN114848744A (en) * | 2022-04-26 | 2022-08-05 | 杭州市中医院 | Traditional Chinese medicine composition for treating qi deficiency and blood stasis type coronary heart disease and preparation method thereof |
-
2005
- 2005-06-01 CN CN2005100136411A patent/CN1872232B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406923A (en) * | 2010-09-26 | 2012-04-11 | 湖北国力生物技术开发有限公司 | Three Chinese medicaments capable of improving activity of nattokinase |
| CN108404048A (en) * | 2018-04-28 | 2018-08-17 | 李太平 | A kind of formula of hypoglycemic body health ball |
| CN114848744A (en) * | 2022-04-26 | 2022-08-05 | 杭州市中医院 | Traditional Chinese medicine composition for treating qi deficiency and blood stasis type coronary heart disease and preparation method thereof |
| CN114848744B (en) * | 2022-04-26 | 2023-08-15 | 杭州市中医院 | Traditional Chinese medicine composition for treating qi deficiency and blood stasis type coronary heart disease and preparation method thereof |
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| Publication number | Publication date |
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| CN1872232B (en) | 2011-07-20 |
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