CN1872230A - A medication for treating coronary heart disease, angina pectoris, and preparation method - Google Patents
A medication for treating coronary heart disease, angina pectoris, and preparation method Download PDFInfo
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- CN1872230A CN1872230A CN 200510013599 CN200510013599A CN1872230A CN 1872230 A CN1872230 A CN 1872230A CN 200510013599 CN200510013599 CN 200510013599 CN 200510013599 A CN200510013599 A CN 200510013599A CN 1872230 A CN1872230 A CN 1872230A
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- radix
- adjuvant
- starch
- xylitol
- medicine
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Landscapes
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Abstract
A medicine for coronary heart disease and angina pectoris is disclosed. Its advantages are high natural level and safety and low toxic by-effect.
Description
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is the treatment treating coronary heart disease and angina pectoris preparation that raw material is made.
Background technology
Coronary heart disease also claims ischemic heart desease, since its sickness rate height, the mortality rate height, and the healthy of the mankind in serious harm, thereby b referred to as " the first human killers ".Angina pectoris is a coronary insufficiency, and cardiac muscle is rapid, of short duration ischemia and the caused clinical syndrome of anoxia.Angina pectoris is the coronary heart disease common sympton, be more common in more than 40 years old in, the old people, the male is more than the women.Angina pectoris usually occurs in fatigue, heavy meal, catch cold and when excited, vexed pain, squeezing pain or constriction that the right occurrence scope of metosteon is not clear, and pain is shoulder, middle finger, the third finger and little finger of toe radiation to the right.At present, it is more to be used for the treatment for the treatment of coronary heart disease and angina pectoris, though Western medicine is rapid-action, curative effect is determined, but the influence of its toxic and side effects, make the patient when curing a kind of disease, the misery that faces other be arranged, and present most of Chinese medicine preparation ubiquity curative effect instability, curative effect is low, onset is slow, consumption is many shortcoming.
The synthetic chemical substance that modern medicine is commonly used has spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people thirst for back to nature more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The purpose of this invention is to provide a kind of is the treatment coronary heart disease of feedstock production, anginal medicine with new type natural substrate adjuvant and Radix Notoginseng, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae.
Another object of the present invention provides a kind of preparation method for the treatment of coronary heart disease, angina drug preparation.
The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
Drug component of the present invention, the selection of consumption and adjuvant thereof also gropes to sum up to draw through the inventor in a large number, this medicine comprises the medicine composition of following weight proportion: 32.6～82.6 parts of Radix Notoginseng, 6.5～32.6 parts of the Radixs Astragali, Radix Salviae Miltiorrhizae 4.3-17.3 part, 6.5～32.6 parts of Radix Scrophulariaes, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose;
Preferred medicine of the present invention comprises the medicine composition of following weight proportion: 39.3～71.7 parts of Radix Notoginseng, 10.9～26.1 parts of the Radixs Astragali, 6.5～13 parts of Radix Salviae Miltiorrhizaes, 10.9～26.1 parts of Radix Scrophulariaes, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose;
Best medicine of the present invention comprises that the medicine of following weight proportion forms: 54.4 parts of Radix Notoginseng, 17.3 parts of the Radixs Astragali, 11 parts of Radix Salviae Miltiorrhizaes, 17.3 parts of Radix Scrophulariaes, appropriate amount of auxiliary materials, filler adjuvant wherein are selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Medicine mesostroma adjuvant of the present invention and amount of drug are than can being the scope that allows on the galenic pharmacy, medicine described here can be that crude drug also can be the effective ingredient extract, in order to adapt to industrialized great production, the ratio range of mesostroma adjuvant of the present invention and medicine refers to the weight proportion of adjuvant and extract drugs extractum, and adjuvant is 1: 0.1～1: 1 with the weight sum ratio that Radix Notoginseng, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae extract extractum; Preferred adjuvant is 1: 0.1～1: 0.6 with the weight sum ratio that Radix Notoginseng, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae extract extractum; Best adjuvant is 1: 0.2～1: 0.4 with the weight sum ratio that Radix Notoginseng, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae extract extractum.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But in order to make each crude drug of this medicine better bring into play drug effect, preferably adopt following technology to extract, make following preparation, but this can not limit protection scope of the present invention raw material.
The preparation method of medicine of the present invention is as follows:
(a) take off the medicine of column weight amount proportioning: 32.6～82.6 parts of Radix Notoginseng, 6.5～32.6 parts of the Radixs Astragali, Radix Salviae Miltiorrhizae 4.3-17.3 part, 6.5～32.6 parts of Radix Scrophulariaes are standby;
(b) earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in appropriate amount of auxiliary materials, add above-mentioned thick paste, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred process for preparing medicine of the present invention comprises that the mixture heated melt temperature is 60～85 ℃, and mixing time is 10～30 minutes, and dripping a system temperature and be 60～85 ℃, dropper bore is 1.1～3.5 millimeters, and condensing agent is 0～18 ℃ liquid paraffin or a methyl-silicone oil.
Best process for preparing medicine of the present invention comprises that the mixture heated melt temperature is 65 ℃, and dripping a system temperature and be 65 ℃, dropper bore is 1.2～2.5 millimeters, and condensing agent is 0 ℃ a methyl-silicone oil.
The best preparation method of medicine of the present invention is:
(a): the medicine that takes off column weight amount proportioning: 54.4 parts of Radix Notoginseng, 17.3 parts of the Radixs Astragali, 11 parts of Radix Salviae Miltiorrhizaes, 17.3 parts of Radix Scrophulariaes are standby;
(b): earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): to ratio an amount of, weight is 1: 0.2～1: 0.3 xylitol and starch mixture; Or the ratio of weight is 1: 0.2～1: 0.3 lactose and starch mixture; Or the ratio of weight is to add above-mentioned thick paste in 1: 0.2～1: 0.4 xylitol and the arabic gum mixture, fully mix, move in the reservoir, mixture stirs at 65 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 65 ℃ of temperature following system, dropper bore and splashes in 0 ℃ the methyl-silicone oil, and liquid coolant is use up and wiped to the drop pill drop of formation, back packing to be dried is made drop pill promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of drop pill taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that coronary heart disease, angina pectoris, myocardial ischemia are treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill made from this adjuvant can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
In order to understand the present invention better, below with adopting the pharmaceutical preparation (being called for short medicine of the present invention) of making according to the present invention of embodiment 1 method preparation, and be that dissolve scattered time limit, the weight differential comparative test that adjuvant is made medicine (abbreviation dripping pills for dredging thrombus) illustrates advantage of the present invention according to document with the Polyethylene Glycol with new substrate.
Test example 1: dissolve scattered time limit, weight differential contrast experiment's example
In vitro tests
Medicine of the present invention and dripping pills for dredging thrombus compare, and by indexs such as mensuration dissolve scattered time limits, investigate its good releasing effect; Whether by weight differential, it is ripe to investigate its preparation technology, whether is fit to suitability for industrialized production.
1. test medication: medicine of the present invention is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; Dripping pills for dredging thrombus prepares according to literature method.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
The medicine of the present invention that three batches in table 1 is made with the new medium adjuvant with the Polyethylene Glycol be the dripping pills for dredging thrombus dissolve scattered time limit made of adjuvant, weight differential relatively
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | |
| Dissolve scattered time limit (newly) (old) | 3′15″ 4′22″ | 3′16″ 4′26″ | 3′18″ 4′21″ | 3′14″ 4′24″ | 3′18″ 4′30″ | 3′22″ 4′29″ | 3′17″ 4′30″ | |
| 2 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (old) | 3′17″ 4′21″ | 3′21″ 4′24″ | 3′22″ 4′25″ | 3′15″ 4′21″ | 3′12″ 4′29″ | 3′15″ 4′30″ | 3′16″ 4′31″ | |
| 3 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (old) | 3′15″ 4′20″ | 3′14″ 4′21″ | 3′16″ 4′25″ | 3′22″ 4′28″ | 3′17″ 4′29″ | 3′15″ 4′29″ | 3′18″ 4′30″ |
Result of the test shows, the dissolve scattered time limit of medicine of the present invention is that the XUESHUANTONG made of adjuvant is few with the Polyethylene Glycol, and the medicine of the present invention and the dripping pills for dredging thrombus ball method of double differences are different all to be controlled in the pharmacopeia prescribed limit.Presentation of results, the molten diffusing speed of the medicine made from novel adjuvant of the present invention is faster, is more conducive to medicine and plays a role in the shortest time; The ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, and the difference not statistically significant illustrates the alternative present chemosynthesis adjuvant of this natural substrates adjuvant, but suitability for industrialized production.
Test example 2: the soft durometer of medicine of the present invention and dripping pills for dredging thrombus, the sticking ball comparative observation of drop pill
1. reagent: medicine of the present invention, dripping pills for dredging thrombus.
2. method and result: three batches of the things of getting it filled are loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the dripping pills for dredging thrombus reserved sample observing that adjuvant is made compares with the Polyethylene Glycol
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly | |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 2 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 3 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
Table 2.2: the three batches of medicines of the present invention with the Polyethylene Glycol be the XUESAITONG drop pill character observation made of adjuvant relatively
| 0 month | January | February | March | June | December | 18 months | ||
| Criterion | The result | |||||||
| 1 batch | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
| 2 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
| 3 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) do not glue (newly) slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly |
Test data shows, the soft durometer of medicine of the present invention changes and be that the dripping pills for dredging thrombus made of adjuvant is similar, strong slightly with the Polyethylene Glycol; The drop pill of medicine of the present invention glues ball variation, firmness change and is that the dripping pills for dredging thrombus made of adjuvant is similar with the Polyethylene Glycol.Presentation of results, medicine of the present invention changes to the sticking ball of dripping pills for dredging thrombus, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
(a) get Radix Notoginseng 54.4g, Radix Astragali 17.3g, Radix Salviae Miltiorrhizae 11g, Radix Scrophulariae 17.3g, xylitol 23.5g, starch 12.7g are standby;
(b) earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in appropriate amount of auxiliary materials, add above-mentioned thick paste, fully mix, fully mix, mixture is at 65 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, and insulation is 1.2～2.5 millimeters at 65 ℃ of temperature following system, dropper bore, splash in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, and 1000 drop pill are made in back packing to be dried.
Embodiment 2
(a) get Radix Notoginseng 82.6g, Radix Astragali 6.5g, Radix Salviae Miltiorrhizae 4.3g, Radix Scrophulariae 32.6g, xylitol 23.5g, starch 12.7g are standby;
(b) earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in xylitol and starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 65 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 65 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1500 drop pill promptly.
Embodiment 3
(a): get Radix Notoginseng 50g, Radix Astragali 30g, Radix Salviae Miltiorrhizae 15g, Radix Scrophulariae 25g, xylitol 57.1g, arabic gum 22.9g are standby;
(b): above four flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid,, filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys), add a spot of kieselguhr, it is standby that (80 ℃) are evaporated to the clear paste of relative density 1.20～1.25 (60 ℃ of surveys); The Radix Astragali, Radix Scrophulariae be with the alcohol heating reflux secondary, filters, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 clear paste;
(c): in xylitol and arabic gum mixture, add above-mentioned clear paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 2000 drop pill promptly.
Embodiment 4
(a): get Radix Notoginseng 70g, Radix Astragali 20g, Radix Salviae Miltiorrhizae 10g, Radix Scrophulariae 18g, xylitol 59.2g, starch 14.8g are standby;
(b): above four flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.05 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 80% alcohol reflux secondary, each 2 hours, merge extractive liquid,, filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.10～1.20 (60 ℃ of surveys), add a spot of kieselguhr, it is standby that (80 ℃) are evaporated to the clear paste of relative density 1.10～1.20 (60 ℃ of surveys); The Radix Astragali, Radix Scrophulariae be with the alcohol heating reflux secondary, filters, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 clear paste;
(c): in xylitol and starch mixture, add the said extracted thing, fully mix, mixture stirs at 85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60 ℃ of temperature following system, dropper bore is 1.1～1.4 millimeters, splashes in 5～8 ℃ the liquid paraffin, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 3000 drop pill promptly.
Embodiment 5
(a): get Radix Notoginseng 40g, Radix Astragali 6.5g, Radix Salviae Miltiorrhizae 4.3g, Radix Scrophulariae 6.5g, xylitol 736g, starch 184g are standby;
(b): above four flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 90 minutes, filter, filtrate merges, and reclaims ethanol and continues to be condensed into clear paste, and is standby; Radix Notoginseng powder is broken into coarse powder, 80～95% alcohol reflux secondaries, and each 3 hours, merge extractive liquid, filtered, filtrate recycling ethanol, and continue to be condensed into clear paste, and adding a spot of kieselguhr, concentrating under reduced pressure becomes clear paste standby; The Radix Astragali, Radix Scrophulariae be with the alcohol heating reflux secondary, filters, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 clear paste;
(c): in xylitol and starch mixture, add above-mentioned clear paste, mixture is at 60～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, and insulation is 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore, splash in 8～12 ℃ the liquid paraffin, liquid coolant is use up and wiped to the drop pill drop that forms, and back packing to be dried is made 30000 drop pill promptly.
Embodiment 6
(a): get Radix Notoginseng 28g, Radix Astragali 26.1g, Radix Salviae Miltiorrhizae 6.5g, Radix Scrophulariae 10.9g, xylitol 14.2g, starch 5.8g are standby;
(b): earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in xylitol and starch mixture, add above-mentioned thick paste, fully mix, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 120 minutes, insulation, at 80 ℃ of temperature following system, dropper bore is 1.1～2.5 millimeters, splashes in 12～18 ℃ the liquid paraffin, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 7
(a): get Radix Notoginseng 71.7g, Radix Astragali 10.9g, Radix Salviae Miltiorrhizae 6.5g, Radix Scrophulariae 10.9g, lactose 16.4g, starch 12.2g are standby;
(b): earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in lactose and starch mixture, add above-mentioned thick paste, fully mix, mixture stirs at 70～85 ℃ of heating and meltings, mixing time is 5 minutes, insulation is 1.2～3.0 millimeters at 60 ℃ of temperature following system, dropper bore, splashes in 8～12 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000 drop pill promptly.
Embodiment 8
(a): get Radix Notoginseng 39.3g, Radix Astragali 15g, Radix Salviae Miltiorrhizae 15g, Radix Scrophulariae 15g, lactose 60.8g, xanthan gum 15.2g are standby;
(b): earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in lactose, xanthan gum mixtures, add above-mentioned thick paste, fully mix, mixture stirs at 85 ℃ of heating and meltings, mixing time is 12 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in-15 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, back packing to be dried is made 2000 drop pill promptly.
Embodiment 9
(a): get Radix Notoginseng 54.4g, Radix Astragali 17.3g, Radix Salviae Miltiorrhizae 11g, Radix Scrophulariae 17.3g, xylitol 56g, starch 14g are standby;
(b): above four flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 50 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.10～1.15 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 80% alcohol reflux secondary, each 1.5 hours, merge extractive liquid,, filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 110～1.15 (60 ℃ of surveys), add a spot of kieselguhr, it is standby that (80 ℃) are evaporated to the clear paste of relative density 1.20～1.25 (60 ℃ of surveys); The Radix Astragali, Radix Scrophulariae be with the alcohol heating reflux secondary, filters, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): add the said extracted thing in xylitol and starch mixture, fully mix, mixture is at 65 ℃ of heating and meltings, stir, mixing time is 20 minutes, and insulation is 1.21～2.5 millimeters at 60 ℃ of temperature following system, dropper bore, splash in 0 ℃ the methyl-silicone oil, pour in the dish that is lined with absorbent paper back packing to be dried into the drop pill drop that forms to the greatest extent and wipe liquid coolant,, make 1000g grain drop pill, promptly.
Embodiment 10
(a): get Radix Notoginseng 45g, Radix Astragali 20g, Radix Salviae Miltiorrhizae 8g, Radix Scrophulariae 12g, xylitol 72.7g, starch 7.2g are standby;
(b): earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): add above-mentioned thick paste in xylitol and starch mixture, fully mix, mixture is at 115 ℃ of heating and meltings, stir, mixing time is 5 minutes, and insulation is 1.3～3.5 millimeters at 45 ℃ of temperature following system, dropper bore, splash in 8～12 ℃ the vegetable oil, pour in the dish that is lined with absorbent paper back packing to be dried into the drop pill drop that forms to the greatest extent and wipe liquid coolant,, make 1000 drop pill, promptly.
Embodiment 11
(a): get Radix Notoginseng 36g, Radix Astragali 25g, Radix Salviae Miltiorrhizae 12g, Radix Scrophulariae 25g, xylitol 45g, arabic gum 5.9g are standby;
(b): earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): add above-mentioned thick paste in xylitol and arabic gum mixture, fully mix, mixture is at 100 ℃ of heating and meltings, stir, mixing time is 3 minutes, and insulation is 1.1～2.5 millimeters at 95 ℃ of temperature following system, dropper bore, splash in 8～12 ℃ the liquid paraffin, pour in the dish that is lined with absorbent paper back packing to be dried into the drop pill drop that forms to the greatest extent and wipe liquid coolant,, make 1000 drop pill, promptly.
Embodiment 12
(a): get Radix Notoginseng 75g, Radix Astragali 30g, Radix Salviae Miltiorrhizae 1g, Radix Scrophulariae 32g, xylitol 50g, Furcellaran 9g, methylcellulose 5.5g is standby;
(b): earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in xylitol, Furcellaran and methylcellulose mixture, add above-mentioned thick paste, fully mix, mixture stirs at 90 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.1～3.5 millimeters at 85 ℃ of temperature following system, dropper bore and splashes in-5～8 ℃ the methyl-silicone oil, and liquid coolant is use up and wiped to the drop pill drop of formation, pour in the dish that is lined with absorbent paper, back packing to be dried is made 2000 drop pill, promptly.
Embodiment 13
(a): get Radix Notoginseng 82.6g, Radix Astragali 17.3g, Radix Salviae Miltiorrhizae 11g, Radix Scrophulariae 17.3g, sorbitol 65g, xanthan gum 5.5g, modified starch 9.5g is standby;
(b): earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in sorbitol, xanthan gum and modified starch mixture, add above-mentioned thick paste, fully mix, mixture stirs at 60～85 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.1～2.5 millimeters at 60～85 ℃ of temperature following system, dropper bore and splashes in 8～12 ℃ the liquid paraffin, and liquid coolant is use up and wiped to the drop pill drop of formation, pour in the dish that is lined with absorbent paper, back packing to be dried is made 3000 drop pill, promptly.
Embodiment 14
(a): get Radix Notoginseng 71.7g, Radix Astragali 26.1g, Radix Salviae Miltiorrhizae 13g, Radix Scrophulariae 26.1g, xylitol 35g, chitin 25g are standby;
(b): above four flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid,, filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys), add a spot of kieselguhr, it is standby that (80 ℃) are evaporated to the clear paste of relative density 1.20～1.25 (60 ℃ of surveys); The Radix Astragali, Radix Scrophulariae be with the alcohol heating reflux secondary, filters, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c) in xylitol and chitin mixture, add the said extracted thing, fully mix, mixture stirs at 75 ℃ of heating and meltings, mixing time is 20 minutes, insulation is 1.4～2.5 millimeters at 75 ℃ of temperature following system, dropper bore and splashes in 0 ℃ the liquid paraffin, and liquid coolant is use up and wiped to the drop pill drop of formation, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000 drop pill, promptly.
Embodiment 15
(a): get Radix Notoginseng 39.3g, Radix Astragali 10.9g, Radix Salviae Miltiorrhizae 6.5g, Radix Scrophulariae 10.9g, sorbitol 535g, sodium stearate 65g, cyclodextrin 115g is standby;
(b): above four flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 90 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.15～1.35, and is standby; Radix Notoginseng powder is broken into coarse powder, 80% alcohol reflux secondary, each 3 hours, merge extractive liquid,, filter, filtrate recycling ethanol, and continue to be concentrated at 60 ℃, the clear paste of relative density 1.25～1.35, add a spot of kieselguhr, be evaporated at 60 ℃, the clear paste of relative density 1.25～1.35 standby; The Radix Astragali, Radix Scrophulariae be with the alcohol heating reflux secondary, filters, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in sorbitol, cyclodextrin and sodium stearate mixture, add above-mentioned thick paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.25～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 8～12 ℃ the liquid paraffin, liquid coolant is use up and wiped to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, back packing to be dried is made 20000 drop pill promptly.
Embodiment 16
(a): get Radix Notoginseng 60g, Radix Astragali 25g, Radix Salviae Miltiorrhizae 7.5g, Radix Scrophulariae 15g, xylitol 60g, alginic acid 7.3g are standby;
(b): above four flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 75 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.05～1.15, and is standby; Radix Notoginseng powder is broken into coarse powder, 75% alcohol reflux secondary, each 2.5 hours, merge extractive liquid,, filter, filtrate recycling ethanol, and continue to be concentrated at 60 ℃, the clear paste of relative density 1.05～1.15, add a spot of kieselguhr, be evaporated at 60 ℃, the clear paste of relative density 1.25～1.35 standby; The Radix Astragali, Radix Scrophulariae be with the alcohol heating reflux secondary, filters, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in xylitol, alginic acid mixture, add the said extracted thing, fully mix, mixture stirs at 80 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, be 2.0～3.5 millimeters at 64 ℃ of temperature following system, dropper bore and splash in 12～20 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, pour in the dish that is lined with absorbent paper, back packing to be dried is made 3000 drop pill promptly.
Embodiment 17
Get and obtain according to embodiment 1 method
Thick paste 15g, xylitol 20.5g, chitin 6.2g, xanthan gum 4.3g be standby;
Xylitol, chitin, xanthan gum are mixed evenly, place in the container, add above-mentioned thick paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 18
It is standby to get thick paste 10g, the Furcellaran 5g, sorbitol 15g, the carboxymethyl starch 3.5g that obtain according to embodiment 2 methods;
Furcellaran, sorbitol, carboxymethyl starch are mixed evenly, place in the container, add above-mentioned thick paste, fully mix, mixture stirs at 58～64 ℃ of heating and meltings, and mixing time is 30～50 minutes, insulation, at 58～64 ℃ of temperature following system, dropper bore is 1.25～2.5 millimeters, splashes in 10 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 19
Get thick paste 8.5g, the xylitol 20.4g, starch 4.1g, the tragakanta 2g that obtain according to embodiment 3 methods;
Xylitol, starch, tragakanta are mixed evenly, place in the container, add above-mentioned thick paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 20
It is standby to get thick paste 10g, the xylitol 13.5g, the starch 9g that obtain according to embodiment 4 methods;
In xylitol and starch mixture, add above-mentioned thick paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 21
Get and obtain according to embodiment 3 methods
Thick paste 8g, lactose 13.5g, starch 9g be standby;
In lactose and starch mixture, add above-mentioned thick paste, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000 drop pill promptly.
Embodiment 22
It is standby to get thick paste 28g, the xylitol 83.3g, the chitin 16.7g that obtain according to embodiment 6 methods;
Get xylitol and chitin mix homogeneously, adding above-mentioned thick paste mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 4000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 23
It is standby to get thick paste 18g, the lactose 76.9g, the carrageenan 23.1g that obtain according to embodiment 16 methods;
Get lactose and carrageenan mix homogeneously, adding above-mentioned thick paste fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 5000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 24
It is standby to get thick paste 40g, the xylitol 71.4g, the agar 28.6g that obtain according to embodiment 13 methods;
Get xylitol and agar mix homogeneously, adding above-mentioned thick paste fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 5000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 27
It is standby to get thick paste 55g, the xylitol 80g, the hydroxypropyl starch 20g that obtain according to embodiment 10 methods;
Get xylitol and hydroxypropyl starch mix homogeneously, adding above-mentioned thick paste fully mixes, mixture stirs at 45～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～70 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in-10～10 ℃ the methyl-silicone oil, makes 5000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 28
It is standby to get thick paste 25g, the xylitol 62.5g, the cross-linking sodium carboxymethyl cellulose 37.5g that obtain according to embodiment 5 methods;
Get xylitol and cross-linking sodium carboxymethyl cellulose mix homogeneously, add above-mentioned thick paste, mixture stirs at 45～115 ℃ of heating and meltings, and mixing time is 1～30 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 4000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 29
It is standby to get thick paste 15g, the trehalose 100g, the hydroxypropyl starch 20g that obtain according to embodiment 1 method;
Get trehalose, hydroxypropyl starch mix homogeneously, add above-mentioned thick paste, mixture stirs at 55～75 ℃ of heating and meltings, and mixing time is 5～12 minutes, insulation, at 55～75 ℃ of temperature following system, dropper bore is 1.20～3.0 millimeters, splashes in 0～15 ℃ the liquid paraffin, makes 4000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly
Embodiment 30
It is standby to get thick paste 20g, the xylitol 80g, the microcrystalline Cellulose 20g that obtain according to embodiment 11 methods;
Get xylitol and microcrystalline Cellulose mixing mixing, add above-mentioned thick paste, mixture stirs at 45～115 ℃ of heating and meltings, mixing time is 5～20 minutes, and insulation is dripped system 58～70 ℃ of insulations, splash in 12 ℃ of liquid paraffin, make 4000 drop pill of drop pill, promptly.
Embodiment 31
It is standby to get thick paste 30g, the xylitol 99g, the pregelatinized Starch 10g that obtain according to embodiment 8 methods;
Get xylitol and pregelatinized Starch mix homogeneously, add above-mentioned thick paste, mixture stirs at 60～75 ℃ of heating and meltings, and mixing time is 10～60 minutes, insulation, at 55～65 ℃ of temperature following system, dropper bore is 1.0～3.5 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 4000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 33
It is standby to get thick paste 3.5g, the trehalose 16.6g, the starch 3.4g that obtain according to embodiment 15 methods;
Get mixing of trehalose and starch, add above-mentioned thick paste, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～75 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 33
It is standby to get thick paste 4.0g, the xylitol 22.5g, the hydroxyethyl-cellulose 7.5g that obtain according to embodiment 1 method;
Get xylitol and hydroxyethyl-cellulose mixing mixing, add above-mentioned thick paste, mixture stirs at 60～80 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 34
It is standby to get thick paste 4.5g, the xylitol 18.0g, the alginic acid 5.0g that obtain according to embodiment 1 method;
Get xylitol and alginic acid mixing mixing, add above-mentioned thick paste, mixture stirs at 70～75 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～75 ℃ of temperature following system, dropper bore is 1.21～3.5 millimeters, splashes in 0～15 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 35
It is standby to get thick paste 5.0g, the xylitol 16.6g, the sodium carboxymethyl cellulose 3.4g that obtain according to embodiment 1 method;
Get xylitol and sodium carboxymethyl cellulose mix homogeneously, add above-mentioned thick paste, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～20 minutes, insulation, at 60～75 ℃ of temperature following system, dropper bore is 1.5～3.5 millimeters, splashes in 10～18 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 36
It is standby to get thick paste 3.5g, the lactose 24.0g, the agar 5.0g that obtain according to embodiment 1 method;
Get lactose and agar mix homogeneously, add above-mentioned thick paste, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 63～67 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 4 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 37
It is standby to get thick paste 5.5g, the xylitol 18.5g, the methylcellulose 6.5g that obtain according to embodiment 1 method;
Get xylitol and methylcellulose mix homogeneously, add above-mentioned thick paste, mixture stirs at 55～85 ℃ of heating and meltings, and mixing time is 5～30 minutes, insulation, at 58～68 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 38
It is standby to get thick paste 6.0g, the lactose 27.0g, the hydroxypropyl emthylcellulose 12.0g that obtain according to embodiment 3 methods;
Getting lactose and hydroxypropyl emthylcellulose mixes, add above-mentioned thick paste, fully mix, mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, and insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splash in 0 ℃ the methyl-silicone oil, make 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 39
It is standby to get thick paste 7.0g, the xylitol 16.0g, the methylcellulose 4.0g that obtain according to embodiment 1 method;
Get xylitol and methylcellulose mixing, adding above-mentioned thick paste fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 40
It is standby to get thick paste 15g, the sorbitol 15g, the crospolyvinylpyrrolidone 5g that obtain according to embodiment 1 method;
Get sorbitol and crospolyvinylpyrrolidone mixing, adding above-mentioned thick paste fully mixes, mixture stirs at 58～78 ℃ of heating and meltings, and mixing time is 20～50 minutes, insulation, at 58～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0～10 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 41
It is standby to get thick paste 9.5g, the xylitol 25.5g, the sodium stearate 5.0g that obtain according to embodiment 1 method;
Get xylitol and sodium stearate mixing, adding above-mentioned thick paste fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 15～25 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0～15 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Claims (10)
1, a kind of pharmaceutical composition, this medicine of its feature comprises the medicine composition of following weight proportion: 32.6～82.6 parts of Radix Notoginseng, 6.5～32.6 parts of the Radixs Astragali, Radix Salviae Miltiorrhizae 4.3-17.3 part, 6.5～32.6 parts of Radix Scrophulariaes, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
2, pharmaceutical composition as claimed in claim 1, this medicine of its feature comprises the medicine composition of following weight proportion: 39.3～71.7 parts of Radix Notoginseng, 10.9～26.1 parts of the Radixs Astragali, 6.5～13 parts of Radix Salviae Miltiorrhizaes, 10.9～26.1 parts of Radix Scrophulariaes, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose.
3, pharmaceutical composition as claimed in claim 2, this medicine of its feature comprises that the medicine of following weight proportion forms: 54.4 parts of Radix Notoginseng, 17.3 parts of the Radixs Astragali, 11 parts of Radix Salviae Miltiorrhizaes, 17.3 parts of Radix Scrophulariaes, appropriate amount of auxiliary materials, filler adjuvant wherein are selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
4, pharmaceutical composition as claimed in claim 3 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Perhaps be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Perhaps be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
5,, it is characterized in that adjuvant and the weight sum ratio that Radix Notoginseng, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae extract extractum are 1: 0.1～1: 1 as claim 1,2 or 3 described pharmaceutical compositions.
6,, it is characterized in that adjuvant and the weight sum ratio that Radix Notoginseng, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae extract extractum are 1: 0.1～1: 0.6 as claim 1,2 or 3 described pharmaceutical compositions.
7,, it is characterized in that adjuvant and the weight sum ratio that Radix Notoginseng, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae extract extractum are 1: 0.2～1: 0.4 as claim 1,2 or 3 described pharmaceutical compositions.
8, a kind of preparation of drug combination method is characterized in that this method comprises the steps:
(a) take off the medicine of column weight amount proportioning: 32.6～82.6 parts of Radix Notoginseng, 6.5～32.6 parts of the Radixs Astragali, Radix Salviae Miltiorrhizae 4.3-17.3 part, 6.5～32.6 parts of Radix Scrophulariaes are standby;
(b) earlier Radix Notoginseng powder is broken into coarse powder, with alcohol dipping ultrasonic extraction secondary, filters, merging filtrate reclaims ethanol, is condensed into thick paste; The Radix Astragali, Radix Salviae Miltiorrhizae, Radix Scrophulariae three flavor medical materials filter with the alcohol heating reflux secondary, and merging filtrate reclaims ethanol, and to be concentrated into relative density be 1.20～1.35 thick paste;
(c): in appropriate amount of auxiliary materials, add above-mentioned thick paste, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
9, preparation of drug combination method as claimed in claim 8, it is characterized in that the mixture heated melt temperature is 60～85 ℃, mixing time is 10～30 minutes, dripping the system temperature and be 60～85 ℃, dropper bore is 1.1～3.5 millimeters, and condensing agent is 0～18 ℃ liquid paraffin or a methyl-silicone oil.
10, preparation of drug combination method as claimed in claim 9 is characterized in that the mixture heated melt temperature is 65 ℃, and dripping a system temperature and be 65 ℃, dropper bore is 1.2～2.5 millimeters, and condensing agent is 0 ℃ a methyl-silicone oil.
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| CN2005100135993A CN1872230B (en) | 2005-06-01 | 2005-06-01 | A medication for treating coronary heart disease and preparation method |
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| CN2005100135993A CN1872230B (en) | 2005-06-01 | 2005-06-01 | A medication for treating coronary heart disease and preparation method |
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| CN1872230B CN1872230B (en) | 2011-10-05 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716254B (en) * | 2009-12-30 | 2010-12-01 | 广东众生药业股份有限公司 | Compound thrombus-clearing Chinese medicinal preparation and preparation method thereof |
| CN101716253B (en) * | 2009-12-30 | 2010-12-01 | 广东众生药业股份有限公司 | Chinese medicinal preparation containing panax notoginseng, and preparation method thereof |
-
2005
- 2005-06-01 CN CN2005100135993A patent/CN1872230B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716254B (en) * | 2009-12-30 | 2010-12-01 | 广东众生药业股份有限公司 | Compound thrombus-clearing Chinese medicinal preparation and preparation method thereof |
| CN101716253B (en) * | 2009-12-30 | 2010-12-01 | 广东众生药业股份有限公司 | Chinese medicinal preparation containing panax notoginseng, and preparation method thereof |
Also Published As
| Publication number | Publication date |
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| CN1872230B (en) | 2011-10-05 |
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