CN1857627A - Apoplexy treating Chinese medicine preparation and its preparing process - Google Patents

Apoplexy treating Chinese medicine preparation and its preparing process Download PDF

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CN1857627A
CN1857627A CN 200610200338 CN200610200338A CN1857627A CN 1857627 A CN1857627 A CN 1857627A CN 200610200338 CN200610200338 CN 200610200338 CN 200610200338 A CN200610200338 A CN 200610200338A CN 1857627 A CN1857627 A CN 1857627A
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rhizoma gastrodiae
radix
ramulus uncariae
uncariae cum
cum uncis
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CN1857627B (en
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周强
王利平
王井洪
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GUIYANG LIDUO DRUG TECHNOLOGY DEVELOPMENT Co Ltd
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GUIYANG LIDUO DRUG TECHNOLOGY DEVELOPMENT Co Ltd
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Abstract

The present invention provides a kind of apoplexy treating Chinese medicine preparation and its preparation process. The Chinese medicine preparation is prepared with Aleppo avens and gastrodia tuber as basic material and other 13 kinds of optional Chinese medicinal materials, including eucommia bark, hooked uncaria, giant knotweed, etc. The Chinese medicine preparation has the functions of calming wind, dredging meridian passage, promoting blood circulation to disperse blood clots, and relieving pain. It is used in treating apoplexy in recovery stage and apoplexy sequela, and is safe and effective.

Description

Chinese medicine preparation of treatment apoplexy and preparation method thereof
Technical field: the present invention relates to a kind of Chinese medicine preparation for the treatment of apoplexy and preparation method thereof, belong to technical field of Chinese medicines.
Background technology: apoplexy is person in middle and old age's commonly encountered diseases, a frequently-occurring disease, is that the world today endangers one of 3 kinds of maximum diseases to the mankind, has many " four is high by more than the one " characteristics of sickness rate height, mortality rate height, disability rate height, relapse rate height and complication.Apoplexy occupies second in the cause of death of China, be only second to malignant tumor, and some cities, the north have risen to first.China should disease sickness rate be 120～1,80/,100,000, mortality rate is about 60～1,20/,100,000, that is to say, China's annual New Development apoplexy case 1,500,000, it is nearly 1,000,000 to die from apoplexy person every year, number of patients is especially up to more than nearly 1,000,000 people.The 3/4 labour force's forfeiture that has in various degree in the survivor, severe disabled person accounts for more than 40%.There is 500,000 people morbidity every year in the U.S., wherein 150,000 people's death, need among the survivor Medicare have 200 surplus ten thousand people.In recent years, because the raising of treatment level, the mortality rate of apoplexy decreases, but disability rate is still high, and about 80% survivor still has dysfunction in various degree, and promptly apoplexy sequela has brought white elephant for patient family and society.Therefore reduce disability rate, improving rehabilitation speed is the task of top priority for the treatment of primary disease at present.Apoplexy sequela comprises cerebral hemorrhage in modern medicine, cerebral thrombosis, and cerebral embolism, cerebral vasospasm and subarachnoid hemorrhage etc. are sick plants, mainly show as quadriplegia, aphasia, facial hemiparalysis, dysphagia, bradyphrenia, association's difficulty, hypomnesis, irritated depression etc.
This Chinese medicine preparation is made up of flavour of a drug such as Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, the Cortex Eucommiae, largespike woodnettle root, Rhizoma Polygoni Cuspidati, has expelling wind and activating blood circulation, the effect of the meridian and relieving pain that relaxes.The one side of something that is used for stroke in convalescent stage and apoplexy sequela is unable, numb limbs and tense tendons, and myalgia, Light-headedness, language is unable etc.The development and use of this medicine will provide a kind of new Chinese medicine of safe, effective, quality controllable treatment apoplexy for market, help the human beings'health cause, will produce good social benefit and economic benefit.
Summary of the invention:
The objective of the invention is to: a kind of Chinese medicine preparation for the treatment of apoplexy and preparation method thereof is provided, it is the primary raw material medicine that the present invention selects Radix seu Herba Gei aleppici and Rhizoma Gastrodiae for use, perhaps use with medical material compatibilities such as the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, have the endogenous wind stopping collateral dredging, the effect of blood circulation promoting and blood stasis dispelling, the one side of something that is used for stroke in convalescent stage and apoplexy sequela is unable, numb limbs and tense tendons, myalgia, Light-headedness, language is unable etc.
The present invention constitutes like this: it is mainly made by the crude drug of following weight ratio example: Radix seu Herba Gei aleppici 20%～90% and Rhizoma Gastrodiae 10%～80%.
Consumption is preferably: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g.
The preparation method of this medicine is: gets Rhizoma Gastrodiae and pulverizes, cross 100 mesh sieves, and standby; Radix seu Herba Gei aleppici decocts with water 2 times, decocts 2 hours at every turn, filters, and it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Perhaps get Radix seu Herba Gei aleppici and Rhizoma Gastrodiae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
Drug component of the present invention also can be Radix seu Herba Gei aleppici 10%～80%, Rhizoma Gastrodiae 10%～70%, Ramulus Uncariae Cum Uncis 10%～60%.
Be preferably: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g.
The preparation method of this medicine is: gets Rhizoma Gastrodiae and pulverizes, cross 100 mesh sieves, and standby; Radix seu Herba Gei aleppici and Ramulus Uncariae Cum Uncis decoct with water 2 times, decoct 2 hours at every turn, filter, and it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae and Ramulus Uncariae Cum Uncis, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
Drug component of the present invention can also be Radix seu Herba Gei aleppici 10%～70%, Rhizoma Gastrodiae 10%～50%, Ramulus Uncariae Cum Uncis 10%～40%, the Cortex Eucommiae 10%～30%.
Be preferably: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g, Cortex Eucommiae 67g.
The preparation method of this medicine is: gets Rhizoma Gastrodiae and pulverizes, cross 100 mesh sieves, and standby; Radix seu Herba Gei aleppici, Ramulus Uncariae Cum Uncis and the Cortex Eucommiae decoct with water 2 times, decoct 2 hours at every turn, filter, and it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis and the Cortex Eucommiae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
Drug component of the present invention can also be Radix seu Herba Gei aleppici 5%～30%, Rhizoma Gastrodiae 4%～25%, Ramulus Uncariae Cum Uncis 3%～15%, largespike woodnettle root 5%～40%, Radix Salviae Miltiorrhizae 5%～30%, the Radix Astragali 5%～40%, Fructus Ligustri Lucidi 4%～25%, Caulis Spatholobi 5%～30%, Spica Prunellae 5%～40%.
Be preferably: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 200g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Fructus Ligustri Lucidi 133g, Caulis Spatholobi 167g, Spica Prunellae 200g.
The preparation method of this medicine is: gets Rhizoma Gastrodiae and pulverizes, cross 100 mesh sieves, and standby; Radix seu Herba Gei aleppici, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae decoct with water 2 times, decoct 2 hours at every turn, filter, and it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
Drug component of the present invention can also be Radix seu Herba Gei aleppici 5%～30%, Rhizoma Gastrodiae 4%～20%, Ramulus Uncariae Cum Uncis 2%～10%, largespike woodnettle root 5%～40%, Rhizoma Polygoni Cuspidati 5%～40%, Radix Salviae Miltiorrhizae 5%～30%, the Radix Astragali 5%～40%, Fructus Ligustri Lucidi 4%～20%, Caulis Spatholobi 5%～30%, Spica Prunellae 5%～40%.
Be preferably: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 200g, Rhizoma Polygoni Cuspidati 200g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Fructus Ligustri Lucidi 133g, Caulis Spatholobi 167g, Spica Prunellae 200g.
The preparation method of this medicine is: gets Rhizoma Gastrodiae and pulverizes, cross 100 mesh sieves, and standby; Radix seu Herba Gei aleppici, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae decoct with water 2 times, decoct 2 hours at every turn, filter, and it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
Drug component of the present invention can also be Radix seu Herba Gei aleppici 5%～30%, Rhizoma Gastrodiae 4%～20%, the Cortex Eucommiae 2%～10%, Ramulus Uncariae Cum Uncis 2%～15%, largespike woodnettle root 5%～40%, Radix Salviae Miltiorrhizae 5%～30%, the Radix Astragali 5%～40%, Folium Ilicis 2%～10%, Flos Carthami 2%～10%, Spica Prunellae 5%～40%, Herba Lycopodii 2%～10%.
Be preferably: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Cortex Eucommiae 67g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 200g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Folium Ilicis 53g, Flos Carthami 53g, Spica Prunellae 200g, Herba Lycopodii 53g.
The preparation method of this medicine is: gets Rhizoma Gastrodiae and pulverizes, cross 100 mesh sieves, and standby; Radix seu Herba Gei aleppici, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ilicis, Flos Carthami, Spica Prunellae and Herba Lycopodii decoct with water 2 times, decoct 2 hours at every turn, filter, and it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ilicis, Flos Carthami, Spica Prunellae and Herba Lycopodii, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
Drug component of the present invention may further be Radix seu Herba Gei aleppici 5%～20%, Rhizoma Gastrodiae 3%～15%, the Cortex Eucommiae 2%～10%, Ramulus Uncariae Cum Uncis 3%～10%, largespike woodnettle root 5%～25%, Rhizoma Polygoni Cuspidati 5%～25%, Radix Salviae Miltiorrhizae 4%～20%, the Radix Astragali 5%～25%, Fructus Ligustri Lucidi 3%～15%, Caulis Spatholobi 4%～20%, Folium Ilicis 2%～8%, Flos Carthami 2%～8%, Spica Prunellae 5%～25%, Herba Lycopodii 2%～8%, Lycopodium clavatum 2%～8%.
Be preferably: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Cortex Eucommiae 67g, largespike woodnettle root 200g, Rhizoma Polygoni Cuspidati 200g, Ramulus Uncariae Cum Uncis 100g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Fructus Ligustri Lucidi 133g, Caulis Spatholobi 167g, Folium Ilicis 53g, Flos Carthami 53g, Spica Prunellae 200g, Herba Lycopodii 53g, Lycopodium clavatum 53g.
The preparation method of this medicine is: gets Rhizoma Gastrodiae and pulverizes, cross 100 mesh sieves, and standby; Radix seu Herba Gei aleppici, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi, Folium Ilicis, Flos Carthami, Spica Prunellae, Herba Lycopodii and Lycopodium clavatum decoct with water 2 times, the each decoction 2 hours, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi, Folium Ilicis, Flos Carthami, Spica Prunellae, Herba Lycopodii and Lycopodium clavatum, decoct with water 2 times, the each decoction 2 hours, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
Chinese medicine preparation of the present invention is granule, powder, oral liquid, mixture, syrup, soft extract, pill, various tablet, hard capsule, soft capsule or drop pill and other peroral dosage form.
Side of the present invention separates: apoplexy is because QI and blood is disorderly contrary, produces wind, fire, expectorant, the stasis of blood, causes outside resistance of brain BI-syndrome involved the blood vessels or the blood oozing from the body openings or subcuta neous tissue brain feeling pulse.Clinical with unexpected confused servant, hemiplegia, dispute not tiltedly, speech stuttering puckery or in silence, hemianesthesia is primary symptom.Primary disease roughly is equivalent to the ischemic and the hemorrhagic apoplexy of doctor trained in Western medicine.Apoplexy is many to cause stagnation of blood stasis, accumulation of phlegm-heat in the interior because of long-pending damage just declines, overstrain internal injury, eating and drinking without temperance, emotional stress etc., or hyperactive liver-YANG causing syndrome of liver-wind, bleeding resulting from adverse flow of QI, and causes that resistance of brain BI-syndrome involved the blood vessels or blood oozing from the body openings or subcuta neous tissue brain feeling pulse send out outward.Its inducement is common: the weather cataclysm, to bother excessively, and feelings will swashs mutually, falls to pounce on and exerts wound etc.The apoplexy position is at brain, and is closely related with the heart, kidney,liver,spleen.Its pathogenesis has void (deficiency of YIN, the deficiency of vital energy), fire (liver-fire, heart-fire), wind (liver-wind, exogenous wind), expectorant (wind-phlegm, damp-phlegm), gas (QI rising in reverse order), blood (blood stasis) six ends, and interacts reciprocal causation under certain condition.Characteristic of disease mostly is deficiency in origin and excess in superficiality, upper excess and lower deficiency, originally lacks for the hepatic and renal YIN deficiency, QI and blood decline, and is designated as fire and wind stirring up each other, phlegm-damp heap soil or fertilizer over and around the roots Sheng, stagnation of blood stasis, QI and blood against random.Its basic pathogenesis then is that QI and blood is contrary disorderly, on disturb in brain.The treatment of apoplexy, acute stage, worked as based on eliminating evil, methods such as suppressing the hyperactive liver to relieve the wind syndrome, removing heat-phlegm commonly used, the pain of reducing phlegm internal organs, promoting blood circulation to remove obstruction in the collateral, consciousness and resuscitation restoring.Excess syndrome of stroke is controlled with the eliminating evil refreshment of having one's ideas straightened out, and the depletion syndrome is controlled with strengthening body resistance, rescuing YIN recuperating depleted YANG.Convalescent period and sequela phase, control suitable strengthening vital QI to eliminate pathogenic factors, methods such as nourishing YIN commonly used relieves dizziness, high fever, infantile convulsions, epilepsy, etc., benefiting QI for activating blood circulation.
We are monarch drug with the Radix seu Herba Gei aleppici, and merit is at checking hyperfunction of the liver for relieving convulsion, promoting blood circulation to remove blood stasis, heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Being equipped with Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae is ministerial drug, because Rhizoma Gastrodiae endogenous wind stopping spasmolytic, and Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion, the two increases the checking hyperfunction of the liver for relieving convulsion effect of its monarch drug jointly, the Rhizoma Gastrodiae tool eliminating impediment effect of dispeling the wind simultaneously; The largespike woodnettle root expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, the Rhizoma Polygoni Cuspidati blood circulation promoting and blood stasis dispelling, heat clearing away, dampness removing, detoxifcation, the Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, three flavors help monarch to increase the merit of promoting blood circulation to remove blood stasis; In the side in addition Caulis Spatholobi, Herba Lycopodii, Lycopodium clavatum, the Radix Astragali, Spica Prunellae be messenger drug, wherein Caulis Spatholobi, Herba Lycopodii, the nourshing blood and promoting blood circulation of Lycopodium clavatum tool, the effect of channels sootheing and network vessel quickening, Radix Astragali invigorating the spleen and replenishing QI, benefit is defended consolidating superficial resistance, the Spica Prunellae mass dissipating and swelling eliminating; All the other are adjuvant drug, the wherein Cortex Eucommiae, Fructus Ligustri Lucidi invigorating the liver and kidney, the clear sharp head of Folium Ilicis, Flos Carthami promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.All medicines are harmonious, and play expelling wind and activating blood circulation altogether, the merit of the meridian and relieving pain that relaxes.
Function of the present invention cures mainly: Chinese medicine preparation of the present invention has the endogenous wind stopping collateral dredging, the effect of blood circulation promoting and blood stasis dispelling, and the one side of something that is used for stroke in convalescent stage and apoplexy sequela is unable, numb limbs and tense tendons, myalgia, Light-headedness, language is unable etc.
In order to verify that medicine of the present invention has excellent curative, the applicant has carried out series of experimental research, and is specific as follows:
Pharmacodynamics test:
(1) the present invention (Rhizoma Gastrodiae piracetam) capsule is to the influence test of rat cerebral ischemia
Test unit: pharmacology teaching and research room of Zunyi Medical College
1. experiment material
(1) animal: the SD rat, body weight 250-300 gram, male; Kunming mouse 18-22 gram, male and female half and half provide by big level ground hospital of Third Military Medical University Experimental Animal Center, the quality certification number: CSXK (Chongqing) 2002003.
(2) medicine and reagent: be subjected to reagent: the Rhizoma Gastrodiae Piracetam Capsule is provided by Guiyang Liduo Drug Technology Development Co., Ltd., lot number: 0051001.Specification is the 0.4g/ grain, and distilled water preparation suspension is standby.Positive control drug: nimodipine is Zhengda Qingchunbao Pharmaceutical Co., Ltd's product, lot number: 0507001.Red tetrazolium (TTC): Ling Jin Fine Chemical Co., Ltd in Shanghai provides lot number: 20050508.
(3) instrument: BS110S precise electronic balance (Beijing Sai Duolisi joint-stock company), SHA-C temperature controlled water bath oscillator (sky, Shenzhen Nan Shenghai north industrial corporation), LXJ-B low speed large capacity centrifuge (going up Hai'an booth instrument and equipment factory), 7170 type full automatic biochemical apparatus (Hitachi, Ltd) etc.
2. experimental technique
2.1 mice anoxia enduring experiment
2.1.1 mice normal pressure anoxia enduring experiment: get 50 of mices, be divided into 5 groups at random, blank group, Rhizoma Gastrodiae Piracetam Capsule low dose group (0.375/kg), middle agent group (0.75/kg), high dose group (1.5/kg), nimodipine group (0.006/kg).Gastric infusion, every day 1 time, successive administration 5 days, behind the last administration 1h, place the 125ml wide mouthed bottle of demarcating through capacity respectively, the built-in 10g sodica calx of bottle, from being closed to the time of respiratory arrest, result and matched group are relatively in bottle for vaseline sealing bottleneck, mensuration mice.
2.1.2 cerebral anoxia experiment due to the mice broken end: grouping and medication are with 1.1.Behind the last administration 1h, break end rapidly, write down and dehisce to breathe the persistent period after each mice breaks end in the mouse ear bottom.
2.2 the Rhizoma Gastrodiae Piracetam Capsule is to the influence of middle cerebral artery focal ischemia
2.2.1 animal grouping and administration: get male SD rat, divide 5 groups at random, be respectively sham operated rats, model control group (middle cerebral artery infraction group) is subjected to the reagent low dose group, is subjected to dosage group in the reagent, is subjected to the reagent high dose group, positive drug control group.
2.2.2 modelling: adopt suture method to prepare the middle cerebral artery cerebral infarction models, the SD rat, 10% chloral hydrate (350-400mg/kg) intraperitoneal anesthesia along cervical region medisection skin, separates right common carotid artery, and neck reaches internal carotid artery outward.Common carotid artery closes with the bulldog clamp folder, and external carotid artery is cut off in the ligation of external carotid artery distal end, and nylon wire is inserted by external carotid artery, along internal carotid artery, goes into cranium through foramen lacerum, is inserted into middle cerebral artery, and insertion depth is 17-20mm, intraluminal middle cerebral artery occlusion in rats infraction 24h.
It is total only to peel off neck behind the sham operated rats rat anesthesia, reach external carotid artery and not ligation in the neck, model control group (MCAO): rat is only accepted middle cerebral artery infraction 24 hours, be subjected to the basic, normal, high dosage group of reagent (being respectively 0.375g/kg, 0.75g/kg, 1.5g/kg), every day, gastric infusion was 1 time, successive administration 5 days, and the last administration is after 1 hour, carried out intraluminal middle cerebral artery occlusion in rats infraction 24 hours, gastric infusion is once again for postoperative 6 hours and 24 hours.
2.2.3 the scoring of apoplexy nervous symptoms: modelling finishes the method that Bederson is pressed in the back, and every animal is marked.Divide 3 grades according to its symptom degree, totally 10 minutes.Concrete methods of marking is as follows:
Method Symptom Classification Mark
1,+2+,3+4 1. mentions rat tails, and rat is liftoff about a chi, and the normal rat forelimb is stretched downwards.2. put animal in smooth flat, push the side respectively with hands.3. put animal and observe its walking in smooth earth 1, the interior medial rotations of offside forelimb are received and are damaged back offside muscular strength decline after the damage of 2,3,4 test feminine genders, easily topple over animal to the side disturbance of consciousness of turn-taking, death to offside 0 grade 1 grade 2 grades 3 grades 0136 10
2.2.4 cerebral infarct size is measured: the rat broken end is got brain, brain is put 20min in-20 ℃ of refrigerators, removes olfactory bulb, behind cerebellum and the low brain stem, on average cuts five cuttves along coronalplane.Rapidly the brain sheet is placed 5ml then, concentration is that 2% red tetrazolium (contains 0.1mol/L K 2HPO 4) in the solution, 37 ℃ of incubation 30min of lucifuge, stir once every 7-8min therebetween, after dyed, normal cerebral tissue is rose, and infarct is organized as white, and digital camera take a picture to be observed behind the ischemic region area white infarct district carefully dug down and weighed, and it is an infarction size to account for the cerebral infarction percentage calculation with blocking tissue's weight.
2.2.5 the cerebral tissue pathological tissue is observed: behind the rat cerebral ischemia, broken end is got brain and was placed 4% paraformaldehyde phosphate buffer fixed pattern 24 hours, rat crown position section, get moving infarct cerebral tissue in the brain, every thickness is 2mm, paraffin embedding, 5 μ m serial section, conventional H E dyeing.
2.2.6 hemorheology index is measured: the intraluminal middle cerebral artery occlusion in rats infraction is after 24 hours, with 10% chloral hydrate (400mg/kg) intraperitoneal anesthesia, abdominal aortic blood 5ml is injected into anticoagulant in vitro, measures its different blood viscosities and hemorheological indexes with the hemorheology instrument.
2.2.7 Serum LDH determination of activity: intraluminal middle cerebral artery occlusion in rats was blocked after 24 hours, after 10% chloral hydrate (400mg/kg) intraperitoneal anesthesia, and abdominal aortic blood, Hitachi's full automatic biochemical apparatus is measured the Serum LDH activity.
2.3 the Rhizoma Gastrodiae Piracetam Capsule is to the cerebral index of bilateral ligation ischemia-reperfusion, the influence of cerebral edema
Grouping and administration be with 1.1, and the last administration is after 1 hour, 10% chloral hydrate (400mg/kg) intraperitoneal anesthesia, and folder closes bilateral common carotid arteries 30min, pours into 24 hours again, and broken end is got brain and is placed and remove the following position of brain stem on the ice pan and weigh the calculating cerebral index rapidly.Cerebral tissue is weighed to be placed in 105 ℃ of baking boxs and is baked to constant weight on the left of getting, and calculates its brain water content.
Cerebral index=full brain weight/body weight * 100%
Brain water content=cutaneous horn weight-brain stem weight/cutaneous horn is heavy
3. experimental result
3.1 the Rhizoma Gastrodiae Piracetam Capsule is to the influence of mice normal pressure anoxia enduring: can prolong the time-to-live (P＜0.05) of normobaric hypoxia mice with matched group comparison Rhizoma Gastrodiae Piracetam Capsule high dose group; In, low dose group and matched group relatively, the mice time-to-live prolongs to some extent, but does not have significant difference, the results are shown in Table 1.
Table 1 Rhizoma Gastrodiae Piracetam Capsule is to the influence of mice normobaric hypoxia
Group Dosage (g/kg) Number of animals (only) Time-to-live (min)
Dosage group high dose group nimodipine in the matched group low dose group 0.375 0.75 1.5 0.012 10 10 10 10 10 37.2±11.4 41.7±10.3 44.4±11.4 46.6±9.7* 46.1±10.2*
Compare * p＜0.05 with matched group.
3.2 the Rhizoma Gastrodiae Piracetam Capsule is to the breathe influence of time of mice broken end: with matched group relatively, the middle and high dosage group of Rhizoma Gastrodiae Piracetam Capsule all can obviously prolong dehisce the time of breathing (P＜0.05) of broken end back mice, the results are shown in Table 2:
Table 2 Rhizoma Gastrodiae Piracetam Capsule is to the influence of mice broken end hypoxic-ischemic
Group Dosage (g/kg) Number of animals (only) (s) dehisces the time of breathing
Dosage group high dose group nimodipine group in the matched group low dose group 0.325 0.75 1.5 0.006 10 10 10 10 10 16.8±2.04 17.5±2.14 19.5±2.7* 19.2±2.3* 18.9±2.1*
Compare * p＜0.05 with matched group.
3.3 the Rhizoma Gastrodiae piracetam is to the influence of focal rats with cerebral ischemia nervous symptoms and cerebral infarction scope: scoring of sham operated rats rat nervous symptoms and cerebral infarct size are 0, obvious neurological handicap symptom and focus of infarct in various degree appear in the model control group rat, compare with model control group, the administration of Rhizoma Gastrodiae Piracetam Capsule 0.75g/kg, 1.5g/kg group can obviously reduce the infraction degree, its nervous symptoms also obviously improves (p＜0.05), the results are shown in Table 3.
Table 3 Rhizoma Gastrodiae piracetam is to the influence of focal rats with cerebral ischemia cerebral infarction scope and nervous symptoms
Group Dosage (g/kg) Cerebral infarction scope (%) Nervous symptoms scoring (score value)
Dosage group high dose group nimodipine in the sham operated rats model group low dose group 0.375 0.75 1.5 0.012 0±0 17±8.5 12±9.5 9.0±9.5* 7.2±10* 3.7±5.1* 0±0 6.2±2.3 4.5±3.4 3.4±2.1* 2.9±2.2* 2.8±1.9*
Compare * p＜0.05 with model group; (n=10, X ± s)
3.4 the Rhizoma Gastrodiae Piracetam Capsule is to the hemorheological influence of focal rats with cerebral ischemia: with the blank group relatively, model control group plasma viscosity, the high, medium and low index of cutting of whole blood all raise, basic, normal, high dosage group of Rhizoma Gastrodiae Piracetam Capsule and model group be more above-mentioned all reduction, not statistically significant (p＞0.05).But Rhizoma Gastrodiae Piracetam Capsule high dose all reduces (p＜0.05) to erythrocyte aggregation index, erythrodegeneration index and erythrocyte rigidity index, and all the other do not have obviously influence, the results are shown in Table 4.
Table 4 Rhizoma Gastrodiae Piracetam Capsule is to the hemorheological influence of focal rats with cerebral ischemia
Group Plasma viscosity The whole blood height is cut Cut in the whole blood Whole blood is low to be cut The whole blood reduced viscosity
Blank group 1.43±0.05 7.36±0.59 8.92±0.76 15.96±1.28 13.03±0.73
Model group 1.60±0.26 8.52±0.99 10.34±1.29 18.12±1.87 13.97±2.49
Low dose group 1.50±0.16 6.64±1.34 8.0±1.68 14.65±2.73 11.02±2.36
Middle dosage group 1.68±0.12 7.44±1.16 9.03±1.47 16.23±2.37 12.43±2.07
High dose group 1.69±0.35 7.40±1.11 8.98±1.45 16.21±2.68 12.11±1.56
The positive drug group 1.66±0.12 8.50±0.76 10.35±0.96 18.18±1.51 15.58±1.99
Continuous table 4 Rhizoma Gastrodiae Piracetam Capsule is to the hemorheological influence of focal rats with cerebral ischemia
Group Packed cell volume Erythrocyte aggregation index Deformable index The erythrocyte rigidity index
Blank group 0.49±0.04 11.18±0.89 0.99±0.06 8.51±0.44
Model group 0.54±0.05 11.43±1.13 0.91±0.12 8.17±1.83
Low dose group 0.51±0.07 9.81±2.02 0.88±0.13 6.79±2.10
Middle dosage group 0.52±0.02 9.73±1.38 0.87±0.07 6.69±1.33
High dose group 0.53±0.05 9.67±1.26* 0.85±0.07* 6.50±0.89*
The positive drug group 0.48±0.04 11.09±1.59 1.0±0.10 8.69±1.70
Compare with the blank group, and * p＜0.05 (n=10, X ± s); Compare #p＜0.05 with model group.
3.5 the Rhizoma Gastrodiae Piracetam Capsule is to the active influence of focal rats with cerebral ischemia Serum LDH: with the blank group relatively, model group rat blood serum LDH is active obviously to raise, middle and high dosage group of Rhizoma Gastrodiae Piracetam Capsule and model group comparison can obviously reduce LDH activity (p＜0.05), though low dose group and model group comparison LDH have reduction trend, but do not have obvious statistical significance (p＞0.05), the results are shown in Table 5.
Table 5 Rhizoma Gastrodiae Piracetam Capsule is to the active influence of focal rats with cerebral ischemia Serum LDH
Group Dosage (g/kg) Number of animals (only) The LDH activity (μ/L)
Blank group 10 350±188
Model group 10 1834±1240
Low dose group 0.375 10 948±123
Middle dosage group 0.75 10 752±149*
High dose group 1.5 10 705±176*
The positive drug group 0.012 10 819±41*
Compare with the blank group, and #p＜0.05 (n=10, X ± s); Compare * p＜0.05 with model group.
3.6 the Rhizoma Gastrodiae Piracetam Capsule is not seen obvious damage to the influence of focal rats with cerebral ischemia histopathology: sham operated rats HE dyeing cortex, cellularity is complete.The model group cellularity is impaired, and intercellular substance increases, the neuron edema.Low, the middle dosage group of Rhizoma Gastrodiae Piracetam Capsule is similar to model group, and the cortical cell damage pathological change due to the middle cerebral artery infraction is not had obvious influence.Rhizoma Gastrodiae Piracetam Capsule high dose group and model group compare, and cell injury obviously alleviates, rarely seen individual cells edema.
Sham operated rats Hippocampus CA1 district HE staining cell level is more, is evenly distributed, and arranges closely, and cellular morphology is complete.The model group cell is arranged loose, sees the cell cytosol engrain, the karyon pyknosis.Low, the middle dosage group of Rhizoma Gastrodiae Piracetam Capsule is similar to model group, but Rhizoma Gastrodiae Piracetam Capsule high dose group cellular morphology is complete, does not have obvious karyopyknosis, shows obviously to alleviate neuronal damage.
3.7 the Rhizoma Gastrodiae Piracetam Capsule is to the influence of rats with cerebral ischemia cerebral index, brain water content: with sham operated rats relatively, the model group brain water content significantly increases (p＜0.05), and cerebral index also has increase trend, but no significant difference.Obvious neurological handicap symptom and focus of infarct in various degree appear in the model group rat, can obviously reduce the infraction degree with model group comparison Rhizoma Gastrodiae Piracetam Capsule 0.75g/kg group, the administration of 1.5g/kg group, its nervous symptoms also obviously improves (p＜0.05), the results are shown in Table 6.
Table 6 Rhizoma Gastrodiae Piracetam Capsule is to the influence of rats with cerebral ischemia cerebral index, brain water content
Group Dosage (g/kg) Number of animals (only) Cerebral index (mg/g body weight) Brain water content (%)
Blank group 10 63±6.77 76±0.05
Model group 10 69±5.63 80±0.04
Low dose group 0.375 10 61±7.14 77±0.05
Middle dosage group 0.75 10 57±10.70* 75±0.06*
High dose group 1.5 10 62±7.70* 72±0.06*
The positive drug group 0.012 10 63±6.08* 68±0.06*
Compare with the blank group, and #p＜0.05 (n=10, X ± s); Compare * p＜0.05 with model group.
(2) influence hemorrhage to mice and blood coagulation of the present invention (Rhizoma Gastrodiae piracetam) capsule is tested
Test unit: pharmacology teaching and research room of Zunyi Medical College
1, experiment material
1.1 animal: Kunming mouse 18-22 gram, male and female half and half are provided by big level ground hospital of Third Military Medical University Experimental Animal Center, the quality certification number: CSXK (Chongqing) 2002003.
1.2 medicine: the Rhizoma Gastrodiae Piracetam Capsule is provided by Guiyang Liduo Drug Technology Development Co., Ltd., lot number: 0051001, and the 0.4g/ grain; Facing the time spent, to be made into suspension with distilled water standby; Nimodipine is a honest QINGCHUN BAO Pharma Inc. product, lot number: 0507001.
2, method and result
2.1 the Rhizoma Gastrodiae Piracetam Capsule is to the influence in mice docking bleeding time: 60 of mices, divide 5 groups at random, every group 12, male and female half and half promptly are divided into blank group, Rhizoma Gastrodiae Piracetam Capsule low dose group, middle dosage group, high dose group, positive drug group (nimodipine).Irritate stomach during experiment respectively and give Rhizoma Gastrodiae Piracetam Capsule (0.37g/kg, 0.75g/kg, 1.5g/kg), nimodipine 0.012g/kg, the blank group gives the equal-volume normal saline, every day 1 time, successive administration 5 days is put into mice the self-control fixed bin respectively in not inferior administration after 1 hour, it is fixing that the Mus tail stretches out the back, walk crosswise in tail point 0.5cm place and to cut off, blood flows out the back timing automatically, inhales with filter paper every 15s and dehematizes droplet once, stop until the blood nature of going out, and the record bleeding time.
The result shows that each administration group of Rhizoma Gastrodiae Piracetam Capsule compares no significant difference (p＞0.05) to mice bleeding time and matched group, the results are shown in Table 7.
Table 7 Rhizoma Gastrodiae Piracetam Capsule is to bleeding time of mice influence (x ± s)
Group Dosage (g/kg) Number of animals (only) Bleeding time (s)
Dosage group high dose group nimodipine in the matched group low dose group 0.375 0.75 1.5 0.012 10 10 10 10 10 10.5±2.5 12.4±4.1 10.2±2.1 8.50±2.2 12.3±2.3
Compare * p＜0.05 with matched group.
2.2 the Rhizoma Gastrodiae Piracetam Capsule is to the influence of clotting time of mice: grouping and medication are the same, adopt the blood capillary method to measure clotting time, respectively mice is fixed after 1 hour in not inferior administration, inserting mice angular vein clump with internal diameter 1mm capillary glass tube gets blood blood post to the capillary tube and reaches 5cm, fracture the capillary glass-tube once every 30s behind the 3min, inspection has or not the blood streak, calculates from the capillary tube blood sampling to the blood clotting silk time occurring.The result shows that each administration group of Rhizoma Gastrodiae Piracetam Capsule and matched group be no significant difference (p＞0.05) relatively, the results are shown in Table 8.
Table 8 Rhizoma Gastrodiae Piracetam Capsule is to the bleeding time influence of mice
Group Dosage (g/kg) Number of animals (only) Clotting time (s)
Dosage group high dose group nimodipine in the matched group low dose group 0.375 0.75 1.50 0.012 10 10 10 10 10 7.5±2.5 7.4±4.1 7.2±2.1 8.5±2.2 8.1±2.3
Compare * p＜0.05 with matched group.
(3) the present invention (Rhizoma Gastrodiae piracetam) capsule forms external thrombus and the influence of platelet aggregation is tested
Test unit: pharmacology teaching and research room of Zunyi Medical College
1, experiment material
1.1 animal: the SD rat, body weight 280-300g, male, provide the quality certification number by big level ground hospital of Third Military Medical University Experimental Animal Center: CSXK (Chongqing) 2002003.Rabbit, body weight 2.0 ± 0.2kg is provided by Zunyi Medical College's Experimental Animal Center.
1.2 medicine and reagent: be subjected to reagent: the Rhizoma Gastrodiae Piracetam Capsule is provided by Guiyang Liduo Drug Technology Development Co., Ltd., the 0.4g/ grain, and lot number: 0051001, prepare with Sal water before the experiment.Positive control drug: nimodipine is a Zhengda Qingchunbao Pharmaceutical Co., Ltd.Lot number: 0507001.Aspirin is an A fohnson Matthey company product, lot number: CAS#50-78-2.Adenosine diphosphate (ADP) is Shanghai Huamei Bio-Engrg Co., product, lot number: 961024.Thrombin is the The Biochemical Pharmaceutical Factory of Zhuhai SEZ product, lot number: 204007.Sodium citrate is Shanghai reagent one factory's product, lot number: 860903.
1.3 instrument: the precise electronic balance is company of a German DESAY product, LBJ Applause J2 blood pool instrument is that the general instrument in Beijing is given birth to the centre product, SHA-C temperature controlled water bath oscillator is sky, a Shenzhen Nan Shenghai north industrial corporation product, and the LXJ-B low speed large capacity centrifuge is last Hai'an booth instrument and equipment factory product.
2, experimental technique
2.1 the influence that the Rhizoma Gastrodiae Piracetam Capsule forms external thrombus
2.1.1 grouping and administration: rat is divided 5 groups at random, every group 10, be blank group (waiting the capacity normal saline), Rhizoma Gastrodiae Piracetam Capsule low dose group (0.375g/kg), middle agent group (0.75g/kg), high dose group (1.5g/kg) (be respectively clinical people's consumption 2.5,7.5,14 times), positive drug control group (nimodipine group 0.012g/kg).Gastric infusion, every day 1 time, successive administration 5 days, 60min promptly begins operation after the last administration.
2.1.2 modeling method: rats by intraperitoneal injection 10% chloral hydrate (350mg/kg) anesthesia, face upward the position and fix, separate right carotid.Get a polyethylene tube, long 100cm, internal diameter 0.2cm, one end inserts right neck artery, and the other end inserts left external jugular vein, is full of heparin 50U/ml in the pipe of two ends, interlude is put into one and longly is No. 0 surgical thread (weighing) of 8cm, sets up the bypass of arteriovenous thrombosis, takes off sleeve pipe behind the 20min, removal of thromboses, on moistening filter paper, remove unnecessary blood, on cellophane, claim its weight in wet base, be placed on then and toast 1 hour in 65 ℃ of baking boxs to constant weight, cooling is taken out and is weighed, and promptly gets the thrombosis dry weight.
2.2 the Rhizoma Gastrodiae Piracetam Capsule is to the influence of platelet aggregation
2.2.1 grouping and administration: get 25 of rabbit, be divided into 5 groups at random, be i.e. normal saline matched group, Rhizoma Gastrodiae Piracetam Capsule low dose group (0.75/kg), high dose group (1.5/kg), 5 every group.Gastric infusion, every day 1 time, successive administration 5 days, 1 hour begins to test after the last administration.
2.2.2 hematoblastic preparation: get above-mentioned rabbit and claim its body weight, with 3% barbital sodium (30mg/kg) auricular vein anesthesia, the left common carotid artery intubate get blood (blood: 3.8% sodium citrate=9: 1), with 800 rev/mins of centrifugal 10min, get supernatant, be platelet rich plasma (PRP).Remainder partly to get supernatant behind 4000 rev/mins of centrifugal 10min, is promptly got platelet poor plasma (PPP).With PPP PRP is adjusted to 4 * 10 9Stand-by.
2.2.3 the Rhizoma Gastrodiae Piracetam Capsule is to the accumulative influence of ADP induced platelet
Get the above-mentioned PRP 200ul that adjusts, after 37 ℃ of constant temperature are educated 5min, add ADP (1.5 * 10 -5Umol/L), use the turbidimetry for Determination platelet aggregation rate, platelet aggregation inhibition rate (AIR).
Calculate as follows:
Figure A20061020033800171
2.2.4 the Rhizoma Gastrodiae Piracetam Capsule is to the accumulative influence of Thr induced platelet: get the above-mentioned PRP200ul that adjusts, after 37 ℃ of constant temperature are educated 5min, add Thr (0.5u/ml), assay method is the same.
2.2.5 statistics: data are represented with X ± s, comparative control t check carrying out statistical analysis between the employing group.
3, experimental result
3.1 the influence that the Rhizoma Gastrodiae Piracetam Capsule forms external thrombus
The result shows, compares with the blank group, and the basic, normal, high dosage group of Rhizoma Gastrodiae Piracetam Capsule all can suppress thrombosis (p＜0.05) and the results are shown in Table 9.
Table 9 Rhizoma Gastrodiae Piracetam Capsule is to the thrombotic influence of rat arteriovenous shut (X ± s)
Group Dosage (g/kg) Number of animals (only) The wet amount of thrombosis (mg) Thrombosis dry measure (mg)
Dosage group high dose group nimodipine in the matched group low dose group 0.375 0.75 1.5 0.012 10 10 10 10 10 7.2±1.1 6.1±0.7* 5.8±1.0* 6.2±0.9* 6.1±0.7* 4.9±0.1 3.0±0.1* 2.8±0.3* 2.8±0.3* 2.7±0.4*
Compare * p＜0.05 with matched group.
3.2 the Rhizoma Gastrodiae Piracetam Capsule is to the influence of the inductive platelet aggregation of ADP
The result shows, compares with the normal saline group, and Rhizoma Gastrodiae Piracetam Capsule 0.75g/kg and 1.5g/kg group all can suppress the inductive platelet aggregation of ADP (P＜0.05), and low dose group is not seen obvious influence, the results are shown in Table 10.
Table 10 Rhizoma Gastrodiae Piracetam Capsule vivo medicine-feeding is to the little accumulative influence of the inductive blood of ADP (X ± s)
Group Dosage (g/kg) The different time platelet aggregation rate Maximum platelet aggregation rate
1min 3min 5min
Dosage group high dose group in the matched group low dose group 0.375 0.75 1.50 38±5.8 38±5.7 26±5.2** 22±11** 46±7.0 47±8.1 37.8±8.1** 37±9.5** 46±10.2 47±10.5 37±10** 37±10** 48±6.3 46±7.1 39±7.1** 38±9.4**
Compare * p＜0.05 with matched group.
3.3 the Rhizoma Gastrodiae Piracetam Capsule is to the influence of the inductive platelet aggregation of Thr
The result shows, compares with the normal saline group, and Rhizoma Gastrodiae Piracetam Capsule 1.5g/kg group can obviously suppress the inductive platelet aggregation of ADP (P＜0.05), and low dosage and middle dosage group are not seen obvious influence, the results are shown in Table 11:
Table 11 Rhizoma Gastrodiae Piracetam Capsule is to the influence of the inductive platelet aggregation of Thr
Group Dosage (g/kg) The aggregation rate of different time platelet The platelet maximum agglutination rate
1min 3min 5min
Dosage group high dose group in the matched group low dose group 0.375 0.75 1.50 23±21 20±17 21±18 12.±11** 73±12 69±11 70±11 52±10** 71±12 73±9.2 74±9.2 55±10** 79±9.7 77±7.1 76±7.0 58±9.4**
Compare * p＜0.05 with matched group.Effect, be used for.
Compared with prior art, preparation of the present invention has the endogenous wind stopping collateral dredging, blood circulation promoting and blood stasis dispelling, the effect of the meridian and relieving pain that relaxes, clinical practice is unable in one side of something of stroke in convalescent stage and apoplexy sequela, numb limbs and tense tendons, myalgia, Light-headedness, language is unable etc., and not having obvious toxic-side effects, is a kind of new Chinese medicine of safe, effective, quality controllable treatment apoplexy, is worth clinical application.
The specific embodiment:
Embodiments of the invention 1: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g
Get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici decocts with water 2 times, decocts 2 hours at every turn, filters, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing, with an amount of 95% alcohol granulation, in 60 ℃ of dryings, granulate incapsulates, make 1000, promptly.Nomenclature of drug: Rhizoma Gastrodiae Piracetam Capsule; Specification: every dress 0.4g; Usage and dosage: oral, one time 2～3,3 times on the one.
Embodiments of the invention 2: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae and Ramulus Uncariae Cum Uncis, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, drying under reduced pressure, pulverize, cross 120 mesh sieves, other gets soybean oil and Cera Flava, in 80 ℃ of heating and meltings, be chilled to room temperature after, add above-mentioned extract powder, through the colloid mill mix homogeneously, 1000 soft capsules are made in fill, setting, drying, promptly.Nomenclature of drug: Rhizoma Gastrodiae piracetam soft capsule; Specification: every dress 0.6g; Usage and dosage: oral, one time 2～3,3 times on the one.
Embodiments of the invention 3: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g, Cortex Eucommiae 67g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis and the Cortex Eucommiae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, adds an amount of ethanol, shake up, left standstill 24 hours, filter, filtrate recycling ethanol and concentrating under reduced pressure (0.06～-0.08Mpa, 80 ℃) to relative density be the extractum of 1.30 (80 ℃), drying under reduced pressure (0.06～-0.08Mpa, 70 ℃), pulverize, cross 120 mesh sieves, get extract powder.Other gets PEG6000, in 80 ℃ of heating and meltings, be chilled to room temperature after, add above-mentioned extract powder, through the colloid mill mix homogeneously, drip and to make 1000 drop pill, setting, drying, promptly.Nomenclature of drug: Rhizoma Gastrodiae piracetam drop pill; Specification: every heavy 45mg; Usage and dosage: oral, one time 20,3 times on the one.
Embodiments of the invention 4: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 200g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Fructus Ligustri Lucidi 133g, Caulis Spatholobi 167g, Spica Prunellae 200g
Get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae decoct with water 2 times, decoct 2 hours at every turn, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing, with an amount of 95% alcohol granulation, in 60 ℃ of dryings, granulate, tabletting, coating is made 1000, promptly.Nomenclature of drug: Rhizoma Gastrodiae Piracetam Tablet; Specification: every heavy 0.4g; Usage and dosage: oral, one time 2～3,3 times on the one.
Embodiments of the invention 5: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 200g, Rhizoma Polygoni Cuspidati 200g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Fructus Ligustri Lucidi 133g, Caulis Spatholobi 167g, Spica Prunellae 200g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and drying under reduced pressure is pulverized, cross 80 mesh sieves, add right amount of auxiliary materials, the system granule is in 60 ℃ of dryings, make 1000g, promptly.Nomenclature of drug: Rhizoma Gastrodiae piracetam granule; Specification: every packed 10g; Usage and dosage: oral, a 10g, 3 times on the one.
Embodiments of the invention 6: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Cortex Eucommiae 67g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 200g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Folium Ilicis 53g, Flos Carthami 53g, Spica Prunellae 200g, Herba Lycopodii 53g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ilicis, Flos Carthami, Spica Prunellae and Herba Lycopodii, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, adds an amount of ethanol, shake up, left standstill 24 hours, filter, filtrate recycling ethanol and concentrating under reduced pressure (0.06～-0.08Mpa, 80 ℃) to about 800ml, filter, add right amount of auxiliary materials, add water to 1000ml, stir evenly, fill, promptly.Nomenclature of drug: Rhizoma Gastrodiae piracetam oral liquid; Specification: every bottled 10ml; Usage and dosage: oral, a 10ml, 3 times on the one.
Embodiments of the invention 7: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Cortex Eucommiae 67g, largespike woodnettle root 200g, Rhizoma Polygoni Cuspidati 200g, Ramulus Uncariae Cum Uncis 100g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Fructus Ligustri Lucidi 133g, Caulis Spatholobi 167g, Folium Ilicis 53g, Flos Carthami 53g, Spica Prunellae 200g, Herba Lycopodii 53g, Lycopodium clavatum 53g
Get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi, Folium Ilicis, Flos Carthami, Spica Prunellae, Herba Lycopodii and Lycopodium clavatum decoct with water 2 times, decoct 2 hours at every turn, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing, with an amount of 95% alcohol granulation, in 60 ℃ of dryings, granulate incapsulates, make 1000, promptly get the Rhizoma Gastrodiae Piracetam Capsule.
Embodiments of the invention 8: Radix seu Herba Gei aleppici 270g, Rhizoma Gastrodiae 30g
Get Radix seu Herba Gei aleppici and Rhizoma Gastrodiae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, drying under reduced pressure, pulverize, cross 120 mesh sieves, other gets soybean oil and Cera Flava, in 80 ℃ of heating and meltings, be chilled to room temperature after, add above-mentioned extract powder, through the colloid mill mix homogeneously, 1000 soft capsules are made in fill, setting, drying promptly gets Rhizoma Gastrodiae piracetam soft capsule.
Embodiments of the invention 9: Radix seu Herba Gei aleppici 60g, Rhizoma Gastrodiae 240g
Get Radix seu Herba Gei aleppici and Rhizoma Gastrodiae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, adds an amount of ethanol, shake up, left standstill 24 hours, filter, filtrate recycling ethanol and concentrating under reduced pressure (0.06～-0.08Mpa, 80 ℃) to relative density be the extractum of 1.30 (80 ℃), drying under reduced pressure (0.06～-0.08Mpa, 70 ℃), pulverize, cross 120 mesh sieves, get extract powder.Other gets PEG6000, in 80 ℃ of heating and meltings, be chilled to room temperature after, add above-mentioned extract powder, through the colloid mill mix homogeneously, drip and to make 1000 drop pill, setting, drying promptly gets Rhizoma Gastrodiae piracetam drop pill.
Embodiments of the invention 10: Radix seu Herba Gei aleppici 100g, Rhizoma Gastrodiae 700g, Ramulus Uncariae Cum Uncis 100g
Get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici and Ramulus Uncariae Cum Uncis decoct with water 2 times, decoct 2 hours at every turn, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing, with an amount of 95% alcohol granulation, in 60 ℃ of dryings, granulate, tabletting, coating is made 1000, promptly gets the Rhizoma Gastrodiae Piracetam Tablet.
Embodiments of the invention 11: Radix seu Herba Gei aleppici 168g, Rhizoma Gastrodiae 21g, Ramulus Uncariae Cum Uncis 126g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae and Ramulus Uncariae Cum Uncis, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, drying under reduced pressure is pulverized, and crosses 80 mesh sieves, adds right amount of auxiliary materials, the system granule in 60 ℃ of dryings, is made 1000g, promptly gets Rhizoma Gastrodiae piracetam granule.
Embodiments of the invention 12: Radix seu Herba Gei aleppici 100g, Rhizoma Gastrodiae 500g, Ramulus Uncariae Cum Uncis 100g, Cortex Eucommiae 300g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis and the Cortex Eucommiae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, adds an amount of ethanol, shake up, left standstill 24 hours, filter, filtrate recycling ethanol and concentrating under reduced pressure (0.06～-0.08Mpa, 80 ℃) to about 800ml, filter, add right amount of auxiliary materials, add water to 1000ml, stir evenly, fill promptly gets Rhizoma Gastrodiae piracetam oral liquid.
Embodiments of the invention 13: Radix seu Herba Gei aleppici 560g, Rhizoma Gastrodiae 80g, Ramulus Uncariae Cum Uncis 320g, Cortex Eucommiae 80g
Get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, Ramulus Uncariae Cum Uncis and the Cortex Eucommiae decoct with water 2 times, decoct 2 hours at every turn, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing, with an amount of 95% alcohol granulation, in 60 ℃ of dryings, granulate incapsulates, make 1000, promptly get the Rhizoma Gastrodiae Piracetam Capsule.
Embodiments of the invention 14: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 134g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 167g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 167g, Fructus Ligustri Lucidi 134g, Caulis Spatholobi 167g, Spica Prunellae 167g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, drying under reduced pressure, pulverize, cross 120 mesh sieves, other gets soybean oil and Cera Flava, in 80 ℃ of heating and meltings, be chilled to room temperature after, add above-mentioned extract powder, through the colloid mill mix homogeneously, 1000 soft capsules are made in fill, setting, drying promptly gets Rhizoma Gastrodiae piracetam soft capsule.
Embodiments of the invention 15: Radix seu Herba Gei aleppici 168g, Rhizoma Gastrodiae 140g, Ramulus Uncariae Cum Uncis 84g, largespike woodnettle root 224g, Radix Salviae Miltiorrhizae 168g, Radix Astragali 224g, Fructus Ligustri Lucidi 140g, Caulis Spatholobi 168g, Spica Prunellae 224g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, adds an amount of ethanol, shake up, left standstill 24 hours, filter, filtrate recycling ethanol and concentrating under reduced pressure (0.06～-0.08Mpa, 80 ℃) to relative density be the extractum of 1.30 (80 ℃), drying under reduced pressure (0.06～-0.08Mpa, 70 ℃), pulverize, cross 120 mesh sieves, get extract powder.Other gets PEG6000, in 80 ℃ of heating and meltings, be chilled to room temperature after, add above-mentioned extract powder, through the colloid mill mix homogeneously, drip and to make 1000 drop pill, setting, drying promptly gets Rhizoma Gastrodiae piracetam drop pill.
Embodiments of the invention 16: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 134g, Ramulus Uncariae Cum Uncis 67g, largespike woodnettle root 167g, Rhizoma Polygoni Cuspidati 167g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 167g, Fructus Ligustri Lucidi 134g, Caulis Spatholobi 167g, Spica Prunellae 167g
Get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae decoct with water 2 times, decoct 2 hours at every turn, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing, with an amount of 95% alcohol granulation, in 60 ℃ of dryings, granulate, tabletting, coating is made 1000, promptly gets the Rhizoma Gastrodiae Piracetam Tablet.
Embodiments of the invention 17: Radix seu Herba Gei aleppici 168g, Rhizoma Gastrodiae 112g, Ramulus Uncariae Cum Uncis 56g, largespike woodnettle root 224g, Rhizoma Polygoni Cuspidati 224g, Radix Salviae Miltiorrhizae 168g, Radix Astragali 224g, Fructus Ligustri Lucidi 112g, Caulis Spatholobi 168g, Spica Prunellae 224g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and drying under reduced pressure is pulverized, cross 80 mesh sieves, add right amount of auxiliary materials, the system granule is in 60 ℃ of dryings, make 1000g, promptly get Rhizoma Gastrodiae piracetam granule.
Embodiments of the invention 18: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 134g, Cortex Eucommiae 67g, Ramulus Uncariae Cum Uncis 67g, largespike woodnettle root 167g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 167g, Folium Ilicis 67g, Flos Carthami 67g, Spica Prunellae 167g, Herba Lycopodii 67g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ilicis, Flos Carthami, Spica Prunellae and Herba Lycopodii, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, adds an amount of ethanol, shake up, left standstill 24 hours, filter, filtrate recycling ethanol and concentrating under reduced pressure (0.06～-0.08Mpa, 80 ℃) to about 800ml, filter, add right amount of auxiliary materials, add water to 1000ml, stir evenly, fill promptly gets Rhizoma Gastrodiae piracetam oral liquid.
Embodiments of the invention 19: Radix seu Herba Gei aleppici 168g, Rhizoma Gastrodiae 112g, Cortex Eucommiae 56g, Ramulus Uncariae Cum Uncis 84g, largespike woodnettle root 224g, Radix Salviae Miltiorrhizae 168g, Radix Astragali 224g, Folium Ilicis 56g, Flos Carthami 56g, Spica Prunellae 224g, Herba Lycopodii 56g
Get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ilicis, Flos Carthami, Spica Prunellae and Herba Lycopodii decoct with water 2 times, decoct 2 hours at every turn, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing, with an amount of 95% alcohol granulation, in 60 ℃ of dryings, granulate incapsulates, make 1000, promptly get the Rhizoma Gastrodiae Piracetam Capsule.
Embodiments of the invention 20: Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 100g, Cortex Eucommiae 67g, largespike woodnettle root 167g, Rhizoma Polygoni Cuspidati 167g, Ramulus Uncariae Cum Uncis 100g, Radix Salviae Miltiorrhizae 134g, Radix Astragali 167g, Fructus Ligustri Lucidi 100g, Caulis Spatholobi 134g, Folium Ilicis 67g, Flos Carthami 67g, Spica Prunellae 167g, Herba Lycopodii 67g, Lycopodium clavatum 67g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi, Folium Ilicis, Flos Carthami, Spica Prunellae, Herba Lycopodii and Lycopodium clavatum, decoct with water 2 times, the each decoction 2 hours, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, drying under reduced pressure, pulverize, cross 120 mesh sieves, other gets soybean oil and Cera Flava, in 80 ℃ of heating and meltings, after being chilled to room temperature, add above-mentioned extract powder, through colloid mill mix homogeneously, fill, make 1000 soft capsules, setting, drying promptly gets Rhizoma Gastrodiae piracetam soft capsule.
Embodiments of the invention 21: Radix seu Herba Gei aleppici 168g, Rhizoma Gastrodiae 126g, Cortex Eucommiae 84g, largespike woodnettle root 210g, Rhizoma Polygoni Cuspidati 210g, Ramulus Uncariae Cum Uncis 84g, Radix Salviae Miltiorrhizae 168g, Radix Astragali 210g, Fructus Ligustri Lucidi 126g, Caulis Spatholobi 168g, Folium Ilicis 67g, Flos Carthami 67g, Spica Prunellae 210g, Herba Lycopodii 67g, Lycopodium clavatum 67g
Get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi, Folium Ilicis, Flos Carthami, Spica Prunellae, Herba Lycopodii and Lycopodium clavatum, decoct with water 2 times, the each decoction 2 hours, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, add an amount of ethanol, shake up, left standstill 24 hours, filter, filtrate recycling ethanol and concentrating under reduced pressure (0.06～-0.08Mpa, 80 ℃) to relative density be the extractum of 1.30 (80 ℃), drying under reduced pressure (0.06～-0.08Mpa, 70 ℃), pulverize, cross 120 mesh sieves, get extract powder.Other gets PEG6000, in 80 ℃ of heating and meltings, be chilled to room temperature after, add above-mentioned extract powder, through the colloid mill mix homogeneously, drip and to make 1000 drop pill, setting, drying promptly gets Rhizoma Gastrodiae piracetam drop pill.

Claims (22)

1. Chinese medicine preparation for the treatment of apoplexy, it is characterized in that: it is mainly made by the crude drug of following weight ratio example: Radix seu Herba Gei aleppici 20%～90% and Rhizoma Gastrodiae 10%～80%.
2. according to the Chinese medicine preparation of the described treatment apoplexy of claim 1, it is characterized in that: the consumption of crude drug is preferably Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g.
3. treat the preparation method of the Chinese medicine preparation of apoplexy as claimed in claim 1 or 2, it is characterized in that: get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici decocts with water 2 times, decocts 2 hours at every turn, filters, and it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, and cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing; Perhaps get Radix seu Herba Gei aleppici and Rhizoma Gastrodiae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
4. according to the Chinese medicine preparation of the described treatment apoplexy of claim 1, it is characterized in that: wherein crude drug also has Ramulus Uncariae Cum Uncis, and the part by weight of each component is: Radix seu Herba Gei aleppici 10%～80%, Rhizoma Gastrodiae 10%～70%, Ramulus Uncariae Cum Uncis 10%～60%.
5. according to the Chinese medicine preparation of the described treatment apoplexy of claim 4, it is characterized in that: the consumption of each component is preferably Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g.
6. as the preparation method of the Chinese medicine preparation of treatment apoplexy as described in claim 4 or 5, it is characterized in that: get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici and Ramulus Uncariae Cum Uncis decoct with water 2 times, decoct 2 hours at every turn, filter, and it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, and cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae and Ramulus Uncariae Cum Uncis, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
7. according to the Chinese medicine preparation of the described treatment apoplexy of claim 4, it is characterized in that: wherein crude drug also has the Cortex Eucommiae, and the part by weight of each component is: Radix seu Herba Gei aleppici 10%～70%, Rhizoma Gastrodiae 10%～50%, Ramulus Uncariae Cum Uncis 10%～40%, the Cortex Eucommiae 10%～30%.
8. according to the Chinese medicine preparation of the described treatment apoplexy of claim 7, it is characterized in that: the consumption of each component is preferably Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g, Cortex Eucommiae 67g.
9. as the preparation method of the Chinese medicine preparation of treatment apoplexy as described in claim 7 or 8, it is characterized in that: get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, Ramulus Uncariae Cum Uncis and the Cortex Eucommiae decoct with water 2 times, decoct 2 hours at every turn, filter, and it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, and cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis and the Cortex Eucommiae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
10. according to the Chinese medicine preparation of the described treatment apoplexy of claim 4, it is characterized in that: wherein crude drug also has largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae, and the part by weight of each component is: Radix seu Herba Gei aleppici 5%～30%, Rhizoma Gastrodiae 4%～25%, Ramulus Uncariae Cum Uncis 3%～15%, largespike woodnettle root 5%～40%, Radix Salviae Miltiorrhizae 5%～30%, the Radix Astragali 5%～40%, Fructus Ligustri Lucidi 4%～25%, Caulis Spatholobi 5%～30%, Spica Prunellae 5%～40%.
11. the Chinese medicine preparation according to the described treatment apoplexy of claim 10 is characterized in that: the consumption of each component is preferably Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 200g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Fructus Ligustri Lucidi 133g, Caulis Spatholobi 167g, Spica Prunellae 200g.
12. the preparation method as the Chinese medicine preparation of treatment apoplexy as described in claim 10 or 11 is characterized in that: get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae decoct with water 2 times, decoct 2 hours at every turn, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
13. Chinese medicine preparation according to the described treatment apoplexy of claim 10, it is characterized in that: wherein crude drug also has Rhizoma Polygoni Cuspidati, and the part by weight of each component is: Radix seu Herba Gei aleppici 5%～30%, Rhizoma Gastrodiae 4%～20%, Ramulus Uncariae Cum Uncis 2%～10%, largespike woodnettle root 5%～40%, Rhizoma Polygoni Cuspidati 5%～40%, Radix Salviae Miltiorrhizae 5%～30%, the Radix Astragali 5%～40%, Fructus Ligustri Lucidi 4%～20%, Caulis Spatholobi 5%～30%, Spica Prunellae 5%～40%.
14. the Chinese medicine preparation according to the described treatment apoplexy of claim 13 is characterized in that: the consumption of each component is preferably Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 200g, Rhizoma Polygoni Cuspidati 200g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Fructus Ligustri Lucidi 133g, Caulis Spatholobi 167g, Spica Prunellae 200g.
15. the preparation method as the Chinese medicine preparation of treatment apoplexy as described in claim 13 or 14 is characterized in that: get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae decoct with water 2 times, decoct 2 hours at every turn, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, and 60 ℃ of drying under reduced pressure are pulverized, cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi and Spica Prunellae, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
16. Chinese medicine preparation according to the described treatment apoplexy of claim 7, it is characterized in that: wherein crude drug also has largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ilicis, Flos Carthami, Spica Prunellae, Herba Lycopodii, and the part by weight of each component is: Radix seu Herba Gei aleppici 5%～30%, Rhizoma Gastrodiae 4%～20%, the Cortex Eucommiae 2%～10%, Ramulus Uncariae Cum Uncis 2%～15%, largespike woodnettle root 5%～40%, Radix Salviae Miltiorrhizae 5%～30%, the Radix Astragali 5%～40%, Folium Ilicis 2%～10%, Flos Carthami 2%～10%, Spica Prunellae 5%～40%, Herba Lycopodii 2%～10%.
17. the Chinese medicine preparation according to the described treatment apoplexy of claim 16 is characterized in that: the consumption of each component is preferably Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Cortex Eucommiae 67g, Ramulus Uncariae Cum Uncis 100g, largespike woodnettle root 200g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Folium Ilicis 53g, Flos Carthami 53g, Spica Prunellae 200g, Herba Lycopodii 53g.
18. the preparation method as the Chinese medicine preparation of treatment apoplexy as described in claim 16 or 17 is characterized in that: get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ilicis, Flos Carthami, Spica Prunellae and Herba Lycopodii decoct with water 2 times, the each decoction 2 hours, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, 60 ℃ of drying under reduced pressure are pulverized, and cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Radix Salviae Miltiorrhizae, the Radix Astragali, Folium Ilicis, Flos Carthami, Spica Prunellae and Herba Lycopodii, decoct with water 2 times, decocted 2 hours at every turn, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
19. the Chinese medicine preparation according to claim 13 or 16 described treatment apoplexy is characterized in that: crude drug comprises the medical material of following part by weight: Radix seu Herba Gei aleppici 5%～20%, Rhizoma Gastrodiae 3%～15%, the Cortex Eucommiae 2%～10%, Ramulus Uncariae Cum Uncis 3%～10%, largespike woodnettle root 5%～25%, Rhizoma Polygoni Cuspidati 5%～25%, Radix Salviae Miltiorrhizae 4%～20%, the Radix Astragali 5%～25%, Fructus Ligustri Lucidi 3%～15%, Caulis Spatholobi 4%～20%, Folium Ilicis 2%～8%, Flos Carthami 2%～8%, Spica Prunellae 5%～25%, Herba Lycopodii 2%～8%, Lycopodium clavatum 2%～8%.
20. the Chinese medicine preparation according to the described treatment apoplexy of claim 19 is characterized in that: the consumption of each component is preferably Radix seu Herba Gei aleppici 167g, Rhizoma Gastrodiae 133g, Cortex Eucommiae 67g, largespike woodnettle root 200g, Rhizoma Polygoni Cuspidati 200g, Ramulus Uncariae Cum Uncis 100g, Radix Salviae Miltiorrhizae 167g, Radix Astragali 200g, Fructus Ligustri Lucidi 133g, Caulis Spatholobi 167g, Folium Ilicis 53g, Flos Carthami 53g, Spica Prunellae 200g, Herba Lycopodii 53g, Lycopodium clavatum 53g.
21. the preparation method as the Chinese medicine preparation of treatment apoplexy as described in claim 19 or 20 is characterized in that: get Rhizoma Gastrodiae and pulverize, cross 100 mesh sieves, standby; Radix seu Herba Gei aleppici, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi, Folium Ilicis, Flos Carthami, Spica Prunellae, Herba Lycopodii and Lycopodium clavatum decoct with water 2 times, the each decoction 2 hours, filter, it is 1.30 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities, 60 ℃ of drying under reduced pressure are pulverized, and cross 80 mesh sieves, add Rhizoma Gastrodiae fine powder, mixing; Perhaps get Radix seu Herba Gei aleppici, Rhizoma Gastrodiae, the Cortex Eucommiae, Ramulus Uncariae Cum Uncis, largespike woodnettle root, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Astragali, Fructus Ligustri Lucidi, Caulis Spatholobi, Folium Ilicis, Flos Carthami, Spica Prunellae, Herba Lycopodii and Lycopodium clavatum, decoct with water 2 times, the each decoction 2 hours, filter, it is 1.25 extractum that filtrate decompression is concentrated into 60 ℃ of relative densities; Add suitable adjuvant then and make different preparations.
22. the Chinese medicine preparation according to the described treatment apoplexy of claim 1 is characterized in that: described pharmaceutical preparation is granule, powder, oral liquid, mixture, syrup, soft extract, pill, various tablet, hard capsule, soft capsule or drop pill and other peroral dosage form.
CN200610200338A 2006-04-12 2006-04-12 Apoplexy treating Chinese medicine preparation and its preparing process Expired - Fee Related CN1857627B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102573865A (en) * 2009-06-12 2012-07-11 基因雷克斯制药有限公司 Composition used to prevent and treat red blood cell coagulation
CN103142978A (en) * 2013-03-22 2013-06-12 邓广博 Medicine for treating peripheral facial paralysis
CN107890469A (en) * 2017-12-29 2018-04-10 三峡大学 A kind of biological active constituents from natural medicines composition of anti-cerebral ischemia reperfusion injury and preparation method and application

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202852C (en) * 2003-01-07 2005-05-25 贵州民族制药厂 Traditional Chinese medicine for treating wind-cold type of common cold and preparation process thereof
CN1296087C (en) * 2004-10-15 2007-01-24 北京国仁堂医药科技发展有限公司 Compound capsule for treating apoplexy involving the meridians of wind phlegm stasis blockage syndrome type and preparation process thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102573865A (en) * 2009-06-12 2012-07-11 基因雷克斯制药有限公司 Composition used to prevent and treat red blood cell coagulation
CN102573865B (en) * 2009-06-12 2016-08-24 基因雷克斯制药有限公司 Composition used to prevent and treat red blood cell coagulation
CN103142978A (en) * 2013-03-22 2013-06-12 邓广博 Medicine for treating peripheral facial paralysis
CN107890469A (en) * 2017-12-29 2018-04-10 三峡大学 A kind of biological active constituents from natural medicines composition of anti-cerebral ischemia reperfusion injury and preparation method and application

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