CN1852717A - 治疗骨质稀少或雄性骨质疏松的2-亚烷基-19-去甲-维生素d衍生物 - Google Patents
治疗骨质稀少或雄性骨质疏松的2-亚烷基-19-去甲-维生素d衍生物 Download PDFInfo
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- CN1852717A CN1852717A CNA200480026946XA CN200480026946A CN1852717A CN 1852717 A CN1852717 A CN 1852717A CN A200480026946X A CNA200480026946X A CN A200480026946XA CN 200480026946 A CN200480026946 A CN 200480026946A CN 1852717 A CN1852717 A CN 1852717A
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- 238000001953 recrystallisation Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 108010079522 solysime Proteins 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229930193551 sterin Natural products 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- BBDNZMUIQBRBJH-UHFFFAOYSA-N sulfurochloridic acid;toluene Chemical compound OS(Cl)(=O)=O.CC1=CC=CC=C1 BBDNZMUIQBRBJH-UHFFFAOYSA-N 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
- 238000007070 tosylation reaction Methods 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 125000005853 β-dimethylaminoethyl group Chemical group 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
肠钙转运和血清钙(骨钙动员)活性对长期剂量的19-去甲-1,25-(OH)2D3的2-亚甲基衍生物及其20S异构体的反应 | |||
组 | 剂量(pmol/天/7天) | 肠钙转运(S/M) | 血清钙(mg/100ml) |
维生素D缺乏1,25-(OH)2D3治疗的2-亚甲基-19-去甲-1,25-(OH)2D32-亚甲基-19-去甲-20S-1,25-(OH)2D3 | 载体260130260130260 | 5.5±0.26.2±0.45.3±0.44.9±0.65.7±0.84.6±0.7 | 5.1±0.167.2±0.59.9±0.29.6±0.313.8±0.514.4±0.6 |
肠钙转运和血清钙(骨钙动员)活性对长期剂量的19-去甲-1,25-(OH)2D3的2-亚甲基衍生物及其20S异构体的反应 | ||
组 | 肠钙转运(S/M) | 血清钙(mg/100ml) |
-D对照1,25-(OH)2D32-亚甲基-19-去甲-1,25-(OH)2D32-亚甲基-19-去甲-20S-1,25-(OH)2D3 | 4.2±0.35.8±0.35.3±0.55.5±0.6 | 4.7±0.15.7±0.26.4±0.18.0±0.1 |
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50450803P | 2003-09-19 | 2003-09-19 | |
US60/504,508 | 2003-09-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1852717A true CN1852717A (zh) | 2006-10-25 |
CN100413507C CN100413507C (zh) | 2008-08-27 |
Family
ID=34375510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNB200480026946XA Expired - Fee Related CN100413507C (zh) | 2003-09-19 | 2004-09-06 | 治疗骨质稀少或雄性骨质疏松的2-亚烷基-19-去甲-维生素d衍生物 |
Country Status (17)
Country | Link |
---|---|
US (1) | US20050065125A1 (zh) |
EP (1) | EP1667690A1 (zh) |
JP (1) | JP2007505884A (zh) |
KR (1) | KR20060058135A (zh) |
CN (1) | CN100413507C (zh) |
AU (1) | AU2004273667A1 (zh) |
BR (1) | BRPI0414465A (zh) |
CA (1) | CA2539358A1 (zh) |
HK (1) | HK1092063A1 (zh) |
IL (1) | IL173653A0 (zh) |
MX (1) | MXPA06003156A (zh) |
NO (1) | NO20060655L (zh) |
NZ (1) | NZ545393A (zh) |
RU (1) | RU2006108528A (zh) |
TW (1) | TW200512000A (zh) |
WO (1) | WO2005027917A1 (zh) |
ZA (1) | ZA200602258B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106857403A (zh) * | 2017-03-22 | 2017-06-20 | 广东海洋大学 | 25‑oh‑d3促进1‑21日龄白羽肉鸡胫骨发育的应用 |
CN106974078A (zh) * | 2017-03-22 | 2017-07-25 | 广东海洋大学 | 25‑oh‑d3促进21‑42日龄白羽肉鸡胫骨发育的应用 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006227816B2 (en) | 2005-03-15 | 2012-04-05 | Allergan, Inc. | Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems |
WO2012112420A1 (en) | 2011-02-14 | 2012-08-23 | Allergan, Inc. | Treatments using psma ligand endopeptidases |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
JP2898882B2 (ja) * | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | 2−位に置換基を有する19−ノル−ビタミンd3 化合物 |
US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
DE19935771A1 (de) * | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
AU776755B2 (en) * | 2000-01-31 | 2004-09-23 | Leo Pharma A/S | Use of vitamin D-derivatives in the treatment of osteoporosis and related bone disorders, as well as novel vitamin D3-derivatives |
US6806262B2 (en) * | 2000-05-31 | 2004-10-19 | Wisconsin Alumni Research Foundation | 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds |
US20030195175A1 (en) * | 2002-03-25 | 2003-10-16 | Deluca Hector F. | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
-
2004
- 2004-09-06 JP JP2006526716A patent/JP2007505884A/ja active Pending
- 2004-09-06 BR BRPI0414465-1A patent/BRPI0414465A/pt not_active IP Right Cessation
- 2004-09-06 WO PCT/IB2004/002912 patent/WO2005027917A1/en active Application Filing
- 2004-09-06 KR KR1020067005462A patent/KR20060058135A/ko not_active Application Discontinuation
- 2004-09-06 NZ NZ545393A patent/NZ545393A/en unknown
- 2004-09-06 RU RU2006108528/14A patent/RU2006108528A/ru unknown
- 2004-09-06 AU AU2004273667A patent/AU2004273667A1/en not_active Abandoned
- 2004-09-06 EP EP04769311A patent/EP1667690A1/en not_active Ceased
- 2004-09-06 CN CNB200480026946XA patent/CN100413507C/zh not_active Expired - Fee Related
- 2004-09-06 MX MXPA06003156A patent/MXPA06003156A/es unknown
- 2004-09-06 CA CA002539358A patent/CA2539358A1/en not_active Abandoned
- 2004-09-15 TW TW093127917A patent/TW200512000A/zh unknown
- 2004-09-16 US US10/942,377 patent/US20050065125A1/en not_active Abandoned
-
2006
- 2006-02-09 IL IL173653A patent/IL173653A0/en unknown
- 2006-02-09 NO NO20060655A patent/NO20060655L/no not_active Application Discontinuation
- 2006-03-17 ZA ZA200602258A patent/ZA200602258B/en unknown
- 2006-11-23 HK HK06112845.6A patent/HK1092063A1/xx not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106857403A (zh) * | 2017-03-22 | 2017-06-20 | 广东海洋大学 | 25‑oh‑d3促进1‑21日龄白羽肉鸡胫骨发育的应用 |
CN106974078A (zh) * | 2017-03-22 | 2017-07-25 | 广东海洋大学 | 25‑oh‑d3促进21‑42日龄白羽肉鸡胫骨发育的应用 |
Also Published As
Publication number | Publication date |
---|---|
WO2005027917A1 (en) | 2005-03-31 |
TW200512000A (en) | 2005-04-01 |
HK1092063A1 (en) | 2007-02-02 |
JP2007505884A (ja) | 2007-03-15 |
NZ545393A (en) | 2009-10-30 |
ZA200602258B (en) | 2007-11-28 |
IL173653A0 (en) | 2006-07-05 |
CA2539358A1 (en) | 2005-03-31 |
EP1667690A1 (en) | 2006-06-14 |
BRPI0414465A (pt) | 2006-11-14 |
CN100413507C (zh) | 2008-08-27 |
RU2006108528A (ru) | 2006-07-27 |
US20050065125A1 (en) | 2005-03-24 |
NO20060655L (no) | 2006-06-16 |
KR20060058135A (ko) | 2006-05-29 |
MXPA06003156A (es) | 2006-06-05 |
AU2004273667A1 (en) | 2005-03-31 |
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